SrasV1, Main, Exploration, bibRecordById, pubmed:18727488

Innate resistance to flavivirus infections and the functions of 2'-5' oligoadenylate synthetases.

Identifieur interne : 003090 ( Main/Exploration ); précédent : 003089; suivant : 003091

Innate resistance to flavivirus infections and the functions of 2'-5' oligoadenylate synthetases.

Auteurs : T. Mashimo [Japon] ; D. Simon-Chazottes ; J-L Guénet

Source :

Current topics in microbiology and immunology [ 0070-217X ] ; 2008.

RBID : pubmed:18727488

Descripteurs français

KwdFr :
- 2',5'-Oligoadenylate synthetase (génétique), 2',5'-Oligoadenylate synthetase (physiologie), Animaux, Humains, Immunité innée, Infections à flavivirus (immunologie), Infections à flavivirus (étiologie), Prédisposition génétique à une maladie, Souris.
MESH :
- génétique : 2',5'-Oligoadenylate synthetase.
- immunologie : Infections à flavivirus.
- physiologie : 2',5'-Oligoadenylate synthetase.
- étiologie : Infections à flavivirus.
- Animaux, Humains, Immunité innée, Prédisposition génétique à une maladie, Souris.

English descriptors

KwdEn :
- 2',5'-Oligoadenylate Synthetase (genetics), 2',5'-Oligoadenylate Synthetase (physiology), Animals, Flavivirus Infections (etiology), Flavivirus Infections (immunology), Genetic Predisposition to Disease, Humans, Immunity, Innate, Mice.
MESH :
- chemical , genetics : 2',5'-Oligoadenylate Synthetase.
- chemical , physiology : 2',5'-Oligoadenylate Synthetase.
- etiology : Flavivirus Infections.
- immunology : Flavivirus Infections.
- Animals, Genetic Predisposition to Disease, Humans, Immunity, Innate, Mice.

Abstract

Mouse susceptibility to experimental infections with flaviviruses is significantly influenced by a cluster of genes on chromosome 5 encoding a family of proteins with enzymatic properties, the 2'-5' oligoadenylate synthetases (OAS). Positional cloning of the locus in question has revealed that susceptibility of laboratory inbred strains to this class of virus is associated with a nonsense mutation in the gene encoding the OAS1B isoform. Analysis of the molecular structure of the cluster in different mammalian species including human indicates that the cluster is extremely polymorphic with a highly variable number of genes and pseudogenes whose functions are not yet completely established. Although still preliminary, a few recent observations also substantiate a possible role for OAS1 in human susceptibility to viral infections (West Nile virus, SARS, etc.) and its possible involvement in some other diseases such as type 1 diabetes and multiple sclerosis. Finally, convergent observations indicate that the molecules encoded by the 2 '-5' OAS cluster might be involved in other fundamental cellular functions such as cell growth and differentiation, gene regulation, and apoptosis.

DOI: 10.1007/978-3-540-75203-5_4
PubMed: 18727488

Affiliations:

Japon

Le document en format XML

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<front><div type="abstract" xml:lang="en">Mouse susceptibility to experimental infections with flaviviruses is significantly influenced by a cluster of genes on chromosome 5 encoding a family of proteins with enzymatic properties, the 2'-5' oligoadenylate synthetases (OAS). Positional cloning of the locus in question has revealed that susceptibility of laboratory inbred strains to this class of virus is associated with a nonsense mutation in the gene encoding the OAS1B isoform. Analysis of the molecular structure of the cluster in different mammalian species including human indicates that the cluster is extremely polymorphic with a highly variable number of genes and pseudogenes whose functions are not yet completely established. Although still preliminary, a few recent observations also substantiate a possible role for OAS1 in human susceptibility to viral infections (West Nile virus, SARS, etc.) and its possible involvement in some other diseases such as type 1 diabetes and multiple sclerosis. Finally, convergent observations indicate that the molecules encoded by the 2 '-5' OAS cluster might be involved in other fundamental cellular functions such as cell growth and differentiation, gene regulation, and apoptosis.</div>
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Innate resistance to flavivirus infections and the functions of 2'-5' oligoadenylate synthetases.

Innate resistance to flavivirus infections and the functions of 2'-5' oligoadenylate synthetases.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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