Nucleic-acid-based antiviral agents against positive single-stranded RNA viruses.
Identifieur interne : 003E01 ( Main/Exploration ); précédent : 003E00; suivant : 003E02Nucleic-acid-based antiviral agents against positive single-stranded RNA viruses.
Auteurs : Travis W. Lim [Canada] ; Ji Yuan ; Zhen Liu ; Dexin Qiu ; Alhousseynou Sall ; Decheng YangSource :
- Current opinion in molecular therapeutics [ 1464-8431 ] ; 2006.
Descripteurs français
- KwdFr :
- ARN viral (), ARN viral (génétique), Acides nucléiques (), Animaux, Antiviraux (), Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Humains, Littérature de revue comme sujet, Petit ARN interférent (), Petit ARN interférent (pharmacologie), Petit ARN interférent (usage thérapeutique), Réplication virale (), Virus à ARN ().
- MESH :
- génétique : ARN viral.
- pharmacologie : Antiviraux, Petit ARN interférent.
- usage thérapeutique : Antiviraux, Petit ARN interférent.
- ARN viral, Acides nucléiques, Animaux, Antiviraux, Humains, Littérature de revue comme sujet, Petit ARN interférent, Réplication virale, Virus à ARN.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Humans, Nucleic Acids (chemistry), RNA Viruses (drug effects), RNA, Small Interfering (chemistry), RNA, Small Interfering (pharmacology), RNA, Small Interfering (therapeutic use), RNA, Viral (chemistry), RNA, Viral (drug effects), RNA, Viral (genetics), Review Literature as Topic, Virus Replication (drug effects).
- MESH :
- chemical , chemistry : Antiviral Agents, Nucleic Acids, RNA, Small Interfering, RNA, Viral.
- chemical , drug effects : RNA, Viral.
- chemical , genetics : RNA, Viral.
- chemical , pharmacology : Antiviral Agents, RNA, Small Interfering.
- chemical , therapeutic use : Antiviral Agents, RNA, Small Interfering.
- drug effects : RNA Viruses, Virus Replication.
- Animals, Humans, Review Literature as Topic.
Abstract
Positive single-stranded RNA viruses constitute a broad and prevalent group of pathogens that threaten human health and life worldwide. While effective vaccines have been developed for some, such as poliovirus and hepatitis A, others such as coxsackievirus, severe acute respiratory syndrome coronavirus (SARS-CoV) and West Nile virus have no accredited drug treatments. Antisense technologies, which encompass small interfering RNA, antisense oligonucleotides, ribozymes and their chemically modified analogs, involve small sequence-specific nucleic-acid-based molecules that inhibit viral replication at the level of translation. Many antisense oligomers are proven antiviral agents in vitro. In this review, iwe provide an overview of the antiviral antisense field, highlighting specific studies of interest over the past several years, using our experience with coxsackievirus B3 as a reference point. Overall, both the challenges and successes of existing antisense therapies for positive single-stranded RNA viruses can be paralleled to those for other virus groups, and vice versa.
PubMed: 16610761
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Positive single-stranded RNA viruses constitute a broad and prevalent group of pathogens that threaten human health and life worldwide. While effective vaccines have been developed for some, such as poliovirus and hepatitis A, others such as coxsackievirus, severe acute respiratory syndrome coronavirus (SARS-CoV) and West Nile virus have no accredited drug treatments. Antisense technologies, which encompass small interfering RNA, antisense oligonucleotides, ribozymes and their chemically modified analogs, involve small sequence-specific nucleic-acid-based molecules that inhibit viral replication at the level of translation. Many antisense oligomers are proven antiviral agents in vitro. In this review, iwe provide an overview of the antiviral antisense field, highlighting specific studies of interest over the past several years, using our experience with coxsackievirus B3 as a reference point. Overall, both the challenges and successes of existing antisense therapies for positive single-stranded RNA viruses can be paralleled to those for other virus groups, and vice versa.</div>
</front>
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<tree><noCountry><name sortKey="Liu, Zhen" sort="Liu, Zhen" uniqKey="Liu Z" first="Zhen" last="Liu">Zhen Liu</name>
<name sortKey="Qiu, Dexin" sort="Qiu, Dexin" uniqKey="Qiu D" first="Dexin" last="Qiu">Dexin Qiu</name>
<name sortKey="Sall, Alhousseynou" sort="Sall, Alhousseynou" uniqKey="Sall A" first="Alhousseynou" last="Sall">Alhousseynou Sall</name>
<name sortKey="Yang, Decheng" sort="Yang, Decheng" uniqKey="Yang D" first="Decheng" last="Yang">Decheng Yang</name>
<name sortKey="Yuan, Ji" sort="Yuan, Ji" uniqKey="Yuan J" first="Ji" last="Yuan">Ji Yuan</name>
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<country name="Canada"><noRegion><name sortKey="Lim, Travis W" sort="Lim, Travis W" uniqKey="Lim T" first="Travis W" last="Lim">Travis W. Lim</name>
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