Potent and specific inhibition of SARS-CoV antigen expression by RNA interference.
Identifieur interne : 000F58 ( Ncbi/Checkpoint ); précédent : 000F57; suivant : 000F59Potent and specific inhibition of SARS-CoV antigen expression by RNA interference.
Auteurs : Peng Tao [République populaire de Chine] ; Jun Zhang ; Ni Tang ; Bing-Qiang Zhang ; Tong-Chuan He ; Ai-Long HuangSource :
- Chinese medical journal [ 0366-6999 ] ; 2005.
Descripteurs français
- KwdFr :
- Antigènes viraux (génétique), Cellules cultivées, Humains, Interférence par ARN, Protéines nucléocapside (antagonistes et inhibiteurs), Protéines nucléocapside (génétique), Protéines à fluorescence verte (génétique), Syndrome respiratoire aigu sévère (), Vecteurs génétiques, Virus du SRAS (génétique), Virus du SRAS (immunologie).
- MESH :
- antagonistes et inhibiteurs : Protéines nucléocapside.
- génétique : Antigènes viraux, Protéines nucléocapside, Protéines à fluorescence verte, Virus du SRAS.
- immunologie : Virus du SRAS.
- Cellules cultivées, Humains, Interférence par ARN, Syndrome respiratoire aigu sévère, Vecteurs génétiques.
English descriptors
- KwdEn :
- Antigens, Viral (genetics), Cells, Cultured, Genetic Vectors, Green Fluorescent Proteins (genetics), Humans, Nucleocapsid Proteins (antagonists & inhibitors), Nucleocapsid Proteins (genetics), RNA Interference, SARS Virus (genetics), SARS Virus (immunology), Severe Acute Respiratory Syndrome (therapy).
- MESH :
- chemical , antagonists & inhibitors : Nucleocapsid Proteins.
- chemical , genetics : Antigens, Viral, Green Fluorescent Proteins, Nucleocapsid Proteins.
- genetics : SARS Virus.
- immunology : SARS Virus.
- therapy : Severe Acute Respiratory Syndrome.
- Cells, Cultured, Genetic Vectors, Humans, RNA Interference.
Abstract
Severe acute respiratory syndrome (SARS) is an infectious disease caused by SARS-CoV. There are no effective antiviral drugs for SARS although the epidemic of SARS was controlled. The aim of this study was to develop an RNAi (RNA interference) approach that specifically targeted the N gene sequence of severe acute respiratory syndrome associated coronavirus (SARS-CoV) by synthesizing short hairpin RNA (shRNA) in vivo, and to assess the inhibitory effect of this shRNA on SARS-CoV N antigen expression.
PubMed: 15899131
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002731
- to stream PubMed, to step Curation: 002731
- to stream PubMed, to step Checkpoint: 002577
- to stream Ncbi, to step Merge: 000F58
- to stream Ncbi, to step Curation: 000F58
Links to Exploration step
pubmed:15899131Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Potent and specific inhibition of SARS-CoV antigen expression by RNA interference.</title>
<author><name sortKey="Tao, Peng" sort="Tao, Peng" uniqKey="Tao P" first="Peng" last="Tao">Peng Tao</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute for Viral Hepatitis, Chongqing University of Medical Sciences, Chongqing 400010, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The Institute for Viral Hepatitis, Chongqing University of Medical Sciences, Chongqing 400010</wicri:regionArea>
<wicri:noRegion>Chongqing 400010</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Jun" sort="Zhang, Jun" uniqKey="Zhang J" first="Jun" last="Zhang">Jun Zhang</name>
</author>
<author><name sortKey="Tang, Ni" sort="Tang, Ni" uniqKey="Tang N" first="Ni" last="Tang">Ni Tang</name>
</author>
<author><name sortKey="Zhang, Bing Qiang" sort="Zhang, Bing Qiang" uniqKey="Zhang B" first="Bing-Qiang" last="Zhang">Bing-Qiang Zhang</name>
</author>
<author><name sortKey="He, Tong Chuan" sort="He, Tong Chuan" uniqKey="He T" first="Tong-Chuan" last="He">Tong-Chuan He</name>
</author>
<author><name sortKey="Huang, Ai Long" sort="Huang, Ai Long" uniqKey="Huang A" first="Ai-Long" last="Huang">Ai-Long Huang</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2005">2005</date>
<idno type="RBID">pubmed:15899131</idno>
<idno type="pmid">15899131</idno>
<idno type="wicri:Area/PubMed/Corpus">002731</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002731</idno>
<idno type="wicri:Area/PubMed/Curation">002731</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002731</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002577</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002577</idno>
<idno type="wicri:Area/Ncbi/Merge">000F58</idno>
<idno type="wicri:Area/Ncbi/Curation">000F58</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000F58</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Potent and specific inhibition of SARS-CoV antigen expression by RNA interference.</title>
<author><name sortKey="Tao, Peng" sort="Tao, Peng" uniqKey="Tao P" first="Peng" last="Tao">Peng Tao</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute for Viral Hepatitis, Chongqing University of Medical Sciences, Chongqing 400010, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The Institute for Viral Hepatitis, Chongqing University of Medical Sciences, Chongqing 400010</wicri:regionArea>
<wicri:noRegion>Chongqing 400010</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Jun" sort="Zhang, Jun" uniqKey="Zhang J" first="Jun" last="Zhang">Jun Zhang</name>
</author>
<author><name sortKey="Tang, Ni" sort="Tang, Ni" uniqKey="Tang N" first="Ni" last="Tang">Ni Tang</name>
</author>
<author><name sortKey="Zhang, Bing Qiang" sort="Zhang, Bing Qiang" uniqKey="Zhang B" first="Bing-Qiang" last="Zhang">Bing-Qiang Zhang</name>
</author>
<author><name sortKey="He, Tong Chuan" sort="He, Tong Chuan" uniqKey="He T" first="Tong-Chuan" last="He">Tong-Chuan He</name>
</author>
<author><name sortKey="Huang, Ai Long" sort="Huang, Ai Long" uniqKey="Huang A" first="Ai-Long" last="Huang">Ai-Long Huang</name>
</author>
</analytic>
<series><title level="j">Chinese medical journal</title>
<idno type="ISSN">0366-6999</idno>
<imprint><date when="2005" type="published">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigens, Viral (genetics)</term>
<term>Cells, Cultured</term>
<term>Genetic Vectors</term>
<term>Green Fluorescent Proteins (genetics)</term>
<term>Humans</term>
<term>Nucleocapsid Proteins (antagonists & inhibitors)</term>
<term>Nucleocapsid Proteins (genetics)</term>
<term>RNA Interference</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (immunology)</term>
<term>Severe Acute Respiratory Syndrome (therapy)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Antigènes viraux (génétique)</term>
<term>Cellules cultivées</term>
<term>Humains</term>
<term>Interférence par ARN</term>
<term>Protéines nucléocapside (antagonistes et inhibiteurs)</term>
<term>Protéines nucléocapside (génétique)</term>
<term>Protéines à fluorescence verte (génétique)</term>
<term>Syndrome respiratoire aigu sévère ()</term>
<term>Vecteurs génétiques</term>
<term>Virus du SRAS (génétique)</term>
<term>Virus du SRAS (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Nucleocapsid Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Viral</term>
<term>Green Fluorescent Proteins</term>
<term>Nucleocapsid Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protéines nucléocapside</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes viraux</term>
<term>Protéines nucléocapside</term>
<term>Protéines à fluorescence verte</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Cells, Cultured</term>
<term>Genetic Vectors</term>
<term>Humans</term>
<term>RNA Interference</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Cellules cultivées</term>
<term>Humains</term>
<term>Interférence par ARN</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Vecteurs génétiques</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is an infectious disease caused by SARS-CoV. There are no effective antiviral drugs for SARS although the epidemic of SARS was controlled. The aim of this study was to develop an RNAi (RNA interference) approach that specifically targeted the N gene sequence of severe acute respiratory syndrome associated coronavirus (SARS-CoV) by synthesizing short hairpin RNA (shRNA) in vivo, and to assess the inhibitory effect of this shRNA on SARS-CoV N antigen expression.</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><noCountry><name sortKey="He, Tong Chuan" sort="He, Tong Chuan" uniqKey="He T" first="Tong-Chuan" last="He">Tong-Chuan He</name>
<name sortKey="Huang, Ai Long" sort="Huang, Ai Long" uniqKey="Huang A" first="Ai-Long" last="Huang">Ai-Long Huang</name>
<name sortKey="Tang, Ni" sort="Tang, Ni" uniqKey="Tang N" first="Ni" last="Tang">Ni Tang</name>
<name sortKey="Zhang, Bing Qiang" sort="Zhang, Bing Qiang" uniqKey="Zhang B" first="Bing-Qiang" last="Zhang">Bing-Qiang Zhang</name>
<name sortKey="Zhang, Jun" sort="Zhang, Jun" uniqKey="Zhang J" first="Jun" last="Zhang">Jun Zhang</name>
</noCountry>
<country name="République populaire de Chine"><noRegion><name sortKey="Tao, Peng" sort="Tao, Peng" uniqKey="Tao P" first="Peng" last="Tao">Peng Tao</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F58 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 000F58 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Ncbi |étape= Checkpoint |type= RBID |clé= pubmed:15899131 |texte= Potent and specific inhibition of SARS-CoV antigen expression by RNA interference. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:15899131" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |