Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus.
Identifieur interne : 000D91 ( Ncbi/Curation ); précédent : 000D90; suivant : 000D92Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus.
Auteurs : Gerold Hoever [Allemagne] ; Lidia Baltina ; Martin Michaelis ; Rimma Kondratenko ; Lia Baltina ; Genrich A. Tolstikov ; Hans W. Doerr ; Jindrich CinatlSource :
- Journal of medicinal chemistry [ 0022-2623 ] ; 2005.
Descripteurs français
- KwdFr :
- Acide glycyrrhizique (), Acide glycyrrhizique (analogues et dérivés), Acide glycyrrhizique (pharmacologie), Acide glycyrrhizique (synthèse chimique), Animaux, Antiviraux (), Antiviraux (pharmacologie), Antiviraux (synthèse chimique), Cellules Vero, Relation structure-activité, Réplication virale (), Virus du SRAS (), Virus du SRAS (isolement et purification).
- MESH :
- analogues et dérivés : Acide glycyrrhizique.
- isolement et purification : Virus du SRAS.
- pharmacologie : Acide glycyrrhizique, Antiviraux.
- synthèse chimique : Acide glycyrrhizique, Antiviraux.
- Acide glycyrrhizique, Animaux, Antiviraux, Cellules Vero, Relation structure-activité, Réplication virale, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (chemical synthesis), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Chlorocebus aethiops, Glycyrrhizic Acid (analogs & derivatives), Glycyrrhizic Acid (chemical synthesis), Glycyrrhizic Acid (chemistry), Glycyrrhizic Acid (pharmacology), SARS Virus (drug effects), SARS Virus (isolation & purification), Structure-Activity Relationship, Vero Cells, Virus Replication (drug effects).
- MESH :
- chemical , analogs & derivatives : Glycyrrhizic Acid.
- chemical , chemical synthesis : Antiviral Agents, Glycyrrhizic Acid.
- chemical , chemistry : Antiviral Agents, Glycyrrhizic Acid.
- chemical , pharmacology : Antiviral Agents, Glycyrrhizic Acid.
- drug effects : SARS Virus, Virus Replication.
- isolation & purification : SARS Virus.
- Animals, Chlorocebus aethiops, Structure-Activity Relationship, Vero Cells.
Abstract
Glycyrrhizin (GL) was shown to inhibit SARS-coronavirus (SARS-CoV) replication in vitro. Here the anti-SARS-CoV activity of 15 GL derivatives was tested. The introduction of 2-acetamido-beta-d-glucopyranosylamine into the glycoside chain of GL resulted in 10-fold increased anti-SARS-CoV activity compared to GL. Amides of GL and conjugates of GL with two amino acid residues and a free 30-COOH function presented up to 70-fold increased activity against SARS-CoV but also increased cytotoxicity resulting in decreased selectivity index.
DOI: 10.1021/jm0493008
PubMed: 15715493
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pubmed:15715493Le document en format XML
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Doerr</name></author><author><name sortKey="Cinatl, Jindrich" sort="Cinatl, Jindrich" uniqKey="Cinatl J" first="Jindrich" last="Cinatl">Jindrich Cinatl</name></author></analytic><series><title level="j">Journal of medicinal chemistry</title><idno type="ISSN">0022-2623</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (chemical synthesis)</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (pharmacology)</term><term>Chlorocebus aethiops</term><term>Glycyrrhizic Acid (analogs & derivatives)</term><term>Glycyrrhizic Acid (chemical synthesis)</term><term>Glycyrrhizic Acid (chemistry)</term><term>Glycyrrhizic Acid (pharmacology)</term><term>SARS Virus (drug effects)</term><term>SARS Virus (isolation & purification)</term><term>Structure-Activity Relationship</term><term>Vero Cells</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide glycyrrhizique ()</term><term>Acide glycyrrhizique (analogues et dérivés)</term><term>Acide glycyrrhizique (pharmacologie)</term><term>Acide glycyrrhizique (synthèse chimique)</term><term>Animaux</term><term>Antiviraux ()</term><term>Antiviraux (pharmacologie)</term><term>Antiviraux (synthèse chimique)</term><term>Cellules Vero</term><term>Relation structure-activité</term><term>Réplication virale ()</term><term>Virus du SRAS ()</term><term>Virus du SRAS (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Glycyrrhizic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Antiviral Agents</term><term>Glycyrrhizic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term><term>Glycyrrhizic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Glycyrrhizic Acid</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Acide glycyrrhizique</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>SARS Virus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acide glycyrrhizique</term><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Acide glycyrrhizique</term><term>Antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Structure-Activity Relationship</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acide glycyrrhizique</term><term>Animaux</term><term>Antiviraux</term><term>Cellules Vero</term><term>Relation structure-activité</term><term>Réplication virale</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Glycyrrhizin (GL) was shown to inhibit SARS-coronavirus (SARS-CoV) replication in vitro. Here the anti-SARS-CoV activity of 15 GL derivatives was tested. The introduction of 2-acetamido-beta-d-glucopyranosylamine into the glycoside chain of GL resulted in 10-fold increased anti-SARS-CoV activity compared to GL. Amides of GL and conjugates of GL with two amino acid residues and a free 30-COOH function presented up to 70-fold increased activity against SARS-CoV but also increased cytotoxicity resulting in decreased selectivity index.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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