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Mutational patterns correlate with genome organization in SARS and other coronaviruses.

Identifieur interne : 002E77 ( PubMed/Curation ); précédent : 002E76; suivant : 002E78

Mutational patterns correlate with genome organization in SARS and other coronaviruses.

Auteurs : Andrei Grigoriev [Allemagne]

Source :

Trends in genetics : TIG [ 0168-9525 ] ; 2004.

RBID : pubmed:15049309

Descripteurs français

KwdFr :
- Coronavirus (génétique), Exons, Gènes viraux (génétique), Génome viral, Introns, Mutation (génétique), Virus du SRAS (génétique).
MESH :
- génétique : Coronavirus, Gènes viraux, Mutation, Virus du SRAS.
- Exons, Génome viral, Introns.

English descriptors

KwdEn :
- Coronavirus (genetics), Exons, Genes, Viral (genetics), Genome, Viral, Introns, Mutation (genetics), SARS Virus (genetics).
MESH :
- genetics : Coronavirus, Genes, Viral, Mutation, SARS Virus.
- Exons, Genome, Viral, Introns.

Abstract

Focused efforts by several international laboratories have resulted in the sequencing of the genome of the causative agent of severe acute respiratory syndrome (SARS), novel coronavirus SARS-CoV, in record time. Using cumulative skew diagrams, I found tht mutational patterns in the SARS-CoV genome were strikingly different from other coronaviruses in terms of mutation rates, although they were in general agreement with the model of the coronavirus lifecycle. These findings might be relevant for the development of sequence-based diagnostics and the design of agents to treat SARS.

DOI: 10.1016/j.tig.2004.01.009
PubMed: 15049309

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Focused efforts by several international laboratories have resulted in the sequencing of the genome of the causative agent of severe acute respiratory syndrome (SARS), novel coronavirus SARS-CoV, in record time. Using cumulative skew diagrams, I found tht mutational patterns in the SARS-CoV genome were strikingly different from other coronaviruses in terms of mutation rates, although they were in general agreement with the model of the coronavirus lifecycle. These findings might be relevant for the development of sequence-based diagnostics and the design of agents to treat SARS.</div>
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Mutational patterns correlate with genome organization in SARS and other coronaviruses.

Mutational patterns correlate with genome organization in SARS and other coronaviruses.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki