Profile of antibodies to the nucleocapsid protein of the severe acute respiratory syndrome (SARS)-associated coronavirus in probable SARS patients.
Identifieur interne : 000547 ( Ncbi/Checkpoint ); précédent : 000546; suivant : 000548Profile of antibodies to the nucleocapsid protein of the severe acute respiratory syndrome (SARS)-associated coronavirus in probable SARS patients.
Auteurs : Xuan Liu [République populaire de Chine] ; Yulin Shi ; Ping Li ; Linhai Li ; Yanping Yi ; Qingjun Ma ; Cheng CaoSource :
- Clinical and diagnostic laboratory immunology [ 1071-412X ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- diagnostic : Syndrome respiratoire aigu sévère.
- immunologie : Protéines nucléocapside, Syndrome respiratoire aigu sévère, Virus du SRAS.
- sang : Anticorps antiviraux.
- Adulte, Enfant, Facteurs temps, Humains, Test ELISA, Études cas-témoins.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Antibodies, Viral.
- chemical , immunology : Nucleocapsid Proteins.
- diagnosis : Severe Acute Respiratory Syndrome.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome.
- Adult, Case-Control Studies, Child, Enzyme-Linked Immunosorbent Assay, Humans, Time Factors.
Abstract
Profiles of antibodies to the nucleocapsid protein of the severe acute respiratory syndrome (SARS)-associated coronavirus in 445 probable SARS patients and 3,749 healthy people or non-SARS patients were analyzed by antigen-capturing enzyme-linked immunosorbent assay. Antinucleocapsid antibodies were elucidated in 17.5% of the probable SARS patients 1 to 7 days after the onset of symptoms and in 80% of the patients 8 to 14 days after the onset. About 90% of the probable SARS patients were positive 15 or more days after illness. Antibody titers increased up to 70 days, and high antibody titers were maintained at least for another 3 months. Of the healthy people and non-SARS patients, only seven (0.187%) were weakly positive.
DOI: 10.1128/cdli.11.1.227-228.2004
PubMed: 14715574
Affiliations:
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pubmed:14715574Le document en format XML
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<term>Child</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Humans</term>
<term>Nucleocapsid Proteins (immunology)</term>
<term>SARS Virus (immunology)</term>
<term>Severe Acute Respiratory Syndrome (diagnosis)</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
<term>Time Factors</term>
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<term>Anticorps antiviraux (sang)</term>
<term>Enfant</term>
<term>Facteurs temps</term>
<term>Humains</term>
<term>Protéines nucléocapside (immunologie)</term>
<term>Syndrome respiratoire aigu sévère (diagnostic)</term>
<term>Syndrome respiratoire aigu sévère (immunologie)</term>
<term>Test ELISA</term>
<term>Virus du SRAS (immunologie)</term>
<term>Études cas-témoins</term>
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<term>Syndrome respiratoire aigu sévère</term>
<term>Virus du SRAS</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term>
<term>Severe Acute Respiratory Syndrome</term>
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<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
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<term>Case-Control Studies</term>
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<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Humans</term>
<term>Time Factors</term>
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<term>Enfant</term>
<term>Facteurs temps</term>
<term>Humains</term>
<term>Test ELISA</term>
<term>Études cas-témoins</term>
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<front><div type="abstract" xml:lang="en">Profiles of antibodies to the nucleocapsid protein of the severe acute respiratory syndrome (SARS)-associated coronavirus in 445 probable SARS patients and 3,749 healthy people or non-SARS patients were analyzed by antigen-capturing enzyme-linked immunosorbent assay. Antinucleocapsid antibodies were elucidated in 17.5% of the probable SARS patients 1 to 7 days after the onset of symptoms and in 80% of the patients 8 to 14 days after the onset. About 90% of the probable SARS patients were positive 15 or more days after illness. Antibody titers increased up to 70 days, and high antibody titers were maintained at least for another 3 months. Of the healthy people and non-SARS patients, only seven (0.187%) were weakly positive.</div>
</front>
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