Cardiovascular complications of severe acute respiratory syndrome
Identifieur interne : 000737 ( Pmc/Corpus ); précédent : 000736; suivant : 000738Cardiovascular complications of severe acute respiratory syndrome
Auteurs : C-M Yu ; R S-M Wong ; E B Wu ; S-L Kong ; J. Wong ; G W-K Yip ; Y O Y. Soo ; M L S. Chiu ; Y-S Chan ; D. Hui ; N. Lee ; A. Wu ; C-B Leung ; J J-Y SungSource :
- Postgraduate Medical Journal [ 0032-5473 ] ; 2006.
Abstract
Severe acute respiratory syndrome (SARS) is a virulent viral infection that affects a number of organs and systems. This study examined if SARS may result in cardiovascular complications.
121 patients (37.5 (SD13.2) years, 36% male) diagnosed to have SARS were assessed continuously for blood pressure, pulse, and temperature during their stay in hopsital. Hypotension occurred in 61 (50.4%) patients in hospital, and was found in 28.1%, 21.5%, and 14.8% of patients during the first, second, and third week, respectively. Only one patient who had transient echocardiographic evidence of impaired left ventricular systolic function required temporary inotropic support. Tachycardia was present in 87 (71.9%) patients, and was found in 62.8%, 45.4%, and 35.5% of patients from the first to third week. It occurred independent of hypotension, and could not be explained by the presence of fever. Tachycardia was also present in 38.8% of patients at follow up. Bradycardia only occurred in 18 (14.9%) patients as a transient event. Reversible cardiomegaly was reported in 13 (10.7%) patients, but without clinical evidence of heart failure. Transient atrial fibrillation was present in one patient. Corticosteroid therapy was weakly associated with tachycardia during the second (χ2 = 3.99, p = 0.046) and third week (χ2 = 6.53, p = 0.01), although it could not explain tachycardia during follow up.
In patients with SARS, cardiovascular complications including hypotension and tachycardia were common but usually self limiting. Bradycardia and cardiomegaly were less common, while cardiac arrhythmia was rare. However, only tachycardia persisted even when corticosteroid therapy was withdrawn.
Url:
DOI: 10.1136/pgmj.2005.037515
PubMed: 16461478
PubMed Central: 2596695
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cardiovascular complications of severe acute respiratory syndrome</title><author><name sortKey="Yu, C" sort="Yu, C" uniqKey="Yu C" first="C-M" last="Yu">C-M Yu</name></author><author><name sortKey="Wong, R S" sort="Wong, R S" uniqKey="Wong R" first="R S-M" last="Wong">R S-M Wong</name></author><author><name sortKey="Wu, E B" sort="Wu, E B" uniqKey="Wu E" first="E B" last="Wu">E B Wu</name></author><author><name sortKey="Kong, S" sort="Kong, S" uniqKey="Kong S" first="S-L" last="Kong">S-L Kong</name></author><author><name sortKey="Wong, J" sort="Wong, J" uniqKey="Wong J" first="J" last="Wong">J. Wong</name></author><author><name sortKey="Yip, G W" sort="Yip, G W" uniqKey="Yip G" first="G W-K" last="Yip">G W-K Yip</name></author><author><name sortKey="Soo, Y O Y" sort="Soo, Y O Y" uniqKey="Soo Y" first="Y O Y" last="Soo">Y O Y. Soo</name></author><author><name sortKey="Chiu, M L S" sort="Chiu, M L S" uniqKey="Chiu M" first="M L S" last="Chiu">M L S. Chiu</name></author><author><name sortKey="Chan, Y" sort="Chan, Y" uniqKey="Chan Y" first="Y-S" last="Chan">Y-S Chan</name></author><author><name sortKey="Hui, D" sort="Hui, D" uniqKey="Hui D" first="D" last="Hui">D. Hui</name></author><author><name sortKey="Lee, N" sort="Lee, N" uniqKey="Lee N" first="N" last="Lee">N. Lee</name></author><author><name sortKey="Wu, A" sort="Wu, A" uniqKey="Wu A" first="A" last="Wu">A. Wu</name></author><author><name sortKey="Leung, C" sort="Leung, C" uniqKey="Leung C" first="C-B" last="Leung">C-B Leung</name></author><author><name sortKey="Sung, J J" sort="Sung, J J" uniqKey="Sung J" first="J J-Y" last="Sung">J J-Y Sung</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16461478</idno><idno type="pmc">2596695</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596695</idno><idno type="RBID">PMC:2596695</idno><idno type="doi">10.1136/pgmj.2005.037515</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000737</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000737</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cardiovascular complications of severe acute respiratory syndrome</title><author><name sortKey="Yu, C" sort="Yu, C" uniqKey="Yu C" first="C-M" last="Yu">C-M Yu</name></author><author><name sortKey="Wong, R S" sort="Wong, R S" uniqKey="Wong R" first="R S-M" last="Wong">R S-M Wong</name></author><author><name sortKey="Wu, E B" sort="Wu, E B" uniqKey="Wu E" first="E B" last="Wu">E B Wu</name></author><author><name sortKey="Kong, S" sort="Kong, S" uniqKey="Kong S" first="S-L" last="Kong">S-L Kong</name></author><author><name sortKey="Wong, J" sort="Wong, J" uniqKey="Wong J" first="J" last="Wong">J. Wong</name></author><author><name sortKey="Yip, G W" sort="Yip, G W" uniqKey="Yip G" first="G W-K" last="Yip">G W-K Yip</name></author><author><name sortKey="Soo, Y O Y" sort="Soo, Y O Y" uniqKey="Soo Y" first="Y O Y" last="Soo">Y O Y. Soo</name></author><author><name sortKey="Chiu, M L S" sort="Chiu, M L S" uniqKey="Chiu M" first="M L S" last="Chiu">M L S. Chiu</name></author><author><name sortKey="Chan, Y" sort="Chan, Y" uniqKey="Chan Y" first="Y-S" last="Chan">Y-S Chan</name></author><author><name sortKey="Hui, D" sort="Hui, D" uniqKey="Hui D" first="D" last="Hui">D. Hui</name></author><author><name sortKey="Lee, N" sort="Lee, N" uniqKey="Lee N" first="N" last="Lee">N. Lee</name></author><author><name sortKey="Wu, A" sort="Wu, A" uniqKey="Wu A" first="A" last="Wu">A. Wu</name></author><author><name sortKey="Leung, C" sort="Leung, C" uniqKey="Leung C" first="C-B" last="Leung">C-B Leung</name></author><author><name sortKey="Sung, J J" sort="Sung, J J" uniqKey="Sung J" first="J J-Y" last="Sung">J J-Y Sung</name></author></analytic><series><title level="j">Postgraduate Medical Journal</title><idno type="ISSN">0032-5473</idno><idno type="eISSN">1469-0756</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background and Aims</title><p>Severe acute respiratory syndrome (SARS) is a virulent viral infection that affects a number of organs and systems. This study examined if SARS may result in cardiovascular complications.</p></sec><sec><title>Methods and Results</title><p>121 patients (37.5 (SD13.2) years, 36% male) diagnosed to have SARS were assessed continuously for blood pressure, pulse, and temperature during their stay in hopsital. Hypotension occurred in 61 (50.4%) patients in hospital, and was found in 28.1%, 21.5%, and 14.8% of patients during the first, second, and third week, respectively. Only one patient who had transient echocardiographic evidence of impaired left ventricular systolic function required temporary inotropic support. Tachycardia was present in 87 (71.9%) patients, and was found in 62.8%, 45.4%, and 35.5% of patients from the first to third week. It occurred independent of hypotension, and could not be explained by the presence of fever. Tachycardia was also present in 38.8% of patients at follow up. Bradycardia only occurred in 18 (14.9%) patients as a transient event. Reversible cardiomegaly was reported in 13 (10.7%) patients, but without clinical evidence of heart failure. Transient atrial fibrillation was present in one patient. Corticosteroid therapy was weakly associated with tachycardia during the second (χ<sup>2</sup> = 3.99, p = 0.046) and third week (χ<sup>2</sup> = 6.53, p = 0.01), although it could not explain tachycardia during follow up.</p></sec><sec><title>Conclusions</title><p>In patients with SARS, cardiovascular complications including hypotension and tachycardia were common but usually self limiting. Bradycardia and cardiomegaly were less common, while cardiac arrhythmia was rare. However, only tachycardia persisted even when corticosteroid therapy was withdrawn.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Postgrad Med J</journal-id><journal-title>Postgraduate Medical Journal</journal-title><issn pub-type="ppub">0032-5473</issn><issn pub-type="epub">1469-0756</issn><publisher><publisher-name>BMJ Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16461478</article-id><article-id pub-id-type="pmc">2596695</article-id><article-id pub-id-type="publisher-id">pj37515</article-id><article-id pub-id-type="doi">10.1136/pgmj.2005.037515</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Cardiovascular complications of severe acute respiratory syndrome</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Yu</surname><given-names>C‐M</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wong</surname><given-names>R S‐M</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>E B</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kong</surname><given-names>S‐L</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wong</surname><given-names>J</given-names></name></contrib><contrib contrib-type="author"><name><surname>Yip</surname><given-names>G W‐K</given-names></name></contrib><contrib contrib-type="author"><name><surname>Soo</surname><given-names>Y O Y</given-names></name></contrib><contrib contrib-type="author"><name><surname>Chiu</surname><given-names>M L S</given-names></name></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>Y‐S</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hui</surname><given-names>D</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>N</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>A</given-names></name></contrib><contrib contrib-type="author"><name><surname>Leung</surname><given-names>C‐B</given-names></name></contrib><contrib contrib-type="author"><name><surname>Sung</surname><given-names>J J‐Y</given-names></name></contrib></contrib-group><aff><bold>C‐M Yu</bold>,<bold>R S‐M Wong</bold>,<bold>E B Wu</bold>,<bold>S‐L Kong</bold>,<bold>J Wong</bold>,<bold>G W‐K Yip</bold>,<bold>Y O Y Soo</bold>,<bold>M L S Chiu</bold>,<bold>Y‐S Chan</bold>,<bold>D Hui</bold>,<bold>N Lee</bold>,<bold>A Wu</bold>,<bold>C‐B Leung</bold>,<bold>J J‐Y Sung</bold>, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong</aff><author-notes><corresp>Correspondence to: Professor C‐M Yu<break></break>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong; cmyu@cuhk.edu.hk</corresp><fn fn-type="conflict"><p>Competing interests: none declared.</p></fn></author-notes><pub-date pub-type="ppub"><month>2</month><year>2006</year></pub-date><volume>82</volume><issue>964</issue><fpage>140</fpage><lpage>144</lpage><history><date date-type="received"><day>22</day><month>5</month><year>2005</year></date><date date-type="accepted"><day>16</day><month>8</month><year>2005</year></date></history><permissions><copyright-statement>Copyright ©2006 The Fellowship of Postgraduate Medicine.</copyright-statement></permissions><abstract><sec><title>Background and Aims</title><p>Severe acute respiratory syndrome (SARS) is a virulent viral infection that affects a number of organs and systems. This study examined if SARS may result in cardiovascular complications.</p></sec><sec><title>Methods and Results</title><p>121 patients (37.5 (SD13.2) years, 36% male) diagnosed to have SARS were assessed continuously for blood pressure, pulse, and temperature during their stay in hopsital. Hypotension occurred in 61 (50.4%) patients in hospital, and was found in 28.1%, 21.5%, and 14.8% of patients during the first, second, and third week, respectively. Only one patient who had transient echocardiographic evidence of impaired left ventricular systolic function required temporary inotropic support. Tachycardia was present in 87 (71.9%) patients, and was found in 62.8%, 45.4%, and 35.5% of patients from the first to third week. It occurred independent of hypotension, and could not be explained by the presence of fever. Tachycardia was also present in 38.8% of patients at follow up. Bradycardia only occurred in 18 (14.9%) patients as a transient event. Reversible cardiomegaly was reported in 13 (10.7%) patients, but without clinical evidence of heart failure. Transient atrial fibrillation was present in one patient. Corticosteroid therapy was weakly associated with tachycardia during the second (χ<sup>2</sup> = 3.99, p = 0.046) and third week (χ<sup>2</sup> = 6.53, p = 0.01), although it could not explain tachycardia during follow up.</p></sec><sec><title>Conclusions</title><p>In patients with SARS, cardiovascular complications including hypotension and tachycardia were common but usually self limiting. Bradycardia and cardiomegaly were less common, while cardiac arrhythmia was rare. However, only tachycardia persisted even when corticosteroid therapy was withdrawn.</p></sec></abstract><kwd-group><kwd>severe acute respiratory syndrome</kwd><kwd>atypical pneumonia</kwd><kwd>blood pressure</kwd><kwd>tachycardia</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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