Potent and selective inhibition of SARS coronavirus replication by aurintricarboxylic acid
Identifieur interne : 005594 ( Main/Merge ); précédent : 005593; suivant : 005595Potent and selective inhibition of SARS coronavirus replication by aurintricarboxylic acid
Auteurs : Runtao He [Canada] ; Anton Adonov [Canada] ; Maya Traykova-Adonova [Canada] ; Jingxin Cao [Canada] ; Todd Cutts [Canada] ; Elsie Grudesky [Canada] ; Yvon Deschambaul [Canada] ; Jody Berry [Canada] ; Michael Drebot [Canada] ; Xuguang Li [Canada]Source :
- Biochemical and Biophysical Research Communications [ 0006-291X ] ; 2004.
Descripteurs français
- KwdFr :
- Acide aurintricarboxylique (pharmacologie), Animaux, Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Cellules Vero, Division cellulaire (), Relation dose-effet des médicaments, Reproductibilité des résultats, Réplication virale (), Sensibilité et spécificité, Syndrome respiratoire aigu sévère (traitement médicamenteux), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (), Virus du SRAS (croissance et développement), Virus du SRAS (ultrastructure).
- MESH :
- croissance et développement : Virus du SRAS.
- pharmacologie : Acide aurintricarboxylique, Antiviraux.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- usage thérapeutique : Antiviraux, Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- Animaux, Cellules Vero, Division cellulaire, Relation dose-effet des médicaments, Reproductibilité des résultats, Réplication virale, Sensibilité et spécificité, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Aurintricarboxylic Acid (pharmacology), Cell Division (drug effects), Chlorocebus aethiops, Dose-Response Relationship, Drug, Reproducibility of Results, SARS Virus (drug effects), SARS Virus (growth & development), SARS Virus (ultrastructure), Sensitivity and Specificity, Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (virology), Vero Cells, Virus Replication (drug effects).
- MESH :
- chemical , pharmacology : Antiviral Agents, Aurintricarboxylic Acid.
- chemical , therapeutic use : Antiviral Agents.
- drug effects : Cell Division, SARS Virus, Virus Replication.
- drug therapy : Severe Acute Respiratory Syndrome.
- growth & development : SARS Virus.
- ultrastructure : SARS Virus.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Chlorocebus aethiops, Dose-Response Relationship, Drug, Reproducibility of Results, Sensitivity and Specificity, Vero Cells.
Abstract
The severe acute respiratory syndrome virus (SARS) is a coronavirus that instigated regional epidemics in Canada and several Asian countries in 2003. The newly identified SARS coronavirus (SARS-CoV) can be transmitted among humans and cause severe or even fatal illnesses. As preventive vaccine development takes years to complete and adverse reactions have been reported to some veterinary coronaviral vaccines, anti-viral compounds must be relentlessly pursued. In this study, we analyzed the effect of aurintricarboxylic acid (ATA) on SARS-CoV replication in cell culture, and found that ATA could drastically inhibit SARS-CoV replication, with viral production being 1000-fold less than that in the untreated control. Importantly, when compared with IFNs α and β, viral production was inhibited by more than 1000-fold as compared with the untreated control. In addition, when compared with IFNs α and β, ATA was approximately 10 times more potent than IFN α and 100 times more than interferon β at their highest concentrations reported in the literature previously. Our data indicated that ATA should be considered as a candidate anti-SARS compound for future clinical evaluation.
Url:
DOI: 10.1016/j.bbrc.2004.06.076
PubMed: 15249217
PubMed Central: 7111066
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PMC:7111066Le document en format XML
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Health Canada, 1015 Arlington St., Winnipeg, MB</wicri:regionArea><wicri:noRegion>MB</wicri:noRegion></affiliation></author><author><name sortKey="Grudesky, Elsie" sort="Grudesky, Elsie" uniqKey="Grudesky E" first="Elsie" last="Grudesky">Elsie Grudesky</name><affiliation wicri:level="1"><nlm:aff id="AFF1">National Microbiology Laboratory, Health Canada, 1015 Arlington St., Winnipeg, MB, Canada R3E 3R2</nlm:aff><country>Canada</country><wicri:regionArea>National Microbiology Laboratory, Health Canada, 1015 Arlington St., Winnipeg, MB</wicri:regionArea><wicri:noRegion>MB</wicri:noRegion></affiliation></author><author><name sortKey="Deschambaul, Yvon" sort="Deschambaul, Yvon" uniqKey="Deschambaul Y" first="Yvon" last="Deschambaul">Yvon Deschambaul</name><affiliation wicri:level="1"><nlm:aff id="AFF1">National Microbiology Laboratory, Health Canada, 1015 Arlington St., Winnipeg, MB, Canada R3E 3R2</nlm:aff><country>Canada</country><wicri:regionArea>National Microbiology Laboratory, Health 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type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Li, Xuguang" sort="Li, Xuguang" uniqKey="Li X" first="Xuguang" last="Li">Xuguang Li</name><affiliation wicri:level="1"><nlm:aff id="AFF3">Centre for Biologics Research, Biologics and Genetic Therapies Directorate, Health Canada, Tunney’s Pasture, Ottawa, ON, Canada K1A 0K9</nlm:aff><country>Canada</country><wicri:regionArea>Centre for Biologics Research, Biologics and Genetic Therapies Directorate, Health Canada, Tunney’s Pasture, Ottawa, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15249217</idno><idno type="pmc">7111066</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111066</idno><idno type="RBID">PMC:7111066</idno><idno type="doi">10.1016/j.bbrc.2004.06.076</idno><date when="2004">2004</date><idno 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Winnipeg, MB, Canada R3T 2N2</nlm:aff><country>Canada</country><wicri:regionArea>Department of Medical Microbiology, School of Medicine, University of Manitoba, Winnipeg, MB</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Adonov, Anton" sort="Adonov, Anton" uniqKey="Adonov A" first="Anton" last="Adonov">Anton Adonov</name><affiliation wicri:level="1"><nlm:aff id="AFF1">National Microbiology Laboratory, Health Canada, 1015 Arlington St., Winnipeg, MB, Canada R3E 3R2</nlm:aff><country>Canada</country><wicri:regionArea>National Microbiology Laboratory, Health Canada, 1015 Arlington St., Winnipeg, MB</wicri:regionArea><wicri:noRegion>MB</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Department of Medical Microbiology, School of Medicine, University of Manitoba, Winnipeg, MB, Canada R3T 2N2</nlm:aff><country>Canada</country><wicri:regionArea>Department of Medical Microbiology, School of Medicine, University of Manitoba, Winnipeg, MB</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Traykova Adonova, Maya" sort="Traykova Adonova, Maya" uniqKey="Traykova Adonova M" first="Maya" last="Traykova-Adonova">Maya Traykova-Adonova</name><affiliation wicri:level="1"><nlm:aff id="AFF1">National Microbiology Laboratory, Health Canada, 1015 Arlington St., Winnipeg, MB, Canada R3E 3R2</nlm:aff><country>Canada</country><wicri:regionArea>National Microbiology Laboratory, Health Canada, 1015 Arlington St., Winnipeg, MB</wicri:regionArea><wicri:noRegion>MB</wicri:noRegion></affiliation></author><author><name sortKey="Cao, Jingxin" sort="Cao, Jingxin" uniqKey="Cao J" first="Jingxin" last="Cao">Jingxin Cao</name><affiliation wicri:level="1"><nlm:aff id="AFF1">National Microbiology Laboratory, Health Canada, 1015 Arlington St., Winnipeg, MB, Canada R3E 3R2</nlm:aff><country>Canada</country><wicri:regionArea>National Microbiology Laboratory, Health Canada, 1015 Arlington St., Winnipeg, MB</wicri:regionArea><wicri:noRegion>MB</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Department of Medical Microbiology, School of Medicine, University of Manitoba, Winnipeg, MB, Canada R3T 2N2</nlm:aff><country>Canada</country><wicri:regionArea>Department of Medical Microbiology, School of Medicine, University of Manitoba, Winnipeg, MB</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Cutts, Todd" sort="Cutts, Todd" uniqKey="Cutts T" first="Todd" last="Cutts">Todd Cutts</name><affiliation wicri:level="1"><nlm:aff id="AFF1">National Microbiology Laboratory, Health Canada, 1015 Arlington St., Winnipeg, MB, Canada R3E 3R2</nlm:aff><country>Canada</country><wicri:regionArea>National Microbiology Laboratory, Health Canada, 1015 Arlington St., Winnipeg, MB</wicri:regionArea><wicri:noRegion>MB</wicri:noRegion></affiliation></author><author><name sortKey="Grudesky, Elsie" sort="Grudesky, Elsie" uniqKey="Grudesky E" first="Elsie" last="Grudesky">Elsie Grudesky</name><affiliation wicri:level="1"><nlm:aff id="AFF1">National Microbiology Laboratory, Health Canada, 1015 Arlington St., Winnipeg, MB, Canada R3E 3R2</nlm:aff><country>Canada</country><wicri:regionArea>National Microbiology Laboratory, Health Canada, 1015 Arlington St., Winnipeg, MB</wicri:regionArea><wicri:noRegion>MB</wicri:noRegion></affiliation></author><author><name sortKey="Deschambaul, Yvon" sort="Deschambaul, Yvon" uniqKey="Deschambaul Y" first="Yvon" last="Deschambaul">Yvon Deschambaul</name><affiliation wicri:level="1"><nlm:aff id="AFF1">National Microbiology Laboratory, Health Canada, 1015 Arlington St., Winnipeg, MB, Canada R3E 3R2</nlm:aff><country>Canada</country><wicri:regionArea>National Microbiology Laboratory, Health Canada, 1015 Arlington St., Winnipeg, MB</wicri:regionArea><wicri:noRegion>MB</wicri:noRegion></affiliation></author><author><name sortKey="Berry, Jody" sort="Berry, Jody" uniqKey="Berry J" first="Jody" last="Berry">Jody Berry</name><affiliation wicri:level="1"><nlm:aff id="AFF1">National Microbiology Laboratory, Health Canada, 1015 Arlington St., Winnipeg, MB, Canada R3E 3R2</nlm:aff><country>Canada</country><wicri:regionArea>National Microbiology Laboratory, Health Canada, 1015 Arlington St., Winnipeg, MB</wicri:regionArea><wicri:noRegion>MB</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Department of Medical Microbiology, School of Medicine, University of Manitoba, Winnipeg, MB, Canada R3T 2N2</nlm:aff><country>Canada</country><wicri:regionArea>Department of Medical Microbiology, School of Medicine, University of Manitoba, Winnipeg, MB</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Drebot, Michael" sort="Drebot, Michael" uniqKey="Drebot M" first="Michael" last="Drebot">Michael Drebot</name><affiliation wicri:level="1"><nlm:aff id="AFF1">National Microbiology Laboratory, Health Canada, 1015 Arlington St., Winnipeg, MB, Canada R3E 3R2</nlm:aff><country>Canada</country><wicri:regionArea>National Microbiology Laboratory, Health Canada, 1015 Arlington St., Winnipeg, MB</wicri:regionArea><wicri:noRegion>MB</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Department of Medical Microbiology, School of Medicine, University of Manitoba, Winnipeg, MB, Canada R3T 2N2</nlm:aff><country>Canada</country><wicri:regionArea>Department of Medical Microbiology, School of Medicine, University of Manitoba, Winnipeg, MB</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Li, Xuguang" sort="Li, Xuguang" uniqKey="Li X" first="Xuguang" last="Li">Xuguang Li</name><affiliation wicri:level="1"><nlm:aff id="AFF3">Centre for Biologics Research, Biologics and Genetic Therapies Directorate, Health Canada, Tunney’s Pasture, Ottawa, ON, Canada K1A 0K9</nlm:aff><country>Canada</country><wicri:regionArea>Centre for Biologics Research, Biologics and Genetic Therapies Directorate, Health Canada, Tunney’s Pasture, Ottawa, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biochemical and Biophysical Research Communications</title><idno type="ISSN">0006-291X</idno><idno type="eISSN">1090-2104</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Antiviral Agents (therapeutic use)</term><term>Aurintricarboxylic Acid (pharmacology)</term><term>Cell Division (drug effects)</term><term>Chlorocebus aethiops</term><term>Dose-Response Relationship, Drug</term><term>Reproducibility of Results</term><term>SARS Virus (drug effects)</term><term>SARS Virus (growth & development)</term><term>SARS Virus (ultrastructure)</term><term>Sensitivity and Specificity</term><term>Severe Acute Respiratory Syndrome (drug therapy)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Vero Cells</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide aurintricarboxylique (pharmacologie)</term><term>Animaux</term><term>Antiviraux (pharmacologie)</term><term>Antiviraux (usage thérapeutique)</term><term>Cellules Vero</term><term>Division cellulaire ()</term><term>Relation dose-effet des médicaments</term><term>Reproductibilité des résultats</term><term>Réplication virale ()</term><term>Sensibilité et spécificité</term><term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS ()</term><term>Virus du SRAS (croissance et développement)</term><term>Virus du SRAS (ultrastructure)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Aurintricarboxylic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Division</term><term>SARS Virus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acide aurintricarboxylique</term><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Dose-Response Relationship, Drug</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules Vero</term><term>Division cellulaire</term><term>Relation dose-effet des médicaments</term><term>Reproductibilité des résultats</term><term>Réplication virale</term><term>Sensibilité et spécificité</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The severe acute respiratory syndrome virus (SARS) is a coronavirus that instigated regional epidemics in Canada and several Asian countries in 2003. The newly identified SARS coronavirus (SARS-CoV) can be transmitted among humans and cause severe or even fatal illnesses. As preventive vaccine development takes years to complete and adverse reactions have been reported to some veterinary coronaviral vaccines, anti-viral compounds must be relentlessly pursued. In this study, we analyzed the effect of aurintricarboxylic acid (ATA) on SARS-CoV replication in cell culture, and found that ATA could drastically inhibit SARS-CoV replication, with viral production being 1000-fold less than that in the untreated control. Importantly, when compared with IFNs α and β, viral production was inhibited by more than 1000-fold as compared with the untreated control. In addition, when compared with IFNs α and β, ATA was approximately 10 times more potent than IFN α and 100 times more than interferon β at their highest concentrations reported in the literature previously. Our data indicated that ATA should be considered as a candidate anti-SARS compound for future clinical evaluation.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Marra, M A" uniqKey="Marra M">M.A. Marra</name></author><author><name sortKey="Jones, S J M" uniqKey="Jones S">S.J.M. Jones</name></author><author><name sortKey="Astell, C R" uniqKey="Astell C">C.R. Astell</name></author><author><name sortKey="Holt, R A" uniqKey="Holt R">R.A. Holt</name></author><author><name sortKey="Brooks Wilson, A" uniqKey="Brooks Wilson A">A. Brooks-Wilson</name></author><author><name sortKey="Butterfield, Y S N" uniqKey="Butterfield Y">Y.S.N. Butterfield</name></author><author><name sortKey="Kattra, J" uniqKey="Kattra J">J. Kattra</name></author><author><name sortKey="Asano, J K" uniqKey="Asano J">J.K. Asano</name></author><author><name sortKey="Barber, S A" uniqKey="Barber S">S.A. 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