Inactivation of SARS coronavirus by means of povidone-iodine, physical conditions and chemical reagents.
Identifieur interne : 004038 ( Main/Merge ); précédent : 004037; suivant : 004039Inactivation of SARS coronavirus by means of povidone-iodine, physical conditions and chemical reagents.
Auteurs : Hiroaki Kariwa [Japon] ; Nobuhiro Fujii ; Ikuo TakashimaSource :
- Dermatology (Basel, Switzerland) [ 1018-8665 ] ; 2006.
Descripteurs français
- KwdFr :
- Acétone (pharmacologie), Animaux, Anti-infectieux locaux (pharmacologie), Antiviraux (pharmacologie), Cellules Vero, Formaldéhyde (pharmacologie), Glutaraldéhyde (pharmacologie), Inactivation virale, Indicateurs et réactifs (pharmacologie), Méthanol (pharmacologie), Povidone iodée (pharmacologie), Rayons ultraviolets, Température élevée, Virus du SRAS (), Virus du SRAS (effets des radiations), Éthanol (pharmacologie).
- MESH :
- effets des radiations : Virus du SRAS.
- pharmacologie : Acétone, Anti-infectieux locaux, Antiviraux, Formaldéhyde, Glutaraldéhyde, Indicateurs et réactifs, Méthanol, Povidone iodée, Éthanol.
- Animaux, Cellules Vero, Inactivation virale, Rayons ultraviolets, Température élevée, Virus du SRAS.
English descriptors
- KwdEn :
- Acetone (pharmacology), Animals, Anti-Infective Agents, Local (pharmacology), Antiviral Agents (pharmacology), Chlorocebus aethiops, Ethanol (pharmacology), Formaldehyde (pharmacology), Glutaral (pharmacology), Hot Temperature, Indicators and Reagents (pharmacology), Methanol (pharmacology), Povidone-Iodine (pharmacology), SARS Virus (drug effects), SARS Virus (radiation effects), Ultraviolet Rays, Vero Cells, Virus Inactivation.
- MESH :
- chemical , pharmacology : Acetone, Anti-Infective Agents, Local, Antiviral Agents, Ethanol, Formaldehyde, Glutaral, Indicators and Reagents, Methanol, Povidone-Iodine.
- drug effects : SARS Virus.
- radiation effects : SARS Virus.
- Animals, Chlorocebus aethiops, Hot Temperature, Ultraviolet Rays, Vero Cells, Virus Inactivation.
Abstract
The efficacy of several povidone-iodine (PVP-I) products, a number of other chemical agents and various physical conditions were evaluated for their ability to inactivate the severe acute respiratory syndrome coronavirus (SARS-CoV). Treatment of SARS-CoV with PVP-I products for 2 min reduced the virus infectivity from 1.17 x 10(6) TCID(50)/ml to below the detectable level. The efficacy of 70% ethanol was equivalent to that of PVP-I products. Fixation of SARS-CoV-infected Vero E6 cells with a fixative including formalin, glutaraldehyde, methanol and acetone for 5 min or longer eliminated all infectivity. Heating the virus at 56 degrees C for 60 min or longer reduced the infectivity of the virus from 2.6 x 10(7) to undetectable levels. Irradiation with ultraviolet light at 134 microW/cm(2) for 15 min reduced the infectivity from 3.8 x 10(7) to 180 TCID(50)/ml; however, prolonged irradiation (60 min) failed to eliminate the remaining virus, leaving 18.8 TCID(50)/ml.
DOI: 10.1159/000089211
PubMed: 16490989
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pubmed:16490989Le document en format XML
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<term>Antiviral Agents (pharmacology)</term>
<term>Chlorocebus aethiops</term>
<term>Ethanol (pharmacology)</term>
<term>Formaldehyde (pharmacology)</term>
<term>Glutaral (pharmacology)</term>
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<term>SARS Virus (drug effects)</term>
<term>SARS Virus (radiation effects)</term>
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<term>Animaux</term>
<term>Anti-infectieux locaux (pharmacologie)</term>
<term>Antiviraux (pharmacologie)</term>
<term>Cellules Vero</term>
<term>Formaldéhyde (pharmacologie)</term>
<term>Glutaraldéhyde (pharmacologie)</term>
<term>Inactivation virale</term>
<term>Indicateurs et réactifs (pharmacologie)</term>
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<term>Povidone iodée (pharmacologie)</term>
<term>Rayons ultraviolets</term>
<term>Température élevée</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (effets des radiations)</term>
<term>Éthanol (pharmacologie)</term>
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<term>Formaldehyde</term>
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<term>Anti-infectieux locaux</term>
<term>Antiviraux</term>
<term>Formaldéhyde</term>
<term>Glutaraldéhyde</term>
<term>Indicateurs et réactifs</term>
<term>Méthanol</term>
<term>Povidone iodée</term>
<term>Éthanol</term>
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<term>Chlorocebus aethiops</term>
<term>Hot Temperature</term>
<term>Ultraviolet Rays</term>
<term>Vero Cells</term>
<term>Virus Inactivation</term>
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<term>Cellules Vero</term>
<term>Inactivation virale</term>
<term>Rayons ultraviolets</term>
<term>Température élevée</term>
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<front><div type="abstract" xml:lang="en">The efficacy of several povidone-iodine (PVP-I) products, a number of other chemical agents and various physical conditions were evaluated for their ability to inactivate the severe acute respiratory syndrome coronavirus (SARS-CoV). Treatment of SARS-CoV with PVP-I products for 2 min reduced the virus infectivity from 1.17 x 10(6) TCID(50)/ml to below the detectable level. The efficacy of 70% ethanol was equivalent to that of PVP-I products. Fixation of SARS-CoV-infected Vero E6 cells with a fixative including formalin, glutaraldehyde, methanol and acetone for 5 min or longer eliminated all infectivity. Heating the virus at 56 degrees C for 60 min or longer reduced the infectivity of the virus from 2.6 x 10(7) to undetectable levels. Irradiation with ultraviolet light at 134 microW/cm(2) for 15 min reduced the infectivity from 3.8 x 10(7) to 180 TCID(50)/ml; however, prolonged irradiation (60 min) failed to eliminate the remaining virus, leaving 18.8 TCID(50)/ml.</div>
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