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Mutational patterns correlate with genome organization in SARS and other coronaviruses

Identifieur interne : 000721 ( Ncbi/Curation ); précédent : 000720; suivant : 000722

Mutational patterns correlate with genome organization in SARS and other coronaviruses

Auteurs : Andrei Grigoriev

Source :

RBID : PMC:7127256

Descripteurs français

English descriptors

Abstract

Focused efforts by several international laboratories have resulted in the sequencing of the genome of the causative agent of severe acute respiratory syndrome (SARS), novel coronavirus SARS-CoV, in record time. Using cumulative skew diagrams, I found that mutational patterns in the SARS-CoV genome were strikingly different from other coronaviruses in terms of mutation rates, although they were in general agreement with the model of the coronavirus lifecycle. These findings might be relevant for the development of sequence-based diagnostics and the design of agents to treat SARS.


Url:
DOI: 10.1016/j.tig.2004.01.009
PubMed: 15049309
PubMed Central: 7127256

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PMC:7127256

Le document en format XML

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<p>Focused efforts by several international laboratories have resulted in the sequencing of the genome of the causative agent of severe acute respiratory syndrome (SARS), novel coronavirus SARS-CoV, in record time. Using cumulative skew diagrams, I found that mutational patterns in the SARS-CoV genome were strikingly different from other coronaviruses in terms of mutation rates, although they were in general agreement with the model of the coronavirus lifecycle. These findings might be relevant for the development of sequence-based diagnostics and the design of agents to treat SARS.</p>
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