SrasV1, Main, Exploration, bibRecord, 003091

In Vitro Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses.

Identifieur interne : 003091 ( Main/Exploration ); précédent : 003090; suivant : 003092

In Vitro Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses.

Auteurs : P. Selvam [Inde] ; N. Murgesh ; M. Chandramohan ; E. De Clercq ; E. Keyaerts ; L. Vijgen ; P. Maes ; J. Neyts ; M V Ranst

Source :

Indian journal of pharmaceutical sciences [ 1998-3743 ] ; 2008.

RBID : pubmed:20390088

Abstract

4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N(4,6-dimethyl-2-pyrimidiny)benzene sulphonamide and its derivatives were evaluated for antiviral activity against Pathogenic viruses such as Hepatitis C Virus and SARS-CoV in Vero and Huh 5-2 cells, respectively. The 5-fluoro derivative inhibited the HCV RNA synthesis at 6 mug/ml, without toxicity at a concentration up to 42 mug/ml in Huh 5-2 cells. Among the compounds tested SPIII-5F exhibits the 45% maximum protection against replication of SARS-CoV in Vero cells.

DOI: 10.4103/0250-474X.40339
PubMed: 20390088

Affiliations:

Inde

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In Vitro Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses.

In Vitro Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses.

Source :

Abstract

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Le document en format XML

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