Spatiotemporal interplay of severe acute respiratory syndrome coronavirus and respiratory mucosal cells drives viral dissemination in rhesus macaques
Identifieur interne : 001245 ( Main/Merge ); précédent : 001244; suivant : 001246Spatiotemporal interplay of severe acute respiratory syndrome coronavirus and respiratory mucosal cells drives viral dissemination in rhesus macaques
Auteurs : L. Liu ; Q. Wei [République populaire de Chine] ; K. Nishiura ; J. Peng ; H. Wang ; C. Midkiff ; X. Alvarez ; C. Qin [République populaire de Chine] ; A. Lackner ; Z. ChenSource :
- Mucosal Immunology [ 1933-0219 ] ; 2015.
Descripteurs français
- KwdFr :
- ARN viral (immunologie), Animaux, Cellules cultivées, Cellules dendritiques (immunologie), Cellules dendritiques (virologie), Charge virale, Coronavirus (physiologie), Différenciation cellulaire, Excrétion virale, Humains, Immunité innée, Lymphocytes T (immunologie), Lymphocytes T (virologie), Macaca mulatta (immunologie), Macrophages (immunologie), Macrophages (virologie), Mouvement cellulaire, Muqueuse respiratoire (immunologie), Muqueuse respiratoire (virologie), Réplication virale, Syndrome respiratoire aigu sévère (immunologie), Échappement immunitaire.
- MESH :
- immunologie : ARN viral, Cellules dendritiques, Lymphocytes T, Macaca mulatta, Macrophages, Muqueuse respiratoire, Syndrome respiratoire aigu sévère.
- physiologie : Coronavirus.
- virologie : Cellules dendritiques, Lymphocytes T, Macrophages, Muqueuse respiratoire.
- Animaux, Cellules cultivées, Charge virale, Différenciation cellulaire, Excrétion virale, Humains, Immunité innée, Mouvement cellulaire, Réplication virale, Échappement immunitaire.
English descriptors
- KwdEn :
- Animals, Cell Differentiation, Cell Movement, Cells, Cultured, Coronavirus (physiology), Dendritic Cells (immunology), Dendritic Cells (virology), Humans, Immune Evasion, Immunity, Innate, Macaca mulatta (immunology), Macrophages (immunology), Macrophages (virology), RNA, Viral (immunology), Respiratory Mucosa (immunology), Respiratory Mucosa (virology), Severe Acute Respiratory Syndrome (immunology), T-Lymphocytes (immunology), T-Lymphocytes (virology), Viral Load, Virus Replication, Virus Shedding.
- MESH :
- chemical , immunology : RNA, Viral.
- immunology : Dendritic Cells, Macaca mulatta, Macrophages, Respiratory Mucosa, Severe Acute Respiratory Syndrome, T-Lymphocytes.
- physiology : Coronavirus.
- virology : Dendritic Cells, Macrophages, Respiratory Mucosa, T-Lymphocytes.
- Animals, Cell Differentiation, Cell Movement, Cells, Cultured, Humans, Immune Evasion, Immunity, Innate, Viral Load, Virus Replication, Virus Shedding.
Abstract
Innate immune responses have a critical role in the control of early virus replication and dissemination. It remains unknown, however, how severe acute respiratory syndrome coronavirus (SARS-CoV) evades respiratory innate immunity to establish a systemic infection. Here we show in Chinese macaques that SARS-CoV traversed the mucosa through the respiratory tract within 2 days, resulting in extensive mucosal infiltration by T cells, MAC387+, and CD163+ monocytes/macrophages followed by limited viral replication in the lung but persistent viral shedding into the upper airway. Mucosal monocytes/macrophages sequestered virions in intracellular vesicles together with infected Langerhans cells and migrated into the tonsils and/or draining lymph nodes within 2 days. In lymphoid tissues, viral RNA and proteins were detected in infected monocytes upon differentiation into dendritic cells (DCs) within 3 days. Systemic viral dissemination was observed within 7 days. This study provides a comprehensive overview of the spatiotemporal interactions of SARS-CoV, monocytes/macrophages, and the DC network in mucosal tissues and highlights the fact that, while these innate cells contribute to viral clearance, they probably also serve as shelters and vehicles to provide a mechanism for the virus to escape host mucosal innate immunity and disseminate systemically.
The online version of this article (doi:10.1038/mi.2015.127) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1038/mi.2015.127
PubMed: 26647718
PubMed Central: 4900951
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PMC:4900951Le document en format XML
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<term>Immunité innée</term>
<term>Mouvement cellulaire</term>
<term>Réplication virale</term>
<term>Échappement immunitaire</term>
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<front><div type="abstract" xml:lang="en"><p id="Par1">Innate immune responses have a critical role in the control of early virus replication and dissemination. It remains unknown, however, how severe acute respiratory syndrome coronavirus (SARS-CoV) evades respiratory innate immunity to establish a systemic infection. Here we show in Chinese macaques that SARS-CoV traversed the mucosa through the respiratory tract within 2 days, resulting in extensive mucosal infiltration by T cells, MAC387<sup>+</sup>
, and CD163<sup>+</sup>
monocytes/macrophages followed by limited viral replication in the lung but persistent viral shedding into the upper airway. Mucosal monocytes/macrophages sequestered virions in intracellular vesicles together with infected Langerhans cells and migrated into the tonsils and/or draining lymph nodes within 2 days. In lymphoid tissues, viral RNA and proteins were detected in infected monocytes upon differentiation into dendritic cells (DCs) within 3 days. Systemic viral dissemination was observed within 7 days. This study provides a comprehensive overview of the spatiotemporal interactions of SARS-CoV, monocytes/macrophages, and the DC network in mucosal tissues and highlights the fact that, while these innate cells contribute to viral clearance, they probably also serve as shelters and vehicles to provide a mechanism for the virus to escape host mucosal innate immunity and disseminate systemically.</p>
<sec><title>Supplementary information</title>
<p>The online version of this article (doi:10.1038/mi.2015.127) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
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