MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis
Identifieur interne : 002E39 ( Ncbi/Checkpoint ); précédent : 002E38; suivant : 002E40MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis
Auteurs : Vineet D. Menachery [États-Unis] ; Hugh D. Mitchell [États-Unis] ; Adam S. Cockrell [États-Unis] ; Lisa E. Gralinski [États-Unis] ; Boyd L. Yount [États-Unis] ; Rachel L. Graham [États-Unis] ; Eileen T. Mcanarney [États-Unis] ; Madeline G. Douglas [États-Unis] ; Trevor Scobey [États-Unis] ; Anne Beall [États-Unis] ; Kenneth Dinnon [États-Unis] ; Jacob F. Kocher [États-Unis] ; Andrew E. Hale [États-Unis] ; Kelly G. Stratton [États-Unis] ; Katrina M. Waters [États-Unis] ; Ralph S. Baric [États-Unis]Source :
- mBio [ 2150-7511 ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Cadres ouverts de lecture, Cellules cultivées, Cellules épithéliales (virologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité), Facteur de transcription NF-kappa B (métabolisme), Génétique inverse, Humains, Infections à coronavirus (virologie), Inflammation, Interactions hôte-pathogène, Interférons (génétique), Interférons (métabolisme), Lignée cellulaire, Mutation, Réplication virale (génétique), Souris, Transduction du signal.
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Interférons, Réplication virale.
- métabolisme : Facteur de transcription NF-kappa B, Interférons.
- pathogénicité : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Cellules épithéliales, Infections à coronavirus.
- Animaux, Cadres ouverts de lecture, Cellules cultivées, Génétique inverse, Humains, Inflammation, Interactions hôte-pathogène, Lignée cellulaire, Mutation, Souris, Transduction du signal.
English descriptors
- KwdEn :
- Animals, Cell Line, Cells, Cultured, Coronavirus Infections (virology), Epithelial Cells (virology), Host-Pathogen Interactions, Humans, Inflammation, Interferons (genetics), Interferons (metabolism), Mice, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (pathogenicity), Mutation, NF-kappa B (metabolism), Open Reading Frames, Reverse Genetics, Signal Transduction, Virus Replication (genetics).
- MESH :
- chemical , genetics : Interferons.
- chemical , metabolism : Interferons, NF-kappa B.
- genetics : Middle East Respiratory Syndrome Coronavirus, Virus Replication.
- pathogenicity : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections, Epithelial Cells.
- Animals, Cell Line, Cells, Cultured, Host-Pathogen Interactions, Humans, Inflammation, Mice, Mutation, Open Reading Frames, Reverse Genetics, Signal Transduction.
Abstract
While dispensable for viral replication, coronavirus (CoV) accessory open reading frame (ORF) proteins often play critical roles during infection and pathogenesis. Utilizing a previously generated mutant, we demonstrate that the absence of all four Middle East respiratory syndrome CoV (MERS-CoV) accessory ORFs (deletion of ORF3, -4a, -4b, and -5 [dORF3-5]) has major implications for viral replication and pathogenesis. Importantly, attenuation of the dORF3-5 mutant is primarily driven by dysregulated host responses, including disrupted cell processes, augmented interferon (IFN) pathway activation, and robust inflammation.
Url:
DOI: 10.1128/mBio.00665-17
PubMed: 28830941
PubMed Central: 5565963
Affiliations:
- États-Unis
- Caroline du Nord, Texas, Washington (État)
- Chapel Hill (Caroline du Nord)
- Université de Caroline du Nord à Chapel Hill
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001627
- to stream Pmc, to step Curation: 001627
- to stream Pmc, to step Checkpoint: 000611
- to stream PubMed, to step Corpus: 000A89
- to stream PubMed, to step Curation: 000A89
- to stream PubMed, to step Checkpoint: 000B00
- to stream Ncbi, to step Merge: 002E39
- to stream Ncbi, to step Curation: 002E39
Links to Exploration step
PMC:5565963Le document en format XML
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<author><name sortKey="Scobey, Trevor" sort="Scobey, Trevor" uniqKey="Scobey T" first="Trevor" last="Scobey">Trevor Scobey</name>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
</author>
<author><name sortKey="Beall, Anne" sort="Beall, Anne" uniqKey="Beall A" first="Anne" last="Beall">Anne Beall</name>
<affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
</author>
<author><name sortKey="Dinnon, Kenneth" sort="Dinnon, Kenneth" uniqKey="Dinnon K" first="Kenneth" last="Dinnon">Kenneth Dinnon</name>
<affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina</wicri:regionArea>
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</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
</author>
<author><name sortKey="Kocher, Jacob F" sort="Kocher, Jacob F" uniqKey="Kocher J" first="Jacob F." last="Kocher">Jacob F. Kocher</name>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
</author>
<author><name sortKey="Hale, Andrew E" sort="Hale, Andrew E" uniqKey="Hale A" first="Andrew E." last="Hale">Andrew E. Hale</name>
<affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
</author>
<author><name sortKey="Stratton, Kelly G" sort="Stratton, Kelly G" uniqKey="Stratton K" first="Kelly G." last="Stratton">Kelly G. Stratton</name>
<affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>Pacific Northwest National Laboratory, Richland, Washington, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Pacific Northwest National Laboratory, Richland, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Waters, Katrina M" sort="Waters, Katrina M" uniqKey="Waters K" first="Katrina M." last="Waters">Katrina M. Waters</name>
<affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>Pacific Northwest National Laboratory, Richland, Washington, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Pacific Northwest National Laboratory, Richland, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">mBio</title>
<idno type="eISSN">2150-7511</idno>
<imprint><date when="2017">2017</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Cells, Cultured</term>
<term>Coronavirus Infections (virology)</term>
<term>Epithelial Cells (virology)</term>
<term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>Inflammation</term>
<term>Interferons (genetics)</term>
<term>Interferons (metabolism)</term>
<term>Mice</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Middle East Respiratory Syndrome Coronavirus (pathogenicity)</term>
<term>Mutation</term>
<term>NF-kappa B (metabolism)</term>
<term>Open Reading Frames</term>
<term>Reverse Genetics</term>
<term>Signal Transduction</term>
<term>Virus Replication (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cadres ouverts de lecture</term>
<term>Cellules cultivées</term>
<term>Cellules épithéliales (virologie)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité)</term>
<term>Facteur de transcription NF-kappa B (métabolisme)</term>
<term>Génétique inverse</term>
<term>Humains</term>
<term>Infections à coronavirus (virologie)</term>
<term>Inflammation</term>
<term>Interactions hôte-pathogène</term>
<term>Interférons (génétique)</term>
<term>Interférons (métabolisme)</term>
<term>Lignée cellulaire</term>
<term>Mutation</term>
<term>Réplication virale (génétique)</term>
<term>Souris</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Interferons</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Interferons</term>
<term>NF-kappa B</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Interférons</term>
<term>Réplication virale</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de transcription NF-kappa B</term>
<term>Interférons</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cellules épithéliales</term>
<term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Epithelial Cells</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Cells, Cultured</term>
<term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>Inflammation</term>
<term>Mice</term>
<term>Mutation</term>
<term>Open Reading Frames</term>
<term>Reverse Genetics</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cadres ouverts de lecture</term>
<term>Cellules cultivées</term>
<term>Génétique inverse</term>
<term>Humains</term>
<term>Inflammation</term>
<term>Interactions hôte-pathogène</term>
<term>Lignée cellulaire</term>
<term>Mutation</term>
<term>Souris</term>
<term>Transduction du signal</term>
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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>While dispensable for viral replication, coronavirus (CoV) accessory open reading frame (ORF) proteins often play critical roles during infection and pathogenesis. Utilizing a previously generated mutant, we demonstrate that the absence of all four Middle East respiratory syndrome CoV (MERS-CoV) accessory ORFs (deletion of ORF3, -4a, -4b, and -5 [dORF3-5]) has major implications for viral replication and pathogenesis. Importantly, attenuation of the dORF3-5 mutant is primarily driven by dysregulated host responses, including disrupted cell processes, augmented interferon (IFN) pathway activation, and robust inflammation. <italic>In vitro</italic>
replication attenuation also extends to <italic>in vivo</italic>
models, allowing use of dORF3-5 as a live attenuated vaccine platform. Finally, examination of ORF5 implicates a partial role in modulation of NF-κB-mediated inflammation. Together, the results demonstrate the importance of MERS-CoV accessory ORFs for pathogenesis and highlight them as potential targets for surveillance and therapeutic treatments moving forward.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zumla, A" uniqKey="Zumla A">A Zumla</name>
</author>
<author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name>
</author>
<author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Anthony, Sj" uniqKey="Anthony S">SJ Anthony</name>
</author>
<author><name sortKey="Gilardi, K" uniqKey="Gilardi K">K Gilardi</name>
</author>
<author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
<author><name sortKey="Goldstein, T" uniqKey="Goldstein T">T Goldstein</name>
</author>
<author><name sortKey="Ssebide, B" uniqKey="Ssebide B">B Ssebide</name>
</author>
<author><name sortKey="Mbabazi, R" uniqKey="Mbabazi R">R Mbabazi</name>
</author>
<author><name sortKey="Navarrete Macias, I" uniqKey="Navarrete Macias I">I Navarrete-Macias</name>
</author>
<author><name sortKey="Liang, E" uniqKey="Liang E">E Liang</name>
</author>
<author><name sortKey="Wells, H" uniqKey="Wells H">H Wells</name>
</author>
<author><name sortKey="Hicks, A" uniqKey="Hicks A">A Hicks</name>
</author>
<author><name sortKey="Petrosov, A" uniqKey="Petrosov A">A Petrosov</name>
</author>
<author><name sortKey="Byarugaba, Dk" uniqKey="Byarugaba D">DK Byarugaba</name>
</author>
<author><name sortKey="Debbink, K" uniqKey="Debbink K">K Debbink</name>
</author>
<author><name sortKey="Dinnon, Kh" uniqKey="Dinnon K">KH Dinnon</name>
</author>
<author><name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name>
</author>
<author><name sortKey="Randell, Sh" uniqKey="Randell S">SH Randell</name>
</author>
<author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
<author><name sortKey="Cranfield, M" uniqKey="Cranfield M">M Cranfield</name>
</author>
<author><name sortKey="Johnson, Ck" uniqKey="Johnson C">CK Johnson</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
<author><name sortKey="Lipkin, Wi" uniqKey="Lipkin W">WI Lipkin</name>
</author>
<author><name sortKey="Mazet, Jak" uniqKey="Mazet J">JAK Mazet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name>
</author>
<author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name>
</author>
<author><name sortKey="Koopmans, Mp" uniqKey="Koopmans M">MP Koopmans</name>
</author>
<author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name>
</author>
<author><name sortKey="Van Den Brand, Jm" uniqKey="Van Den Brand J">JM van den Brand</name>
</author>
<author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name>
</author>
<author><name sortKey="Volz, A" uniqKey="Volz A">A Volz</name>
</author>
<author><name sortKey="Wohlsein, P" uniqKey="Wohlsein P">P Wohlsein</name>
</author>
<author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name>
</author>
<author><name sortKey="Schipper, D" uniqKey="Schipper D">D Schipper</name>
</author>
<author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name>
</author>
<author><name sortKey="Okba, N" uniqKey="Okba N">N Okba</name>
</author>
<author><name sortKey="Fux, R" uniqKey="Fux R">R Fux</name>
</author>
<author><name sortKey="Bensaid, A" uniqKey="Bensaid A">A Bensaid</name>
</author>
<author><name sortKey="Solanes Foz, D" uniqKey="Solanes Foz D">D Solanes Foz</name>
</author>
<author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name>
</author>
<author><name sortKey="Baumg Rtner, W" uniqKey="Baumg Rtner W">W Baumgärtner</name>
</author>
<author><name sortKey="Segales, J" uniqKey="Segales J">J Segalés</name>
</author>
<author><name sortKey="Sutter, G" uniqKey="Sutter G">G Sutter</name>
</author>
<author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ciancanelli, Mj" uniqKey="Ciancanelli M">MJ Ciancanelli</name>
</author>
<author><name sortKey="Abel, L" uniqKey="Abel L">L Abel</name>
</author>
<author><name sortKey="Zhang, Sy" uniqKey="Zhang S">SY Zhang</name>
</author>
<author><name sortKey="Casanova, Jl" uniqKey="Casanova J">JL Casanova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Xl" uniqKey="Yang X">XL Yang</name>
</author>
<author><name sortKey="Hu, B" uniqKey="Hu B">B Hu</name>
</author>
<author><name sortKey="Wang, B" uniqKey="Wang B">B Wang</name>
</author>
<author><name sortKey="Wang, Mn" uniqKey="Wang M">MN Wang</name>
</author>
<author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name>
</author>
<author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name>
</author>
<author><name sortKey="Wu, Lj" uniqKey="Wu L">LJ Wu</name>
</author>
<author><name sortKey="Ge, Xy" uniqKey="Ge X">XY Ge</name>
</author>
<author><name sortKey="Zhang, Yz" uniqKey="Zhang Y">YZ Zhang</name>
</author>
<author><name sortKey="Daszak, P" uniqKey="Daszak P">P Daszak</name>
</author>
<author><name sortKey="Wang, Lf" uniqKey="Wang L">LF Wang</name>
</author>
<author><name sortKey="Shi, Zl" uniqKey="Shi Z">ZL Shi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="He, B" uniqKey="He B">B He</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Xu, L" uniqKey="Xu L">L Xu</name>
</author>
<author><name sortKey="Yang, W" uniqKey="Yang W">W Yang</name>
</author>
<author><name sortKey="Yang, F" uniqKey="Yang F">F Yang</name>
</author>
<author><name sortKey="Feng, Y" uniqKey="Feng Y">Y Feng</name>
</author>
<author><name sortKey="Xia, L" uniqKey="Xia L">L Xia</name>
</author>
<author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name>
</author>
<author><name sortKey="Zhen, W" uniqKey="Zhen W">W Zhen</name>
</author>
<author><name sortKey="Feng, Y" uniqKey="Feng Y">Y Feng</name>
</author>
<author><name sortKey="Guo, H" uniqKey="Guo H">H Guo</name>
</author>
<author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name>
</author>
<author><name sortKey="Tu, C" uniqKey="Tu C">C Tu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ge, Xy" uniqKey="Ge X">XY Ge</name>
</author>
<author><name sortKey="Li, Jl" uniqKey="Li J">JL Li</name>
</author>
<author><name sortKey="Yang, Xl" uniqKey="Yang X">XL Yang</name>
</author>
<author><name sortKey="Chmura, Aa" uniqKey="Chmura A">AA Chmura</name>
</author>
<author><name sortKey="Zhu, G" uniqKey="Zhu G">G Zhu</name>
</author>
<author><name sortKey="Epstein, Jh" uniqKey="Epstein J">JH Epstein</name>
</author>
<author><name sortKey="Mazet, Jk" uniqKey="Mazet J">JK Mazet</name>
</author>
<author><name sortKey="Hu, B" uniqKey="Hu B">B Hu</name>
</author>
<author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name>
</author>
<author><name sortKey="Peng, C" uniqKey="Peng C">C Peng</name>
</author>
<author><name sortKey="Zhang, Yj" uniqKey="Zhang Y">YJ Zhang</name>
</author>
<author><name sortKey="Luo, Cm" uniqKey="Luo C">CM Luo</name>
</author>
<author><name sortKey="Tan, B" uniqKey="Tan B">B Tan</name>
</author>
<author><name sortKey="Wang, N" uniqKey="Wang N">N Wang</name>
</author>
<author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y Zhu</name>
</author>
<author><name sortKey="Crameri, G" uniqKey="Crameri G">G Crameri</name>
</author>
<author><name sortKey="Zhang, Sy" uniqKey="Zhang S">SY Zhang</name>
</author>
<author><name sortKey="Wang, Lf" uniqKey="Wang L">LF Wang</name>
</author>
<author><name sortKey="Daszak, P" uniqKey="Daszak P">P Daszak</name>
</author>
<author><name sortKey="Shi, Zl" uniqKey="Shi Z">ZL Shi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
<author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
<author><name sortKey="Debbink, K" uniqKey="Debbink K">K Debbink</name>
</author>
<author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name>
</author>
<author><name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name>
</author>
<author><name sortKey="Plante, Ja" uniqKey="Plante J">JA Plante</name>
</author>
<author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name>
</author>
<author><name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name>
</author>
<author><name sortKey="Ge, Xy" uniqKey="Ge X">XY Ge</name>
</author>
<author><name sortKey="Donaldson, Ef" uniqKey="Donaldson E">EF Donaldson</name>
</author>
<author><name sortKey="Randell, Sh" uniqKey="Randell S">SH Randell</name>
</author>
<author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A Lanzavecchia</name>
</author>
<author><name sortKey="Marasco, Wa" uniqKey="Marasco W">WA Marasco</name>
</author>
<author><name sortKey="Shi, Zl" uniqKey="Shi Z">ZL Shi</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
<author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
<author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name>
</author>
<author><name sortKey="Debbink, K" uniqKey="Debbink K">K Debbink</name>
</author>
<author><name sortKey="Agnihothram, Ss" uniqKey="Agnihothram S">SS Agnihothram</name>
</author>
<author><name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name>
</author>
<author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name>
</author>
<author><name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name>
</author>
<author><name sortKey="Plante, Ja" uniqKey="Plante J">JA Plante</name>
</author>
<author><name sortKey="Royal, Sr" uniqKey="Royal S">SR Royal</name>
</author>
<author><name sortKey="Swanstrom, J" uniqKey="Swanstrom J">J Swanstrom</name>
</author>
<author><name sortKey="Sheahan, Tp" uniqKey="Sheahan T">TP Sheahan</name>
</author>
<author><name sortKey="Pickles, Rj" uniqKey="Pickles R">RJ Pickles</name>
</author>
<author><name sortKey="Corti, D" uniqKey="Corti D">D Corti</name>
</author>
<author><name sortKey="Randell, Sh" uniqKey="Randell S">SH Randell</name>
</author>
<author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A Lanzavecchia</name>
</author>
<author><name sortKey="Marasco, Wa" uniqKey="Marasco W">WA Marasco</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kindler, E" uniqKey="Kindler E">E Kindler</name>
</author>
<author><name sortKey="J Nsd Ttir, Hr" uniqKey="J Nsd Ttir H">HR Jónsdóttir</name>
</author>
<author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name>
</author>
<author><name sortKey="Hamming, Oj" uniqKey="Hamming O">OJ Hamming</name>
</author>
<author><name sortKey="Hartmann, R" uniqKey="Hartmann R">R Hartmann</name>
</author>
<author><name sortKey="Rodriguez, R" uniqKey="Rodriguez R">R Rodriguez</name>
</author>
<author><name sortKey="Geffers, R" uniqKey="Geffers R">R Geffers</name>
</author>
<author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name>
</author>
<author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
<author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Müller</name>
</author>
<author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R Dijkman</name>
</author>
<author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name>
</author>
<author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name>
</author>
<author><name sortKey="Rasmussen, Al" uniqKey="Rasmussen A">AL Rasmussen</name>
</author>
<author><name sortKey="Feldmann, F" uniqKey="Feldmann F">F Feldmann</name>
</author>
<author><name sortKey="Okumura, A" uniqKey="Okumura A">A Okumura</name>
</author>
<author><name sortKey="Scott, Dp" uniqKey="Scott D">DP Scott</name>
</author>
<author><name sortKey="Brining, D" uniqKey="Brining D">D Brining</name>
</author>
<author><name sortKey="Bushmaker, T" uniqKey="Bushmaker T">T Bushmaker</name>
</author>
<author><name sortKey="Martellaro, C" uniqKey="Martellaro C">C Martellaro</name>
</author>
<author><name sortKey="Baseler, L" uniqKey="Baseler L">L Baseler</name>
</author>
<author><name sortKey="Benecke, Ag" uniqKey="Benecke A">AG Benecke</name>
</author>
<author><name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name>
</author>
<author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name>
</author>
<author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Wilde, Ah" uniqKey="De Wilde A">AH de Wilde</name>
</author>
<author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name>
</author>
<author><name sortKey="Oudshoorn, D" uniqKey="Oudshoorn D">D Oudshoorn</name>
</author>
<author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name>
</author>
<author><name sortKey="Van Nieuwkoop, S" uniqKey="Van Nieuwkoop S">S van Nieuwkoop</name>
</author>
<author><name sortKey="Limpens, Rw" uniqKey="Limpens R">RW Limpens</name>
</author>
<author><name sortKey="Posthuma, Cc" uniqKey="Posthuma C">CC Posthuma</name>
</author>
<author><name sortKey="Van Der Meer, Y" uniqKey="Van Der Meer Y">Y van der Meer</name>
</author>
<author><name sortKey="Barcena, M" uniqKey="Barcena M">M Bárcena</name>
</author>
<author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name>
</author>
<author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name>
</author>
<author><name sortKey="Van Den Hoogen, Bg" uniqKey="Van Den Hoogen B">BG van den Hoogen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Josset, L" uniqKey="Josset L">L Josset</name>
</author>
<author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
<author><name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name>
</author>
<author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name>
</author>
<author><name sortKey="Sova, P" uniqKey="Sova P">P Sova</name>
</author>
<author><name sortKey="Carter, Vs" uniqKey="Carter V">VS Carter</name>
</author>
<author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
<author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
<author><name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
<author><name sortKey="Eisfeld, Aj" uniqKey="Eisfeld A">AJ Eisfeld</name>
</author>
<author><name sortKey="Sch Fer, A" uniqKey="Sch Fer A">A Schäfer</name>
</author>
<author><name sortKey="Josset, L" uniqKey="Josset L">L Josset</name>
</author>
<author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name>
</author>
<author><name sortKey="Proll, S" uniqKey="Proll S">S Proll</name>
</author>
<author><name sortKey="Fan, S" uniqKey="Fan S">S Fan</name>
</author>
<author><name sortKey="Li, C" uniqKey="Li C">C Li</name>
</author>
<author><name sortKey="Neumann, G" uniqKey="Neumann G">G Neumann</name>
</author>
<author><name sortKey="Tilton, Sc" uniqKey="Tilton S">SC Tilton</name>
</author>
<author><name sortKey="Chang, J" uniqKey="Chang J">J Chang</name>
</author>
<author><name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name>
</author>
<author><name sortKey="Long, C" uniqKey="Long C">C Long</name>
</author>
<author><name sortKey="Green, R" uniqKey="Green R">R Green</name>
</author>
<author><name sortKey="Williams, Cm" uniqKey="Williams C">CM Williams</name>
</author>
<author><name sortKey="Weiss, J" uniqKey="Weiss J">J Weiss</name>
</author>
<author><name sortKey="Matzke, Mm" uniqKey="Matzke M">MM Matzke</name>
</author>
<author><name sortKey="Webb Robertson, Bj" uniqKey="Webb Robertson B">BJ Webb-Robertson</name>
</author>
<author><name sortKey="Schepmoes, Aa" uniqKey="Schepmoes A">AA Schepmoes</name>
</author>
<author><name sortKey="Shukla, Ak" uniqKey="Shukla A">AK Shukla</name>
</author>
<author><name sortKey="Metz, To" uniqKey="Metz T">TO Metz</name>
</author>
<author><name sortKey="Smith, Rd" uniqKey="Smith R">RD Smith</name>
</author>
<author><name sortKey="Waters, Km" uniqKey="Waters K">KM Waters</name>
</author>
<author><name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name>
</author>
<author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yount, B" uniqKey="Yount B">B Yount</name>
</author>
<author><name sortKey="Roberts, Rs" uniqKey="Roberts R">RS Roberts</name>
</author>
<author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name>
</author>
<author><name sortKey="Deming, D" uniqKey="Deming D">D Deming</name>
</author>
<author><name sortKey="Frieman, Mb" uniqKey="Frieman M">MB Frieman</name>
</author>
<author><name sortKey="Sparks, J" uniqKey="Sparks J">J Sparks</name>
</author>
<author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name>
</author>
<author><name sortKey="Davis, N" uniqKey="Davis N">N Davis</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rabouw, Hh" uniqKey="Rabouw H">HH Rabouw</name>
</author>
<author><name sortKey="Langereis, Ma" uniqKey="Langereis M">MA Langereis</name>
</author>
<author><name sortKey="Knaap, Rc" uniqKey="Knaap R">RC Knaap</name>
</author>
<author><name sortKey="Dalebout, Tj" uniqKey="Dalebout T">TJ Dalebout</name>
</author>
<author><name sortKey="Canton, J" uniqKey="Canton J">J Canton</name>
</author>
<author><name sortKey="Sola, I" uniqKey="Sola I">I Sola</name>
</author>
<author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L Enjuanes</name>
</author>
<author><name sortKey="Bredenbeek, Pj" uniqKey="Bredenbeek P">PJ Bredenbeek</name>
</author>
<author><name sortKey="Kikkert, M" uniqKey="Kikkert M">M Kikkert</name>
</author>
<author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name>
</author>
<author><name sortKey="Van Kuppeveld, Fj" uniqKey="Van Kuppeveld F">FJ van Kuppeveld</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matthews, Kl" uniqKey="Matthews K">KL Matthews</name>
</author>
<author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name>
</author>
<author><name sortKey="Van Der Meer, Y" uniqKey="Van Der Meer Y">Y van der Meer</name>
</author>
<author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name>
</author>
<author><name sortKey="Frieman, Mb" uniqKey="Frieman M">MB Frieman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name>
</author>
<author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
<author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name>
</author>
<author><name sortKey="Donaldson, Ef" uniqKey="Donaldson E">EF Donaldson</name>
</author>
<author><name sortKey="Agnihothram, Ss" uniqKey="Agnihothram S">SS Agnihothram</name>
</author>
<author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
<author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name>
</author>
<author><name sortKey="Swanstrom, J" uniqKey="Swanstrom J">J Swanstrom</name>
</author>
<author><name sortKey="Bove, Pf" uniqKey="Bove P">PF Bove</name>
</author>
<author><name sortKey="Kim, Jd" uniqKey="Kim J">JD Kim</name>
</author>
<author><name sortKey="Grego, S" uniqKey="Grego S">S Grego</name>
</author>
<author><name sortKey="Randell, Sh" uniqKey="Randell S">SH Randell</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Almazan, F" uniqKey="Almazan F">F Almazán</name>
</author>
<author><name sortKey="Dediego, Ml" uniqKey="Dediego M">ML DeDiego</name>
</author>
<author><name sortKey="Sola, I" uniqKey="Sola I">I Sola</name>
</author>
<author><name sortKey="Zu Iga, S" uniqKey="Zu Iga S">S Zuñiga</name>
</author>
<author><name sortKey="Nieto Torres, Jl" uniqKey="Nieto Torres J">JL Nieto-Torres</name>
</author>
<author><name sortKey="Marquez Jurado, S" uniqKey="Marquez Jurado S">S Marquez-Jurado</name>
</author>
<author><name sortKey="Andres, G" uniqKey="Andres G">G Andrés</name>
</author>
<author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L Enjuanes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cockrell, As" uniqKey="Cockrell A">AS Cockrell</name>
</author>
<author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
<author><name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name>
</author>
<author><name sortKey="Jensen, K" uniqKey="Jensen K">K Jensen</name>
</author>
<author><name sortKey="Douglas, M" uniqKey="Douglas M">M Douglas</name>
</author>
<author><name sortKey="Beall, A" uniqKey="Beall A">A Beall</name>
</author>
<author><name sortKey="Tang, Xc" uniqKey="Tang X">XC Tang</name>
</author>
<author><name sortKey="Marasco, Wa" uniqKey="Marasco W">WA Marasco</name>
</author>
<author><name sortKey="Heise, Mt" uniqKey="Heise M">MT Heise</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thornbrough, Jm" uniqKey="Thornbrough J">JM Thornbrough</name>
</author>
<author><name sortKey="Jha, Bk" uniqKey="Jha B">BK Jha</name>
</author>
<author><name sortKey="Yount, B" uniqKey="Yount B">B Yount</name>
</author>
<author><name sortKey="Goldstein, Sa" uniqKey="Goldstein S">SA Goldstein</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Elliott, R" uniqKey="Elliott R">R Elliott</name>
</author>
<author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
<author><name sortKey="Silverman, Rh" uniqKey="Silverman R">RH Silverman</name>
</author>
<author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Siu, Kl" uniqKey="Siu K">KL Siu</name>
</author>
<author><name sortKey="Yeung, Ml" uniqKey="Yeung M">ML Yeung</name>
</author>
<author><name sortKey="Kok, Kh" uniqKey="Kok K">KH Kok</name>
</author>
<author><name sortKey="Yuen, Ks" uniqKey="Yuen K">KS Yuen</name>
</author>
<author><name sortKey="Kew, C" uniqKey="Kew C">C Kew</name>
</author>
<author><name sortKey="Lui, Py" uniqKey="Lui P">PY Lui</name>
</author>
<author><name sortKey="Chan, Cp" uniqKey="Chan C">CP Chan</name>
</author>
<author><name sortKey="Tse, H" uniqKey="Tse H">H Tse</name>
</author>
<author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name>
</author>
<author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name>
</author>
<author><name sortKey="Jin, Dy" uniqKey="Jin D">DY Jin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Totura, Al" uniqKey="Totura A">AL Totura</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Niemeyer, D" uniqKey="Niemeyer D">D Niemeyer</name>
</author>
<author><name sortKey="Zillinger, T" uniqKey="Zillinger T">T Zillinger</name>
</author>
<author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name>
</author>
<author><name sortKey="Zielecki, F" uniqKey="Zielecki F">F Zielecki</name>
</author>
<author><name sortKey="Horvath, G" uniqKey="Horvath G">G Horvath</name>
</author>
<author><name sortKey="Suliman, T" uniqKey="Suliman T">T Suliman</name>
</author>
<author><name sortKey="Barchet, W" uniqKey="Barchet W">W Barchet</name>
</author>
<author><name sortKey="Weber, F" uniqKey="Weber F">F Weber</name>
</author>
<author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
<author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Müller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
<author><name sortKey="Crosson, S" uniqKey="Crosson S">S Crosson</name>
</author>
<author><name sortKey="Damania, B" uniqKey="Damania B">B Damania</name>
</author>
<author><name sortKey="Miller, Si" uniqKey="Miller S">SI Miller</name>
</author>
<author><name sortKey="Rubin, Ej" uniqKey="Rubin E">EJ Rubin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Le Sage, V" uniqKey="Le Sage V">V Le Sage</name>
</author>
<author><name sortKey="Cinti, A" uniqKey="Cinti A">A Cinti</name>
</author>
<author><name sortKey="Valiente Echeverria, F" uniqKey="Valiente Echeverria F">F Valiente-Echeverría</name>
</author>
<author><name sortKey="Mouland, Aj" uniqKey="Mouland A">AJ Mouland</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ortiz, Da" uniqKey="Ortiz D">DA Ortiz</name>
</author>
<author><name sortKey="Glassbrook, Je" uniqKey="Glassbrook J">JE Glassbrook</name>
</author>
<author><name sortKey="Pellett, Pe" uniqKey="Pellett P">PE Pellett</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lamers, Mm" uniqKey="Lamers M">MM Lamers</name>
</author>
<author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name>
</author>
<author><name sortKey="Shafei, M" uniqKey="Shafei M">M Shafei</name>
</author>
<author><name sortKey="Ali, Ss" uniqKey="Ali S">SS Ali</name>
</author>
<author><name sortKey="Abdallh, Sm" uniqKey="Abdallh S">SM Abdallh</name>
</author>
<author><name sortKey="Gazo, M" uniqKey="Gazo M">M Gazo</name>
</author>
<author><name sortKey="Nofal, S" uniqKey="Nofal S">S Nofal</name>
</author>
<author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name>
</author>
<author><name sortKey="Erdman, Dd" uniqKey="Erdman D">DD Erdman</name>
</author>
<author><name sortKey="Koopmans, Mp" uniqKey="Koopmans M">MP Koopmans</name>
</author>
<author><name sortKey="Abdallat, M" uniqKey="Abdallat M">M Abdallat</name>
</author>
<author><name sortKey="Haddadin, A" uniqKey="Haddadin A">A Haddadin</name>
</author>
<author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Xie, Q" uniqKey="Xie Q">Q Xie</name>
</author>
<author><name sortKey="Cao, Y" uniqKey="Cao Y">Y Cao</name>
</author>
<author><name sortKey="Su, J" uniqKey="Su J">J Su</name>
</author>
<author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name>
</author>
<author><name sortKey="Wu, X" uniqKey="Wu X">X Wu</name>
</author>
<author><name sortKey="Wan, C" uniqKey="Wan C">C Wan</name>
</author>
<author><name sortKey="He, M" uniqKey="He M">M He</name>
</author>
<author><name sortKey="Ke, C" uniqKey="Ke C">C Ke</name>
</author>
<author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name>
</author>
<author><name sortKey="Zhao, W" uniqKey="Zhao W">W Zhao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Okba, Nm" uniqKey="Okba N">NM Okba</name>
</author>
<author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name>
</author>
<author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Almazan, F" uniqKey="Almazan F">F Almazán</name>
</author>
<author><name sortKey="Dediego, Ml" uniqKey="Dediego M">ML DeDiego</name>
</author>
<author><name sortKey="Galan, C" uniqKey="Galan C">C Galán</name>
</author>
<author><name sortKey="Alvarez, E" uniqKey="Alvarez E">E Alvarez</name>
</author>
<author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L Enjuanes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bolles, M" uniqKey="Bolles M">M Bolles</name>
</author>
<author><name sortKey="Deming, D" uniqKey="Deming D">D Deming</name>
</author>
<author><name sortKey="Long, K" uniqKey="Long K">K Long</name>
</author>
<author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name>
</author>
<author><name sortKey="Whitmore, A" uniqKey="Whitmore A">A Whitmore</name>
</author>
<author><name sortKey="Ferris, M" uniqKey="Ferris M">M Ferris</name>
</author>
<author><name sortKey="Funkhouser, W" uniqKey="Funkhouser W">W Funkhouser</name>
</author>
<author><name sortKey="Gralinski, L" uniqKey="Gralinski L">L Gralinski</name>
</author>
<author><name sortKey="Totura, A" uniqKey="Totura A">A Totura</name>
</author>
<author><name sortKey="Heise, M" uniqKey="Heise M">M Heise</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Spruth, M" uniqKey="Spruth M">M Spruth</name>
</author>
<author><name sortKey="Kistner, O" uniqKey="Kistner O">O Kistner</name>
</author>
<author><name sortKey="Savidis Dacho, H" uniqKey="Savidis Dacho H">H Savidis-Dacho</name>
</author>
<author><name sortKey="Hitter, E" uniqKey="Hitter E">E Hitter</name>
</author>
<author><name sortKey="Crowe, B" uniqKey="Crowe B">B Crowe</name>
</author>
<author><name sortKey="Gerencer, M" uniqKey="Gerencer M">M Gerencer</name>
</author>
<author><name sortKey="Bruhl, P" uniqKey="Bruhl P">P Brühl</name>
</author>
<author><name sortKey="Grillberger, L" uniqKey="Grillberger L">L Grillberger</name>
</author>
<author><name sortKey="Reiter, M" uniqKey="Reiter M">M Reiter</name>
</author>
<author><name sortKey="Tauer, C" uniqKey="Tauer C">C Tauer</name>
</author>
<author><name sortKey="Mundt, W" uniqKey="Mundt W">W Mundt</name>
</author>
<author><name sortKey="Barrett, Pn" uniqKey="Barrett P">PN Barrett</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Sheahan, T" uniqKey="Sheahan T">T Sheahan</name>
</author>
<author><name sortKey="Rockx, B" uniqKey="Rockx B">B Rockx</name>
</author>
<author><name sortKey="Donaldson, E" uniqKey="Donaldson E">E Donaldson</name>
</author>
<author><name sortKey="Sims, A" uniqKey="Sims A">A Sims</name>
</author>
<author><name sortKey="Pickles, R" uniqKey="Pickles R">R Pickles</name>
</author>
<author><name sortKey="Corti, D" uniqKey="Corti D">D Corti</name>
</author>
<author><name sortKey="Baric, R" uniqKey="Baric R">R Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jimenez Guarde O, Jm" uniqKey="Jimenez Guarde O J">JM Jimenez-Guardeño</name>
</author>
<author><name sortKey="Regla Nava, Ja" uniqKey="Regla Nava J">JA Regla-Nava</name>
</author>
<author><name sortKey="Nieto Torres, Jl" uniqKey="Nieto Torres J">JL Nieto-Torres</name>
</author>
<author><name sortKey="Dediego, Ml" uniqKey="Dediego M">ML DeDiego</name>
</author>
<author><name sortKey="Casta O Rodriguez, C" uniqKey="Casta O Rodriguez C">C Castaño-Rodriguez</name>
</author>
<author><name sortKey="Fernandez Delgado, R" uniqKey="Fernandez Delgado R">R Fernandez-Delgado</name>
</author>
<author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name>
</author>
<author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L Enjuanes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name>
</author>
<author><name sortKey="Becker, Mm" uniqKey="Becker M">MM Becker</name>
</author>
<author><name sortKey="Eckerle, Ld" uniqKey="Eckerle L">LD Eckerle</name>
</author>
<author><name sortKey="Bolles, M" uniqKey="Bolles M">M Bolles</name>
</author>
<author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, C" uniqKey="Li C">C Li</name>
</author>
<author><name sortKey="Bankhead, A" uniqKey="Bankhead A">A Bankhead</name>
</author>
<author><name sortKey="Eisfeld, Aj" uniqKey="Eisfeld A">AJ Eisfeld</name>
</author>
<author><name sortKey="Hatta, Y" uniqKey="Hatta Y">Y Hatta</name>
</author>
<author><name sortKey="Jeng, S" uniqKey="Jeng S">S Jeng</name>
</author>
<author><name sortKey="Chang, Jh" uniqKey="Chang J">JH Chang</name>
</author>
<author><name sortKey="Aicher, Ld" uniqKey="Aicher L">LD Aicher</name>
</author>
<author><name sortKey="Proll, S" uniqKey="Proll S">S Proll</name>
</author>
<author><name sortKey="Ellis, Al" uniqKey="Ellis A">AL Ellis</name>
</author>
<author><name sortKey="Law, Gl" uniqKey="Law G">GL Law</name>
</author>
<author><name sortKey="Waters, Km" uniqKey="Waters K">KM Waters</name>
</author>
<author><name sortKey="Neumann, G" uniqKey="Neumann G">G Neumann</name>
</author>
<author><name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name>
</author>
<author><name sortKey="Mcweeney, S" uniqKey="Mcweeney S">S McWeeney</name>
</author>
<author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name>
</author>
<author><name sortKey="Tilton, Sc" uniqKey="Tilton S">SC Tilton</name>
</author>
<author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
<author><name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name>
</author>
<author><name sortKey="Sch Fer, A" uniqKey="Sch Fer A">A Schäfer</name>
</author>
<author><name sortKey="Matzke, Mm" uniqKey="Matzke M">MM Matzke</name>
</author>
<author><name sortKey="Webb Robertson, Bj" uniqKey="Webb Robertson B">BJ Webb-Robertson</name>
</author>
<author><name sortKey="Chang, J" uniqKey="Chang J">J Chang</name>
</author>
<author><name sortKey="Luna, Ml" uniqKey="Luna M">ML Luna</name>
</author>
<author><name sortKey="Long, Ce" uniqKey="Long C">CE Long</name>
</author>
<author><name sortKey="Shukla, Ak" uniqKey="Shukla A">AK Shukla</name>
</author>
<author><name sortKey="Bankhead, Ar" uniqKey="Bankhead A">AR Bankhead</name>
</author>
<author><name sortKey="Burkett, Se" uniqKey="Burkett S">SE Burkett</name>
</author>
<author><name sortKey="Zornetzer, G" uniqKey="Zornetzer G">G Zornetzer</name>
</author>
<author><name sortKey="Tseng, Ct" uniqKey="Tseng C">CT Tseng</name>
</author>
<author><name sortKey="Metz, To" uniqKey="Metz T">TO Metz</name>
</author>
<author><name sortKey="Pickles, R" uniqKey="Pickles R">R Pickles</name>
</author>
<author><name sortKey="Mcweeney, S" uniqKey="Mcweeney S">S McWeeney</name>
</author>
<author><name sortKey="Smith, Rd" uniqKey="Smith R">RD Smith</name>
</author>
<author><name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name>
</author>
<author><name sortKey="Waters, Km" uniqKey="Waters K">KM Waters</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
<author><name sortKey="Kallies, R" uniqKey="Kallies R">R Kallies</name>
</author>
<author><name sortKey="Philipps, H" uniqKey="Philipps H">H Philipps</name>
</author>
<author><name sortKey="Gopner, G" uniqKey="Gopner G">G Göpner</name>
</author>
<author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Müller</name>
</author>
<author><name sortKey="Eckerle, I" uniqKey="Eckerle I">I Eckerle</name>
</author>
<author><name sortKey="Brunink, S" uniqKey="Brunink S">S Brünink</name>
</author>
<author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
<author><name sortKey="Drexler, Jf" uniqKey="Drexler J">JF Drexler</name>
</author>
</analytic>
</biblStruct>
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</div1>
</back>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Caroline du Nord</li>
<li>Texas</li>
<li>Washington (État)</li>
</region>
<settlement><li>Chapel Hill (Caroline du Nord)</li>
</settlement>
<orgName><li>Université de Caroline du Nord à Chapel Hill</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Texas"><name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D." last="Menachery">Vineet D. Menachery</name>
</region>
<name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name>
<name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name>
<name sortKey="Beall, Anne" sort="Beall, Anne" uniqKey="Beall A" first="Anne" last="Beall">Anne Beall</name>
<name sortKey="Cockrell, Adam S" sort="Cockrell, Adam S" uniqKey="Cockrell A" first="Adam S." last="Cockrell">Adam S. Cockrell</name>
<name sortKey="Dinnon, Kenneth" sort="Dinnon, Kenneth" uniqKey="Dinnon K" first="Kenneth" last="Dinnon">Kenneth Dinnon</name>
<name sortKey="Douglas, Madeline G" sort="Douglas, Madeline G" uniqKey="Douglas M" first="Madeline G." last="Douglas">Madeline G. Douglas</name>
<name sortKey="Graham, Rachel L" sort="Graham, Rachel L" uniqKey="Graham R" first="Rachel L." last="Graham">Rachel L. Graham</name>
<name sortKey="Gralinski, Lisa E" sort="Gralinski, Lisa E" uniqKey="Gralinski L" first="Lisa E." last="Gralinski">Lisa E. Gralinski</name>
<name sortKey="Hale, Andrew E" sort="Hale, Andrew E" uniqKey="Hale A" first="Andrew E." last="Hale">Andrew E. Hale</name>
<name sortKey="Kocher, Jacob F" sort="Kocher, Jacob F" uniqKey="Kocher J" first="Jacob F." last="Kocher">Jacob F. Kocher</name>
<name sortKey="Mcanarney, Eileen T" sort="Mcanarney, Eileen T" uniqKey="Mcanarney E" first="Eileen T." last="Mcanarney">Eileen T. Mcanarney</name>
<name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D." last="Menachery">Vineet D. Menachery</name>
<name sortKey="Mitchell, Hugh D" sort="Mitchell, Hugh D" uniqKey="Mitchell H" first="Hugh D." last="Mitchell">Hugh D. Mitchell</name>
<name sortKey="Scobey, Trevor" sort="Scobey, Trevor" uniqKey="Scobey T" first="Trevor" last="Scobey">Trevor Scobey</name>
<name sortKey="Stratton, Kelly G" sort="Stratton, Kelly G" uniqKey="Stratton K" first="Kelly G." last="Stratton">Kelly G. Stratton</name>
<name sortKey="Waters, Katrina M" sort="Waters, Katrina M" uniqKey="Waters K" first="Katrina M." last="Waters">Katrina M. Waters</name>
<name sortKey="Yount, Boyd L" sort="Yount, Boyd L" uniqKey="Yount B" first="Boyd L." last="Yount">Boyd L. Yount</name>
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</tree>
</affiliations>
</record>
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