SrasV1, PubMed, Corpus, bibRecord, 002914

Civets are equally susceptible to experimental infection by two different severe acute respiratory syndrome coronavirus isolates.

Identifieur interne : 002914 ( PubMed/Corpus ); précédent : 002913; suivant : 002915

Civets are equally susceptible to experimental infection by two different severe acute respiratory syndrome coronavirus isolates.

Auteurs : Donglai Wu ; Changchun Tu ; Chaoan Xin ; Hua Xuan ; Qingwen Meng ; Yonggang Liu ; Yedong Yu ; Yuntao Guan ; Yu Jiang ; Xunnan Yin ; Gary Crameri ; Muping Wang ; Changwen Li ; Shengwang Liu ; Ming Liao ; Li Feng ; Hua Xiang ; Jinfu Sun ; Jinding Chen ; Yanwei Sun ; Shoulin Gu ; Nihong Liu ; Dexia Fu ; Bryan T. Eaton ; Lin-Fa Wang ; Xiangang Kong

Source :

Journal of virology [ 0022-538X ] ; 2005.

RBID : pubmed:15681462

English descriptors

KwdEn :
- Animals, Cat Diseases (physiopathology), Cat Diseases (transmission), Cats, Disease Models, Animal, Disease Susceptibility, SARS Virus (classification), SARS Virus (genetics), SARS Virus (immunology), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (physiopathology), Severe Acute Respiratory Syndrome (prevention & control), Severe Acute Respiratory Syndrome (virology), Viverridae.
MESH :
- classification : SARS Virus.
- genetics : SARS Virus.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome.
- pathogenicity : SARS Virus.
- physiopathology : Cat Diseases, Severe Acute Respiratory Syndrome.
- prevention & control : Severe Acute Respiratory Syndrome.
- transmission : Cat Diseases.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Cats, Disease Models, Animal, Disease Susceptibility, Viverridae.

Abstract

Severe acute respiratory syndrome (SARS) was caused by a novel virus now known as SARS coronavirus (SARS-CoV). The discovery of SARS-CoV-like viruses in masked palm civets (Paguma larvata) raises the possibility that civets play a role in SARS-CoV transmission. To test the susceptibility of civets to experimental infection by different SARS-CoV isolates, 10 civets were inoculated with two human isolates of SARS-CoV, BJ01 (with a 29-nucleotide deletion) and GZ01 (without the 29-nucleotide deletion). All inoculated animals displayed clinical symptoms, such as fever, lethargy, and loss of aggressiveness, and the infection was confirmed by virus isolation, detection of viral genomic RNA, and serum-neutralizing antibodies. Our data show that civets were equally susceptible to SARS-CoV isolates GZ01 and BJ01.

DOI: 10.1128/JVI.79.4.2620-2625.2005
PubMed: 15681462

Links to Exploration step

pubmed:15681462

Le document en format XML

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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) was caused by a novel virus now known as SARS coronavirus (SARS-CoV). The discovery of SARS-CoV-like viruses in masked palm civets (Paguma larvata) raises the possibility that civets play a role in SARS-CoV transmission. To test the susceptibility of civets to experimental infection by different SARS-CoV isolates, 10 civets were inoculated with two human isolates of SARS-CoV, BJ01 (with a 29-nucleotide deletion) and GZ01 (without the 29-nucleotide deletion). All inoculated animals displayed clinical symptoms, such as fever, lethargy, and loss of aggressiveness, and the infection was confirmed by virus isolation, detection of viral genomic RNA, and serum-neutralizing antibodies. Our data show that civets were equally susceptible to SARS-CoV isolates GZ01 and BJ01.</div>
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<Abstract><AbstractText>Severe acute respiratory syndrome (SARS) was caused by a novel virus now known as SARS coronavirus (SARS-CoV). The discovery of SARS-CoV-like viruses in masked palm civets (Paguma larvata) raises the possibility that civets play a role in SARS-CoV transmission. To test the susceptibility of civets to experimental infection by different SARS-CoV isolates, 10 civets were inoculated with two human isolates of SARS-CoV, BJ01 (with a 29-nucleotide deletion) and GZ01 (without the 29-nucleotide deletion). All inoculated animals displayed clinical symptoms, such as fever, lethargy, and loss of aggressiveness, and the infection was confirmed by virus isolation, detection of viral genomic RNA, and serum-neutralizing antibodies. Our data show that civets were equally susceptible to SARS-CoV isolates GZ01 and BJ01.</AbstractText>
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Civets are equally susceptible to experimental infection by two different severe acute respiratory syndrome coronavirus isolates.

Civets are equally susceptible to experimental infection by two different severe acute respiratory syndrome coronavirus isolates.

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