Identification of a novel coronavirus in patients with severe acute respiratory syndrome.
Identifieur interne : 003440 ( PubMed/Curation ); précédent : 003439; suivant : 003441Identification of a novel coronavirus in patients with severe acute respiratory syndrome.
Auteurs : Christian Drosten [Allemagne] ; Stephan Günther ; Wolfgang Preiser ; Sylvie Van Der Werf ; Hans-Reinhard Brodt ; Stephan Becker ; Holger Rabenau ; Marcus Panning ; Larissa Kolesnikova ; Ron A M. Fouchier ; Annemarie Berger ; Ana-Maria Burguière ; Jindrich Cinatl ; Markus Eickmann ; Nicolas Escriou ; Klaus Grywna ; Stefanie Kramme ; Jean-Claude Manuguerra ; Stefanie Müller ; Volker Rickerts ; Martin Stürmer ; Simon Vieth ; Hans-Dieter Klenk ; Albert D M E. Osterhaus ; Herbert Schmitz ; Hans Wilhelm DoerrSource :
- The New England journal of medicine [ 1533-4406 ] ; 2003.
Descripteurs français
- KwdFr :
- ADN viral (analyse), ARN viral (analyse), ARN viral (sang), Adulte, Animaux, Bovins, Coronavirus (génétique), Données de séquences moléculaires, Expectoration (virologie), Femelle, Flambées de maladies, Humains, Mâle, Phylogénie, Réaction de polymérisation en chaîne, Similitude de séquences d'acides nucléiques, Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Séquence d'acides aminés, Séquence nucléotidique, Virus du SRAS (), Virus du SRAS (génétique), Virus du SRAS (isolement et purification).
- MESH :
- analyse : ADN viral, ARN viral.
- génétique : Coronavirus, Virus du SRAS.
- isolement et purification : Virus du SRAS.
- sang : ARN viral.
- virologie : Expectoration, Syndrome respiratoire aigu sévère.
- épidémiologie : Syndrome respiratoire aigu sévère.
- Adulte, Animaux, Bovins, Données de séquences moléculaires, Femelle, Flambées de maladies, Humains, Mâle, Phylogénie, Réaction de polymérisation en chaîne, Similitude de séquences d'acides nucléiques, Séquence d'acides aminés, Séquence nucléotidique, Virus du SRAS.
English descriptors
- KwdEn :
- Adult, Amino Acid Sequence, Animals, Base Sequence, Cattle, Coronavirus (genetics), DNA, Viral (analysis), Disease Outbreaks, Female, Humans, Male, Molecular Sequence Data, Phylogeny, Polymerase Chain Reaction, RNA, Viral (analysis), RNA, Viral (blood), SARS Virus (classification), SARS Virus (genetics), SARS Virus (isolation & purification), Sequence Homology, Nucleic Acid, Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (virology), Sputum (virology).
- MESH :
- chemical , analysis : DNA, Viral, RNA, Viral.
- chemical , blood : RNA, Viral.
- classification : SARS Virus.
- epidemiology : Severe Acute Respiratory Syndrome.
- genetics : Coronavirus, SARS Virus.
- isolation & purification : SARS Virus.
- virology : Severe Acute Respiratory Syndrome, Sputum.
- Adult, Amino Acid Sequence, Animals, Base Sequence, Cattle, Disease Outbreaks, Female, Humans, Male, Molecular Sequence Data, Phylogeny, Polymerase Chain Reaction, Sequence Homology, Nucleic Acid.
Abstract
The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent.
DOI: 10.1056/NEJMoa030747
PubMed: 12690091
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Fouchier</name></author><author><name sortKey="Berger, Annemarie" sort="Berger, Annemarie" uniqKey="Berger A" first="Annemarie" last="Berger">Annemarie Berger</name></author><author><name sortKey="Burguiere, Ana Maria" sort="Burguiere, Ana Maria" uniqKey="Burguiere A" first="Ana-Maria" last="Burguière">Ana-Maria Burguière</name></author><author><name sortKey="Cinatl, Jindrich" sort="Cinatl, Jindrich" uniqKey="Cinatl J" first="Jindrich" last="Cinatl">Jindrich Cinatl</name></author><author><name sortKey="Eickmann, Markus" sort="Eickmann, Markus" uniqKey="Eickmann M" first="Markus" last="Eickmann">Markus Eickmann</name></author><author><name sortKey="Escriou, Nicolas" sort="Escriou, Nicolas" uniqKey="Escriou N" first="Nicolas" last="Escriou">Nicolas Escriou</name></author><author><name sortKey="Grywna, Klaus" sort="Grywna, Klaus" uniqKey="Grywna K" first="Klaus" last="Grywna">Klaus Grywna</name></author><author><name sortKey="Kramme, Stefanie" sort="Kramme, Stefanie" uniqKey="Kramme S" first="Stefanie" last="Kramme">Stefanie Kramme</name></author><author><name sortKey="Manuguerra, Jean Claude" sort="Manuguerra, Jean Claude" uniqKey="Manuguerra J" first="Jean-Claude" last="Manuguerra">Jean-Claude Manuguerra</name></author><author><name sortKey="Muller, Stefanie" sort="Muller, Stefanie" uniqKey="Muller S" first="Stefanie" last="Müller">Stefanie Müller</name></author><author><name sortKey="Rickerts, Volker" sort="Rickerts, Volker" uniqKey="Rickerts V" first="Volker" last="Rickerts">Volker Rickerts</name></author><author><name sortKey="Sturmer, Martin" sort="Sturmer, Martin" uniqKey="Sturmer M" first="Martin" last="Stürmer">Martin Stürmer</name></author><author><name sortKey="Vieth, Simon" sort="Vieth, Simon" uniqKey="Vieth S" first="Simon" last="Vieth">Simon Vieth</name></author><author><name sortKey="Klenk, Hans Dieter" sort="Klenk, Hans Dieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name></author><author><name sortKey="Schmitz, Herbert" sort="Schmitz, Herbert" uniqKey="Schmitz H" first="Herbert" last="Schmitz">Herbert Schmitz</name></author><author><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name></author></analytic><series><title level="j">The New England journal of medicine</title><idno type="eISSN">1533-4406</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Amino Acid Sequence</term><term>Animals</term><term>Base Sequence</term><term>Cattle</term><term>Coronavirus (genetics)</term><term>DNA, Viral (analysis)</term><term>Disease Outbreaks</term><term>Female</term><term>Humans</term><term>Male</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Polymerase Chain Reaction</term><term>RNA, Viral (analysis)</term><term>RNA, Viral (blood)</term><term>SARS Virus (classification)</term><term>SARS Virus (genetics)</term><term>SARS Virus (isolation & purification)</term><term>Sequence Homology, Nucleic Acid</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Sputum (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN viral (analyse)</term><term>ARN viral (analyse)</term><term>ARN viral (sang)</term><term>Adulte</term><term>Animaux</term><term>Bovins</term><term>Coronavirus (génétique)</term><term>Données de séquences moléculaires</term><term>Expectoration (virologie)</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Mâle</term><term>Phylogénie</term><term>Réaction de polymérisation en chaîne</term><term>Similitude de séquences d'acides nucléiques</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Syndrome respiratoire aigu sévère (épidémiologie)</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term><term>Virus du SRAS ()</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>DNA, Viral</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ADN viral</term><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Expectoration</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term><term>Sputum</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Amino Acid Sequence</term><term>Animals</term><term>Base Sequence</term><term>Cattle</term><term>Disease Outbreaks</term><term>Female</term><term>Humans</term><term>Male</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Polymerase Chain Reaction</term><term>Sequence Homology, Nucleic Acid</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Animaux</term><term>Bovins</term><term>Données de séquences moléculaires</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Mâle</term><term>Phylogénie</term><term>Réaction de polymérisation en chaîne</term><term>Similitude de séquences d'acides nucléiques</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12690091</PMID><DateCompleted><Year>2003</Year><Month>05</Month><Day>21</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1533-4406</ISSN><JournalIssue CitedMedium="Internet"><Volume>348</Volume><Issue>20</Issue><PubDate><Year>2003</Year><Month>May</Month><Day>15</Day></PubDate></JournalIssue><Title>The New England journal of medicine</Title><ISOAbbreviation>N. Engl. J. Med.</ISOAbbreviation></Journal><ArticleTitle>Identification of a novel coronavirus in patients with severe acute respiratory syndrome.</ArticleTitle><Pagination><MedlinePgn>1967-76</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Clinical specimens from patients with SARS were searched for unknown viruses with the use of cell cultures and molecular techniques.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A novel coronavirus was identified in patients with SARS. The virus was isolated in cell culture, and a sequence 300 nucleotides in length was obtained by a polymerase-chain-reaction (PCR)-based random-amplification procedure. Genetic characterization indicated that the virus is only distantly related to known coronaviruses (identical in 50 to 60 percent of the nucleotide sequence). On the basis of the obtained sequence, conventional and real-time PCR assays for specific and sensitive detection of the novel virus were established. Virus was detected in a variety of clinical specimens from patients with SARS but not in controls. High concentrations of viral RNA of up to 100 million molecules per milliliter were found in sputum. Viral RNA was also detected at extremely low concentrations in plasma during the acute phase and in feces during the late convalescent phase. Infected patients showed seroconversion on the Vero cells in which the virus was isolated.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The novel coronavirus might have a role in causing SARS.</AbstractText><CopyrightInformation>Copyright 2003 Massachusetts Medical Society</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Drosten</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases, Hamburg, Germany. drosten@bni-hamburg.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Günther</LastName><ForeName>Stephan</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Preiser</LastName><ForeName>Wolfgang</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>van der Werf</LastName><ForeName>Sylvie</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Brodt</LastName><ForeName>Hans-Reinhard</ForeName><Initials>HR</Initials></Author><Author ValidYN="Y"><LastName>Becker</LastName><ForeName>Stephan</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Rabenau</LastName><ForeName>Holger</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Panning</LastName><ForeName>Marcus</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Kolesnikova</LastName><ForeName>Larissa</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Fouchier</LastName><ForeName>Ron A M</ForeName><Initials>RA</Initials></Author><Author ValidYN="Y"><LastName>Berger</LastName><ForeName>Annemarie</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Burguière</LastName><ForeName>Ana-Maria</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>Cinatl</LastName><ForeName>Jindrich</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Eickmann</LastName><ForeName>Markus</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Escriou</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Grywna</LastName><ForeName>Klaus</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Kramme</LastName><ForeName>Stefanie</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Manuguerra</LastName><ForeName>Jean-Claude</ForeName><Initials>JC</Initials></Author><Author ValidYN="Y"><LastName>Müller</LastName><ForeName>Stefanie</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Rickerts</LastName><ForeName>Volker</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Stürmer</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Vieth</LastName><ForeName>Simon</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Klenk</LastName><ForeName>Hans-Dieter</ForeName><Initials>HD</Initials></Author><Author ValidYN="Y"><LastName>Osterhaus</LastName><ForeName>Albert D M E</ForeName><Initials>AD</Initials></Author><Author ValidYN="Y"><LastName>Schmitz</LastName><ForeName>Herbert</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Doerr</LastName><ForeName>Hans Wilhelm</ForeName><Initials>HW</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2003</Year><Month>04</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>N Engl J Med</MedlineTA><NlmUniqueID>0255562</NlmUniqueID><ISSNLinking>0028-4793</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004279">DNA, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>N Engl J Med. 2003 May 15;348(20):1947-8</RefSource><PMID Version="1">12748313</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>N Engl J Med. 2003 May 15;348(20):1948-51</RefSource><PMID Version="1">12748314</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002417" MajorTopicYN="N">Cattle</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017934" MajorTopicYN="N">Coronavirus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004279" MajorTopicYN="N">DNA, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004196" MajorTopicYN="Y">Disease Outbreaks</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012689" MajorTopicYN="N">Sequence Homology, Nucleic Acid</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013183" MajorTopicYN="N">Sputum</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>4</Month><Day>12</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2003</Year><Month>5</Month><Day>22</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>4</Month><Day>12</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12690091</ArticleId><ArticleId IdType="doi">10.1056/NEJMoa030747</ArticleId><ArticleId IdType="pii">NEJMoa030747</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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