Antigenic cross-reactivity between severe acute respiratory syndrome-associated coronavirus and human coronaviruses 229E and OC43
Identifieur interne : 004E73 ( Main/Exploration ); précédent : 004E72; suivant : 004E74Antigenic cross-reactivity between severe acute respiratory syndrome-associated coronavirus and human coronaviruses 229E and OC43
Auteurs : Xiao-Yan Che [République populaire de Chine] ; Li-Wen Qiu [République populaire de Chine] ; Zhi-Yong Liao [République populaire de Chine] ; Ya-Di Wang [République populaire de Chine] ; KUN WEN [République populaire de Chine] ; Yu-Xian Pan [République populaire de Chine] ; WEI HAO [République populaire de Chine] ; Ya-Bo Mei [République populaire de Chine] ; Vincent C. C. Cheng [Hong Kong] ; Kwok-Yung Yuen [Hong Kong]Source :
- The Journal of infectious diseases [ 0022-1899 ] ; 2005.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Coronavirus humain 229E, Coronavirus humain OC43, Virus du SRAS.
- sang : Anticorps antiviraux, Antigènes viraux, Immunoglobuline G, Immunoglobuline M.
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Animals, Antibodies, Viral (blood), Antigens, Viral (blood), Coronavirus 229E, Human (immunology), Coronavirus OC43, Human (immunology), Cross Reactions, Cross reaction, Female, Human coronavirus OC43, Humans, Immunoglobulin G (blood), Immunoglobulin M (blood), Infection, Male, Microbiology, SARS Virus (immunology), Severe acute respiratory syndrome.
- MESH :
- chemical , blood : Antibodies, Viral, Antigens, Viral, Immunoglobulin G, Immunoglobulin M.
- immunology : Coronavirus 229E, Human, Coronavirus OC43, Human, SARS Virus.
- Adult, Animals, Cross Reactions, Female, Humans, Male.
Abstract
Cross-reactivity between antibodies to different human coronaviruses (HCoVs) has not been systematically studied. By use of Western blot analysis, indirect immunofluorescence assay (IFA), and enzyme-linked immunosorbent assay (ELISA), antigenic cross-reactivity between severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) and 2 HCoVs (229E and OC43) was demonstrated in immunized animals and human serum. In 5 of 11 and 10 of 11 patients with SARS, paired serum samples showed a ≥4-fold increase in antibody titers against HCoV-229E and HCoV-OC43, respectively, by IFA. Overall, serum samples from convalescent patients who had SARS had a 1-way cross-reactivity with the 2 known HCoVs. Antigens of SARS-CoV and HCoV-OC43 were more cross-reactive than were those of SARS-CoV and HCoV-229E.
Affiliations:
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Le document en format XML
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<keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term>
<term>Animaux</term>
<term>Coronavirus OC43 humain</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Réaction croisée</term>
<term>Microbiologie</term>
<term>Infection</term>
<term>Réactions croisées</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Cross-reactivity between antibodies to different human coronaviruses (HCoVs) has not been systematically studied. By use of Western blot analysis, indirect immunofluorescence assay (IFA), and enzyme-linked immunosorbent assay (ELISA), antigenic cross-reactivity between severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) and 2 HCoVs (229E and OC43) was demonstrated in immunized animals and human serum. In 5 of 11 and 10 of 11 patients with SARS, paired serum samples showed a ≥4-fold increase in antibody titers against HCoV-229E and HCoV-OC43, respectively, by IFA. Overall, serum samples from convalescent patients who had SARS had a 1-way cross-reactivity with the 2 known HCoVs. Antigens of SARS-CoV and HCoV-OC43 were more cross-reactive than were those of SARS-CoV and HCoV-229E.</div>
</front>
</TEI>
<affiliations><list><country><li>Hong Kong</li>
<li>République populaire de Chine</li>
</country>
<region><li>Guangdong</li>
</region>
<settlement><li>Jiangmen</li>
</settlement>
</list>
<tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Che, Xiao Yan" sort="Che, Xiao Yan" uniqKey="Che X" first="Xiao-Yan" last="Che">Xiao-Yan Che</name>
</region>
<name sortKey="Kun Wen" sort="Kun Wen" uniqKey="Kun Wen" last="Kun Wen">KUN WEN</name>
<name sortKey="Liao, Zhi Yong" sort="Liao, Zhi Yong" uniqKey="Liao Z" first="Zhi-Yong" last="Liao">Zhi-Yong Liao</name>
<name sortKey="Mei, Ya Bo" sort="Mei, Ya Bo" uniqKey="Mei Y" first="Ya-Bo" last="Mei">Ya-Bo Mei</name>
<name sortKey="Pan, Yu Xian" sort="Pan, Yu Xian" uniqKey="Pan Y" first="Yu-Xian" last="Pan">Yu-Xian Pan</name>
<name sortKey="Qiu, Li Wen" sort="Qiu, Li Wen" uniqKey="Qiu L" first="Li-Wen" last="Qiu">Li-Wen Qiu</name>
<name sortKey="Wang, Ya Di" sort="Wang, Ya Di" uniqKey="Wang Y" first="Ya-Di" last="Wang">Ya-Di Wang</name>
<name sortKey="Wei Hao" sort="Wei Hao" uniqKey="Wei Hao" last="Wei Hao">WEI HAO</name>
</country>
<country name="Hong Kong"><noRegion><name sortKey="Cheng, Vincent C C" sort="Cheng, Vincent C C" uniqKey="Cheng V" first="Vincent C. C." last="Cheng">Vincent C. C. Cheng</name>
</noRegion>
<name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name>
</country>
</tree>
</affiliations>
</record>
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