¿Es esperable que haya cuadros neurológicos por la pandemia por SARS-CoV-2?
Identifieur interne : 001655 ( Pmc/Curation ); précédent : 001654; suivant : 001656¿Es esperable que haya cuadros neurológicos por la pandemia por SARS-CoV-2?
Auteurs : J. Matías-Guiu ; U. Gomez-Pinedo ; P. Montero-Escribano ; P. Gomez-Iglesias ; J. Porta-Etessam ; J. A. Matias-GuiuSource :
- Neurologia (Barcelona, Spain) [ 0213-4853 ] ; 2020.
Abstract
Diversas evidencias sugieren que el SARS-CoV-2 puede penetrar en el sistema nervioso central (SNC). Los autores revisan los datos de la literatura sobre los hallazgos de coronavirus en el SNC asociado a enfermedades neurológicas.
En las distintas epidemias con SARS-CoV y MERS-CoV la presencia de cuadros neurológicos es baja, pero se describen cuadros aislados de pacientes. También existen casos asociados a OC43-CoV y 229E-CoV. La existencia de lesiones neurológicas, especialmente desmielinizantes en el modelo MHV-CoV pueden explicar mecanismos de penetración de los CoV en el SNC y especialmente aquellos relacionados con la respuesta inmune, que puede justificar la existencia de CoV en pacientes con esclerosis múltiple. Los autores revisan aspectos diferenciales de SARS-CoV-2 y se plantean si debido al alto número de infectados, el virus puede afectar de forma mayor al SNC.
Aunque la presencia de síntomas neurológicos en las epidemias de CoV es baja, la mayor frecuencia de infectados por SARS-CoV-2 podría justificar el paso del virus y la posibilidad de clínica neurológica precoz o tardía con mayor incidencia. El seguimiento de los pacientes de la epidemia debe atender con cuidado a la evaluación del SNC.
Url:
DOI: 10.1016/j.nrl.2020.03.001
PubMed: 32299636
PubMed Central: 7136883
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">¿Es esperable que haya cuadros neurológicos por la pandemia por SARS-CoV-2?</title><author><name sortKey="Matias Guiu, J" sort="Matias Guiu, J" uniqKey="Matias Guiu J" first="J." last="Matías-Guiu">J. Matías-Guiu</name></author><author><name sortKey="Gomez Pinedo, U" sort="Gomez Pinedo, U" uniqKey="Gomez Pinedo U" first="U." last="Gomez-Pinedo">U. Gomez-Pinedo</name></author><author><name sortKey="Montero Escribano, P" sort="Montero Escribano, P" uniqKey="Montero Escribano P" first="P." last="Montero-Escribano">P. Montero-Escribano</name></author><author><name sortKey="Gomez Iglesias, P" sort="Gomez Iglesias, P" uniqKey="Gomez Iglesias P" first="P." last="Gomez-Iglesias">P. Gomez-Iglesias</name></author><author><name sortKey="Porta Etessam, J" sort="Porta Etessam, J" uniqKey="Porta Etessam J" first="J." last="Porta-Etessam">J. Porta-Etessam</name></author><author><name sortKey="Matias Guiu, J A" sort="Matias Guiu, J A" uniqKey="Matias Guiu J" first="J. A." last="Matias-Guiu">J. A. Matias-Guiu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32299636</idno><idno type="pmc">7136883</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136883</idno><idno type="RBID">PMC:7136883</idno><idno type="doi">10.1016/j.nrl.2020.03.001</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">001655</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001655</idno><idno type="wicri:Area/Pmc/Curation">001655</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001655</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">¿Es esperable que haya cuadros neurológicos por la pandemia por SARS-CoV-2?</title><author><name sortKey="Matias Guiu, J" sort="Matias Guiu, J" uniqKey="Matias Guiu J" first="J." last="Matías-Guiu">J. Matías-Guiu</name></author><author><name sortKey="Gomez Pinedo, U" sort="Gomez Pinedo, U" uniqKey="Gomez Pinedo U" first="U." last="Gomez-Pinedo">U. Gomez-Pinedo</name></author><author><name sortKey="Montero Escribano, P" sort="Montero Escribano, P" uniqKey="Montero Escribano P" first="P." last="Montero-Escribano">P. Montero-Escribano</name></author><author><name sortKey="Gomez Iglesias, P" sort="Gomez Iglesias, P" uniqKey="Gomez Iglesias P" first="P." last="Gomez-Iglesias">P. Gomez-Iglesias</name></author><author><name sortKey="Porta Etessam, J" sort="Porta Etessam, J" uniqKey="Porta Etessam J" first="J." last="Porta-Etessam">J. Porta-Etessam</name></author><author><name sortKey="Matias Guiu, J A" sort="Matias Guiu, J A" uniqKey="Matias Guiu J" first="J. A." last="Matias-Guiu">J. A. Matias-Guiu</name></author></analytic><series><title level="j">Neurologia (Barcelona, Spain)</title><idno type="ISSN">0213-4853</idno><idno type="eISSN">1578-1968</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Resumen</title><sec><title>Introducción</title><p>Diversas evidencias sugieren que el SARS-CoV-2 puede penetrar en el sistema nervioso central (SNC). Los autores revisan los datos de la literatura sobre los hallazgos de coronavirus en el SNC asociado a enfermedades neurológicas.</p></sec><sec><title>Desarrollo</title><p>En las distintas epidemias con SARS-CoV y MERS-CoV la presencia de cuadros neurológicos es baja, pero se describen cuadros aislados de pacientes. También existen casos asociados a OC43-CoV y 229E-CoV. La existencia de lesiones neurológicas, especialmente desmielinizantes en el modelo MHV-CoV pueden explicar mecanismos de penetración de los CoV en el SNC y especialmente aquellos relacionados con la respuesta inmune, que puede justificar la existencia de CoV en pacientes con esclerosis múltiple. Los autores revisan aspectos diferenciales de SARS-CoV-2 y se plantean si debido al alto número de infectados, el virus puede afectar de forma mayor al SNC.</p></sec><sec><title>Conclusión</title><p>Aunque la presencia de síntomas neurológicos en las epidemias de CoV es baja, la mayor frecuencia de infectados por SARS-CoV-2 podría justificar el paso del virus y la posibilidad de clínica neurológica precoz o tardía con mayor incidencia. El seguimiento de los pacientes de la epidemia debe atender con cuidado a la evaluación del SNC.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Corman, V M" uniqKey="Corman V">V.M. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Neurologia</journal-id><journal-id journal-id-type="iso-abbrev">Neurologia</journal-id><journal-title-group><journal-title>Neurologia (Barcelona, Spain)</journal-title></journal-title-group><issn pub-type="ppub">0213-4853</issn><issn pub-type="epub">1578-1968</issn><publisher><publisher-name>Published by Elsevier España, S.L.U. on behalf of Sociedad Española de Neurología.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32299636</article-id><article-id pub-id-type="pmc">7136883</article-id><article-id pub-id-type="publisher-id">S0213-4853(20)30065-7</article-id><article-id pub-id-type="doi">10.1016/j.nrl.2020.03.001</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>¿Es esperable que haya cuadros neurológicos por la pandemia por SARS-CoV-2?</article-title><trans-title-group xml:lang="en"><trans-title>Should we expect neurological symptoms in the SARS-CoV-2 epidemic?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Matías-Guiu</surname><given-names>J.</given-names></name><email>neurol.hcsc@salud.madrid.org</email><xref rid="cor0005" ref-type="corresp">⁎</xref></contrib><contrib contrib-type="author" id="aut0010"><name><surname>Gomez-Pinedo</surname><given-names>U.</given-names></name></contrib><contrib contrib-type="author" id="aut0015"><name><surname>Montero-Escribano</surname><given-names>P.</given-names></name></contrib><contrib contrib-type="author" id="aut0020"><name><surname>Gomez-Iglesias</surname><given-names>P.</given-names></name></contrib><contrib contrib-type="author" id="aut0025"><name><surname>Porta-Etessam</surname><given-names>J.</given-names></name></contrib><contrib contrib-type="author" id="aut0030"><name><surname>Matias-Guiu</surname><given-names>J.A.</given-names></name></contrib></contrib-group><aff id="aff0005">Servicio de Neurología, Instituto de Neurociencias, Hospital Clínico San Carlos, San Carlos, IdISSC, Madrid, España</aff><author-notes><corresp id="cor0005"><label>⁎</label>Autor para correspondencia. <email>neurol.hcsc@salud.madrid.org</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>6</day><month>4</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="epub"><day>6</day><month>4</month><year>2020</year></pub-date><history><date date-type="received"><day>27</day><month>3</month><year>2020</year></date><date date-type="accepted"><day>31</day><month>3</month><year>2020</year></date></history><permissions><copyright-statement>© 2020 Published by Elsevier España, S.L.U. on behalf of Sociedad Española de Neurología.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="abs0010"><title>Resumen</title><sec><title>Introducción</title><p>Diversas evidencias sugieren que el SARS-CoV-2 puede penetrar en el sistema nervioso central (SNC). Los autores revisan los datos de la literatura sobre los hallazgos de coronavirus en el SNC asociado a enfermedades neurológicas.</p></sec><sec><title>Desarrollo</title><p>En las distintas epidemias con SARS-CoV y MERS-CoV la presencia de cuadros neurológicos es baja, pero se describen cuadros aislados de pacientes. También existen casos asociados a OC43-CoV y 229E-CoV. La existencia de lesiones neurológicas, especialmente desmielinizantes en el modelo MHV-CoV pueden explicar mecanismos de penetración de los CoV en el SNC y especialmente aquellos relacionados con la respuesta inmune, que puede justificar la existencia de CoV en pacientes con esclerosis múltiple. Los autores revisan aspectos diferenciales de SARS-CoV-2 y se plantean si debido al alto número de infectados, el virus puede afectar de forma mayor al SNC.</p></sec><sec><title>Conclusión</title><p>Aunque la presencia de síntomas neurológicos en las epidemias de CoV es baja, la mayor frecuencia de infectados por SARS-CoV-2 podría justificar el paso del virus y la posibilidad de clínica neurológica precoz o tardía con mayor incidencia. El seguimiento de los pacientes de la epidemia debe atender con cuidado a la evaluación del SNC.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>There is growing evidence that SARS-CoV-2 can gain access to the central nervous system (CNS). We revise the literature on coronavirus infection of the CNS associated with neurological diseases.</p></sec><sec><title>Development</title><p>Neurological symptoms were rarely reported in the SARS-CoV and MERS-CoV epidemics, although isolated cases were described. There are also reports of cases of neurological symptoms associated with CoV-OC43 and CoV-229E infection. The presence of neurological lesions, especially demyelinating lesions in the mouse hepatitis virus model, may explain the mechanisms by which coronaviruses enter the CNS, particularly those related with the immune response. This may explain the presence of coronavirus in patients with multiple sclerosis. We review the specific characteristics of SARS-CoV-2 and address the question of whether the high number of cases may be associated with greater CNS involvement.</p></sec><sec><title>Conclusion</title><p>Although neurological symptoms are not frequent in coronavirus epidemics, the high number of patients with SARS-CoV-2 infection may explain the presence of the virus in the CNS and increase the likelihood of early- or delayed-onset neurological symptoms. Follow-up of patients affected by the SARS-CoV-2 epidemic should include careful assessment of the CNS.</p></sec></trans-abstract><kwd-group id="kwd0005"><title>Palabras clave</title><kwd>Coronavirus</kwd><kwd>SARS-CoV</kwd><kwd>MERS-CoV</kwd><kwd>Esclerosis múltiple</kwd><kwd>SARS-CoV-2</kwd><kwd>Virus murino de la hepatitis</kwd><kwd>Síntomas neurológicos</kwd><kwd>Sistema nervioso central</kwd></kwd-group><kwd-group xml:lang="en" id="kwd0010"><title>Keywords</title><kwd>Coronavirus</kwd><kwd>SARS-CoV</kwd><kwd>MERS-CoV</kwd><kwd>Multiple sclerosis</kwd><kwd>SARS-CoV-2</kwd><kwd>Mouse hepatitis virus</kwd><kwd>Neurological symptoms</kwd><kwd>Central nervous system</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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