Identification of a novel coronavirus in patients with severe acute respiratory syndrome.
Identifieur interne : 006469 ( Main/Merge ); précédent : 006468; suivant : 006470Identification of a novel coronavirus in patients with severe acute respiratory syndrome.
Auteurs : Christian Drosten [Allemagne] ; Stephan Günther ; Wolfgang Preiser ; Sylvie Van Der Werf ; Hans-Reinhard Brodt ; Stephan Becker ; Holger Rabenau ; Marcus Panning ; Larissa Kolesnikova ; Ron A M. Fouchier ; Annemarie Berger ; Ana-Maria Burguière ; Jindrich Cinatl ; Markus Eickmann ; Nicolas Escriou ; Klaus Grywna ; Stefanie Kramme ; Jean-Claude Manuguerra ; Stefanie Müller ; Volker Rickerts ; Martin Stürmer ; Simon Vieth ; Hans-Dieter Klenk ; Albert D M E. Osterhaus ; Herbert Schmitz ; Hans Wilhelm DoerrSource :
- The New England journal of medicine [ 1533-4406 ] ; 2003.
Descripteurs français
- KwdFr :
- ADN viral (analyse), ARN viral (analyse), ARN viral (sang), Adulte, Animaux, Bovins, Coronavirus (génétique), Données de séquences moléculaires, Expectoration (virologie), Femelle, Flambées de maladies, Humains, Mâle, Phylogénie, Réaction de polymérisation en chaîne, Similitude de séquences d'acides nucléiques, Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Séquence d'acides aminés, Séquence nucléotidique, Virus du SRAS (), Virus du SRAS (génétique), Virus du SRAS (isolement et purification).
- MESH :
- analyse : ADN viral, ARN viral.
- génétique : Coronavirus, Virus du SRAS.
- isolement et purification : Virus du SRAS.
- sang : ARN viral.
- virologie : Expectoration, Syndrome respiratoire aigu sévère.
- épidémiologie : Syndrome respiratoire aigu sévère.
- Adulte, Animaux, Bovins, Données de séquences moléculaires, Femelle, Flambées de maladies, Humains, Mâle, Phylogénie, Réaction de polymérisation en chaîne, Similitude de séquences d'acides nucléiques, Séquence d'acides aminés, Séquence nucléotidique, Virus du SRAS.
English descriptors
- KwdEn :
- Adult, Amino Acid Sequence, Animals, Base Sequence, Cattle, Coronavirus (genetics), DNA, Viral (analysis), Disease Outbreaks, Female, Humans, Male, Molecular Sequence Data, Phylogeny, Polymerase Chain Reaction, RNA, Viral (analysis), RNA, Viral (blood), SARS Virus (classification), SARS Virus (genetics), SARS Virus (isolation & purification), Sequence Homology, Nucleic Acid, Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (virology), Sputum (virology).
- MESH :
- chemical , analysis : DNA, Viral, RNA, Viral.
- chemical , blood : RNA, Viral.
- classification : SARS Virus.
- epidemiology : Severe Acute Respiratory Syndrome.
- genetics : Coronavirus, SARS Virus.
- isolation & purification : SARS Virus.
- virology : Severe Acute Respiratory Syndrome, Sputum.
- Adult, Amino Acid Sequence, Animals, Base Sequence, Cattle, Disease Outbreaks, Female, Humans, Male, Molecular Sequence Data, Phylogeny, Polymerase Chain Reaction, Sequence Homology, Nucleic Acid.
Abstract
The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent.
Url:
DOI: 10.1056/NEJMoa030747
PubMed: 12690091
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Links to Exploration step
pubmed:12690091Le document en format XML
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am Main</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-302435" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302435" type="direct"><org type="institution" xml:id="struct-302435" status="VALID"> <orgName>Goethe-Universität Frankfurt am Main</orgName> <desc> <address> <addrLine>Theodor-W.-Adorno-Platz 1 , 60323 Frankfurt am Main</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.goethe-university-frankfurt.de/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Burguiere, Ana Maria" sort="Burguiere, Ana Maria" uniqKey="Burguiere A" first="Ana-Maria" last="Burguière">Ana-Maria Burguière</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-31889" status="OLD"> <orgName>Génétique Moléculaire des Virus Respiratoires</orgName> <desc> <address> <addrLine>25-28 rue du Docteur Roux, F-75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300027" type="direct"></relation> <relation active="#struct-300301" type="direct"></relation> <relation name="URA1966" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID"> <idno type="IdRef">027936643</idno> <idno type="ISNI">0000 0001 2353 6535</idno> <orgName>Institut Pasteur [Paris]</orgName> <date type="start">1887-06-04</date> <desc> <address> <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur.fr</ref> </desc> </org></tutelle><tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="OLD"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle name="URA1966" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Cinatl, Jindrich" sort="Cinatl, Jindrich" uniqKey="Cinatl J" first="Jindrich" last="Cinatl">Jindrich Cinatl</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42423" status="INCOMING"> <orgName>Institute of Medical Virology</orgName> <desc> <address> <addrLine>Frankfurt am Main</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-302435" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302435" type="direct"><org type="institution" xml:id="struct-302435" status="VALID"> <orgName>Goethe-Universität Frankfurt am Main</orgName> <desc> <address> <addrLine>Theodor-W.-Adorno-Platz 1 , 60323 Frankfurt am Main</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.goethe-university-frankfurt.de/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Eickmann, Markus" sort="Eickmann, Markus" uniqKey="Eickmann M" first="Markus" last="Eickmann">Markus Eickmann</name><affiliation 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<addrLine>25-28 rue du Docteur Roux, F-75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300027" type="direct"></relation> <relation active="#struct-300301" type="direct"></relation> <relation name="URA1966" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID"> <idno type="IdRef">027936643</idno> <idno type="ISNI">0000 0001 2353 6535</idno> <orgName>Institut Pasteur [Paris]</orgName> <date type="start">1887-06-04</date> <desc> <address> <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur.fr</ref> </desc> </org></tutelle><tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="OLD"> <idno type="ISNI">0000000121514068</idno> <idno 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last="Grywna">Klaus Grywna</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42422" status="INCOMING"> <orgName>Bernhard Nocht Institute for Tropical Medicine</orgName> <desc> <address> <addrLine>Hambourg</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-310341" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-310341" type="direct"><org type="institution" xml:id="struct-310341" status="INCOMING"> <orgName>National Reference Center for tropical Infectious Diseases</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Kramme, Stefanie" sort="Kramme, Stefanie" uniqKey="Kramme S" first="Stefanie" last="Kramme">Stefanie Kramme</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42422" status="INCOMING"> <orgName>Bernhard Nocht Institute for Tropical Medicine</orgName> <desc> <address> <addrLine>Hambourg</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-310341" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-310341" type="direct"><org type="institution" xml:id="struct-310341" status="INCOMING"> <orgName>National Reference Center for tropical Infectious Diseases</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Manuguerra, Jean Claude" sort="Manuguerra, Jean Claude" uniqKey="Manuguerra J" first="Jean-Claude" last="Manuguerra">Jean-Claude Manuguerra</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-31889" status="OLD"> <orgName>Génétique Moléculaire des Virus Respiratoires</orgName> <desc> <address> <addrLine>25-28 rue du Docteur 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Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle name="URA1966" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Muller, Stefanie" sort="Muller, Stefanie" uniqKey="Muller S" first="Stefanie" last="Müller">Stefanie Müller</name><affiliation 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active="#struct-304549" type="direct"><org type="institution" xml:id="struct-304549" status="INCOMING"> <orgName>Philipps University</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. 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<addrLine>Hambourg</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-310341" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-310341" type="direct"><org type="institution" xml:id="struct-310341" status="INCOMING"> <orgName>National Reference Center for tropical Infectious Diseases</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42423" status="INCOMING"> <orgName>Institute of Medical Virology</orgName> <desc> <address> <addrLine>Frankfurt am Main</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-302435" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302435" type="direct"><org type="institution" xml:id="struct-302435" status="VALID"> <orgName>Goethe-Universität Frankfurt am Main</orgName> <desc> <address> <addrLine>Theodor-W.-Adorno-Platz 1 , 60323 Frankfurt am Main</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.goethe-university-frankfurt.de/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:pasteur-00167033</idno><idno type="halId">pasteur-00167033</idno><idno type="halUri">https://hal-pasteur.archives-ouvertes.fr/pasteur-00167033</idno><idno type="url">https://hal-pasteur.archives-ouvertes.fr/pasteur-00167033</idno><idno type="doi">10.1056/NEJMoa030747</idno><date when="2003-05-15">2003-05-15</date><idno type="wicri:Area/Hal/Corpus">000082</idno><idno type="wicri:Area/Hal/Curation">000082</idno><idno type="wicri:Area/Hal/Checkpoint">000195</idno><idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000195</idno><idno type="wicri:doubleKey">0028-4793:2003:Drosten C:identification:of:a</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Identification of a novel coronavirus in patients with severe acute respiratory syndrome.</title><author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42422" status="INCOMING"> <orgName>Bernhard Nocht Institute for Tropical Medicine</orgName> <desc> <address> <addrLine>Hambourg</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-310341" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-310341" type="direct"><org type="institution" xml:id="struct-310341" status="INCOMING"> <orgName>National Reference Center for tropical Infectious Diseases</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Gunther, Stephan" sort="Gunther, Stephan" uniqKey="Gunther S" first="Stephan" last="Günther">Stephan Günther</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42422" status="INCOMING"> <orgName>Bernhard Nocht Institute for Tropical Medicine</orgName> <desc> <address> <addrLine>Hambourg</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-310341" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-310341" type="direct"><org type="institution" xml:id="struct-310341" status="INCOMING"> <orgName>National Reference Center for tropical Infectious Diseases</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Preiser, Wolfgang" sort="Preiser, Wolfgang" uniqKey="Preiser W" first="Wolfgang" last="Preiser">Wolfgang Preiser</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42423" status="INCOMING"> <orgName>Institute of Medical Virology</orgName> <desc> <address> <addrLine>Frankfurt am Main</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-302435" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302435" type="direct"><org type="institution" xml:id="struct-302435" status="VALID"> <orgName>Goethe-Universität Frankfurt am Main</orgName> <desc> <address> <addrLine>Theodor-W.-Adorno-Platz 1 , 60323 Frankfurt am Main</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.goethe-university-frankfurt.de/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-31889" status="OLD"> <orgName>Génétique Moléculaire des Virus Respiratoires</orgName> <desc> <address> <addrLine>25-28 rue du Docteur Roux, F-75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300027" type="direct"></relation> <relation active="#struct-300301" type="direct"></relation> <relation name="URA1966" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID"> <idno type="IdRef">027936643</idno> <idno type="ISNI">0000 0001 2353 6535</idno> <orgName>Institut Pasteur [Paris]</orgName> <date type="start">1887-06-04</date> <desc> <address> <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur.fr</ref> </desc> </org></tutelle><tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="OLD"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle name="URA1966" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Brodt, Hans Reinhard" sort="Brodt, Hans Reinhard" uniqKey="Brodt H" first="Hans-Reinhard" last="Brodt">Hans-Reinhard Brodt</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42424" status="INCOMING"> <orgName>Medical Clinic III</orgName> <desc> <address> <addrLine>Frankfurt am Main</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-302435" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302435" type="direct"><org type="institution" xml:id="struct-302435" status="VALID"> <orgName>Goethe-Universität Frankfurt am Main</orgName> <desc> <address> <addrLine>Theodor-W.-Adorno-Platz 1 , 60323 Frankfurt am Main</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.goethe-university-frankfurt.de/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-221820" status="VALID"> <orgName>Institut für Virologie</orgName> <desc> <address> <addrLine>AG Parasitologie, Marburg D-35043</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-304549" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-304549" type="direct"><org type="institution" xml:id="struct-304549" status="INCOMING"> <orgName>Philipps University</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Rabenau, Holger" sort="Rabenau, Holger" uniqKey="Rabenau H" first="Holger" last="Rabenau">Holger Rabenau</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42423" status="INCOMING"> <orgName>Institute of Medical Virology</orgName> <desc> <address> <addrLine>Frankfurt am Main</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-302435" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302435" type="direct"><org type="institution" xml:id="struct-302435" status="VALID"> <orgName>Goethe-Universität Frankfurt am Main</orgName> <desc> <address> <addrLine>Theodor-W.-Adorno-Platz 1 , 60323 Frankfurt am Main</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.goethe-university-frankfurt.de/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Panning, Marcus" sort="Panning, Marcus" uniqKey="Panning M" first="Marcus" last="Panning">Marcus Panning</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42422" status="INCOMING"> <orgName>Bernhard Nocht Institute for Tropical Medicine</orgName> <desc> <address> <addrLine>Hambourg</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-310341" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-310341" type="direct"><org type="institution" xml:id="struct-310341" status="INCOMING"> <orgName>National Reference Center for tropical Infectious Diseases</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Kolesnikova, Larissa" sort="Kolesnikova, Larissa" uniqKey="Kolesnikova L" first="Larissa" last="Kolesnikova">Larissa Kolesnikova</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-221820" status="VALID"> <orgName>Institut für Virologie</orgName> <desc> <address> <addrLine>AG Parasitologie, Marburg D-35043</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-304549" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-304549" type="direct"><org type="institution" xml:id="struct-304549" status="INCOMING"> <orgName>Philipps University</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A M" last="Fouchier">Ron A M. Fouchier</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42427" status="INCOMING"> <orgName>Institute of Virology</orgName> <desc> <address> <addrLine>Rotterdam</addrLine> <country key="NL"></country> </address> </desc> <listRelation> <relation active="#struct-308804" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-308804" type="direct"><org type="institution" xml:id="struct-308804" status="INCOMING"> <orgName>Erasmus university</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Pays-Bas</country></affiliation></author><author><name sortKey="Berger, Annemarie" sort="Berger, Annemarie" uniqKey="Berger A" first="Annemarie" last="Berger">Annemarie Berger</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42423" status="INCOMING"> <orgName>Institute of Medical Virology</orgName> <desc> <address> <addrLine>Frankfurt am Main</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-302435" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302435" type="direct"><org type="institution" xml:id="struct-302435" status="VALID"> <orgName>Goethe-Universität Frankfurt am Main</orgName> <desc> <address> <addrLine>Theodor-W.-Adorno-Platz 1 , 60323 Frankfurt am Main</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.goethe-university-frankfurt.de/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Burguiere, Ana Maria" sort="Burguiere, Ana Maria" uniqKey="Burguiere A" first="Ana-Maria" last="Burguière">Ana-Maria Burguière</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-31889" status="OLD"> <orgName>Génétique Moléculaire des Virus Respiratoires</orgName> <desc> <address> <addrLine>25-28 rue du Docteur Roux, F-75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300027" type="direct"></relation> <relation active="#struct-300301" type="direct"></relation> <relation name="URA1966" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID"> <idno type="IdRef">027936643</idno> <idno type="ISNI">0000 0001 2353 6535</idno> <orgName>Institut Pasteur [Paris]</orgName> <date type="start">1887-06-04</date> <desc> <address> <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur.fr</ref> </desc> </org></tutelle><tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="OLD"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle name="URA1966" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Cinatl, Jindrich" sort="Cinatl, Jindrich" uniqKey="Cinatl J" first="Jindrich" last="Cinatl">Jindrich Cinatl</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42423" status="INCOMING"> <orgName>Institute of Medical Virology</orgName> <desc> <address> <addrLine>Frankfurt am Main</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-302435" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302435" type="direct"><org type="institution" xml:id="struct-302435" status="VALID"> <orgName>Goethe-Universität Frankfurt am Main</orgName> <desc> <address> <addrLine>Theodor-W.-Adorno-Platz 1 , 60323 Frankfurt am Main</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.goethe-university-frankfurt.de/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Eickmann, Markus" sort="Eickmann, Markus" uniqKey="Eickmann M" first="Markus" last="Eickmann">Markus Eickmann</name><affiliation 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<addrLine>25-28 rue du Docteur Roux, F-75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300027" type="direct"></relation> <relation active="#struct-300301" type="direct"></relation> <relation name="URA1966" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID"> <idno type="IdRef">027936643</idno> <idno type="ISNI">0000 0001 2353 6535</idno> <orgName>Institut Pasteur [Paris]</orgName> <date type="start">1887-06-04</date> <desc> <address> <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur.fr</ref> </desc> </org></tutelle><tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="OLD"> <idno type="ISNI">0000000121514068</idno> <idno 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last="Grywna">Klaus Grywna</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42422" status="INCOMING"> <orgName>Bernhard Nocht Institute for Tropical Medicine</orgName> <desc> <address> <addrLine>Hambourg</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-310341" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-310341" type="direct"><org type="institution" xml:id="struct-310341" status="INCOMING"> <orgName>National Reference Center for tropical Infectious Diseases</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Kramme, Stefanie" sort="Kramme, Stefanie" uniqKey="Kramme S" first="Stefanie" last="Kramme">Stefanie Kramme</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42422" status="INCOMING"> 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Roux, F-75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300027" type="direct"></relation> <relation active="#struct-300301" type="direct"></relation> <relation name="URA1966" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID"> <idno type="IdRef">027936643</idno> <idno type="ISNI">0000 0001 2353 6535</idno> <orgName>Institut Pasteur [Paris]</orgName> <date type="start">1887-06-04</date> <desc> <address> <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur.fr</ref> </desc> </org></tutelle><tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="OLD"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle name="URA1966" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Muller, Stefanie" sort="Muller, Stefanie" uniqKey="Muller S" first="Stefanie" last="Müller">Stefanie Müller</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42422" status="INCOMING"> <orgName>Bernhard Nocht Institute for Tropical Medicine</orgName> <desc> <address> <addrLine>Hambourg</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-310341" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-310341" type="direct"><org type="institution" xml:id="struct-310341" status="INCOMING"> <orgName>National Reference Center for tropical Infectious Diseases</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Rickerts, Volker" sort="Rickerts, Volker" uniqKey="Rickerts V" first="Volker" last="Rickerts">Volker Rickerts</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42424" status="INCOMING"> <orgName>Medical Clinic III</orgName> <desc> <address> <addrLine>Frankfurt am Main</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-302435" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302435" type="direct"><org type="institution" xml:id="struct-302435" status="VALID"> <orgName>Goethe-Universität Frankfurt am Main</orgName> <desc> <address> <addrLine>Theodor-W.-Adorno-Platz 1 , 60323 Frankfurt am Main</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.goethe-university-frankfurt.de/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Sturmer, Martin" sort="Sturmer, Martin" uniqKey="Sturmer M" first="Martin" last="Stürmer">Martin Stürmer</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42423" status="INCOMING"> <orgName>Institute of Medical Virology</orgName> <desc> <address> <addrLine>Frankfurt am Main</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-302435" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302435" type="direct"><org type="institution" xml:id="struct-302435" status="VALID"> <orgName>Goethe-Universität Frankfurt am Main</orgName> <desc> <address> <addrLine>Theodor-W.-Adorno-Platz 1 , 60323 Frankfurt am Main</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.goethe-university-frankfurt.de/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Vieth, Simon" sort="Vieth, Simon" uniqKey="Vieth S" first="Simon" last="Vieth">Simon Vieth</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42422" status="INCOMING"> <orgName>Bernhard Nocht Institute for Tropical Medicine</orgName> <desc> <address> <addrLine>Hambourg</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-310341" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-310341" type="direct"><org type="institution" xml:id="struct-310341" status="INCOMING"> <orgName>National Reference Center for tropical Infectious Diseases</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Klenk, Hans Dieter" sort="Klenk, Hans Dieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-221820" status="VALID"> <orgName>Institut für Virologie</orgName> <desc> <address> <addrLine>AG Parasitologie, Marburg D-35043</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-304549" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-304549" type="direct"><org type="institution" xml:id="struct-304549" status="INCOMING"> <orgName>Philipps University</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42427" status="INCOMING"> <orgName>Institute of Virology</orgName> <desc> <address> <addrLine>Rotterdam</addrLine> <country key="NL"></country> </address> </desc> <listRelation> <relation active="#struct-308804" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-308804" type="direct"><org type="institution" xml:id="struct-308804" status="INCOMING"> <orgName>Erasmus university</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Pays-Bas</country></affiliation></author><author><name sortKey="Schmitz, Herbert" sort="Schmitz, Herbert" uniqKey="Schmitz H" first="Herbert" last="Schmitz">Herbert Schmitz</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42422" status="INCOMING"> <orgName>Bernhard Nocht Institute for Tropical Medicine</orgName> <desc> <address> <addrLine>Hambourg</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-310341" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-310341" type="direct"><org type="institution" xml:id="struct-310341" status="INCOMING"> <orgName>National Reference Center for tropical Infectious Diseases</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-42423" status="INCOMING"> <orgName>Institute of Medical Virology</orgName> <desc> <address> <addrLine>Frankfurt am Main</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-302435" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302435" type="direct"><org type="institution" xml:id="struct-302435" status="VALID"> <orgName>Goethe-Universität Frankfurt am Main</orgName> <desc> <address> <addrLine>Theodor-W.-Adorno-Platz 1 , 60323 Frankfurt am Main</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.goethe-university-frankfurt.de/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author></analytic><idno type="DOI">10.1056/NEJMoa030747</idno><series><title level="j">New England Journal of Medicine</title><idno type="ISSN">0028-4793</idno><imprint><date type="datePub">2003-05-15</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>BACKGROUND: The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent. METHODS: Clinical specimens from patients with SARS were searched for unknown viruses with the use of cell cultures and molecular techniques. RESULTS: A novel coronavirus was identified in patients with SARS. The virus was isolated in cell culture, and a sequence 300 nucleotides in length was obtained by a polymerase-chain-reaction (PCR)-based random-amplification procedure. Genetic characterization indicated that the virus is only distantly related to known coronaviruses (identical in 50 to 60 percent of the nucleotide sequence). On the basis of the obtained sequence, conventional and real-time PCR assays for specific and sensitive detection of the novel virus were established. Virus was detected in a variety of clinical specimens from patients with SARS but not in controls. High concentrations of viral RNA of up to 100 million molecules per milliliter were found in sputum. Viral RNA was also detected at extremely low concentrations in plasma during the acute phase and in feces during the late convalescent phase. Infected patients showed seroconversion on the Vero cells in which the virus was isolated. CONCLUSIONS: The novel coronavirus might have a role in causing SARS.</p> </div></front></TEI></HAL><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Identification of a novel coronavirus in patients with severe acute respiratory syndrome.</title><author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><affiliation wicri:level="3"><nlm:affiliation>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases, Hamburg, Germany. drosten@bni-hamburg.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Gunther, Stephan" sort="Gunther, Stephan" uniqKey="Gunther S" first="Stephan" last="Günther">Stephan Günther</name></author><author><name sortKey="Preiser, Wolfgang" sort="Preiser, Wolfgang" uniqKey="Preiser W" first="Wolfgang" last="Preiser">Wolfgang Preiser</name></author><author><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name></author><author><name sortKey="Brodt, Hans Reinhard" sort="Brodt, Hans Reinhard" uniqKey="Brodt H" first="Hans-Reinhard" last="Brodt">Hans-Reinhard Brodt</name></author><author><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name></author><author><name sortKey="Rabenau, Holger" sort="Rabenau, Holger" uniqKey="Rabenau H" first="Holger" last="Rabenau">Holger Rabenau</name></author><author><name sortKey="Panning, Marcus" sort="Panning, Marcus" uniqKey="Panning M" first="Marcus" last="Panning">Marcus Panning</name></author><author><name sortKey="Kolesnikova, Larissa" sort="Kolesnikova, Larissa" uniqKey="Kolesnikova L" first="Larissa" last="Kolesnikova">Larissa Kolesnikova</name></author><author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A M" last="Fouchier">Ron A M. Fouchier</name></author><author><name sortKey="Berger, Annemarie" sort="Berger, Annemarie" uniqKey="Berger A" first="Annemarie" last="Berger">Annemarie Berger</name></author><author><name sortKey="Burguiere, Ana Maria" sort="Burguiere, Ana Maria" uniqKey="Burguiere A" first="Ana-Maria" last="Burguière">Ana-Maria Burguière</name></author><author><name sortKey="Cinatl, Jindrich" sort="Cinatl, Jindrich" uniqKey="Cinatl J" first="Jindrich" last="Cinatl">Jindrich Cinatl</name></author><author><name sortKey="Eickmann, Markus" sort="Eickmann, Markus" uniqKey="Eickmann M" first="Markus" last="Eickmann">Markus Eickmann</name></author><author><name sortKey="Escriou, Nicolas" sort="Escriou, Nicolas" uniqKey="Escriou N" first="Nicolas" last="Escriou">Nicolas Escriou</name></author><author><name sortKey="Grywna, Klaus" sort="Grywna, Klaus" uniqKey="Grywna K" first="Klaus" last="Grywna">Klaus Grywna</name></author><author><name sortKey="Kramme, Stefanie" sort="Kramme, Stefanie" uniqKey="Kramme S" first="Stefanie" last="Kramme">Stefanie Kramme</name></author><author><name sortKey="Manuguerra, Jean Claude" sort="Manuguerra, Jean Claude" uniqKey="Manuguerra J" first="Jean-Claude" last="Manuguerra">Jean-Claude Manuguerra</name></author><author><name sortKey="Muller, Stefanie" sort="Muller, Stefanie" uniqKey="Muller S" first="Stefanie" last="Müller">Stefanie Müller</name></author><author><name sortKey="Rickerts, Volker" sort="Rickerts, Volker" uniqKey="Rickerts V" first="Volker" last="Rickerts">Volker Rickerts</name></author><author><name sortKey="Sturmer, Martin" sort="Sturmer, Martin" uniqKey="Sturmer M" first="Martin" last="Stürmer">Martin Stürmer</name></author><author><name sortKey="Vieth, Simon" sort="Vieth, Simon" uniqKey="Vieth S" first="Simon" last="Vieth">Simon Vieth</name></author><author><name sortKey="Klenk, Hans Dieter" sort="Klenk, Hans Dieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name></author><author><name sortKey="Schmitz, Herbert" sort="Schmitz, Herbert" uniqKey="Schmitz H" first="Herbert" last="Schmitz">Herbert Schmitz</name></author><author><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12690091</idno><idno type="pmid">12690091</idno><idno type="doi">10.1056/NEJMoa030747</idno><idno type="wicri:Area/PubMed/Corpus">003440</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003440</idno><idno type="wicri:Area/PubMed/Curation">003440</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003440</idno><idno type="wicri:Area/PubMed/Checkpoint">003222</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003222</idno><idno type="wicri:Area/Ncbi/Merge">000035</idno><idno type="wicri:Area/Ncbi/Curation">000035</idno><idno type="wicri:Area/Ncbi/Checkpoint">000035</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Identification of a novel coronavirus in patients with severe acute respiratory syndrome.</title><author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><affiliation wicri:level="3"><nlm:affiliation>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases, Hamburg, Germany. drosten@bni-hamburg.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Gunther, Stephan" sort="Gunther, Stephan" uniqKey="Gunther S" first="Stephan" last="Günther">Stephan Günther</name></author><author><name sortKey="Preiser, Wolfgang" sort="Preiser, Wolfgang" uniqKey="Preiser W" first="Wolfgang" last="Preiser">Wolfgang Preiser</name></author><author><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name></author><author><name sortKey="Brodt, Hans Reinhard" sort="Brodt, Hans Reinhard" uniqKey="Brodt H" first="Hans-Reinhard" last="Brodt">Hans-Reinhard Brodt</name></author><author><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name></author><author><name sortKey="Rabenau, Holger" sort="Rabenau, Holger" uniqKey="Rabenau H" first="Holger" last="Rabenau">Holger Rabenau</name></author><author><name sortKey="Panning, Marcus" sort="Panning, Marcus" uniqKey="Panning M" first="Marcus" last="Panning">Marcus Panning</name></author><author><name sortKey="Kolesnikova, Larissa" sort="Kolesnikova, Larissa" uniqKey="Kolesnikova L" first="Larissa" last="Kolesnikova">Larissa Kolesnikova</name></author><author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A M" last="Fouchier">Ron A M. Fouchier</name></author><author><name sortKey="Berger, Annemarie" sort="Berger, Annemarie" uniqKey="Berger A" first="Annemarie" last="Berger">Annemarie Berger</name></author><author><name sortKey="Burguiere, Ana Maria" sort="Burguiere, Ana Maria" uniqKey="Burguiere A" first="Ana-Maria" last="Burguière">Ana-Maria Burguière</name></author><author><name sortKey="Cinatl, Jindrich" sort="Cinatl, Jindrich" uniqKey="Cinatl J" first="Jindrich" last="Cinatl">Jindrich Cinatl</name></author><author><name sortKey="Eickmann, Markus" sort="Eickmann, Markus" uniqKey="Eickmann M" first="Markus" last="Eickmann">Markus Eickmann</name></author><author><name sortKey="Escriou, Nicolas" sort="Escriou, Nicolas" uniqKey="Escriou N" first="Nicolas" last="Escriou">Nicolas Escriou</name></author><author><name sortKey="Grywna, Klaus" sort="Grywna, Klaus" uniqKey="Grywna K" first="Klaus" last="Grywna">Klaus Grywna</name></author><author><name sortKey="Kramme, Stefanie" sort="Kramme, Stefanie" uniqKey="Kramme S" first="Stefanie" last="Kramme">Stefanie Kramme</name></author><author><name sortKey="Manuguerra, Jean Claude" sort="Manuguerra, Jean Claude" uniqKey="Manuguerra J" first="Jean-Claude" last="Manuguerra">Jean-Claude Manuguerra</name></author><author><name sortKey="Muller, Stefanie" sort="Muller, Stefanie" uniqKey="Muller S" first="Stefanie" last="Müller">Stefanie Müller</name></author><author><name sortKey="Rickerts, Volker" sort="Rickerts, Volker" uniqKey="Rickerts V" first="Volker" last="Rickerts">Volker Rickerts</name></author><author><name sortKey="Sturmer, Martin" sort="Sturmer, Martin" uniqKey="Sturmer M" first="Martin" last="Stürmer">Martin Stürmer</name></author><author><name sortKey="Vieth, Simon" sort="Vieth, Simon" uniqKey="Vieth S" first="Simon" last="Vieth">Simon Vieth</name></author><author><name sortKey="Klenk, Hans Dieter" sort="Klenk, Hans Dieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name></author><author><name sortKey="Schmitz, Herbert" sort="Schmitz, Herbert" uniqKey="Schmitz H" first="Herbert" last="Schmitz">Herbert Schmitz</name></author><author><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name></author></analytic><series><title level="j">The New England journal of medicine</title><idno type="eISSN">1533-4406</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Amino Acid Sequence</term><term>Animals</term><term>Base Sequence</term><term>Cattle</term><term>Coronavirus (genetics)</term><term>DNA, Viral (analysis)</term><term>Disease Outbreaks</term><term>Female</term><term>Humans</term><term>Male</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Polymerase Chain Reaction</term><term>RNA, Viral (analysis)</term><term>RNA, Viral (blood)</term><term>SARS Virus (classification)</term><term>SARS Virus (genetics)</term><term>SARS Virus (isolation & purification)</term><term>Sequence Homology, Nucleic Acid</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Sputum (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN viral (analyse)</term><term>ARN viral (analyse)</term><term>ARN viral (sang)</term><term>Adulte</term><term>Animaux</term><term>Bovins</term><term>Coronavirus (génétique)</term><term>Données de séquences moléculaires</term><term>Expectoration (virologie)</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Mâle</term><term>Phylogénie</term><term>Réaction de polymérisation en chaîne</term><term>Similitude de séquences d'acides nucléiques</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Syndrome respiratoire aigu sévère (épidémiologie)</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term><term>Virus du SRAS ()</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>DNA, Viral</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ADN viral</term><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Expectoration</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term><term>Sputum</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Amino Acid Sequence</term><term>Animals</term><term>Base Sequence</term><term>Cattle</term><term>Disease Outbreaks</term><term>Female</term><term>Humans</term><term>Male</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Polymerase Chain Reaction</term><term>Sequence Homology, Nucleic Acid</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Animaux</term><term>Bovins</term><term>Données de séquences moléculaires</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Mâle</term><term>Phylogénie</term><term>Réaction de polymérisation en chaîne</term><term>Similitude de séquences d'acides nucléiques</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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