Inactivation of SARS coronavirus by means of povidone-iodine, physical conditions and chemical reagents.
Identifieur interne : 001387 ( Ncbi/Merge ); précédent : 001386; suivant : 001388Inactivation of SARS coronavirus by means of povidone-iodine, physical conditions and chemical reagents.
Auteurs : Hiroaki Kariwa [Japon] ; Nobuhiro Fujii ; Ikuo TakashimaSource :
- Dermatology (Basel, Switzerland) [ 1018-8665 ] ; 2006.
Descripteurs français
- KwdFr :
- Acétone (pharmacologie), Animaux, Anti-infectieux locaux (pharmacologie), Antiviraux (pharmacologie), Cellules Vero, Formaldéhyde (pharmacologie), Glutaraldéhyde (pharmacologie), Inactivation virale, Indicateurs et réactifs (pharmacologie), Méthanol (pharmacologie), Povidone iodée (pharmacologie), Rayons ultraviolets, Température élevée, Virus du SRAS (), Virus du SRAS (effets des radiations), Éthanol (pharmacologie).
- MESH :
- effets des radiations : Virus du SRAS.
- pharmacologie : Acétone, Anti-infectieux locaux, Antiviraux, Formaldéhyde, Glutaraldéhyde, Indicateurs et réactifs, Méthanol, Povidone iodée, Éthanol.
- Animaux, Cellules Vero, Inactivation virale, Rayons ultraviolets, Température élevée, Virus du SRAS.
English descriptors
- KwdEn :
- Acetone (pharmacology), Animals, Anti-Infective Agents, Local (pharmacology), Antiviral Agents (pharmacology), Chlorocebus aethiops, Ethanol (pharmacology), Formaldehyde (pharmacology), Glutaral (pharmacology), Hot Temperature, Indicators and Reagents (pharmacology), Methanol (pharmacology), Povidone-Iodine (pharmacology), SARS Virus (drug effects), SARS Virus (radiation effects), Ultraviolet Rays, Vero Cells, Virus Inactivation.
- MESH :
- chemical , pharmacology : Acetone, Anti-Infective Agents, Local, Antiviral Agents, Ethanol, Formaldehyde, Glutaral, Indicators and Reagents, Methanol, Povidone-Iodine.
- drug effects : SARS Virus.
- radiation effects : SARS Virus.
- Animals, Chlorocebus aethiops, Hot Temperature, Ultraviolet Rays, Vero Cells, Virus Inactivation.
Abstract
The efficacy of several povidone-iodine (PVP-I) products, a number of other chemical agents and various physical conditions were evaluated for their ability to inactivate the severe acute respiratory syndrome coronavirus (SARS-CoV). Treatment of SARS-CoV with PVP-I products for 2 min reduced the virus infectivity from 1.17 x 10(6) TCID(50)/ml to below the detectable level. The efficacy of 70% ethanol was equivalent to that of PVP-I products. Fixation of SARS-CoV-infected Vero E6 cells with a fixative including formalin, glutaraldehyde, methanol and acetone for 5 min or longer eliminated all infectivity. Heating the virus at 56 degrees C for 60 min or longer reduced the infectivity of the virus from 2.6 x 10(7) to undetectable levels. Irradiation with ultraviolet light at 134 microW/cm(2) for 15 min reduced the infectivity from 3.8 x 10(7) to 180 TCID(50)/ml; however, prolonged irradiation (60 min) failed to eliminate the remaining virus, leaving 18.8 TCID(50)/ml.
DOI: 10.1159/000089211
PubMed: 16490989
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Hiroaki" uniqKey="Kariwa H" first="Hiroaki" last="Kariwa">Hiroaki Kariwa</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Public Health, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan. kariwa@vetmed.hokudai.ac.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Public Health, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818</wicri:regionArea><wicri:noRegion>Sapporo 060-0818</wicri:noRegion></affiliation></author><author><name sortKey="Fujii, Nobuhiro" sort="Fujii, Nobuhiro" uniqKey="Fujii N" first="Nobuhiro" last="Fujii">Nobuhiro Fujii</name></author><author><name sortKey="Takashima, Ikuo" sort="Takashima, Ikuo" uniqKey="Takashima I" first="Ikuo" last="Takashima">Ikuo Takashima</name></author></analytic><series><title level="j">Dermatology (Basel, Switzerland)</title><idno type="ISSN">1018-8665</idno><imprint><date when="2006" 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Vero</term><term>Formaldéhyde (pharmacologie)</term><term>Glutaraldéhyde (pharmacologie)</term><term>Inactivation virale</term><term>Indicateurs et réactifs (pharmacologie)</term><term>Méthanol (pharmacologie)</term><term>Povidone iodée (pharmacologie)</term><term>Rayons ultraviolets</term><term>Température élevée</term><term>Virus du SRAS ()</term><term>Virus du SRAS (effets des radiations)</term><term>Éthanol (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Acetone</term><term>Anti-Infective Agents, Local</term><term>Antiviral Agents</term><term>Ethanol</term><term>Formaldehyde</term><term>Glutaral</term><term>Indicators and Reagents</term><term>Methanol</term><term>Povidone-Iodine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acétone</term><term>Anti-infectieux locaux</term><term>Antiviraux</term><term>Formaldéhyde</term><term>Glutaraldéhyde</term><term>Indicateurs et réactifs</term><term>Méthanol</term><term>Povidone iodée</term><term>Éthanol</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Hot Temperature</term><term>Ultraviolet Rays</term><term>Vero Cells</term><term>Virus Inactivation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules Vero</term><term>Inactivation virale</term><term>Rayons ultraviolets</term><term>Température élevée</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The efficacy of several povidone-iodine (PVP-I) products, a number of other chemical agents and various physical conditions were evaluated for their ability to inactivate the severe acute respiratory syndrome coronavirus (SARS-CoV). Treatment of SARS-CoV with PVP-I products for 2 min reduced the virus infectivity from 1.17 x 10(6) TCID(50)/ml to below the detectable level. The efficacy of 70% ethanol was equivalent to that of PVP-I products. Fixation of SARS-CoV-infected Vero E6 cells with a fixative including formalin, glutaraldehyde, methanol and acetone for 5 min or longer eliminated all infectivity. Heating the virus at 56 degrees C for 60 min or longer reduced the infectivity of the virus from 2.6 x 10(7) to undetectable levels. Irradiation with ultraviolet light at 134 microW/cm(2) for 15 min reduced the infectivity from 3.8 x 10(7) to 180 TCID(50)/ml; however, prolonged irradiation (60 min) failed to eliminate the remaining virus, leaving 18.8 TCID(50)/ml.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16490989</PMID><DateCompleted><Year>2006</Year><Month>06</Month><Day>22</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1018-8665</ISSN><JournalIssue CitedMedium="Print"><Volume>212 Suppl 1</Volume><PubDate><Year>2006</Year></PubDate></JournalIssue><Title>Dermatology (Basel, Switzerland)</Title><ISOAbbreviation>Dermatology (Basel)</ISOAbbreviation></Journal><ArticleTitle>Inactivation of SARS coronavirus by means of povidone-iodine, physical conditions and chemical reagents.</ArticleTitle><Pagination><MedlinePgn>119-23</MedlinePgn></Pagination><Abstract><AbstractText>The efficacy of several povidone-iodine (PVP-I) products, a number of other chemical agents and various physical conditions were evaluated for their ability to inactivate the severe acute respiratory syndrome coronavirus (SARS-CoV). Treatment of SARS-CoV with PVP-I products for 2 min reduced the virus infectivity from 1.17 x 10(6) TCID(50)/ml to below the detectable level. The efficacy of 70% ethanol was equivalent to that of PVP-I products. Fixation of SARS-CoV-infected Vero E6 cells with a fixative including formalin, glutaraldehyde, methanol and acetone for 5 min or longer eliminated all infectivity. Heating the virus at 56 degrees C for 60 min or longer reduced the infectivity of the virus from 2.6 x 10(7) to undetectable levels. Irradiation with ultraviolet light at 134 microW/cm(2) for 15 min reduced the infectivity from 3.8 x 10(7) to 180 TCID(50)/ml; however, prolonged irradiation (60 min) failed to eliminate the remaining virus, leaving 18.8 TCID(50)/ml.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kariwa</LastName><ForeName>Hiroaki</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Laboratory of Public Health, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan. kariwa@vetmed.hokudai.ac.jp</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fujii</LastName><ForeName>Nobuhiro</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Takashima</LastName><ForeName>Ikuo</ForeName><Initials>I</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. 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Inactivation</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>2</Month><Day>24</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>6</Month><Day>23</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>2</Month><Day>24</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16490989</ArticleId><ArticleId IdType="pii">89211</ArticleId><ArticleId IdType="doi">10.1159/000089211</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Fujii, Nobuhiro" sort="Fujii, Nobuhiro" uniqKey="Fujii N" first="Nobuhiro" last="Fujii">Nobuhiro Fujii</name><name sortKey="Takashima, Ikuo" sort="Takashima, Ikuo" uniqKey="Takashima I" first="Ikuo" last="Takashima">Ikuo Takashima</name></noCountry><country name="Japon"><noRegion><name sortKey="Kariwa, Hiroaki" sort="Kariwa, Hiroaki" uniqKey="Kariwa H" first="Hiroaki" last="Kariwa">Hiroaki Kariwa</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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