SrasV1, Ncbi, Curation, bibRecord, 000265

Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome

Identifieur interne : 000265 ( Ncbi/Curation ); précédent : 000264; suivant : 000266

Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome

Auteurs : Thijs Kuiken [Pays-Bas] ; Ron Am Fouchier [Pays-Bas] ; Martin Schutten [Pays-Bas] ; Guus F. Rimmelzwaan [Pays-Bas] ; Geert Van Amerongen [Pays-Bas] ; Debby Van Riel [Pays-Bas] ; Jon D. Laman [Pays-Bas] ; Ton De Jong [Pays-Bas] ; Gerard Van Doornum [Pays-Bas] ; Wilina Lim [République populaire de Chine] ; Ai Ee Ling [Singapour] ; Paul Ks Chan [Hong Kong] ; John S. Tam [Hong Kong] ; Maria C. Zambon [Royaume-Uni] ; Robin Gopal [Royaume-Uni] ; Christian Drosten [Allemagne] ; Sylvie Van Der Werf [France] ; Nicolas Escriou [France] ; Jean-Claude Manuguerra [France] ; Klaus Stöhr [Suisse] ; J S Malik Peiris ; Albert Dme Osterhaus [Pays-Bas]

Source :

Lancet (London, England) [ 0140-6736 ] ; 2003.

RBID : PMC:7112434

Descripteurs français

KwdFr :
- Alvéoles pulmonaires (anatomopathologie), Alvéoles pulmonaires (virologie), Animaux, Chine (épidémiologie), Flambées de maladies, Humains, Macaca fascicularis, Maladies transmissibles émergentes (virologie), Maladies transmissibles émergentes (épidémiologie), Modèles animaux de maladie humaine, Santé mondiale, Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Virus du SRAS (isolement et purification), Virus du SRAS (pathogénicité).
MESH :
- anatomopathologie : Alvéoles pulmonaires, Syndrome respiratoire aigu sévère.
- isolement et purification : Virus du SRAS.
- pathogénicité : Virus du SRAS.
- virologie : Alvéoles pulmonaires, Maladies transmissibles émergentes, Syndrome respiratoire aigu sévère.
- épidémiologie : Chine, Maladies transmissibles émergentes, Syndrome respiratoire aigu sévère.
- Animaux, Flambées de maladies, Humains, Macaca fascicularis, Modèles animaux de maladie humaine, Santé mondiale.
Wicri :
- geographic : République populaire de Chine.

English descriptors

KwdEn :
- Animals, China (epidemiology), Communicable Diseases, Emerging (epidemiology), Communicable Diseases, Emerging (virology), Disease Models, Animal, Disease Outbreaks, Global Health, Humans, Macaca fascicularis, Pulmonary Alveoli (pathology), Pulmonary Alveoli (virology), SARS Virus (isolation & purification), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (virology).
MESH :
- geographic , epidemiology : China.
- epidemiology : Communicable Diseases, Emerging, Severe Acute Respiratory Syndrome.
- isolation & purification : SARS Virus.
- pathogenicity : SARS Virus.
- pathology : Pulmonary Alveoli, Severe Acute Respiratory Syndrome.
- virology : Communicable Diseases, Emerging, Pulmonary Alveoli, Severe Acute Respiratory Syndrome.
- Animals, Disease Models, Animal, Disease Outbreaks, Global Health, Humans, Macaca fascicularis.

Abstract

SummaryBackground

The worldwide outbreak of severe acute respiratory syndrome (SARS) is associated with a newly discovered coronavirus, SARS-associated coronavirus (SARSCoV). We did clinical and experimental studies to assess the role of this virus in the cause of SARS.

Methods

We tested clinical and postmortem samples from 436 SARS patients in six countries for infection with SARSCoV, human metapneumovirus, and other respiratory pathogens. We infected four cynomolgus macaques (Macaca fascicularis) with SARS-CoV in an attempt to replicate SARS and did necropsies on day 6 after infection.

Findings

SARS-CoV infection was diagnosed in 329 (75%) of 436 patients fitting the case definition of SARS; human metapneumovirus was diagnosed in 41 (12%) of 335, and other respiratory pathogens were diagnosed only sporadically. SARS-CoV was, therefore, the most likely causal agent of SARS. The four SARS-CoV-infected macaques excreted SARS-CoV from nose, mouth, and pharynx from 2 days after infection. Three of four macaques developed diffuse alveolar damage, similar to that in SARS patients, and characterised by epithelial necrosis, serosanguineous exudate, formation of hyaline membranes, type 2 pneumocyte hyperplasia, and the presence of syncytia. SARS-CoV was detected in pneumonic areas by virus isolation and RT-PCR, and was localised to alveolar epithelial cells and syncytia by immunohistochemistry and transmission electron microscopy.

Interpretation

Replication in SARS-CoV-infected macaques of pneumonia similar to that in human beings with SARS, combined with the high prevalence of SARS-CoV infection in SARS patients, fulfill the criteria required to prove that SARS-CoV is the primary cause of SARS.

Published online July 22, 2003 http://image.thelancet.com/extras/03art6318web.pdf

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112434

DOI: 10.1016/S0140-6736(03)13967-0
PubMed: 12892955
PubMed Central: 7112434

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J S Malik Peiris

<affiliation><nlm:aff id="aff11">Department of Microbiology and Medicine, Queen Mary Hospital, University of Hong Kong</nlm:aff>
<wicri:noCountry code="subfield">University of Hong Kong</wicri:noCountry>
</affiliation>

Le document en format XML

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<author><name sortKey="Laman, Jon D" sort="Laman, Jon D" uniqKey="Laman J" first="Jon D" last="Laman">Jon D. Laman</name>
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</author>
<author><name sortKey="De Jong, Ton" sort="De Jong, Ton" uniqKey="De Jong T" first="Ton" last="De Jong">Ton De Jong</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">Department of Pathology, Erasmus Medical Centre, PO Box 1738, 3000 DR Rotterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pathology, Erasmus Medical Centre, PO Box 1738, 3000 DR Rotterdam</wicri:regionArea>
<wicri:noRegion>3000 DR Rotterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Doornum, Gerard" sort="Van Doornum, Gerard" uniqKey="Van Doornum G" first="Gerard" last="Van Doornum">Gerard Van Doornum</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Virology, Erasmus Medical Centre, PO Box 1738, 3000 DR Rotterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Virology, Erasmus Medical Centre, PO Box 1738, 3000 DR Rotterdam</wicri:regionArea>
<wicri:noRegion>3000 DR Rotterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lim, Wilina" sort="Lim, Wilina" uniqKey="Lim W" first="Wilina" last="Lim">Wilina Lim</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Government Virus Unit, Public Health Laboratory Centre, Shek Kip Mei, Kowloon, Hong Kong Special Administrative Region, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Government Virus Unit, Public Health Laboratory Centre, Shek Kip Mei, Kowloon, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ling, Ai Ee" sort="Ling, Ai Ee" uniqKey="Ling A" first="Ai Ee" last="Ling">Ai Ee Ling</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">Department of Pathology, Singapore General Hospital, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Department of Pathology, Singapore General Hospital</wicri:regionArea>
<wicri:noRegion>Singapore General Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chan, Paul Ks" sort="Chan, Paul Ks" uniqKey="Chan P" first="Paul Ks" last="Chan">Paul Ks Chan</name>
<affiliation wicri:level="4"><nlm:aff id="aff6">Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tam, John S" sort="Tam, John S" uniqKey="Tam J" first="John S" last="Tam">John S. Tam</name>
<affiliation wicri:level="4"><nlm:aff id="aff6">Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zambon, Maria C" sort="Zambon, Maria C" uniqKey="Zambon M" first="Maria C" last="Zambon">Maria C. Zambon</name>
<affiliation wicri:level="3"><nlm:aff id="aff7">Enteric Respiratory and Neurological Virus Laboratory, Health Protection Agency, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Enteric Respiratory and Neurological Virus Laboratory, Health Protection Agency, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gopal, Robin" sort="Gopal, Robin" uniqKey="Gopal R" first="Robin" last="Gopal">Robin Gopal</name>
<affiliation wicri:level="3"><nlm:aff id="aff7">Enteric Respiratory and Neurological Virus Laboratory, Health Protection Agency, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Enteric Respiratory and Neurological Virus Laboratory, Health Protection Agency, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
<affiliation wicri:level="3"><nlm:aff id="aff8">Department of Virology, Bernhard-Nocht Institute for Tropical Medicine, Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Virology, Bernhard-Nocht Institute for Tropical Medicine, Hamburg</wicri:regionArea>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name>
<affiliation wicri:level="3"><nlm:aff id="aff9">Unité de Génétique Moléculaire des Virus Respiratoires, Institut Pasteur, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Génétique Moléculaire des Virus Respiratoires, Institut Pasteur, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Escriou, Nicolas" sort="Escriou, Nicolas" uniqKey="Escriou N" first="Nicolas" last="Escriou">Nicolas Escriou</name>
<affiliation wicri:level="3"><nlm:aff id="aff9">Unité de Génétique Moléculaire des Virus Respiratoires, Institut Pasteur, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Génétique Moléculaire des Virus Respiratoires, Institut Pasteur, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Manuguerra, Jean Claude" sort="Manuguerra, Jean Claude" uniqKey="Manuguerra J" first="Jean-Claude" last="Manuguerra">Jean-Claude Manuguerra</name>
<affiliation wicri:level="3"><nlm:aff id="aff9">Unité de Génétique Moléculaire des Virus Respiratoires, Institut Pasteur, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Génétique Moléculaire des Virus Respiratoires, Institut Pasteur, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stohr, Klaus" sort="Stohr, Klaus" uniqKey="Stohr K" first="Klaus" last="Stöhr">Klaus Stöhr</name>
<affiliation wicri:level="1"><nlm:aff id="aff10">SARS Aetiology Study Group, WHO, Geneva, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>SARS Aetiology Study Group, WHO, Geneva</wicri:regionArea>
<wicri:noRegion>Geneva</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J S Malik" last="Peiris">J S Malik Peiris</name>
<affiliation><nlm:aff id="aff11">Department of Microbiology and Medicine, Queen Mary Hospital, University of Hong Kong</nlm:aff>
<wicri:noCountry code="subfield">University of Hong Kong</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Osterhaus, Albert Dme" sort="Osterhaus, Albert Dme" uniqKey="Osterhaus A" first="Albert Dme" last="Osterhaus">Albert Dme Osterhaus</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Virology, Erasmus Medical Centre, PO Box 1738, 3000 DR Rotterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Virology, Erasmus Medical Centre, PO Box 1738, 3000 DR Rotterdam</wicri:regionArea>
<wicri:noRegion>3000 DR Rotterdam</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Lancet (London, England)</title>
<idno type="ISSN">0140-6736</idno>
<idno type="eISSN">1474-547X</idno>
<imprint><date when="2003">2003</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>China (epidemiology)</term>
<term>Communicable Diseases, Emerging (epidemiology)</term>
<term>Communicable Diseases, Emerging (virology)</term>
<term>Disease Models, Animal</term>
<term>Disease Outbreaks</term>
<term>Global Health</term>
<term>Humans</term>
<term>Macaca fascicularis</term>
<term>Pulmonary Alveoli (pathology)</term>
<term>Pulmonary Alveoli (virology)</term>
<term>SARS Virus (isolation & purification)</term>
<term>SARS Virus (pathogenicity)</term>
<term>Severe Acute Respiratory Syndrome (epidemiology)</term>
<term>Severe Acute Respiratory Syndrome (pathology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Alvéoles pulmonaires (anatomopathologie)</term>
<term>Alvéoles pulmonaires (virologie)</term>
<term>Animaux</term>
<term>Chine (épidémiologie)</term>
<term>Flambées de maladies</term>
<term>Humains</term>
<term>Macaca fascicularis</term>
<term>Maladies transmissibles émergentes (virologie)</term>
<term>Maladies transmissibles émergentes (épidémiologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Santé mondiale</term>
<term>Syndrome respiratoire aigu sévère (anatomopathologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Syndrome respiratoire aigu sévère (épidémiologie)</term>
<term>Virus du SRAS (isolement et purification)</term>
<term>Virus du SRAS (pathogénicité)</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>China</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Alvéoles pulmonaires</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Communicable Diseases, Emerging</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Pulmonary Alveoli</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Alvéoles pulmonaires</term>
<term>Maladies transmissibles émergentes</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Communicable Diseases, Emerging</term>
<term>Pulmonary Alveoli</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Chine</term>
<term>Maladies transmissibles émergentes</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Models, Animal</term>
<term>Disease Outbreaks</term>
<term>Global Health</term>
<term>Humans</term>
<term>Macaca fascicularis</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Flambées de maladies</term>
<term>Humains</term>
<term>Macaca fascicularis</term>
<term>Modèles animaux de maladie humaine</term>
<term>Santé mondiale</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Summary</title>
<sec><title>Background</title>
<p>The worldwide outbreak of severe acute respiratory syndrome (SARS) is associated with a newly discovered coronavirus, SARS-associated coronavirus (SARSCoV). We did clinical and experimental studies to assess the role of this virus in the cause of SARS.</p>
</sec>
<sec><title>Methods</title>
<p>We tested clinical and postmortem samples from 436 SARS patients in six countries for infection with SARSCoV, human metapneumovirus, and other respiratory pathogens. We infected four cynomolgus macaques (Macaca fascicularis) with SARS-CoV in an attempt to replicate SARS and did necropsies on day 6 after infection.</p>
</sec>
<sec><title>Findings</title>
<p>SARS-CoV infection was diagnosed in 329 (75%) of 436 patients fitting the case definition of SARS; human metapneumovirus was diagnosed in 41 (12%) of 335, and other respiratory pathogens were diagnosed only sporadically. SARS-CoV was, therefore, the most likely causal agent of SARS. The four SARS-CoV-infected macaques excreted SARS-CoV from nose, mouth, and pharynx from 2 days after infection. Three of four macaques developed diffuse alveolar damage, similar to that in SARS patients, and characterised by epithelial necrosis, serosanguineous exudate, formation of hyaline membranes, type 2 pneumocyte hyperplasia, and the presence of syncytia. SARS-CoV was detected in pneumonic areas by virus isolation and RT-PCR, and was localised to alveolar epithelial cells and syncytia by immunohistochemistry and transmission electron microscopy.</p>
</sec>
<sec><title>Interpretation</title>
<p>Replication in SARS-CoV-infected macaques of pneumonia similar to that in human beings with SARS, combined with the high prevalence of SARS-CoV infection in SARS patients, fulfill the criteria required to prove that SARS-CoV is the primary cause of SARS.</p>
<p>Published online July 22, 2003 http://image.thelancet.com/extras/03art6318web.pdf</p>
</sec>
</div>
</front>
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HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i   -Sk "pubmed:12892955" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration SRAS

Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome

Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome

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