Cardiovascular complications of severe acute respiratory syndrome
Identifieur interne : 004537 ( Main/Merge ); précédent : 004536; suivant : 004538Cardiovascular complications of severe acute respiratory syndrome
Auteurs : C-M Yu [Hong Kong] ; R S-M Wong [Hong Kong] ; E B Wu [Hong Kong] ; S-L Kong [Hong Kong] ; J. Wong [Hong Kong] ; G W-K Yip [Hong Kong] ; Y O Y. Soo [Hong Kong] ; M L S. Chiu [Hong Kong] ; Y-S Chan [Hong Kong] ; D. Hui [Hong Kong] ; N. Lee [Hong Kong] ; A. Wu [Hong Kong] ; C-B Leung [Hong Kong] ; J J-Y Sung [Hong Kong]Source :
- Postgraduate Medical Journal [ 0032-5473 ] ; 2006-02.
English descriptors
- KwdEn :
- Teeft :
- Admission value, Arrhythmia, Blood pressure, Bradycardia, Cardiac, Cardiac arrhythmia, Cardiomegaly, Cardiovascular, Cardiovascular complications, Complication, Coronavirus, Corticosteroid, Corticosteroid therapy, Diastolic, Diastolic blood pressure, First week, Heart failure, Heart rate, Hong kong, Hospitalisation, Hospitalisation period, Hypotension, Intensive care unit, Novel coronavirus, Other hand, Outpatient, Parametric variables, Pulse rate, Respiratory syndrome, Ribavarin therapy, Sars, Significant hypotension, Sinus tachycardia, Syndrome, Systolic, Tachycardia, Temporary inotropic support, Third week, Wong.
Abstract
Background and Aims: Severe acute respiratory syndrome (SARS) is a virulent viral infection that affects a number of organs and systems. This study examined if SARS may result in cardiovascular complications. Methods and Results: 121 patients (37.5 (SD13.2) years, 36% male) diagnosed to have SARS were assessed continuously for blood pressure, pulse, and temperature during their stay in hopsital. Hypotension occurred in 61 (50.4%) patients in hospital, and was found in 28.1%, 21.5%, and 14.8% of patients during the first, second, and third week, respectively. Only one patient who had transient echocardiographic evidence of impaired left ventricular systolic function required temporary inotropic support. Tachycardia was present in 87 (71.9%) patients, and was found in 62.8%, 45.4%, and 35.5% of patients from the first to third week. It occurred independent of hypotension, and could not be explained by the presence of fever. Tachycardia was also present in 38.8% of patients at follow up. Bradycardia only occurred in 18 (14.9%) patients as a transient event. Reversible cardiomegaly was reported in 13 (10.7%) patients, but without clinical evidence of heart failure. Transient atrial fibrillation was present in one patient. Corticosteroid therapy was weakly associated with tachycardia during the second (χ2 = 3.99, p = 0.046) and third week (χ2 = 6.53, p = 0.01), although it could not explain tachycardia during follow up. Conclusions: In patients with SARS, cardiovascular complications including hypotension and tachycardia were common but usually self limiting. Bradycardia and cardiomegaly were less common, while cardiac arrhythmia was rare. However, only tachycardia persisted even when corticosteroid therapy was withdrawn.
Url:
- https://api.istex.fr/ark:/67375/NVC-PBMWQ52W-D/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596695
DOI: 10.1136/pgmj.2005.037515
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Soo</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Chiu, M L S" sort="Chiu, M L S" uniqKey="Chiu M" first="M L S" last="Chiu">M L S. Chiu</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Chan, Y S" sort="Chan, Y S" uniqKey="Chan Y" first="Y-S" last="Chan">Y-S Chan</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Hui, D" sort="Hui, D" uniqKey="Hui D" first="D" last="Hui">D. Hui</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Lee, N" sort="Lee, N" uniqKey="Lee N" first="N" last="Lee">N. Lee</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Wu, A" sort="Wu, A" uniqKey="Wu A" first="A" last="Wu">A. Wu</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Leung, C B" sort="Leung, C B" uniqKey="Leung C" first="C-B" last="Leung">C-B Leung</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Sung, J J Y" sort="Sung, J J Y" uniqKey="Sung J" first="J J-Y" last="Sung">J J-Y Sung</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Postgraduate Medical Journal</title><title level="j" type="abbrev">Postgrad Med J</title><idno type="ISSN">0032-5473</idno><idno type="eISSN">1469-0756</idno><imprint><publisher>The Fellowship of Postgraduate Medicine</publisher><date type="published" when="2006-02">2006-02</date><biblScope unit="volume">82</biblScope><biblScope unit="issue">964</biblScope><biblScope unit="page" from="140">140</biblScope></imprint><idno type="ISSN">0032-5473</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0032-5473</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>atypical pneumonia</term><term>blood pressure</term><term>severe acute respiratory syndrome</term><term>tachycardia</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Admission value</term><term>Arrhythmia</term><term>Blood pressure</term><term>Bradycardia</term><term>Cardiac</term><term>Cardiac arrhythmia</term><term>Cardiomegaly</term><term>Cardiovascular</term><term>Cardiovascular complications</term><term>Complication</term><term>Coronavirus</term><term>Corticosteroid</term><term>Corticosteroid therapy</term><term>Diastolic</term><term>Diastolic blood pressure</term><term>First week</term><term>Heart failure</term><term>Heart rate</term><term>Hong kong</term><term>Hospitalisation</term><term>Hospitalisation period</term><term>Hypotension</term><term>Intensive care unit</term><term>Novel coronavirus</term><term>Other hand</term><term>Outpatient</term><term>Parametric variables</term><term>Pulse rate</term><term>Respiratory syndrome</term><term>Ribavarin therapy</term><term>Sars</term><term>Significant hypotension</term><term>Sinus tachycardia</term><term>Syndrome</term><term>Systolic</term><term>Tachycardia</term><term>Temporary inotropic support</term><term>Third week</term><term>Wong</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background and Aims: Severe acute respiratory syndrome (SARS) is a virulent viral infection that affects a number of organs and systems. This study examined if SARS may result in cardiovascular complications. Methods and Results: 121 patients (37.5 (SD13.2) years, 36% male) diagnosed to have SARS were assessed continuously for blood pressure, pulse, and temperature during their stay in hopsital. Hypotension occurred in 61 (50.4%) patients in hospital, and was found in 28.1%, 21.5%, and 14.8% of patients during the first, second, and third week, respectively. Only one patient who had transient echocardiographic evidence of impaired left ventricular systolic function required temporary inotropic support. Tachycardia was present in 87 (71.9%) patients, and was found in 62.8%, 45.4%, and 35.5% of patients from the first to third week. It occurred independent of hypotension, and could not be explained by the presence of fever. Tachycardia was also present in 38.8% of patients at follow up. Bradycardia only occurred in 18 (14.9%) patients as a transient event. Reversible cardiomegaly was reported in 13 (10.7%) patients, but without clinical evidence of heart failure. Transient atrial fibrillation was present in one patient. Corticosteroid therapy was weakly associated with tachycardia during the second (χ2 = 3.99, p = 0.046) and third week (χ2 = 6.53, p = 0.01), although it could not explain tachycardia during follow up. Conclusions: In patients with SARS, cardiovascular complications including hypotension and tachycardia were common but usually self limiting. Bradycardia and cardiomegaly were less common, while cardiac arrhythmia was rare. However, only tachycardia persisted even when corticosteroid therapy was withdrawn.</div></front></TEI><double doi="10.1136/pgmj.2005.037515"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cardiovascular complications of severe acute respiratory syndrome</title><author><name sortKey="Yu, C M" sort="Yu, C M" uniqKey="Yu C" first="C-M" last="Yu">C-M Yu</name></author><author><name sortKey="Wong, R S M" sort="Wong, R S M" uniqKey="Wong R" first="R S-M" last="Wong">R S-M Wong</name></author><author><name sortKey="Wu, E B" sort="Wu, E B" uniqKey="Wu E" first="E B" last="Wu">E B Wu</name></author><author><name sortKey="Kong, S L" sort="Kong, S L" uniqKey="Kong S" first="S-L" last="Kong">S-L Kong</name></author><author><name sortKey="Wong, J" sort="Wong, J" uniqKey="Wong J" first="J" last="Wong">J. Wong</name></author><author><name sortKey="Yip, G W K" sort="Yip, G W K" uniqKey="Yip G" first="G W-K" last="Yip">G W-K Yip</name></author><author><name sortKey="Soo, Y O Y" sort="Soo, Y O Y" uniqKey="Soo Y" first="Y O Y" last="Soo">Y O Y. Soo</name></author><author><name sortKey="Chiu, M L S" sort="Chiu, M L S" uniqKey="Chiu M" first="M L S" last="Chiu">M L S. Chiu</name></author><author><name sortKey="Chan, Y S" sort="Chan, Y S" uniqKey="Chan Y" first="Y-S" last="Chan">Y-S Chan</name></author><author><name sortKey="Hui, D" sort="Hui, D" uniqKey="Hui D" first="D" last="Hui">D. Hui</name></author><author><name sortKey="Lee, N" sort="Lee, N" uniqKey="Lee N" first="N" last="Lee">N. Lee</name></author><author><name sortKey="Wu, A" sort="Wu, A" uniqKey="Wu A" first="A" last="Wu">A. Wu</name></author><author><name sortKey="Leung, C B" sort="Leung, C B" uniqKey="Leung C" first="C-B" last="Leung">C-B Leung</name></author><author><name sortKey="Sung, J J Y" sort="Sung, J J Y" uniqKey="Sung J" first="J J-Y" last="Sung">J J-Y Sung</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:989D560E22CC6F5E461F619E7A28FD4FFD4DD30B</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1136/pgmj.2005.037515</idno><idno type="url">https://api.istex.fr/ark:/67375/NVC-PBMWQ52W-D/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000859</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000859</idno><idno type="wicri:Area/Istex/Curation">000859</idno><idno type="wicri:Area/Istex/Checkpoint">001747</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001747</idno><idno type="wicri:doubleKey">0032-5473:2006:Yu C:cardiovascular:complications:of</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cardiovascular complications of severe acute respiratory syndrome</title><author><name sortKey="Yu, C M" sort="Yu, C M" uniqKey="Yu C" first="C-M" last="Yu">C-M Yu</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Wong, R S M" sort="Wong, R S M" uniqKey="Wong R" first="R S-M" last="Wong">R S-M Wong</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Wu, E B" sort="Wu, E B" uniqKey="Wu E" first="E B" last="Wu">E B Wu</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Kong, S L" sort="Kong, S L" uniqKey="Kong S" first="S-L" last="Kong">S-L Kong</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Wong, J" sort="Wong, J" uniqKey="Wong J" first="J" last="Wong">J. Wong</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Yip, G W K" sort="Yip, G W K" uniqKey="Yip G" first="G W-K" last="Yip">G W-K Yip</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Soo, Y O Y" sort="Soo, Y O Y" uniqKey="Soo Y" first="Y O Y" last="Soo">Y O Y. Soo</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Chiu, M L S" sort="Chiu, M L S" uniqKey="Chiu M" first="M L S" last="Chiu">M L S. Chiu</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Chan, Y S" sort="Chan, Y S" uniqKey="Chan Y" first="Y-S" last="Chan">Y-S Chan</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Hui, D" sort="Hui, D" uniqKey="Hui D" first="D" last="Hui">D. Hui</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Lee, N" sort="Lee, N" uniqKey="Lee N" first="N" last="Lee">N. Lee</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Wu, A" sort="Wu, A" uniqKey="Wu A" first="A" last="Wu">A. Wu</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Leung, C B" sort="Leung, C B" uniqKey="Leung C" first="C-B" last="Leung">C-B Leung</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Sung, J J Y" sort="Sung, J J Y" uniqKey="Sung J" first="J J-Y" last="Sung">J J-Y Sung</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Postgraduate Medical Journal</title><title level="j" type="abbrev">Postgrad Med J</title><idno type="ISSN">0032-5473</idno><idno type="eISSN">1469-0756</idno><imprint><publisher>The Fellowship of Postgraduate Medicine</publisher><date type="published" when="2006-02">2006-02</date><biblScope unit="volume">82</biblScope><biblScope unit="issue">964</biblScope><biblScope unit="page" from="140">140</biblScope></imprint><idno type="ISSN">0032-5473</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0032-5473</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>atypical pneumonia</term><term>blood pressure</term><term>severe acute respiratory syndrome</term><term>tachycardia</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Admission value</term><term>Arrhythmia</term><term>Blood pressure</term><term>Bradycardia</term><term>Cardiac</term><term>Cardiac arrhythmia</term><term>Cardiomegaly</term><term>Cardiovascular</term><term>Cardiovascular complications</term><term>Complication</term><term>Coronavirus</term><term>Corticosteroid</term><term>Corticosteroid therapy</term><term>Diastolic</term><term>Diastolic blood pressure</term><term>First week</term><term>Heart failure</term><term>Heart rate</term><term>Hong kong</term><term>Hospitalisation</term><term>Hospitalisation period</term><term>Hypotension</term><term>Intensive care unit</term><term>Novel coronavirus</term><term>Other hand</term><term>Outpatient</term><term>Parametric variables</term><term>Pulse rate</term><term>Respiratory syndrome</term><term>Ribavarin therapy</term><term>Sars</term><term>Significant hypotension</term><term>Sinus tachycardia</term><term>Syndrome</term><term>Systolic</term><term>Tachycardia</term><term>Temporary inotropic support</term><term>Third week</term><term>Wong</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background and Aims: Severe acute respiratory syndrome (SARS) is a virulent viral infection that affects a number of organs and systems. This study examined if SARS may result in cardiovascular complications. Methods and Results: 121 patients (37.5 (SD13.2) years, 36% male) diagnosed to have SARS were assessed continuously for blood pressure, pulse, and temperature during their stay in hopsital. Hypotension occurred in 61 (50.4%) patients in hospital, and was found in 28.1%, 21.5%, and 14.8% of patients during the first, second, and third week, respectively. Only one patient who had transient echocardiographic evidence of impaired left ventricular systolic function required temporary inotropic support. Tachycardia was present in 87 (71.9%) patients, and was found in 62.8%, 45.4%, and 35.5% of patients from the first to third week. It occurred independent of hypotension, and could not be explained by the presence of fever. Tachycardia was also present in 38.8% of patients at follow up. Bradycardia only occurred in 18 (14.9%) patients as a transient event. Reversible cardiomegaly was reported in 13 (10.7%) patients, but without clinical evidence of heart failure. Transient atrial fibrillation was present in one patient. Corticosteroid therapy was weakly associated with tachycardia during the second (χ2 = 3.99, p = 0.046) and third week (χ2 = 6.53, p = 0.01), although it could not explain tachycardia during follow up. Conclusions: In patients with SARS, cardiovascular complications including hypotension and tachycardia were common but usually self limiting. Bradycardia and cardiomegaly were less common, while cardiac arrhythmia was rare. However, only tachycardia persisted even when corticosteroid therapy was withdrawn.</div></front></TEI></ISTEX><PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cardiovascular complications of severe acute respiratory syndrome</title><author><name sortKey="Yu, C" sort="Yu, C" uniqKey="Yu C" first="C-M" last="Yu">C-M Yu</name></author><author><name sortKey="Wong, R S" sort="Wong, R S" uniqKey="Wong R" first="R S-M" last="Wong">R S-M Wong</name></author><author><name sortKey="Wu, E B" sort="Wu, E B" uniqKey="Wu E" first="E B" last="Wu">E B Wu</name></author><author><name sortKey="Kong, S" sort="Kong, S" uniqKey="Kong S" first="S-L" last="Kong">S-L Kong</name></author><author><name sortKey="Wong, J" sort="Wong, J" uniqKey="Wong J" first="J" last="Wong">J. Wong</name></author><author><name sortKey="Yip, G W" sort="Yip, G W" uniqKey="Yip G" first="G W-K" last="Yip">G W-K Yip</name></author><author><name sortKey="Soo, Y O Y" sort="Soo, Y O Y" uniqKey="Soo Y" first="Y O Y" last="Soo">Y O Y. Soo</name></author><author><name sortKey="Chiu, M L S" sort="Chiu, M L S" uniqKey="Chiu M" first="M L S" last="Chiu">M L S. Chiu</name></author><author><name sortKey="Chan, Y" sort="Chan, Y" uniqKey="Chan Y" first="Y-S" last="Chan">Y-S Chan</name></author><author><name sortKey="Hui, D" sort="Hui, D" uniqKey="Hui D" first="D" last="Hui">D. Hui</name></author><author><name sortKey="Lee, N" sort="Lee, N" uniqKey="Lee N" first="N" last="Lee">N. Lee</name></author><author><name sortKey="Wu, A" sort="Wu, A" uniqKey="Wu A" first="A" last="Wu">A. Wu</name></author><author><name sortKey="Leung, C" sort="Leung, C" uniqKey="Leung C" first="C-B" last="Leung">C-B Leung</name></author><author><name sortKey="Sung, J J" sort="Sung, J J" uniqKey="Sung J" first="J J-Y" last="Sung">J J-Y Sung</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16461478</idno><idno type="pmc">2596695</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596695</idno><idno type="RBID">PMC:2596695</idno><idno type="doi">10.1136/pgmj.2005.037515</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000737</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000737</idno><idno type="wicri:Area/Pmc/Curation">000737</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000737</idno><idno type="wicri:Area/Pmc/Checkpoint">001160</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001160</idno><idno type="wicri:Area/Ncbi/Merge">001367</idno><idno type="wicri:Area/Ncbi/Curation">001367</idno><idno type="wicri:Area/Ncbi/Checkpoint">001367</idno><idno type="wicri:doubleKey">0032-5473:2006:Yu C:cardiovascular:complications:of</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cardiovascular complications of severe acute respiratory syndrome</title><author><name sortKey="Yu, C" sort="Yu, C" uniqKey="Yu C" first="C-M" last="Yu">C-M Yu</name></author><author><name sortKey="Wong, R S" sort="Wong, R S" uniqKey="Wong R" first="R S-M" last="Wong">R S-M Wong</name></author><author><name sortKey="Wu, E B" sort="Wu, E B" uniqKey="Wu E" first="E B" last="Wu">E B Wu</name></author><author><name sortKey="Kong, S" sort="Kong, S" uniqKey="Kong S" first="S-L" last="Kong">S-L Kong</name></author><author><name sortKey="Wong, J" sort="Wong, J" uniqKey="Wong J" first="J" last="Wong">J. Wong</name></author><author><name sortKey="Yip, G W" sort="Yip, G W" uniqKey="Yip G" first="G W-K" last="Yip">G W-K Yip</name></author><author><name sortKey="Soo, Y O Y" sort="Soo, Y O Y" uniqKey="Soo Y" first="Y O Y" last="Soo">Y O Y. Soo</name></author><author><name sortKey="Chiu, M L S" sort="Chiu, M L S" uniqKey="Chiu M" first="M L S" last="Chiu">M L S. Chiu</name></author><author><name sortKey="Chan, Y" sort="Chan, Y" uniqKey="Chan Y" first="Y-S" last="Chan">Y-S Chan</name></author><author><name sortKey="Hui, D" sort="Hui, D" uniqKey="Hui D" first="D" last="Hui">D. Hui</name></author><author><name sortKey="Lee, N" sort="Lee, N" uniqKey="Lee N" first="N" last="Lee">N. Lee</name></author><author><name sortKey="Wu, A" sort="Wu, A" uniqKey="Wu A" first="A" last="Wu">A. Wu</name></author><author><name sortKey="Leung, C" sort="Leung, C" uniqKey="Leung C" first="C-B" last="Leung">C-B Leung</name></author><author><name sortKey="Sung, J J" sort="Sung, J J" uniqKey="Sung J" first="J J-Y" last="Sung">J J-Y Sung</name></author></analytic><series><title level="j">Postgraduate Medical Journal</title><idno type="ISSN">0032-5473</idno><idno type="eISSN">1469-0756</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background and Aims</title><p>Severe acute respiratory syndrome (SARS) is a virulent viral infection that affects a number of organs and systems. This study examined if SARS may result in cardiovascular complications.</p></sec><sec><title>Methods and Results</title><p>121 patients (37.5 (SD13.2) years, 36% male) diagnosed to have SARS were assessed continuously for blood pressure, pulse, and temperature during their stay in hopsital. Hypotension occurred in 61 (50.4%) patients in hospital, and was found in 28.1%, 21.5%, and 14.8% of patients during the first, second, and third week, respectively. Only one patient who had transient echocardiographic evidence of impaired left ventricular systolic function required temporary inotropic support. Tachycardia was present in 87 (71.9%) patients, and was found in 62.8%, 45.4%, and 35.5% of patients from the first to third week. It occurred independent of hypotension, and could not be explained by the presence of fever. Tachycardia was also present in 38.8% of patients at follow up. Bradycardia only occurred in 18 (14.9%) patients as a transient event. Reversible cardiomegaly was reported in 13 (10.7%) patients, but without clinical evidence of heart failure. Transient atrial fibrillation was present in one patient. Corticosteroid therapy was weakly associated with tachycardia during the second (χ<sup>2</sup> = 3.99, p = 0.046) and third week (χ<sup>2</sup> = 6.53, p = 0.01), although it could not explain tachycardia during follow up.</p></sec><sec><title>Conclusions</title><p>In patients with SARS, cardiovascular complications including hypotension and tachycardia were common but usually self limiting. Bradycardia and cardiomegaly were less common, while cardiac arrhythmia was rare. However, only tachycardia persisted even when corticosteroid therapy was withdrawn.</p></sec></div></front></TEI></PMC></double></record>Pour manipuler ce document sous Unix (Dilib)
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