Anti-HIV, anti-poxvirus, and anti-SARS activity of a nontoxic, acidic plant extract from the Trifollium species Secomet-V/anti-vac suggests that it contains a novel broad-spectrum antiviral.
Identifieur interne : 002390 ( PubMed/Corpus ); précédent : 002389; suivant : 002391Anti-HIV, anti-poxvirus, and anti-SARS activity of a nontoxic, acidic plant extract from the Trifollium species Secomet-V/anti-vac suggests that it contains a novel broad-spectrum antiviral.
Auteurs : Girish J. Kotwal ; Jennifer N. Kaczmarek ; Steven Leivers ; Yohannes T. Ghebremariam ; Amod P. Kulkarni ; Gabriele Bauer ; Corena De Beer ; Wolfgang Preiser ; Abdu Rahman MohamedSource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2005.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Anti-HIV Agents.
- drug effects : HIV, Poxviridae, SARS Virus.
- growth & development : Poxviridae.
- chemical , toxicity : Plant Extracts, Viral Proteins.
- Cell Line, Humans, Phytotherapy, Trifolium.
Abstract
Enveloped animal viruses such as human immunodeficiency virus (HIV), hepatitis B virus, hepatitis C virus, human papillomavirus, Marburg, and influenza are major public health concerns around the world. The prohibitive cost of antiretroviral (ARV) drugs for most HIV-infected patients in sub-Saharan Africa and the serious side effects in those who have access to ARV drugs make a compelling case for the study of complementary and alternative therapies. Such therapies should have scientifically proved antiviral activity and minimal toxic effects. A plant extract, Secomet-V, with an anecdotal indication in humans for promise as an anti-HIV treatment, was investigated. Using a previously described attenuated vaccinia virus vGK5, we established the antiviral activity of Secomet-V. Chemical analysis showed that it has an acidic pH, nontoxic traces of iron (<10 ppm), and almost undetectable levels of arsenic (<1.0 ppm). The color varies from colorless to pale yellow to dark brown. The active agent is heat stable at least up to sterilizing temperature of 121 degrees C. The crude plant extract is a mixture of several small molecules separable by high-pressure liquid chromatography. The HIV viral loads were significantly reduced over several months in a few patients monitored after treatment with Secomet-V. Secomet-V was also found to have antiviral activity against the SARS virus but not against the West Nile virus. Secomet-V, therefore, is a broad-spectrum antiviral, which possibly works by neutralizing viral infectivity, resulting in the prevention of viral attachment.
DOI: 10.1196/annals.1352.014
PubMed: 16387696
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pubmed:16387696Le document en format XML
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Kaczmarek</name></author><author><name sortKey="Leivers, Steven" sort="Leivers, Steven" uniqKey="Leivers S" first="Steven" last="Leivers">Steven Leivers</name></author><author><name sortKey="Ghebremariam, Yohannes T" sort="Ghebremariam, Yohannes T" uniqKey="Ghebremariam Y" first="Yohannes T" last="Ghebremariam">Yohannes T. Ghebremariam</name></author><author><name sortKey="Kulkarni, Amod P" sort="Kulkarni, Amod P" uniqKey="Kulkarni A" first="Amod P" last="Kulkarni">Amod P. Kulkarni</name></author><author><name sortKey="Bauer, Gabriele" sort="Bauer, Gabriele" uniqKey="Bauer G" first="Gabriele" last="Bauer">Gabriele Bauer</name></author><author><name sortKey="De Beer, Corena" sort="De Beer, Corena" uniqKey="De Beer C" first="Corena" last="De Beer">Corena De Beer</name></author><author><name sortKey="Preiser, Wolfgang" sort="Preiser, Wolfgang" uniqKey="Preiser W" first="Wolfgang" last="Preiser">Wolfgang Preiser</name></author><author><name sortKey="Mohamed, Abdu Rahman" sort="Mohamed, Abdu Rahman" uniqKey="Mohamed A" first="Abdu Rahman" last="Mohamed">Abdu Rahman Mohamed</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:16387696</idno><idno type="pmid">16387696</idno><idno type="doi">10.1196/annals.1352.014</idno><idno type="wicri:Area/PubMed/Corpus">002390</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002390</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Anti-HIV, anti-poxvirus, and anti-SARS activity of a nontoxic, acidic plant extract from the Trifollium species Secomet-V/anti-vac suggests that it contains a novel broad-spectrum antiviral.</title><author><name sortKey="Kotwal, Girish J" sort="Kotwal, Girish J" uniqKey="Kotwal G" first="Girish J" last="Kotwal">Girish J. Kotwal</name><affiliation><nlm:affiliation>Division of Medical Virology, IIDMM, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town 7925, South Africa. gjkotw01@yahoo.com</nlm:affiliation></affiliation></author><author><name sortKey="Kaczmarek, Jennifer N" sort="Kaczmarek, Jennifer N" uniqKey="Kaczmarek J" first="Jennifer N" last="Kaczmarek">Jennifer N. Kaczmarek</name></author><author><name sortKey="Leivers, Steven" sort="Leivers, Steven" uniqKey="Leivers S" first="Steven" last="Leivers">Steven Leivers</name></author><author><name sortKey="Ghebremariam, Yohannes T" sort="Ghebremariam, Yohannes T" uniqKey="Ghebremariam Y" first="Yohannes T" last="Ghebremariam">Yohannes T. Ghebremariam</name></author><author><name sortKey="Kulkarni, Amod P" sort="Kulkarni, Amod P" uniqKey="Kulkarni A" first="Amod P" last="Kulkarni">Amod P. Kulkarni</name></author><author><name sortKey="Bauer, Gabriele" sort="Bauer, Gabriele" uniqKey="Bauer G" first="Gabriele" last="Bauer">Gabriele Bauer</name></author><author><name sortKey="De Beer, Corena" sort="De Beer, Corena" uniqKey="De Beer C" first="Corena" last="De Beer">Corena De Beer</name></author><author><name sortKey="Preiser, Wolfgang" sort="Preiser, Wolfgang" uniqKey="Preiser W" first="Wolfgang" last="Preiser">Wolfgang Preiser</name></author><author><name sortKey="Mohamed, Abdu Rahman" sort="Mohamed, Abdu Rahman" uniqKey="Mohamed A" first="Abdu Rahman" last="Mohamed">Abdu Rahman Mohamed</name></author></analytic><series><title level="j">Annals of the New York Academy of Sciences</title><idno type="ISSN">0077-8923</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-HIV Agents (therapeutic use)</term><term>Cell Line</term><term>HIV (drug effects)</term><term>Humans</term><term>Phytotherapy</term><term>Plant Extracts (toxicity)</term><term>Poxviridae (drug effects)</term><term>Poxviridae (growth & development)</term><term>SARS Virus (drug effects)</term><term>Trifolium</term><term>Viral Proteins (toxicity)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>HIV</term><term>Poxviridae</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Poxviridae</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Plant Extracts</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line</term><term>Humans</term><term>Phytotherapy</term><term>Trifolium</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Enveloped animal viruses such as human immunodeficiency virus (HIV), hepatitis B virus, hepatitis C virus, human papillomavirus, Marburg, and influenza are major public health concerns around the world. The prohibitive cost of antiretroviral (ARV) drugs for most HIV-infected patients in sub-Saharan Africa and the serious side effects in those who have access to ARV drugs make a compelling case for the study of complementary and alternative therapies. Such therapies should have scientifically proved antiviral activity and minimal toxic effects. A plant extract, Secomet-V, with an anecdotal indication in humans for promise as an anti-HIV treatment, was investigated. Using a previously described attenuated vaccinia virus vGK5, we established the antiviral activity of Secomet-V. Chemical analysis showed that it has an acidic pH, nontoxic traces of iron (<10 ppm), and almost undetectable levels of arsenic (<1.0 ppm). The color varies from colorless to pale yellow to dark brown. The active agent is heat stable at least up to sterilizing temperature of 121 degrees C. The crude plant extract is a mixture of several small molecules separable by high-pressure liquid chromatography. The HIV viral loads were significantly reduced over several months in a few patients monitored after treatment with Secomet-V. Secomet-V was also found to have antiviral activity against the SARS virus but not against the West Nile virus. Secomet-V, therefore, is a broad-spectrum antiviral, which possibly works by neutralizing viral infectivity, resulting in the prevention of viral attachment.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16387696</PMID><DateCompleted><Year>2007</Year><Month>04</Month><Day>05</Day></DateCompleted><DateRevised><Year>2007</Year><Month>08</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0077-8923</ISSN><JournalIssue CitedMedium="Print"><Volume>1056</Volume><PubDate><Year>2005</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Annals of the New York Academy of Sciences</Title><ISOAbbreviation>Ann. N. Y. Acad. Sci.</ISOAbbreviation></Journal><ArticleTitle>Anti-HIV, anti-poxvirus, and anti-SARS activity of a nontoxic, acidic plant extract from the Trifollium species Secomet-V/anti-vac suggests that it contains a novel broad-spectrum antiviral.</ArticleTitle><Pagination><MedlinePgn>293-302</MedlinePgn></Pagination><Abstract><AbstractText>Enveloped animal viruses such as human immunodeficiency virus (HIV), hepatitis B virus, hepatitis C virus, human papillomavirus, Marburg, and influenza are major public health concerns around the world. The prohibitive cost of antiretroviral (ARV) drugs for most HIV-infected patients in sub-Saharan Africa and the serious side effects in those who have access to ARV drugs make a compelling case for the study of complementary and alternative therapies. Such therapies should have scientifically proved antiviral activity and minimal toxic effects. A plant extract, Secomet-V, with an anecdotal indication in humans for promise as an anti-HIV treatment, was investigated. Using a previously described attenuated vaccinia virus vGK5, we established the antiviral activity of Secomet-V. Chemical analysis showed that it has an acidic pH, nontoxic traces of iron (<10 ppm), and almost undetectable levels of arsenic (<1.0 ppm). The color varies from colorless to pale yellow to dark brown. The active agent is heat stable at least up to sterilizing temperature of 121 degrees C. The crude plant extract is a mixture of several small molecules separable by high-pressure liquid chromatography. The HIV viral loads were significantly reduced over several months in a few patients monitored after treatment with Secomet-V. Secomet-V was also found to have antiviral activity against the SARS virus but not against the West Nile virus. Secomet-V, therefore, is a broad-spectrum antiviral, which possibly works by neutralizing viral infectivity, resulting in the prevention of viral attachment.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kotwal</LastName><ForeName>Girish J</ForeName><Initials>GJ</Initials><AffiliationInfo><Affiliation>Division of Medical Virology, IIDMM, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town 7925, South Africa. gjkotw01@yahoo.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaczmarek</LastName><ForeName>Jennifer N</ForeName><Initials>JN</Initials></Author><Author ValidYN="Y"><LastName>Leivers</LastName><ForeName>Steven</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Ghebremariam</LastName><ForeName>Yohannes T</ForeName><Initials>YT</Initials></Author><Author ValidYN="Y"><LastName>Kulkarni</LastName><ForeName>Amod P</ForeName><Initials>AP</Initials></Author><Author ValidYN="Y"><LastName>Bauer</LastName><ForeName>Gabriele</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>De Beer</LastName><ForeName>Corena</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Preiser</LastName><ForeName>Wolfgang</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Mohamed</LastName><ForeName>Abdu Rahman</ForeName><Initials>AR</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Ann N Y Acad Sci</MedlineTA><NlmUniqueID>7506858</NlmUniqueID><ISSNLinking>0077-8923</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019380">Anti-HIV Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D019380" MajorTopicYN="N">Anti-HIV Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006678" MajorTopicYN="N">HIV</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008517" MajorTopicYN="N">Phytotherapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011212" MajorTopicYN="N">Poxviridae</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029921" MajorTopicYN="Y">Trifolium</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014764" MajorTopicYN="N">Viral Proteins</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>1</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>4</Month><Day>6</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>1</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16387696</ArticleId><ArticleId IdType="pii">1056/1/293</ArticleId><ArticleId IdType="doi">10.1196/annals.1352.014</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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