Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus
Identifieur interne : 004E72 ( Main/Exploration ); précédent : 004E71; suivant : 004E73Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus
Auteurs : Gerold Hoever [Allemagne] ; Lidia Baltina [Russie] ; Martin Michaelis [Allemagne] ; Rimma Kondratenko [Russie] ; Lia Baltina [Russie] ; Genrich A. Tolstikov [Russie] ; Hans W. Doerr [Allemagne] ; Jindrich Jr Cinatl [Allemagne]Source :
- Journal of medicinal chemistry : (Print) [ 0022-2623 ] ; 2005.
Descripteurs français
- KwdFr :
- Acide glycyrrhizique (), Acide glycyrrhizique (analogues et dérivés), Acide glycyrrhizique (pharmacologie), Acide glycyrrhizique (synthèse chimique), Animaux, Antiviraux (), Antiviraux (pharmacologie), Antiviraux (synthèse chimique), Cellules Vero, Relation structure-activité, Réplication virale (), Virus du SRAS (), Virus du SRAS (isolement et purification).
- MESH :
- analogues et dérivés : Acide glycyrrhizique.
- isolement et purification : Virus du SRAS.
- pharmacologie : Acide glycyrrhizique, Antiviraux.
- synthèse chimique : Acide glycyrrhizique, Antiviraux.
- Pascal (Inist)
- Acide glycyrrhizique, Animaux, Antiviraux, Cellules Vero, Relation structure activité, Relation structure-activité, Réplication virale, Synthèse chimique, Glycyrrhizique acide, Saponine, Oléanane dérivé, Acide uronique, Glycoside, Triterpène, Terpénoïde, Composé pentacyclique, Enone, Glycosylamine, Glycopeptide, Antiviral, Coronavirus, Syndrome respiratoire aigu sévère, In vitro, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Antiviral, Antiviral Agents (chemical synthesis), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Chemical synthesis, Chlorocebus aethiops, Coronavirus, Enone, Glycopeptide, Glycoside, Glycosylamine, Glycyrrhizic Acid (analogs & derivatives), Glycyrrhizic Acid (chemical synthesis), Glycyrrhizic Acid (chemistry), Glycyrrhizic Acid (pharmacology), Glycyrrhizic acid, In vitro, Oleanane derivatives, Pentacyclic compound, SARS Virus (drug effects), SARS Virus (isolation & purification), Saponin, Severe acute respiratory syndrome, Structure activity relation, Structure-Activity Relationship, Terpenoid, Triterpene, Uronic acid, Vero Cells, Virus Replication (drug effects).
- MESH :
- chemical , analogs & derivatives : Glycyrrhizic Acid.
- chemical , chemical synthesis : Antiviral Agents, Glycyrrhizic Acid.
- chemical , chemistry : Antiviral Agents, Glycyrrhizic Acid.
- chemical , pharmacology : Antiviral Agents, Glycyrrhizic Acid.
- drug effects : SARS Virus, Virus Replication.
- isolation & purification : SARS Virus.
- Animals, Chlorocebus aethiops, Structure-Activity Relationship, Vero Cells.
Abstract
Glycyrrhizin (GL) was shown to inhibit SARS-coronavirus (SARS-CoV) replication in vitro. Here the anti-SARS-CoV activity of 15 GL derivatives was tested. The introduction of 2-acetamido-β-D-glucopyranosylamine into the glycoside chain of GL resulted in 10-fold increased anti-SARS-CoV activity compared to GL. Amides of GL and conjugates of GL with two amino acid residues and a free 30-COOH function presented up to 70-fold increased activity against SARS-CoV but also increased cytotoxicity resulting in decreased selectivity index.
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Glycyrrhizin (GL) was shown to inhibit SARS-coronavirus (SARS-CoV) replication in vitro. Here the anti-SARS-CoV activity of 15 GL derivatives was tested. The introduction of 2-acetamido-β-D-glucopyranosylamine into the glycoside chain of GL resulted in 10-fold increased anti-SARS-CoV activity compared to GL. Amides of GL and conjugates of GL with two amino acid residues and a free 30-COOH function presented up to 70-fold increased activity against SARS-CoV but also increased cytotoxicity resulting in decreased selectivity index.</div>
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<tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Hoever, Gerold" sort="Hoever, Gerold" uniqKey="Hoever G" first="Gerold" last="Hoever">Gerold Hoever</name>
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<name sortKey="Cinatl, Jindrich Jr" sort="Cinatl, Jindrich Jr" uniqKey="Cinatl J" first="Jindrich Jr" last="Cinatl">Jindrich Jr Cinatl</name>
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<name sortKey="Michaelis, Martin" sort="Michaelis, Martin" uniqKey="Michaelis M" first="Martin" last="Michaelis">Martin Michaelis</name>
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<country name="Russie"><noRegion><name sortKey="Baltina, Lidia" sort="Baltina, Lidia" uniqKey="Baltina L" first="Lidia" last="Baltina">Lidia Baltina</name>
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<name sortKey="Baltina, Lia" sort="Baltina, Lia" uniqKey="Baltina L" first="Lia" last="Baltina">Lia Baltina</name>
<name sortKey="Kondratenko, Rimma" sort="Kondratenko, Rimma" uniqKey="Kondratenko R" first="Rimma" last="Kondratenko">Rimma Kondratenko</name>
<name sortKey="Tolstikov, Genrich A" sort="Tolstikov, Genrich A" uniqKey="Tolstikov G" first="Genrich A." last="Tolstikov">Genrich A. Tolstikov</name>
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