Anti-HIV, anti-poxvirus, and anti-SARS activity of a nontoxic, acidic plant extract from the Trifollium species Secomet-V/anti-vac suggests that it contains a novel broad-spectrum antiviral.
Identifieur interne : 004929 ( Main/Exploration ); précédent : 004928; suivant : 004930Anti-HIV, anti-poxvirus, and anti-SARS activity of a nontoxic, acidic plant extract from the Trifollium species Secomet-V/anti-vac suggests that it contains a novel broad-spectrum antiviral.
Auteurs : Girish J. Kotwal [Afrique du Sud] ; Jennifer N. Kaczmarek ; Steven Leivers ; Yohannes T. Ghebremariam ; Amod P. Kulkarni ; Gabriele Bauer ; Corena De Beer ; Wolfgang Preiser ; Abdu Rahman MohamedSource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2005.
Descripteurs français
- KwdFr :
- MESH :
- croissance et développement : Poxviridae.
- toxicité : Extraits de plantes, Protéines virales.
- usage thérapeutique : Agents antiVIH.
- Humains, Lignée cellulaire, Phytothérapie, Poxviridae, Trifolium, VIH (Virus de l'Immunodéficience Humaine), Virus du SRAS.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Anti-HIV Agents.
- drug effects : HIV, Poxviridae, SARS Virus.
- growth & development : Poxviridae.
- chemical , toxicity : Plant Extracts, Viral Proteins.
- Cell Line, Humans, Phytotherapy, Trifolium.
Abstract
Enveloped animal viruses such as human immunodeficiency virus (HIV), hepatitis B virus, hepatitis C virus, human papillomavirus, Marburg, and influenza are major public health concerns around the world. The prohibitive cost of antiretroviral (ARV) drugs for most HIV-infected patients in sub-Saharan Africa and the serious side effects in those who have access to ARV drugs make a compelling case for the study of complementary and alternative therapies. Such therapies should have scientifically proved antiviral activity and minimal toxic effects. A plant extract, Secomet-V, with an anecdotal indication in humans for promise as an anti-HIV treatment, was investigated. Using a previously described attenuated vaccinia virus vGK5, we established the antiviral activity of Secomet-V. Chemical analysis showed that it has an acidic pH, nontoxic traces of iron (<10 ppm), and almost undetectable levels of arsenic (<1.0 ppm). The color varies from colorless to pale yellow to dark brown. The active agent is heat stable at least up to sterilizing temperature of 121 degrees C. The crude plant extract is a mixture of several small molecules separable by high-pressure liquid chromatography. The HIV viral loads were significantly reduced over several months in a few patients monitored after treatment with Secomet-V. Secomet-V was also found to have antiviral activity against the SARS virus but not against the West Nile virus. Secomet-V, therefore, is a broad-spectrum antiviral, which possibly works by neutralizing viral infectivity, resulting in the prevention of viral attachment.
DOI: 10.1196/annals.1352.014
PubMed: 16387696
Affiliations:
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Le document en format XML
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Kotwal</name><affiliation wicri:level="1"><nlm:affiliation>Division of Medical Virology, IIDMM, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town 7925, South Africa. gjkotw01@yahoo.com</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Division of Medical Virology, IIDMM, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town 7925</wicri:regionArea><wicri:noRegion>Cape Town 7925</wicri:noRegion></affiliation></author><author><name sortKey="Kaczmarek, Jennifer N" sort="Kaczmarek, Jennifer N" uniqKey="Kaczmarek J" first="Jennifer N" last="Kaczmarek">Jennifer N. Kaczmarek</name></author><author><name sortKey="Leivers, Steven" sort="Leivers, Steven" uniqKey="Leivers S" first="Steven" last="Leivers">Steven Leivers</name></author><author><name sortKey="Ghebremariam, Yohannes T" sort="Ghebremariam, Yohannes T" uniqKey="Ghebremariam Y" first="Yohannes T" last="Ghebremariam">Yohannes T. Ghebremariam</name></author><author><name sortKey="Kulkarni, Amod P" sort="Kulkarni, Amod P" uniqKey="Kulkarni A" first="Amod P" last="Kulkarni">Amod P. Kulkarni</name></author><author><name sortKey="Bauer, Gabriele" sort="Bauer, Gabriele" uniqKey="Bauer G" first="Gabriele" last="Bauer">Gabriele Bauer</name></author><author><name sortKey="De Beer, Corena" sort="De Beer, Corena" uniqKey="De Beer C" first="Corena" last="De Beer">Corena De Beer</name></author><author><name sortKey="Preiser, Wolfgang" sort="Preiser, Wolfgang" uniqKey="Preiser W" first="Wolfgang" last="Preiser">Wolfgang Preiser</name></author><author><name sortKey="Mohamed, Abdu Rahman" sort="Mohamed, Abdu Rahman" uniqKey="Mohamed A" first="Abdu Rahman" last="Mohamed">Abdu Rahman Mohamed</name></author></analytic><series><title level="j">Annals of the New York Academy of Sciences</title><idno type="ISSN">0077-8923</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-HIV Agents (therapeutic use)</term><term>Cell Line</term><term>HIV (drug effects)</term><term>Humans</term><term>Phytotherapy</term><term>Plant Extracts (toxicity)</term><term>Poxviridae (drug effects)</term><term>Poxviridae (growth & development)</term><term>SARS Virus (drug effects)</term><term>Trifolium</term><term>Viral Proteins (toxicity)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agents antiVIH (usage thérapeutique)</term><term>Extraits de plantes (toxicité)</term><term>Humains</term><term>Lignée cellulaire</term><term>Phytothérapie</term><term>Poxviridae ()</term><term>Poxviridae (croissance et développement)</term><term>Protéines virales (toxicité)</term><term>Trifolium</term><term>VIH (Virus de l'Immunodéficience Humaine) ()</term><term>Virus du SRAS ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Poxviridae</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>HIV</term><term>Poxviridae</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Poxviridae</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Plant Extracts</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Extraits de plantes</term><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents antiVIH</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line</term><term>Humans</term><term>Phytotherapy</term><term>Trifolium</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Lignée cellulaire</term><term>Phytothérapie</term><term>Poxviridae</term><term>Trifolium</term><term>VIH (Virus de l'Immunodéficience Humaine)</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Enveloped animal viruses such as human immunodeficiency virus (HIV), hepatitis B virus, hepatitis C virus, human papillomavirus, Marburg, and influenza are major public health concerns around the world. The prohibitive cost of antiretroviral (ARV) drugs for most HIV-infected patients in sub-Saharan Africa and the serious side effects in those who have access to ARV drugs make a compelling case for the study of complementary and alternative therapies. Such therapies should have scientifically proved antiviral activity and minimal toxic effects. A plant extract, Secomet-V, with an anecdotal indication in humans for promise as an anti-HIV treatment, was investigated. Using a previously described attenuated vaccinia virus vGK5, we established the antiviral activity of Secomet-V. Chemical analysis showed that it has an acidic pH, nontoxic traces of iron (<10 ppm), and almost undetectable levels of arsenic (<1.0 ppm). The color varies from colorless to pale yellow to dark brown. The active agent is heat stable at least up to sterilizing temperature of 121 degrees C. The crude plant extract is a mixture of several small molecules separable by high-pressure liquid chromatography. The HIV viral loads were significantly reduced over several months in a few patients monitored after treatment with Secomet-V. Secomet-V was also found to have antiviral activity against the SARS virus but not against the West Nile virus. Secomet-V, therefore, is a broad-spectrum antiviral, which possibly works by neutralizing viral infectivity, resulting in the prevention of viral attachment.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li></country></list><tree><noCountry><name sortKey="Bauer, Gabriele" sort="Bauer, Gabriele" uniqKey="Bauer G" first="Gabriele" last="Bauer">Gabriele Bauer</name><name sortKey="De Beer, Corena" sort="De Beer, Corena" uniqKey="De Beer C" first="Corena" last="De Beer">Corena De Beer</name><name sortKey="Ghebremariam, Yohannes T" sort="Ghebremariam, Yohannes T" uniqKey="Ghebremariam Y" first="Yohannes T" last="Ghebremariam">Yohannes T. Ghebremariam</name><name sortKey="Kaczmarek, Jennifer N" sort="Kaczmarek, Jennifer N" uniqKey="Kaczmarek J" first="Jennifer N" last="Kaczmarek">Jennifer N. Kaczmarek</name><name sortKey="Kulkarni, Amod P" sort="Kulkarni, Amod P" uniqKey="Kulkarni A" first="Amod P" last="Kulkarni">Amod P. Kulkarni</name><name sortKey="Leivers, Steven" sort="Leivers, Steven" uniqKey="Leivers S" first="Steven" last="Leivers">Steven Leivers</name><name sortKey="Mohamed, Abdu Rahman" sort="Mohamed, Abdu Rahman" uniqKey="Mohamed A" first="Abdu Rahman" last="Mohamed">Abdu Rahman Mohamed</name><name sortKey="Preiser, Wolfgang" sort="Preiser, Wolfgang" uniqKey="Preiser W" first="Wolfgang" last="Preiser">Wolfgang Preiser</name></noCountry><country name="Afrique du Sud"><noRegion><name sortKey="Kotwal, Girish J" sort="Kotwal, Girish J" uniqKey="Kotwal G" first="Girish J" last="Kotwal">Girish J. Kotwal</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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