SrasV1, Ncbi, Checkpoint, bibRecord, 001E40

Comparative analysis of the immunogenicity of SARS-CoV nucleocapsid DNA vaccine administrated with different routes in mouse model

Identifieur interne : 001E40 ( Ncbi/Checkpoint ); précédent : 001E39; suivant : 001E41

Comparative analysis of the immunogenicity of SARS-CoV nucleocapsid DNA vaccine administrated with different routes in mouse model

Auteurs : Hui Hu [République populaire de Chine] ; Xianqing Huang [République populaire de Chine] ; Ling Tao [République populaire de Chine] ; Yi Huang [République populaire de Chine] ; Bao-An Cui [République populaire de Chine] ; Hanzhong Wang [République populaire de Chine]

Source :

Vaccine [ 0264-410X ] ; 2009.

RBID : PMC:7115532

Descripteurs français

KwdFr :
- ADN viral (génétique), ADN viral (immunologie), Administration par voie orale, Animaux, Anticorps antiviraux (analyse), Anticorps antiviraux (biosynthèse), Capside (immunologie), Femelle, Immunité cellulaire (immunologie), Injections musculaires, Interféron gamma (biosynthèse), Interleukine-4 (biosynthèse), Lymphocytes (immunologie), Plasmides (immunologie), Production d'anticorps (immunologie), Prolifération cellulaire, Salmonella typhimurium (immunologie), Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère (immunologie), Vaccins antiviraux (administration et posologie), Vaccins antiviraux (immunologie), Vaccins atténués (immunologie), Vaccins à ADN (administration et posologie), Vaccins à ADN (immunologie), Virus du SRAS (immunologie), Électroporation.
MESH :
- administration et posologie : Vaccins antiviraux, Vaccins à ADN.
- analyse : Anticorps antiviraux.
- biosynthèse : Anticorps antiviraux, Interféron gamma, Interleukine-4.
- génétique : ADN viral.
- immunologie : ADN viral, Capside, Immunité cellulaire, Lymphocytes, Plasmides, Production d'anticorps, Salmonella typhimurium, Syndrome respiratoire aigu sévère, Vaccins antiviraux, Vaccins atténués, Vaccins à ADN, Virus du SRAS.
- Administration par voie orale, Animaux, Femelle, Injections musculaires, Prolifération cellulaire, Souris, Souris de lignée BALB C, Électroporation.

English descriptors

KwdEn :
- Administration, Oral, Animals, Antibodies, Viral (analysis), Antibodies, Viral (biosynthesis), Antibody Formation (immunology), Capsid (immunology), Cell Proliferation, DNA, Viral (genetics), DNA, Viral (immunology), Electroporation, Female, Immunity, Cellular (immunology), Injections, Intramuscular, Interferon-gamma (biosynthesis), Interleukin-4 (biosynthesis), Lymphocytes (immunology), Mice, Mice, Inbred BALB C, Plasmids (immunology), SARS Virus (immunology), Salmonella typhimurium (immunology), Severe Acute Respiratory Syndrome (immunology), Vaccines, Attenuated (immunology), Vaccines, DNA (administration & dosage), Vaccines, DNA (immunology), Viral Vaccines (administration & dosage), Viral Vaccines (immunology).
MESH :
- chemical , administration & dosage : Vaccines, DNA, Viral Vaccines.
- chemical , analysis : Antibodies, Viral.
- chemical , biosynthesis : Antibodies, Viral, Interferon-gamma, Interleukin-4.
- chemical , genetics : DNA, Viral.
- immunology : Antibody Formation, Capsid, DNA, Viral, Immunity, Cellular, Lymphocytes, Plasmids, SARS Virus, Salmonella typhimurium, Severe Acute Respiratory Syndrome, Vaccines, Attenuated, Vaccines, DNA, Viral Vaccines.
- Administration, Oral, Animals, Cell Proliferation, Electroporation, Female, Injections, Intramuscular, Mice, Mice, Inbred BALB C.

Abstract

The development of strategies to augment the immunogenicity of DNA vaccines is critical for improving their clinical utility. One such strategy involves using the different immune routes with DNA vaccines. In the present study, the immunogenicity of SARS-CoV nucleocapsid DNA vaccine, induced by using the current routine vaccination routes (intramuscularly, by electroporation, or orally using live-attenuated Salmonella typhimurium), was compared in mouse model. The comparison between the three vaccination routes indicated that immunization intramuscularly induced a moderate T cell response and antibody response. Mice administrated by electroporation induced the highest antibody response among the three immunization groups and a mid-level of cellular response. In contrast, the orally DNA vaccine evoked vigorous T cell response and a weak antibody production. These results indicated that the distinct types of immune responses were generated by the different routes of DNA immunization. In addition, our results also show that the delivery of DNA vaccines by electroporation and orally using live-attenuated Salmonella in vivo is an effective method to increase the immune responses. Further studies could be carried out using a combination strategy of both oral and electroporation immunizations to stimulate higher cellular and humoral immune responses.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115532

DOI: 10.1016/j.vaccine.2009.01.021
PubMed: 19186202
PubMed Central: 7115532

Affiliations:

Links to Exploration step

PMC:7115532

Le document en format XML

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<term>Antibodies, Viral (biosynthesis)</term>
<term>Antibody Formation (immunology)</term>
<term>Capsid (immunology)</term>
<term>Cell Proliferation</term>
<term>DNA, Viral (genetics)</term>
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<front><div type="abstract" xml:lang="en"><p>The development of strategies to augment the immunogenicity of DNA vaccines is critical for improving their clinical utility. One such strategy involves using the different immune routes with DNA vaccines. In the present study, the immunogenicity of SARS-CoV nucleocapsid DNA vaccine, induced by using the current routine vaccination routes (intramuscularly, by electroporation, or orally using live-attenuated <italic>Salmonella typhimurium</italic>
), was compared in mouse model. The comparison between the three vaccination routes indicated that immunization intramuscularly induced a moderate T cell response and antibody response. Mice administrated by electroporation induced the highest antibody response among the three immunization groups and a mid-level of cellular response. In contrast, the orally DNA vaccine evoked vigorous T cell response and a weak antibody production. These results indicated that the distinct types of immune responses were generated by the different routes of DNA immunization. In addition, our results also show that the delivery of DNA vaccines by electroporation and orally using live-attenuated Salmonella <italic>in vivo</italic>
 is an effective method to increase the immune responses. Further studies could be carried out using a combination strategy of both oral and electroporation immunizations to stimulate higher cellular and humoral immune responses.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Stadler, K" uniqKey="Stadler K">K. Stadler</name>
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<author><name sortKey="Zheng, B J" uniqKey="Zheng B">B.J. Zheng</name>
</author>
<author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shata, M T" uniqKey="Shata M">M.T. Shata</name>
</author>
<author><name sortKey="Reitz, M S" uniqKey="Reitz M">M.S. Reitz</name>
</author>
<author><name sortKey="Devico, A L" uniqKey="Devico A">A.L. DeVico</name>
</author>
<author><name sortKey="Lewis, G K" uniqKey="Lewis G">G.K. Lewis</name>
</author>
<author><name sortKey="Hone, D M" uniqKey="Hone D">D.M. Hone</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Hubei</li>
</region>
<settlement><li>Wuhan</li>
</settlement>
</list>
<tree><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Hu, Hui" sort="Hu, Hui" uniqKey="Hu H" first="Hui" last="Hu">Hui Hu</name>
</region>
<name sortKey="Cui, Bao An" sort="Cui, Bao An" uniqKey="Cui B" first="Bao-An" last="Cui">Bao-An Cui</name>
<name sortKey="Hu, Hui" sort="Hu, Hui" uniqKey="Hu H" first="Hui" last="Hu">Hui Hu</name>
<name sortKey="Huang, Xianqing" sort="Huang, Xianqing" uniqKey="Huang X" first="Xianqing" last="Huang">Xianqing Huang</name>
<name sortKey="Huang, Yi" sort="Huang, Yi" uniqKey="Huang Y" first="Yi" last="Huang">Yi Huang</name>
<name sortKey="Tao, Ling" sort="Tao, Ling" uniqKey="Tao L" first="Ling" last="Tao">Ling Tao</name>
<name sortKey="Wang, Hanzhong" sort="Wang, Hanzhong" uniqKey="Wang H" first="Hanzhong" last="Wang">Hanzhong Wang</name>
</country>
</tree>
</affiliations>
</record>

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HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E40 | SxmlIndent | more

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{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    Ncbi
   |étape=   Checkpoint
   |type=    RBID
   |clé=     PMC:7115532
   |texte=   Comparative analysis of the immunogenicity of SARS-CoV nucleocapsid DNA vaccine administrated with different routes in mouse model
}}

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HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i   -Sk "pubmed:19186202" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

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Comparative analysis of the immunogenicity of SARS-CoV nucleocapsid DNA vaccine administrated with different routes in mouse model

Comparative analysis of the immunogenicity of SARS-CoV nucleocapsid DNA vaccine administrated with different routes in mouse model

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	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.