Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus
Identifieur interne : 003B49 ( Main/Exploration ); précédent : 003B48; suivant : 003B50Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus
Auteurs : Pedro Serrano [États-Unis] ; Margaret A. Johnson [États-Unis] ; Marcius S. Almeida [États-Unis] ; Reto Horst [États-Unis] ; Torsten Herrmann [Suisse] ; Jeremiah S. Joseph [États-Unis] ; Benjamin W. Neuman [États-Unis] ; Vanitha Subramanian [États-Unis] ; Kumar S. Saikatendu [États-Unis] ; Michael J. Buchmeier [États-Unis] ; Raymond C. Stevens [États-Unis] ; Peter Kuhn [États-Unis] ; Kurt Wüthrich [États-Unis]Source :
- Journal of virology [ 0022-538X ] ; 2007.
Descripteurs français
- KwdFr :
- ARN viral (), Conformation des protéines, Conformation moléculaire, Données de séquences moléculaires, Modèles moléculaires, Protéines virales (), Protéines virales non structurales (), Protéines virales non structurales (métabolisme), RNA replicase (), RNA replicase (métabolisme), Relation dose-effet des médicaments, Similitude de séquences d'acides aminés, Spectrométrie de masse, Spectroscopie par résonance magnétique (), Structure secondaire des protéines, Structure tertiaire des protéines, Séquence d'acides aminés, Virus du SRAS (métabolisme).
- MESH :
- métabolisme : Protéines virales non structurales, RNA replicase, Virus du SRAS.
- Pascal (Inist)
- ARN viral, Conformation des protéines, Conformation moléculaire, Coronavirus, Données de séquences moléculaires, Modèles moléculaires, Protéines virales, Protéines virales non structurales, RNA replicase, Relation dose-effet des médicaments, Similitude de séquences d'acides aminés, Spectrométrie de masse, Spectroscopie par résonance magnétique, Structure domaine, Protéine, Aigu, Structure secondaire des protéines, Structure tertiaire des protéines, Séquence d'acides aminés, Virologie.
English descriptors
- KwdEn :
- Acute, Amino Acid Sequence, Coronavirus, Domain structure, Dose-Response Relationship, Drug, Magnetic Resonance Spectroscopy (methods), Mass Spectrometry, Models, Molecular, Molecular Conformation, Molecular Sequence Data, Protein, Protein Conformation, Protein Structure, Secondary, Protein Structure, Tertiary, RNA Replicase (chemistry), RNA Replicase (metabolism), RNA, Viral (chemistry), SARS Virus (metabolism), Sequence Homology, Amino Acid, Viral Nonstructural Proteins (chemistry), Viral Nonstructural Proteins (metabolism), Viral Proteins (chemistry), Virology.
- MESH :
- chemical , chemistry : RNA Replicase, RNA, Viral, Viral Nonstructural Proteins, Viral Proteins.
- chemical , metabolism : RNA Replicase, Viral Nonstructural Proteins.
- metabolism : SARS Virus.
- methods : Magnetic Resonance Spectroscopy.
- Amino Acid Sequence, Dose-Response Relationship, Drug, Mass Spectrometry, Models, Molecular, Molecular Conformation, Molecular Sequence Data, Protein Conformation, Protein Structure, Secondary, Protein Structure, Tertiary, Sequence Homology, Amino Acid.
Abstract
This paper describes the structure determination of nsp3a, the N-terminal domain of the severe acute respiratory syndrome coronavirus (SARS-CoV) nonstructural protein 3. nsp3a exhibits a ubiquitin-like globular fold of residues 1 to 112 and a flexibly extended glutamic acid-rich domain of residues 113 to 183. In addition to the four β-strands and two α-helices that are common to ubiquitin-like folds, the globular domain of nsp3a contains two short helices representing a feature that has not previously been observed in these proteins. Nuclear magnetic resonance chemical shift perturbations showed that these unique structural elements are involved in interactions with single-stranded RNA. Structural similarities with proteins involved in various cell-signaling pathways indicate possible roles of nsp3a in viral infection and persistence.
Affiliations:
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Le document en format XML
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<s3>USA</s3>
<sZ>2 aut.</sZ>
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</author>
<author><name sortKey="Herrmann, Torsten" sort="Herrmann, Torsten" uniqKey="Herrmann T" first="Torsten" last="Herrmann">Torsten Herrmann</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute for Molecular Biology and Biophysics, ETH Zürich</s1>
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<s3>CHE</s3>
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<country>Suisse</country>
<placeName><settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Joseph, Jeremiah S" sort="Joseph, Jeremiah S" uniqKey="Joseph J" first="Jeremiah S." last="Joseph">Jeremiah S. Joseph</name>
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</author>
<author><name sortKey="Neuman, Benjamin W" sort="Neuman, Benjamin W" uniqKey="Neuman B" first="Benjamin W." last="Neuman">Benjamin W. Neuman</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, 10550 North Torrey Pines Road</s1>
<s2>La Jolla, California 92037</s2>
<s3>USA</s3>
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</author>
<author><name sortKey="Subramanian, Vanitha" sort="Subramanian, Vanitha" uniqKey="Subramanian V" first="Vanitha" last="Subramanian">Vanitha Subramanian</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1>
<s2>La Jolla, California 92037</s2>
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</author>
<author><name sortKey="Saikatendu, Kumar S" sort="Saikatendu, Kumar S" uniqKey="Saikatendu K" first="Kumar S." last="Saikatendu">Kumar S. Saikatendu</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1>
<s2>La Jolla, California 92037</s2>
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</author>
<author><name sortKey="Buchmeier, Michael J" sort="Buchmeier, Michael J" uniqKey="Buchmeier M" first="Michael J." last="Buchmeier">Michael J. Buchmeier</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, 10550 North Torrey Pines Road</s1>
<s2>La Jolla, California 92037</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
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<country>États-Unis</country>
<wicri:noRegion>La Jolla, California 92037</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stevens, Raymond C" sort="Stevens, Raymond C" uniqKey="Stevens R" first="Raymond C." last="Stevens">Raymond C. Stevens</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1>
<s2>La Jolla, California 92037</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
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<country>États-Unis</country>
<wicri:noRegion>La Jolla, California 92037</wicri:noRegion>
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</author>
<author><name sortKey="Kuhn, Peter" sort="Kuhn, Peter" uniqKey="Kuhn P" first="Peter" last="Kuhn">Peter Kuhn</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1>
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<wicri:noRegion>La Jolla, California 92037</wicri:noRegion>
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</author>
<author><name sortKey="Wuthrich, Kurt" sort="Wuthrich, Kurt" uniqKey="Wuthrich K" first="Kurt" last="Wüthrich">Kurt Wüthrich</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1>
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<country>États-Unis</country>
<wicri:noRegion>La Jolla, California 92037</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1>
<s2>La Jolla, California 92037</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
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<sZ>3 aut.</sZ>
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<wicri:noRegion>La Jolla, California 92037</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Joint Center for Structural Genomics, The Scripps Research Institute, 10550 North Torrey Pines Road</s1>
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<wicri:noRegion>La Jolla, California 92037</wicri:noRegion>
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<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road</s1>
<s2>La Jolla, California 92037</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
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</analytic>
<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute</term>
<term>Amino Acid Sequence</term>
<term>Coronavirus</term>
<term>Domain structure</term>
<term>Dose-Response Relationship, Drug</term>
<term>Magnetic Resonance Spectroscopy (methods)</term>
<term>Mass Spectrometry</term>
<term>Models, Molecular</term>
<term>Molecular Conformation</term>
<term>Molecular Sequence Data</term>
<term>Protein</term>
<term>Protein Conformation</term>
<term>Protein Structure, Secondary</term>
<term>Protein Structure, Tertiary</term>
<term>RNA Replicase (chemistry)</term>
<term>RNA Replicase (metabolism)</term>
<term>RNA, Viral (chemistry)</term>
<term>SARS Virus (metabolism)</term>
<term>Sequence Homology, Amino Acid</term>
<term>Viral Nonstructural Proteins (chemistry)</term>
<term>Viral Nonstructural Proteins (metabolism)</term>
<term>Viral Proteins (chemistry)</term>
<term>Virology</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral ()</term>
<term>Conformation des protéines</term>
<term>Conformation moléculaire</term>
<term>Données de séquences moléculaires</term>
<term>Modèles moléculaires</term>
<term>Protéines virales ()</term>
<term>Protéines virales non structurales ()</term>
<term>Protéines virales non structurales (métabolisme)</term>
<term>RNA replicase ()</term>
<term>RNA replicase (métabolisme)</term>
<term>Relation dose-effet des médicaments</term>
<term>Similitude de séquences d'acides aminés</term>
<term>Spectrométrie de masse</term>
<term>Spectroscopie par résonance magnétique ()</term>
<term>Structure secondaire des protéines</term>
<term>Structure tertiaire des protéines</term>
<term>Séquence d'acides aminés</term>
<term>Virus du SRAS (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>RNA Replicase</term>
<term>RNA, Viral</term>
<term>Viral Nonstructural Proteins</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>RNA Replicase</term>
<term>Viral Nonstructural Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Spectroscopy</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines virales non structurales</term>
<term>RNA replicase</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Dose-Response Relationship, Drug</term>
<term>Mass Spectrometry</term>
<term>Models, Molecular</term>
<term>Molecular Conformation</term>
<term>Molecular Sequence Data</term>
<term>Protein Conformation</term>
<term>Protein Structure, Secondary</term>
<term>Protein Structure, Tertiary</term>
<term>Sequence Homology, Amino Acid</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>ARN viral</term>
<term>Conformation des protéines</term>
<term>Conformation moléculaire</term>
<term>Coronavirus</term>
<term>Données de séquences moléculaires</term>
<term>Modèles moléculaires</term>
<term>Protéines virales</term>
<term>Protéines virales non structurales</term>
<term>RNA replicase</term>
<term>Relation dose-effet des médicaments</term>
<term>Similitude de séquences d'acides aminés</term>
<term>Spectrométrie de masse</term>
<term>Spectroscopie par résonance magnétique</term>
<term>Structure domaine</term>
<term>Protéine</term>
<term>Aigu</term>
<term>Structure secondaire des protéines</term>
<term>Structure tertiaire des protéines</term>
<term>Séquence d'acides aminés</term>
<term>Virologie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">This paper describes the structure determination of nsp3a, the N-terminal domain of the severe acute respiratory syndrome coronavirus (SARS-CoV) nonstructural protein 3. nsp3a exhibits a ubiquitin-like globular fold of residues 1 to 112 and a flexibly extended glutamic acid-rich domain of residues 113 to 183. In addition to the four β-strands and two α-helices that are common to ubiquitin-like folds, the globular domain of nsp3a contains two short helices representing a feature that has not previously been observed in these proteins. Nuclear magnetic resonance chemical shift perturbations showed that these unique structural elements are involved in interactions with single-stranded RNA. Structural similarities with proteins involved in various cell-signaling pathways indicate possible roles of nsp3a in viral infection and persistence.</div>
</front>
</TEI>
<affiliations><list><country><li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Canton de Zurich</li>
</region>
<settlement><li>Zurich</li>
</settlement>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Serrano, Pedro" sort="Serrano, Pedro" uniqKey="Serrano P" first="Pedro" last="Serrano">Pedro Serrano</name>
</noRegion>
<name sortKey="Almeida, Marcius S" sort="Almeida, Marcius S" uniqKey="Almeida M" first="Marcius S." last="Almeida">Marcius S. Almeida</name>
<name sortKey="Almeida, Marcius S" sort="Almeida, Marcius S" uniqKey="Almeida M" first="Marcius S." last="Almeida">Marcius S. Almeida</name>
<name sortKey="Buchmeier, Michael J" sort="Buchmeier, Michael J" uniqKey="Buchmeier M" first="Michael J." last="Buchmeier">Michael J. Buchmeier</name>
<name sortKey="Horst, Reto" sort="Horst, Reto" uniqKey="Horst R" first="Reto" last="Horst">Reto Horst</name>
<name sortKey="Horst, Reto" sort="Horst, Reto" uniqKey="Horst R" first="Reto" last="Horst">Reto Horst</name>
<name sortKey="Johnson, Margaret A" sort="Johnson, Margaret A" uniqKey="Johnson M" first="Margaret A." last="Johnson">Margaret A. Johnson</name>
<name sortKey="Johnson, Margaret A" sort="Johnson, Margaret A" uniqKey="Johnson M" first="Margaret A." last="Johnson">Margaret A. Johnson</name>
<name sortKey="Johnson, Margaret A" sort="Johnson, Margaret A" uniqKey="Johnson M" first="Margaret A." last="Johnson">Margaret A. Johnson</name>
<name sortKey="Joseph, Jeremiah S" sort="Joseph, Jeremiah S" uniqKey="Joseph J" first="Jeremiah S." last="Joseph">Jeremiah S. Joseph</name>
<name sortKey="Kuhn, Peter" sort="Kuhn, Peter" uniqKey="Kuhn P" first="Peter" last="Kuhn">Peter Kuhn</name>
<name sortKey="Neuman, Benjamin W" sort="Neuman, Benjamin W" uniqKey="Neuman B" first="Benjamin W." last="Neuman">Benjamin W. Neuman</name>
<name sortKey="Saikatendu, Kumar S" sort="Saikatendu, Kumar S" uniqKey="Saikatendu K" first="Kumar S." last="Saikatendu">Kumar S. Saikatendu</name>
<name sortKey="Serrano, Pedro" sort="Serrano, Pedro" uniqKey="Serrano P" first="Pedro" last="Serrano">Pedro Serrano</name>
<name sortKey="Stevens, Raymond C" sort="Stevens, Raymond C" uniqKey="Stevens R" first="Raymond C." last="Stevens">Raymond C. Stevens</name>
<name sortKey="Subramanian, Vanitha" sort="Subramanian, Vanitha" uniqKey="Subramanian V" first="Vanitha" last="Subramanian">Vanitha Subramanian</name>
<name sortKey="Wuthrich, Kurt" sort="Wuthrich, Kurt" uniqKey="Wuthrich K" first="Kurt" last="Wüthrich">Kurt Wüthrich</name>
<name sortKey="Wuthrich, Kurt" sort="Wuthrich, Kurt" uniqKey="Wuthrich K" first="Kurt" last="Wüthrich">Kurt Wüthrich</name>
<name sortKey="Wuthrich, Kurt" sort="Wuthrich, Kurt" uniqKey="Wuthrich K" first="Kurt" last="Wüthrich">Kurt Wüthrich</name>
<name sortKey="Wuthrich, Kurt" sort="Wuthrich, Kurt" uniqKey="Wuthrich K" first="Kurt" last="Wüthrich">Kurt Wüthrich</name>
</country>
<country name="Suisse"><region name="Canton de Zurich"><name sortKey="Herrmann, Torsten" sort="Herrmann, Torsten" uniqKey="Herrmann T" first="Torsten" last="Herrmann">Torsten Herrmann</name>
</region>
</country>
</tree>
</affiliations>
</record>
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