rOv-ASP-1, a recombinant secreted protein of the helminth Onchocercavolvulus, is a potent adjuvant for inducing antibodies to ovalbumin, HIV-1 polypeptide and SARS-CoV peptide antigens.
Identifieur interne : 000F04 ( Ncbi/Checkpoint ); précédent : 000F03; suivant : 000F05rOv-ASP-1, a recombinant secreted protein of the helminth Onchocercavolvulus, is a potent adjuvant for inducing antibodies to ovalbumin, HIV-1 polypeptide and SARS-CoV peptide antigens.
Auteurs : Angus J. Macdonald [États-Unis] ; Long Cao ; Yuxian He ; Qian Zhao ; Shibo Jiang ; Sara LustigmanSource :
- Vaccine [ 0264-410X ] ; 2005.
Descripteurs français
- KwdFr :
- Adjuvants immunologiques (pharmacologie), Animaux, Antigènes d'helminthe (administration et posologie), Antigènes d'helminthe (génétique), Antigènes d'helminthe (immunologie), Antigènes d'helminthe (pharmacologie), Lymphocytes auxiliaires Th1 (immunologie), Lymphocytes auxiliaires Th2 (immunologie), Ovalbumine (), Ovalbumine (immunologie), Protéines d'helminthes (pharmacologie), Protéines recombinantes (immunologie), Protéines recombinantes (pharmacologie), Souris, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie), Vaccins synthétiques (administration et posologie), Vaccins synthétiques (immunologie), Virus du SRAS (), Virus du SRAS (immunologie), Vésicules de sécrétion (métabolisme).
- MESH :
- administration et posologie : Antigènes d'helminthe, Vaccins synthétiques.
- génétique : Antigènes d'helminthe.
- immunologie : Antigènes d'helminthe, Lymphocytes auxiliaires Th1, Lymphocytes auxiliaires Th2, Ovalbumine, Protéines recombinantes, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Vaccins synthétiques, Virus du SRAS.
- métabolisme : Vésicules de sécrétion.
- pharmacologie : Adjuvants immunologiques, Antigènes d'helminthe, Protéines d'helminthes, Protéines recombinantes.
- Animaux, Ovalbumine, Souris, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Virus du SRAS.
English descriptors
- KwdEn :
- Adjuvants, Immunologic (pharmacology), Animals, Antigens, Helminth (administration & dosage), Antigens, Helminth (genetics), Antigens, Helminth (immunology), Antigens, Helminth (pharmacology), HIV-1 (drug effects), HIV-1 (immunology), Helminth Proteins (pharmacology), Mice, Ovalbumin (chemistry), Ovalbumin (immunology), Recombinant Proteins (immunology), Recombinant Proteins (pharmacology), SARS Virus (drug effects), SARS Virus (immunology), Secretory Vesicles (metabolism), Th1 Cells (immunology), Th2 Cells (immunology), Vaccines, Synthetic (administration & dosage), Vaccines, Synthetic (immunology).
- MESH :
- chemical , administration & dosage : Antigens, Helminth, Vaccines, Synthetic.
- chemical , chemistry : Ovalbumin.
- chemical , genetics : Antigens, Helminth.
- chemical , immunology : Antigens, Helminth, Ovalbumin, Recombinant Proteins, Vaccines, Synthetic.
- chemical , pharmacology : Adjuvants, Immunologic, Antigens, Helminth, Helminth Proteins, Recombinant Proteins.
- drug effects : HIV-1, SARS Virus.
- immunology : HIV-1, SARS Virus, Th1 Cells, Th2 Cells.
- metabolism : Secretory Vesicles.
- Animals, Mice.
Abstract
We studied the adjuvanticity of recombinant Onchocerca volvulus activation associated protein-1 (rOv-ASP-1) for ovalbumin (OVA) in mice. After a single immunization and one boost, rOv-ASP-1 exceeded the efficacy of alum or MPL + TDM adjuvants in terms of end-point total IgG or IgG1 and IgG2a anti-OVA titres. Using the helminth-derived adjuvant, IgG isotype responses to OVA were of a mixed Th1/Th2 profile and spleen cell cytokines exclusively Th1-type. The potent adjuvanticity of rOv-ASP-1 was confirmed in mice vaccinated with a 37-mer peptide from the S protein of SARS-CoV and an HIV-1 gp120-CD4 chimeric polypeptide antigen. Unusually for a helminth product, the rOv-ASP-1 adjuvant augmented not only Th2 but also Th1 responses, the latter property being of potential utility in stimulating anti-viral immune responses.
DOI: 10.1016/j.vaccine.2005.01.098
PubMed: 15837368
Affiliations:
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pubmed:15837368Le document en format XML
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(immunologie)</term><term>Vésicules de sécrétion (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antigens, Helminth</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Ovalbumin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term><term>Ovalbumin</term><term>Recombinant Proteins</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Adjuvants, Immunologic</term><term>Antigens, Helminth</term><term>Helminth Proteins</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antigènes 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sécrétion</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Adjuvants immunologiques</term><term>Antigènes d'helminthe</term><term>Protéines d'helminthes</term><term>Protéines recombinantes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Ovalbumine</term><term>Souris</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied the adjuvanticity of recombinant Onchocerca volvulus activation associated protein-1 (rOv-ASP-1) for ovalbumin (OVA) in mice. After a single immunization and one boost, rOv-ASP-1 exceeded the efficacy of alum or MPL + TDM adjuvants in terms of end-point total IgG or IgG1 and IgG2a anti-OVA titres. Using the helminth-derived adjuvant, IgG isotype responses to OVA were of a mixed Th1/Th2 profile and spleen cell cytokines exclusively Th1-type. The potent adjuvanticity of rOv-ASP-1 was confirmed in mice vaccinated with a 37-mer peptide from the S protein of SARS-CoV and an HIV-1 gp120-CD4 chimeric polypeptide antigen. Unusually for a helminth product, the rOv-ASP-1 adjuvant augmented not only Th2 but also Th1 responses, the latter property being of potential utility in stimulating anti-viral immune responses.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><noCountry><name sortKey="Cao, Long" sort="Cao, Long" uniqKey="Cao L" first="Long" last="Cao">Long Cao</name><name sortKey="He, Yuxian" sort="He, Yuxian" uniqKey="He Y" first="Yuxian" last="He">Yuxian He</name><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><name sortKey="Lustigman, Sara" sort="Lustigman, Sara" uniqKey="Lustigman S" first="Sara" last="Lustigman">Sara Lustigman</name><name sortKey="Zhao, Qian" sort="Zhao, Qian" uniqKey="Zhao Q" first="Qian" last="Zhao">Qian Zhao</name></noCountry><country name="États-Unis"><region name="État de New York"><name sortKey="Macdonald, Angus J" sort="Macdonald, Angus J" uniqKey="Macdonald A" first="Angus J" last="Macdonald">Angus J. 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