Selection of SARS-Coronavirus-specific B cell epitopes by phage peptide library screening and evaluation of the immunological effect of epitope-based peptides on mice☆
Identifieur interne : 001743 ( Ncbi/Checkpoint ); précédent : 001742; suivant : 001744Selection of SARS-Coronavirus-specific B cell epitopes by phage peptide library screening and evaluation of the immunological effect of epitope-based peptides on mice☆
Auteurs : Hua Yu [République populaire de Chine] ; Li-Fang Jiang [République populaire de Chine] ; Dan-Yun Fang [République populaire de Chine] ; Hui-Jun Yan [République populaire de Chine] ; Jing-Jiao Zhou [République populaire de Chine] ; Jun-Mei Zhou [République populaire de Chine] ; Yu Liang [République populaire de Chine] ; Yang Gao [République populaire de Chine] ; Wei Zhao [République populaire de Chine] ; Bei-Guo Long [République populaire de Chine]Source :
- Virology [ 0042-6822 ] ; 2006.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (sang), Bactériophages (génétique), Banque de peptides, Déterminants antigéniques des lymphocytes B (), Déterminants antigéniques des lymphocytes B (immunologie), Femelle, Peptides (), Peptides (immunologie), Rate (cytologie), Régulation de l'expression des gènes, Souris, Souris de lignée BALB C, Sous-populations de lymphocytes (métabolisme), Syndrome respiratoire aigu sévère (), Séquence d'acides aminés, Vaccins antiviraux (immunologie), Virus du SRAS (immunologie).
- MESH :
- cytologie : Rate.
- génétique : Bactériophages.
- immunologie : Déterminants antigéniques des lymphocytes B, Peptides, Vaccins antiviraux, Virus du SRAS.
- métabolisme : Sous-populations de lymphocytes.
- sang : Anticorps antiviraux.
- Animaux, Banque de peptides, Déterminants antigéniques des lymphocytes B, Femelle, Peptides, Régulation de l'expression des gènes, Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Antibodies, Viral (blood), Bacteriophages (genetics), Epitopes, B-Lymphocyte (chemistry), Epitopes, B-Lymphocyte (immunology), Female, Gene Expression Regulation, Lymphocyte Subsets (metabolism), Mice, Mice, Inbred BALB C, Peptide Library, Peptides (chemistry), Peptides (immunology), SARS Virus (immunology), Severe Acute Respiratory Syndrome (prevention & control), Spleen (cytology), Viral Vaccines (immunology).
- MESH :
- chemical , blood : Antibodies, Viral.
- chemical , chemistry : Epitopes, B-Lymphocyte, Peptides.
- cytology : Spleen.
- genetics : Bacteriophages.
- chemical , immunology : Epitopes, B-Lymphocyte, Peptides, SARS Virus, Viral Vaccines.
- metabolism : Lymphocyte Subsets.
- prevention & control : Severe Acute Respiratory Syndrome.
- Amino Acid Sequence, Animals, Female, Gene Expression Regulation, Mice, Mice, Inbred BALB C, Peptide Library.
Abstract
Antibodies to
Url:
DOI: 10.1016/j.virol.2006.09.016
PubMed: 17055022
PubMed Central: 7103350
Affiliations:
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PMC:7103350Le document en format XML
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ref-type="fn" rid="d32e2337">☆</xref></sup></title><author><name sortKey="Yu, Hua" sort="Yu, Hua" uniqKey="Yu H" first="Hua" last="Yu">Hua Yu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Microbiology, Zhongshan Medical School, Sun Yat-sen University, 74 Zhong-shan 2-Road, Guangzhou 510080, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, Zhongshan Medical School, Sun Yat-sen University, 74 Zhong-shan 2-Road, Guangzhou 510080</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Jiang, Li Fang" sort="Jiang, Li Fang" uniqKey="Jiang L" first="Li-Fang" last="Jiang">Li-Fang Jiang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Microbiology, Zhongshan Medical School, Sun Yat-sen University, 74 Zhong-shan 2-Road, Guangzhou 510080, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, Zhongshan Medical School, Sun Yat-sen University, 74 Zhong-shan 2-Road, Guangzhou 510080</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Fang, Dan Yun" sort="Fang, Dan Yun" uniqKey="Fang D" first="Dan-Yun" last="Fang">Dan-Yun Fang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Microbiology, Zhongshan Medical School, Sun Yat-sen University, 74 Zhong-shan 2-Road, Guangzhou 510080, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, Zhongshan Medical School, Sun Yat-sen University, 74 Zhong-shan 2-Road, Guangzhou 510080</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Yan, Hui Jun" sort="Yan, Hui Jun" uniqKey="Yan H" first="Hui-Jun" last="Yan">Hui-Jun Yan</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Microbiology, Zhongshan Medical School, Sun Yat-sen University, 74 Zhong-shan 2-Road, Guangzhou 510080, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, Zhongshan Medical School, Sun Yat-sen University, 74 Zhong-shan 2-Road, Guangzhou 510080</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zhou, Jing Jiao" sort="Zhou, Jing Jiao" uniqKey="Zhou J" first="Jing-Jiao" last="Zhou">Jing-Jiao Zhou</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Microbiology, Zhongshan Medical School, Sun Yat-sen University, 74 Zhong-shan 2-Road, Guangzhou 510080, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, Zhongshan Medical School, Sun Yat-sen University, 74 Zhong-shan 2-Road, Guangzhou 510080</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zhou, Jun Mei" sort="Zhou, Jun Mei" uniqKey="Zhou J" first="Jun-Mei" last="Zhou">Jun-Mei Zhou</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Microbiology, Zhongshan Medical School, Sun Yat-sen University, 74 Zhong-shan 2-Road, Guangzhou 510080, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, Zhongshan Medical School, Sun Yat-sen University, 74 Zhong-shan 2-Road, Guangzhou 510080</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Liang, Yu" sort="Liang, Yu" uniqKey="Liang Y" first="Yu" last="Liang">Yu Liang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Microbiology, Zhongshan Medical School, Sun Yat-sen University, 74 Zhong-shan 2-Road, Guangzhou 510080, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, Zhongshan Medical School, Sun Yat-sen University, 74 Zhong-shan 2-Road, Guangzhou 510080</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Gao, Yang" sort="Gao, Yang" uniqKey="Gao Y" first="Yang" last="Gao">Yang Gao</name><affiliation wicri:level="1"><nlm:aff id="aff2">Guangzhou City CDC, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou City CDC</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Wei" sort="Zhao, Wei" uniqKey="Zhao W" first="Wei" last="Zhao">Wei Zhao</name><affiliation wicri:level="3"><nlm:aff id="aff3">Department of Microbiology, Southern Medical University, Guangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, Southern Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Long, Bei Guo" sort="Long, Bei Guo" uniqKey="Long B" first="Bei-Guo" last="Long">Bei-Guo Long</name><affiliation wicri:level="3"><nlm:aff id="aff3">Department of Microbiology, Southern Medical University, Guangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, Southern Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><idno type="eISSN">1096-0341</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Antibodies, Viral (blood)</term><term>Bacteriophages (genetics)</term><term>Epitopes, B-Lymphocyte (chemistry)</term><term>Epitopes, B-Lymphocyte (immunology)</term><term>Female</term><term>Gene Expression Regulation</term><term>Lymphocyte Subsets (metabolism)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Peptide Library</term><term>Peptides (chemistry)</term><term>Peptides (immunology)</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (prevention & control)</term><term>Spleen (cytology)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Bactériophages (génétique)</term><term>Banque de peptides</term><term>Déterminants antigéniques des lymphocytes B ()</term><term>Déterminants antigéniques des lymphocytes B (immunologie)</term><term>Femelle</term><term>Peptides ()</term><term>Peptides (immunologie)</term><term>Rate (cytologie)</term><term>Régulation de l'expression des gènes</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Sous-populations de lymphocytes (métabolisme)</term><term>Syndrome respiratoire aigu sévère ()</term><term>Séquence d'acides aminés</term><term>Vaccins antiviraux (immunologie)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Epitopes, B-Lymphocyte</term><term>Peptides</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Rate</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Spleen</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Bacteriophages</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Bactériophages</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Déterminants antigéniques des lymphocytes B</term><term>Peptides</term><term>Vaccins antiviraux</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Epitopes, B-Lymphocyte</term><term>Peptides</term><term>SARS Virus</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymphocyte Subsets</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Sous-populations de lymphocytes</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Female</term><term>Gene Expression Regulation</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Peptide Library</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Banque de peptides</term><term>Déterminants antigéniques des lymphocytes B</term><term>Femelle</term><term>Peptides</term><term>Régulation de l'expression des gènes</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Syndrome respiratoire aigu sévère</term><term>Séquence d'acides aminés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Antibodies to <italic>SARS-Coronavirus</italic> (<italic>SARS-CoV</italic>)-specific B cell epitopes might recognize the pathogen and interrupt its adherence to and penetration of host cells. Hence, these epitopes could be useful for diagnosis and as vaccine constituents. Using the phage-displayed peptide library screening method and purified Fab fragments of immunoglobulin G (IgG Fab) from normal human sera and convalescent sera from <italic>SARS-CoV</italic>-infected patients as targets, 11 B cell epitopes of <italic>SARS-CoV</italic> spike glycoprotein (S protein) and membrane protein (M protein) were screened. After a bioinformatics tool was used to analyze these epitopes, four epitope-based S protein dodecapeptides corresponding to the predominant epitopes were chosen for synthesis. Their antigenic specificities and immunogenicities were studied <italic>in vitro</italic> and <italic>in vivo.</italic> Flow cytometry and ELISPOT analysis of lymphocytes as well as a serologic analysis of antibody showed that these peptides could trigger a rapid, highly effective, and relatively safe immune response in BALB/c mice. These findings might aid development of SARS diagnostics and vaccines. Moreover, the role of S and M proteins as important surface antigens is confirmed.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adey, N B" uniqKey="Adey N">N.B. Adey</name></author><author><name sortKey="Mataragnon, A H" uniqKey="Mataragnon A">A.H. Mataragnon</name></author><author><name sortKey="Rider, J E" uniqKey="Rider J">J.E. Rider</name></author><author><name sortKey="Carter, J M" uniqKey="Carter J">J.M. Carter</name></author><author><name sortKey="Kay, B K" uniqKey="Kay B">B.K. Kay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Akbar, A N" uniqKey="Akbar A">A.N. Akbar</name></author><author><name sortKey="Salmon, M" uniqKey="Salmon M">M. Salmon</name></author><author><name sortKey="Savill, J" uniqKey="Savill J">J. Savill</name></author><author><name sortKey="Janossy, G" uniqKey="Janossy G">G. 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Shibo</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Guangdong</li></region><settlement><li>Jiangmen</li></settlement></list><tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Yu, Hua" sort="Yu, Hua" uniqKey="Yu H" first="Hua" last="Yu">Hua Yu</name></region><name sortKey="Fang, Dan Yun" sort="Fang, Dan Yun" uniqKey="Fang D" first="Dan-Yun" last="Fang">Dan-Yun Fang</name><name sortKey="Gao, Yang" sort="Gao, Yang" uniqKey="Gao Y" first="Yang" last="Gao">Yang Gao</name><name sortKey="Jiang, Li Fang" sort="Jiang, Li Fang" uniqKey="Jiang L" first="Li-Fang" last="Jiang">Li-Fang Jiang</name><name sortKey="Liang, Yu" sort="Liang, Yu" uniqKey="Liang Y" first="Yu" last="Liang">Yu Liang</name><name sortKey="Long, Bei Guo" sort="Long, Bei Guo" uniqKey="Long B" first="Bei-Guo" last="Long">Bei-Guo Long</name><name sortKey="Yan, Hui Jun" sort="Yan, Hui Jun" uniqKey="Yan H" first="Hui-Jun" last="Yan">Hui-Jun Yan</name><name sortKey="Zhao, Wei" sort="Zhao, Wei" uniqKey="Zhao W" first="Wei" last="Zhao">Wei Zhao</name><name sortKey="Zhou, Jing Jiao" sort="Zhou, Jing Jiao" uniqKey="Zhou J" first="Jing-Jiao" last="Zhou">Jing-Jiao Zhou</name><name sortKey="Zhou, Jun Mei" sort="Zhou, Jun Mei" uniqKey="Zhou J" first="Jun-Mei" last="Zhou">Jun-Mei Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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