Prediction of quaternary assembly of SARS coronavirus peplomer
Identifieur interne : 005202 ( Main/Exploration ); précédent : 005201; suivant : 005203Prediction of quaternary assembly of SARS coronavirus peplomer
Auteurs : Andrea Bernini [Italie] ; Ottavia Spiga [Italie] ; Arianna Ciutti [Italie] ; Stefano Chiellini [Italie] ; Luisa Bracci [Italie] ; Xiyun Yan [République populaire de Chine] ; Bojian Zheng [République populaire de Chine] ; Jiandong Huang [République populaire de Chine] ; Ming-Liang He [République populaire de Chine] ; Huai-Dong Song [République populaire de Chine] ; Pei Hao [République populaire de Chine] ; Guoping Zhao [République populaire de Chine] ; Neri Niccolai [Italie]Source :
- Biochemical and Biophysical Research Communications [ 0006-291X ] ; 2004.
Abstract
The tertiary structures of the S1 and S2 domains of the spike protein of the coronavirus which is responsible of the severe acute respiratory syndrome (SARS) have been recently predicted. Here a molecular assembly of SARS coronavirus peplomer which accounts for the available functional data is suggested. The interaction between S1 and S2 appears to be stabilised by a large hydrophobic network of aromatic side chains present in both domains. This feature results to be common to all coronaviruses, suggesting potential targeting for drugs preventing coronavirus-related infections.
Url:
DOI: 10.1016/j.bbrc.2004.10.156
PubMed: 15555555
PubMed Central: 7092937
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>The tertiary structures of the S1 and S2 domains of the spike protein of the coronavirus which is responsible of the severe acute respiratory syndrome (SARS) have been recently predicted. Here a molecular assembly of SARS coronavirus peplomer which accounts for the available functional data is suggested. The interaction between S1 and S2 appears to be stabilised by a large hydrophobic network of aromatic side chains present in both domains. This feature results to be common to all coronaviruses, suggesting potential targeting for drugs preventing coronavirus-related infections.</p>
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</back>
</TEI>
<affiliations><list><country><li>Italie</li>
<li>République populaire de Chine</li>
</country>
<settlement><li>Pékin</li>
</settlement>
</list>
<tree><country name="Italie"><noRegion><name sortKey="Bernini, Andrea" sort="Bernini, Andrea" uniqKey="Bernini A" first="Andrea" last="Bernini">Andrea Bernini</name>
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<name sortKey="Bracci, Luisa" sort="Bracci, Luisa" uniqKey="Bracci L" first="Luisa" last="Bracci">Luisa Bracci</name>
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<name sortKey="Spiga, Ottavia" sort="Spiga, Ottavia" uniqKey="Spiga O" first="Ottavia" last="Spiga">Ottavia Spiga</name>
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</tree>
</affiliations>
</record>
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