Nucleic-acid-based antiviral agents against positive single-stranded RNA viruses.
Identifieur interne : 002279 ( PubMed/Curation ); précédent : 002278; suivant : 002280Nucleic-acid-based antiviral agents against positive single-stranded RNA viruses.
Auteurs : Travis W. Lim [Canada] ; Ji Yuan ; Zhen Liu ; Dexin Qiu ; Alhousseynou Sall ; Decheng YangSource :
- Current opinion in molecular therapeutics [ 1464-8431 ] ; 2006.
Descripteurs français
- KwdFr :
- ARN viral (), ARN viral (génétique), Acides nucléiques (), Animaux, Antiviraux (), Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Humains, Littérature de revue comme sujet, Petit ARN interférent (), Petit ARN interférent (pharmacologie), Petit ARN interférent (usage thérapeutique), Réplication virale (), Virus à ARN ().
- MESH :
- génétique : ARN viral.
- pharmacologie : Antiviraux, Petit ARN interférent.
- usage thérapeutique : Antiviraux, Petit ARN interférent.
- ARN viral, Acides nucléiques, Animaux, Antiviraux, Humains, Littérature de revue comme sujet, Petit ARN interférent, Réplication virale, Virus à ARN.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Humans, Nucleic Acids (chemistry), RNA Viruses (drug effects), RNA, Small Interfering (chemistry), RNA, Small Interfering (pharmacology), RNA, Small Interfering (therapeutic use), RNA, Viral (chemistry), RNA, Viral (drug effects), RNA, Viral (genetics), Review Literature as Topic, Virus Replication (drug effects).
- MESH :
- chemical , chemistry : Antiviral Agents, Nucleic Acids, RNA, Small Interfering, RNA, Viral.
- chemical , drug effects : RNA, Viral.
- chemical , genetics : RNA, Viral.
- chemical , pharmacology : Antiviral Agents, RNA, Small Interfering.
- chemical , therapeutic use : Antiviral Agents, RNA, Small Interfering.
- drug effects : RNA Viruses, Virus Replication.
- Animals, Humans, Review Literature as Topic.
Abstract
Positive single-stranded RNA viruses constitute a broad and prevalent group of pathogens that threaten human health and life worldwide. While effective vaccines have been developed for some, such as poliovirus and hepatitis A, others such as coxsackievirus, severe acute respiratory syndrome coronavirus (SARS-CoV) and West Nile virus have no accredited drug treatments. Antisense technologies, which encompass small interfering RNA, antisense oligonucleotides, ribozymes and their chemically modified analogs, involve small sequence-specific nucleic-acid-based molecules that inhibit viral replication at the level of translation. Many antisense oligomers are proven antiviral agents in vitro. In this review, iwe provide an overview of the antiviral antisense field, highlighting specific studies of interest over the past several years, using our experience with coxsackievirus B3 as a reference point. Overall, both the challenges and successes of existing antisense therapies for positive single-stranded RNA viruses can be paralleled to those for other virus groups, and vice versa.
PubMed: 16610761
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Lim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Laboratory Medicine, The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul's Hospital, Vancouver, British Columbia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul's Hospital, Vancouver, British Columbia</wicri:regionArea></affiliation></author><author><name sortKey="Yuan, Ji" sort="Yuan, Ji" uniqKey="Yuan J" first="Ji" last="Yuan">Ji Yuan</name></author><author><name sortKey="Liu, Zhen" sort="Liu, Zhen" uniqKey="Liu Z" first="Zhen" last="Liu">Zhen Liu</name></author><author><name sortKey="Qiu, Dexin" sort="Qiu, Dexin" uniqKey="Qiu D" first="Dexin" last="Qiu">Dexin Qiu</name></author><author><name sortKey="Sall, Alhousseynou" sort="Sall, Alhousseynou" uniqKey="Sall A" first="Alhousseynou" last="Sall">Alhousseynou Sall</name></author><author><name sortKey="Yang, Decheng" sort="Yang, Decheng" uniqKey="Yang D" first="Decheng" last="Yang">Decheng Yang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:16610761</idno><idno type="pmid">16610761</idno><idno type="wicri:Area/PubMed/Corpus">002279</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002279</idno><idno type="wicri:Area/PubMed/Curation">002279</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002279</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Nucleic-acid-based antiviral agents against positive single-stranded RNA viruses.</title><author><name sortKey="Lim, Travis W" sort="Lim, Travis W" uniqKey="Lim T" first="Travis W" last="Lim">Travis W. Lim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Laboratory Medicine, The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul's Hospital, Vancouver, British Columbia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul's Hospital, Vancouver, British Columbia</wicri:regionArea></affiliation></author><author><name sortKey="Yuan, Ji" sort="Yuan, Ji" uniqKey="Yuan J" first="Ji" last="Yuan">Ji Yuan</name></author><author><name sortKey="Liu, Zhen" sort="Liu, Zhen" uniqKey="Liu Z" first="Zhen" last="Liu">Zhen Liu</name></author><author><name sortKey="Qiu, Dexin" sort="Qiu, Dexin" uniqKey="Qiu D" first="Dexin" last="Qiu">Dexin Qiu</name></author><author><name sortKey="Sall, Alhousseynou" sort="Sall, Alhousseynou" uniqKey="Sall A" first="Alhousseynou" last="Sall">Alhousseynou Sall</name></author><author><name sortKey="Yang, Decheng" sort="Yang, Decheng" uniqKey="Yang D" first="Decheng" last="Yang">Decheng Yang</name></author></analytic><series><title level="j">Current opinion in molecular therapeutics</title><idno type="ISSN">1464-8431</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (pharmacology)</term><term>Antiviral Agents (therapeutic use)</term><term>Humans</term><term>Nucleic Acids (chemistry)</term><term>RNA Viruses (drug effects)</term><term>RNA, Small Interfering (chemistry)</term><term>RNA, Small Interfering (pharmacology)</term><term>RNA, Small Interfering (therapeutic use)</term><term>RNA, Viral (chemistry)</term><term>RNA, Viral (drug effects)</term><term>RNA, Viral (genetics)</term><term>Review Literature as Topic</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral ()</term><term>ARN viral (génétique)</term><term>Acides nucléiques ()</term><term>Animaux</term><term>Antiviraux ()</term><term>Antiviraux (pharmacologie)</term><term>Antiviraux (usage thérapeutique)</term><term>Humains</term><term>Littérature de revue comme sujet</term><term>Petit ARN interférent ()</term><term>Petit ARN interférent (pharmacologie)</term><term>Petit ARN interférent (usage thérapeutique)</term><term>Réplication virale ()</term><term>Virus à ARN ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term><term>Nucleic Acids</term><term>RNA, Small Interfering</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>RNA, Small Interfering</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>RNA, Small Interfering</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>RNA Viruses</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Petit ARN interférent</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Petit ARN interférent</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Review Literature as Topic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ARN viral</term><term>Acides nucléiques</term><term>Animaux</term><term>Antiviraux</term><term>Humains</term><term>Littérature de revue comme sujet</term><term>Petit ARN interférent</term><term>Réplication virale</term><term>Virus à ARN</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Positive single-stranded RNA viruses constitute a broad and prevalent group of pathogens that threaten human health and life worldwide. While effective vaccines have been developed for some, such as poliovirus and hepatitis A, others such as coxsackievirus, severe acute respiratory syndrome coronavirus (SARS-CoV) and West Nile virus have no accredited drug treatments. Antisense technologies, which encompass small interfering RNA, antisense oligonucleotides, ribozymes and their chemically modified analogs, involve small sequence-specific nucleic-acid-based molecules that inhibit viral replication at the level of translation. Many antisense oligomers are proven antiviral agents in vitro. In this review, iwe provide an overview of the antiviral antisense field, highlighting specific studies of interest over the past several years, using our experience with coxsackievirus B3 as a reference point. Overall, both the challenges and successes of existing antisense therapies for positive single-stranded RNA viruses can be paralleled to those for other virus groups, and vice versa.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16610761</PMID><DateCompleted><Year>2006</Year><Month>05</Month><Day>11</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1464-8431</ISSN><JournalIssue CitedMedium="Print"><Volume>8</Volume><Issue>2</Issue><PubDate><Year>2006</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Current opinion in molecular therapeutics</Title><ISOAbbreviation>Curr. Opin. Mol. Ther.</ISOAbbreviation></Journal><ArticleTitle>Nucleic-acid-based antiviral agents against positive single-stranded RNA viruses.</ArticleTitle><Pagination><MedlinePgn>104-7</MedlinePgn></Pagination><Abstract><AbstractText>Positive single-stranded RNA viruses constitute a broad and prevalent group of pathogens that threaten human health and life worldwide. While effective vaccines have been developed for some, such as poliovirus and hepatitis A, others such as coxsackievirus, severe acute respiratory syndrome coronavirus (SARS-CoV) and West Nile virus have no accredited drug treatments. Antisense technologies, which encompass small interfering RNA, antisense oligonucleotides, ribozymes and their chemically modified analogs, involve small sequence-specific nucleic-acid-based molecules that inhibit viral replication at the level of translation. Many antisense oligomers are proven antiviral agents in vitro. In this review, iwe provide an overview of the antiviral antisense field, highlighting specific studies of interest over the past several years, using our experience with coxsackievirus B3 as a reference point. Overall, both the challenges and successes of existing antisense therapies for positive single-stranded RNA viruses can be paralleled to those for other virus groups, and vice versa.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lim</LastName><ForeName>Travis W</ForeName><Initials>TW</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul's Hospital, Vancouver, British Columbia, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yuan</LastName><ForeName>Ji</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Zhen</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Qiu</LastName><ForeName>Dexin</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Sall</LastName><ForeName>Alhousseynou</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Decheng</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Curr Opin Mol Ther</MedlineTA><NlmUniqueID>100891485</NlmUniqueID><ISSNLinking>1464-8431</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009696">Nucleic Acids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D034741">RNA, Small Interfering</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009696" MajorTopicYN="N">Nucleic Acids</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012328" MajorTopicYN="N">RNA Viruses</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D034741" MajorTopicYN="N">RNA, Small Interfering</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012196" MajorTopicYN="N">Review Literature as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList><NumberOfReferences>30</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>4</Month><Day>14</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>5</Month><Day>12</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>4</Month><Day>14</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16610761</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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