Augmentation of chemokine production by severe acute respiratory syndrome coronavirus 3a/X1 and 7a/X4 proteins through NF-kappaB activation.
Identifieur interne : 001785 ( Ncbi/Checkpoint ); précédent : 001784; suivant : 001786Augmentation of chemokine production by severe acute respiratory syndrome coronavirus 3a/X1 and 7a/X4 proteins through NF-kappaB activation.
Auteurs : Noriyuki Kanzawa [Japon] ; Kazuo Nishigaki ; Takaya Hayashi ; Yuichi Ishii ; Souichi Furukawa ; Ayako Niiro ; Fumihiko Yasui ; Michinori Kohara ; Kouichi Morita ; Kouji Matsushima ; Mai Quynh Le ; Takao Masuda ; Mari KannagiSource :
- FEBS letters [ 0014-5793 ] ; 2006.
Descripteurs français
- KwdFr :
- Activation enzymatique, Chimiokines (biosynthèse), Expression des gènes, Facteur de transcription NF-kappa B (métabolisme), Humains, JNK Mitogen-Activated Protein Kinases (métabolisme), Lignée cellulaire, Protéines de la matrice virale (génétique), Protéines de la matrice virale (métabolisme), Protéines virales (génétique), Protéines virales (métabolisme), Protéines virales structurales (génétique), Protéines virales structurales (métabolisme), Régions promotrices (génétique) (génétique), Virus du SRAS (génétique), Virus du SRAS (métabolisme).
- MESH :
- biosynthèse : Chimiokines.
- génétique : Protéines de la matrice virale, Protéines virales, Protéines virales structurales, Régions promotrices (génétique), Virus du SRAS.
- métabolisme : Facteur de transcription NF-kappa B, JNK Mitogen-Activated Protein Kinases, Protéines de la matrice virale, Protéines virales, Protéines virales structurales, Virus du SRAS.
- Activation enzymatique, Expression des gènes, Humains, Lignée cellulaire.
English descriptors
- KwdEn :
- Cell Line, Chemokines (biosynthesis), Enzyme Activation, Gene Expression, Humans, JNK Mitogen-Activated Protein Kinases (metabolism), NF-kappa B (metabolism), Promoter Regions, Genetic (genetics), SARS Virus (genetics), SARS Virus (metabolism), Viral Matrix Proteins (genetics), Viral Matrix Proteins (metabolism), Viral Proteins (genetics), Viral Proteins (metabolism), Viral Structural Proteins (genetics), Viral Structural Proteins (metabolism).
- MESH :
- chemical , biosynthesis : Chemokines.
- chemical , genetics : Viral Matrix Proteins, Viral Proteins, Viral Structural Proteins.
- chemical , metabolism : JNK Mitogen-Activated Protein Kinases, NF-kappa B, Viral Matrix Proteins, Viral Proteins, Viral Structural Proteins.
- genetics : Promoter Regions, Genetic, SARS Virus.
- metabolism : SARS Virus.
- Cell Line, Enzyme Activation, Gene Expression, Humans.
Abstract
Severe acute respiratory syndrome (SARS) is characterized by rapidly progressing respiratory failure resembling acute/adult respiratory distress syndrome (ARDS) associated with uncontrolled inflammatory responses. Here, we demonstrated that, among five accessory proteins of SARS coronavirus (SARS-CoV) tested, 3a/X1 and 7a/X4 were capable of activating nuclear factor kappa B (NF-kappaB) and c-Jun N-terminal kinase (JNK), and significantly enhanced interleukin 8 (IL-8) promoter activity. Furthermore, 3a/X1 and 7a/X4 expression in A549 cells enhanced production of inflammatory chemokines that were known to be up-regulated in SARS-CoV infection. Our results suggest potential involvement of 3a/X1 and 7a/X4 proteins in the pathological inflammatory responses in SARS.
DOI: 10.1016/j.febslet.2006.11.046
PubMed: 17141229
Affiliations:
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pubmed:17141229Le document en format XML
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<author><name sortKey="Kanzawa, Noriyuki" sort="Kanzawa, Noriyuki" uniqKey="Kanzawa N" first="Noriyuki" last="Kanzawa">Noriyuki Kanzawa</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Immunotherapeutics, Tokyo Medical and Dental University, Graduate School, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.</nlm:affiliation>
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<term>Humans</term>
<term>JNK Mitogen-Activated Protein Kinases (metabolism)</term>
<term>NF-kappa B (metabolism)</term>
<term>Promoter Regions, Genetic (genetics)</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (metabolism)</term>
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<term>Chimiokines (biosynthèse)</term>
<term>Expression des gènes</term>
<term>Facteur de transcription NF-kappa B (métabolisme)</term>
<term>Humains</term>
<term>JNK Mitogen-Activated Protein Kinases (métabolisme)</term>
<term>Lignée cellulaire</term>
<term>Protéines de la matrice virale (génétique)</term>
<term>Protéines de la matrice virale (métabolisme)</term>
<term>Protéines virales (génétique)</term>
<term>Protéines virales (métabolisme)</term>
<term>Protéines virales structurales (génétique)</term>
<term>Protéines virales structurales (métabolisme)</term>
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<term>Virus du SRAS (génétique)</term>
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<term>Viral Proteins</term>
<term>Viral Structural Proteins</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>JNK Mitogen-Activated Protein Kinases</term>
<term>NF-kappa B</term>
<term>Viral Matrix Proteins</term>
<term>Viral Proteins</term>
<term>Viral Structural Proteins</term>
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<term>Protéines virales structurales</term>
<term>Régions promotrices (génétique)</term>
<term>Virus du SRAS</term>
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<term>Protéines virales</term>
<term>Protéines virales structurales</term>
<term>Virus du SRAS</term>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is characterized by rapidly progressing respiratory failure resembling acute/adult respiratory distress syndrome (ARDS) associated with uncontrolled inflammatory responses. Here, we demonstrated that, among five accessory proteins of SARS coronavirus (SARS-CoV) tested, 3a/X1 and 7a/X4 were capable of activating nuclear factor kappa B (NF-kappaB) and c-Jun N-terminal kinase (JNK), and significantly enhanced interleukin 8 (IL-8) promoter activity. Furthermore, 3a/X1 and 7a/X4 expression in A549 cells enhanced production of inflammatory chemokines that were known to be up-regulated in SARS-CoV infection. Our results suggest potential involvement of 3a/X1 and 7a/X4 proteins in the pathological inflammatory responses in SARS.</div>
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<name sortKey="Hayashi, Takaya" sort="Hayashi, Takaya" uniqKey="Hayashi T" first="Takaya" last="Hayashi">Takaya Hayashi</name>
<name sortKey="Ishii, Yuichi" sort="Ishii, Yuichi" uniqKey="Ishii Y" first="Yuichi" last="Ishii">Yuichi Ishii</name>
<name sortKey="Kannagi, Mari" sort="Kannagi, Mari" uniqKey="Kannagi M" first="Mari" last="Kannagi">Mari Kannagi</name>
<name sortKey="Kohara, Michinori" sort="Kohara, Michinori" uniqKey="Kohara M" first="Michinori" last="Kohara">Michinori Kohara</name>
<name sortKey="Le, Mai Quynh" sort="Le, Mai Quynh" uniqKey="Le M" first="Mai Quynh" last="Le">Mai Quynh Le</name>
<name sortKey="Masuda, Takao" sort="Masuda, Takao" uniqKey="Masuda T" first="Takao" last="Masuda">Takao Masuda</name>
<name sortKey="Matsushima, Kouji" sort="Matsushima, Kouji" uniqKey="Matsushima K" first="Kouji" last="Matsushima">Kouji Matsushima</name>
<name sortKey="Morita, Kouichi" sort="Morita, Kouichi" uniqKey="Morita K" first="Kouichi" last="Morita">Kouichi Morita</name>
<name sortKey="Niiro, Ayako" sort="Niiro, Ayako" uniqKey="Niiro A" first="Ayako" last="Niiro">Ayako Niiro</name>
<name sortKey="Nishigaki, Kazuo" sort="Nishigaki, Kazuo" uniqKey="Nishigaki K" first="Kazuo" last="Nishigaki">Kazuo Nishigaki</name>
<name sortKey="Yasui, Fumihiko" sort="Yasui, Fumihiko" uniqKey="Yasui F" first="Fumihiko" last="Yasui">Fumihiko Yasui</name>
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<country name="Japon"><region name="Région de Kantō"><name sortKey="Kanzawa, Noriyuki" sort="Kanzawa, Noriyuki" uniqKey="Kanzawa N" first="Noriyuki" last="Kanzawa">Noriyuki Kanzawa</name>
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