Synthesis and antiviral evaluation of 7-O-arylmethylquercetin derivatives against SARS-associated coronavirus (SCV) and hepatitis C virus (HCV).
Identifieur interne : 002445 ( Ncbi/Checkpoint ); précédent : 002444; suivant : 002446Synthesis and antiviral evaluation of 7-O-arylmethylquercetin derivatives against SARS-associated coronavirus (SCV) and hepatitis C virus (HCV).
Auteurs : Hye Ri Park [Corée du Sud] ; Hyunjun Yoon ; Mi Kyoung Kim ; Sung Dae Lee ; Youhoon ChongSource :
- Archives of pharmacal research [ 0253-6269 ] ; 2012.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Antiviraux, Quercétine.
- physiologie : Hepacivirus, Virus du SRAS.
- synthèse chimique : Antiviraux, Quercétine.
- Hepacivirus, Humains, Lignée cellulaire tumorale, Réplication virale, Virus du SRAS.
English descriptors
- KwdEn :
- MESH :
- chemical , chemical synthesis : Antiviral Agents, Quercetin.
- chemical , pharmacology : Antiviral Agents, Quercetin.
- drug effects : Hepacivirus, SARS Virus, Virus Replication.
- physiology : Hepacivirus, SARS Virus.
- Cell Line, Tumor, Humans.
Abstract
Aryl diketoacid (ADK) is well known for antiviral activity which can be enhanced by introduction of an aromatic arylmethyl substituent. A natural flavonoid quercetin has a 3,5-dihydroxychromone pharmacophore which is in bioisosteric relationship with the 1,3-diketoacid moiety of the ADK. Thus, it was of our interest to test the antiviral activity of the quercetin derivatives with an arylmethyl group attached. In this study, we prepared a series of the 7-O-arylmethylquercetin derivatives with various aromatic substituents and evaluated their antiviral activity against the SARS-associated coronavirus (SARS-CoV, SCV) as well as hepatitis C virus (HCV). Single difference in the aromatic substituent fine-tuned the biological activity of the 7-O-arylmethylquercetin derivatives to result in two different classes of derivatives selectively active against SCV and HCV.
DOI: 10.1007/s12272-012-0108-9
PubMed: 22297745
Affiliations:
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type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Yoon, Hyunjun" sort="Yoon, Hyunjun" uniqKey="Yoon H" first="Hyunjun" last="Yoon">Hyunjun Yoon</name></author><author><name sortKey="Kim, Mi Kyoung" sort="Kim, Mi Kyoung" uniqKey="Kim M" first="Mi Kyoung" last="Kim">Mi Kyoung Kim</name></author><author><name sortKey="Lee, Sung Dae" sort="Lee, Sung Dae" uniqKey="Lee S" first="Sung Dae" last="Lee">Sung Dae Lee</name></author><author><name sortKey="Chong, Youhoon" sort="Chong, Youhoon" uniqKey="Chong Y" first="Youhoon" last="Chong">Youhoon Chong</name></author></analytic><series><title level="j">Archives of pharmacal research</title><idno type="ISSN">0253-6269</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (chemical synthesis)</term><term>Antiviral Agents 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qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Quercetin</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Hepacivirus</term><term>SARS Virus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Quercétine</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Hepacivirus</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hepacivirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Antiviraux</term><term>Quercétine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Hepacivirus</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Réplication virale</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aryl diketoacid (ADK) is well known for antiviral activity which can be enhanced by introduction of an aromatic arylmethyl substituent. A natural flavonoid quercetin has a 3,5-dihydroxychromone pharmacophore which is in bioisosteric relationship with the 1,3-diketoacid moiety of the ADK. Thus, it was of our interest to test the antiviral activity of the quercetin derivatives with an arylmethyl group attached. In this study, we prepared a series of the 7-O-arylmethylquercetin derivatives with various aromatic substituents and evaluated their antiviral activity against the SARS-associated coronavirus (SARS-CoV, SCV) as well as hepatitis C virus (HCV). Single difference in the aromatic substituent fine-tuned the biological activity of the 7-O-arylmethylquercetin derivatives to result in two different classes of derivatives selectively active against SCV and HCV.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><noCountry><name sortKey="Chong, Youhoon" sort="Chong, Youhoon" uniqKey="Chong Y" first="Youhoon" last="Chong">Youhoon Chong</name><name sortKey="Kim, Mi Kyoung" sort="Kim, Mi Kyoung" uniqKey="Kim M" first="Mi Kyoung" last="Kim">Mi Kyoung Kim</name><name sortKey="Lee, Sung Dae" sort="Lee, Sung Dae" uniqKey="Lee S" first="Sung Dae" last="Lee">Sung Dae Lee</name><name sortKey="Yoon, Hyunjun" sort="Yoon, Hyunjun" uniqKey="Yoon H" first="Hyunjun" last="Yoon">Hyunjun Yoon</name></noCountry><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Park, Hye Ri" sort="Park, Hye Ri" uniqKey="Park H" first="Hye Ri" last="Park">Hye Ri Park</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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