¿Es esperable que haya cuadros neurológicos por la pandemia por SARS-CoV-2?
Identifieur interne : 000017 ( Main/Exploration ); précédent : 000016; suivant : 000018¿Es esperable que haya cuadros neurológicos por la pandemia por SARS-CoV-2?
Auteurs : J. Matías-Guiu ; U. Gomez-Pinedo ; P. Montero-Escribano ; P. Gomez-Iglesias ; J. Porta-Etessam ; J. A. Matias-GuiuSource :
- Neurologia (Barcelona, Spain) [ 0213-4853 ] ; 2020.
Abstract
Diversas evidencias sugieren que el SARS-CoV-2 puede penetrar en el sistema nervioso central (SNC). Los autores revisan los datos de la literatura sobre los hallazgos de coronavirus en el SNC asociado a enfermedades neurológicas.
En las distintas epidemias con SARS-CoV y MERS-CoV la presencia de cuadros neurológicos es baja, pero se describen cuadros aislados de pacientes. También existen casos asociados a OC43-CoV y 229E-CoV. La existencia de lesiones neurológicas, especialmente desmielinizantes en el modelo MHV-CoV pueden explicar mecanismos de penetración de los CoV en el SNC y especialmente aquellos relacionados con la respuesta inmune, que puede justificar la existencia de CoV en pacientes con esclerosis múltiple. Los autores revisan aspectos diferenciales de SARS-CoV-2 y se plantean si debido al alto número de infectados, el virus puede afectar de forma mayor al SNC.
Aunque la presencia de síntomas neurológicos en las epidemias de CoV es baja, la mayor frecuencia de infectados por SARS-CoV-2 podría justificar el paso del virus y la posibilidad de clínica neurológica precoz o tardía con mayor incidencia. El seguimiento de los pacientes de la epidemia debe atender con cuidado a la evaluación del SNC.
Url:
DOI: 10.1016/j.nrl.2020.03.001
PubMed: 32299636
PubMed Central: 7136883
Affiliations:
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">¿Es esperable que haya cuadros neurológicos por la pandemia por SARS-CoV-2?</title>
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<author><name sortKey="Gomez Pinedo, U" sort="Gomez Pinedo, U" uniqKey="Gomez Pinedo U" first="U." last="Gomez-Pinedo">U. Gomez-Pinedo</name>
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<author><name sortKey="Montero Escribano, P" sort="Montero Escribano, P" uniqKey="Montero Escribano P" first="P." last="Montero-Escribano">P. Montero-Escribano</name>
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<author><name sortKey="Gomez Iglesias, P" sort="Gomez Iglesias, P" uniqKey="Gomez Iglesias P" first="P." last="Gomez-Iglesias">P. Gomez-Iglesias</name>
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<author><name sortKey="Porta Etessam, J" sort="Porta Etessam, J" uniqKey="Porta Etessam J" first="J." last="Porta-Etessam">J. Porta-Etessam</name>
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<author><name sortKey="Matias Guiu, J A" sort="Matias Guiu, J A" uniqKey="Matias Guiu J" first="J. A." last="Matias-Guiu">J. A. Matias-Guiu</name>
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<series><title level="j">Neurologia (Barcelona, Spain)</title>
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<front><div type="abstract" xml:lang="en"><title>Resumen</title>
<sec><title>Introducción</title>
<p>Diversas evidencias sugieren que el SARS-CoV-2 puede penetrar en el sistema nervioso central (SNC). Los autores revisan los datos de la literatura sobre los hallazgos de coronavirus en el SNC asociado a enfermedades neurológicas.</p>
</sec>
<sec><title>Desarrollo</title>
<p>En las distintas epidemias con SARS-CoV y MERS-CoV la presencia de cuadros neurológicos es baja, pero se describen cuadros aislados de pacientes. También existen casos asociados a OC43-CoV y 229E-CoV. La existencia de lesiones neurológicas, especialmente desmielinizantes en el modelo MHV-CoV pueden explicar mecanismos de penetración de los CoV en el SNC y especialmente aquellos relacionados con la respuesta inmune, que puede justificar la existencia de CoV en pacientes con esclerosis múltiple. Los autores revisan aspectos diferenciales de SARS-CoV-2 y se plantean si debido al alto número de infectados, el virus puede afectar de forma mayor al SNC.</p>
</sec>
<sec><title>Conclusión</title>
<p>Aunque la presencia de síntomas neurológicos en las epidemias de CoV es baja, la mayor frecuencia de infectados por SARS-CoV-2 podría justificar el paso del virus y la posibilidad de clínica neurológica precoz o tardía con mayor incidencia. El seguimiento de los pacientes de la epidemia debe atender con cuidado a la evaluación del SNC.</p>
</sec>
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</front>
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<tree><noCountry><name sortKey="Gomez Iglesias, P" sort="Gomez Iglesias, P" uniqKey="Gomez Iglesias P" first="P." last="Gomez-Iglesias">P. Gomez-Iglesias</name>
<name sortKey="Gomez Pinedo, U" sort="Gomez Pinedo, U" uniqKey="Gomez Pinedo U" first="U." last="Gomez-Pinedo">U. Gomez-Pinedo</name>
<name sortKey="Matias Guiu, J" sort="Matias Guiu, J" uniqKey="Matias Guiu J" first="J." last="Matías-Guiu">J. Matías-Guiu</name>
<name sortKey="Matias Guiu, J A" sort="Matias Guiu, J A" uniqKey="Matias Guiu J" first="J. A." last="Matias-Guiu">J. A. Matias-Guiu</name>
<name sortKey="Montero Escribano, P" sort="Montero Escribano, P" uniqKey="Montero Escribano P" first="P." last="Montero-Escribano">P. Montero-Escribano</name>
<name sortKey="Porta Etessam, J" sort="Porta Etessam, J" uniqKey="Porta Etessam J" first="J." last="Porta-Etessam">J. Porta-Etessam</name>
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