Civets Are Equally Susceptible to Experimental Infection by Two Different Severe Acute Respiratory Syndrome Coronavirus Isolates
Identifieur interne : 004C17 ( Main/Merge ); précédent : 004C16; suivant : 004C18Civets Are Equally Susceptible to Experimental Infection by Two Different Severe Acute Respiratory Syndrome Coronavirus Isolates
Auteurs : Donglai Wu ; Changchun Tu ; Chaoan Xin ; Hua Xuan ; Qingwen Meng ; Yonggang Liu ; Yedong Yu ; Yuntao Guan ; Yu Jiang ; Xunnan Yin ; Gary Crameri ; Muping Wang ; Changwen Li ; Shengwang Liu ; Ming Liao ; Li Feng ; Hua Xiang ; Jinfu Sun ; Jinding Chen ; Yanwei Sun ; Shoulin Gu ; Nihong Liu ; Dexia Fu ; Bryan T. Eaton ; Lin-Fa Wang ; Xiangang KongSource :
- Journal of Virology [ 0022-538X ] ; 2005.
Descripteurs français
- KwdFr :
- Animaux, Chats, Maladies des chats (physiopathologie), Maladies des chats (transmission), Modèles animaux de maladie humaine, Susceptibilité à une maladie, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (physiopathologie), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (), Virus du SRAS (génétique), Virus du SRAS (immunologie), Virus du SRAS (pathogénicité), Viverridae.
- MESH :
- génétique : Virus du SRAS.
- immunologie : Syndrome respiratoire aigu sévère, Virus du SRAS.
- pathogénicité : Virus du SRAS.
- physiopathologie : Maladies des chats, Syndrome respiratoire aigu sévère.
- virologie : Syndrome respiratoire aigu sévère.
- Animaux, Chats, Maladies des chats, Modèles animaux de maladie humaine, Susceptibilité à une maladie, Syndrome respiratoire aigu sévère, Virus du SRAS, Viverridae.
English descriptors
- KwdEn :
- Animals, Cat Diseases (physiopathology), Cat Diseases (transmission), Cats, Disease Models, Animal, Disease Susceptibility, SARS Virus (classification), SARS Virus (genetics), SARS Virus (immunology), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (physiopathology), Severe Acute Respiratory Syndrome (prevention & control), Severe Acute Respiratory Syndrome (virology), Viverridae.
- MESH :
- classification : SARS Virus.
- genetics : SARS Virus.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome.
- pathogenicity : SARS Virus.
- physiopathology : Cat Diseases, Severe Acute Respiratory Syndrome.
- prevention & control : Severe Acute Respiratory Syndrome.
- transmission : Cat Diseases.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Cats, Disease Models, Animal, Disease Susceptibility, Viverridae.
Abstract
Severe acute respiratory syndrome (SARS) was caused by a novel virus now known as SARS coronavirus (SARS-CoV). The discovery of SARS-CoV-like viruses in masked palm civets (
Url:
DOI: 10.1128/JVI.79.4.2620-2625.2005
PubMed: 15681462
PubMed Central: 546564
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PMC:546564Le document en format XML
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<series><title level="j">Journal of Virology</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Cat Diseases (physiopathology)</term>
<term>Cat Diseases (transmission)</term>
<term>Cats</term>
<term>Disease Models, Animal</term>
<term>Disease Susceptibility</term>
<term>SARS Virus (classification)</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (immunology)</term>
<term>SARS Virus (pathogenicity)</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
<term>Severe Acute Respiratory Syndrome (physiopathology)</term>
<term>Severe Acute Respiratory Syndrome (prevention & control)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Viverridae</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Chats</term>
<term>Maladies des chats (physiopathologie)</term>
<term>Maladies des chats (transmission)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Susceptibilité à une maladie</term>
<term>Syndrome respiratoire aigu sévère ()</term>
<term>Syndrome respiratoire aigu sévère (immunologie)</term>
<term>Syndrome respiratoire aigu sévère (physiopathologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (génétique)</term>
<term>Virus du SRAS (immunologie)</term>
<term>Virus du SRAS (pathogénicité)</term>
<term>Viverridae</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Maladies des chats</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cat Diseases</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Cat Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cats</term>
<term>Disease Models, Animal</term>
<term>Disease Susceptibility</term>
<term>Viverridae</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Chats</term>
<term>Maladies des chats</term>
<term>Modèles animaux de maladie humaine</term>
<term>Susceptibilité à une maladie</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Virus du SRAS</term>
<term>Viverridae</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><p>Severe acute respiratory syndrome (SARS) was caused by a novel virus now known as SARS coronavirus (SARS-CoV). The discovery of SARS-CoV-like viruses in masked palm civets (<italic>Paguma larvata</italic>
) raises the possibility that civets play a role in SARS-CoV transmission. To test the susceptibility of civets to experimental infection by different SARS-CoV isolates, 10 civets were inoculated with two human isolates of SARS-CoV, BJ01 (with a 29-nucleotide deletion) and GZ01 (without the 29-nucleotide deletion). All inoculated animals displayed clinical symptoms, such as fever, lethargy, and loss of aggressiveness, and the infection was confirmed by virus isolation, detection of viral genomic RNA, and serum-neutralizing antibodies. Our data show that civets were equally susceptible to SARS-CoV isolates GZ01 and BJ01.</p>
</div>
</front>
</TEI>
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