Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and deISGylating activities
Identifieur interne : 001612 ( Main/Exploration ); précédent : 001611; suivant : 001613Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and deISGylating activities
Auteurs : Anna M. Mielech [États-Unis] ; Yafang Chen [États-Unis] ; Andrew D. Mesecar [États-Unis] ; Susan C. Baker [États-Unis]Source :
- Virus Research [ 0168-1702 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- enzymologie : Nidovirales.
- métabolisme : Enzymes multifonctionnelles, Peptide hydrolases, Ubiquitin-specific proteases.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Multifunctional Enzymes, Peptide Hydrolases, Ubiquitin-Specific Proteases.
- enzymology : Nidovirales.
Abstract
Coronaviruses and arteriviruses encode papain-like protease domains that process the replicase polyprotein and are required for viral replication. Many viral papain-like proteases are multifunctional and have protease, deubiquitinating and deISGylating activity. Structural and enzymatic studies revealed the multifunctional nature of coronavirus and arterivirus papain-like proteases. Viral DUB and deISGylating activity is proposed to modulate the innate immune response. An arterivirus papain-like protease has been shown to modulate the innate immune response to viral infection.
Url:
DOI: 10.1016/j.virusres.2014.01.025
PubMed: 24512893
PubMed Central: 4125544
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><title>Highlights</title>
<p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label>
<p id="par0005">Coronaviruses and arteriviruses encode papain-like protease domains that process the replicase polyprotein and are required for viral replication.</p>
</list-item>
<list-item id="lsti0010"><label>•</label>
<p id="par0010">Many viral papain-like proteases are multifunctional and have protease, deubiquitinating and deISGylating activity.</p>
</list-item>
<list-item id="lsti0015"><label>•</label>
<p id="par0015">Structural and enzymatic studies revealed the multifunctional nature of coronavirus and arterivirus papain-like proteases.</p>
</list-item>
<list-item id="lsti0020"><label>•</label>
<p id="par0020">Viral DUB and deISGylating activity is proposed to modulate the innate immune response.</p>
</list-item>
<list-item id="lsti0025"><label>•</label>
<p id="par0025">An arterivirus papain-like protease has been shown to modulate the innate immune response to viral infection.</p>
</list-item>
</list>
</p>
</div>
</front>
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</back>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Illinois</li>
<li>Indiana</li>
</region>
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<tree><country name="États-Unis"><region name="Illinois"><name sortKey="Mielech, Anna M" sort="Mielech, Anna M" uniqKey="Mielech A" first="Anna M." last="Mielech">Anna M. Mielech</name>
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<name sortKey="Baker, Susan C" sort="Baker, Susan C" uniqKey="Baker S" first="Susan C." last="Baker">Susan C. Baker</name>
<name sortKey="Chen, Yafang" sort="Chen, Yafang" uniqKey="Chen Y" first="Yafang" last="Chen">Yafang Chen</name>
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