The spectrum of pathological changes in severe acute respiratory syndrome (SARS)
Identifieur interne : 005A48 ( Main/Exploration ); précédent : 005A47; suivant : 005A49The spectrum of pathological changes in severe acute respiratory syndrome (SARS)
Auteurs : O. Y. Cheune [Hong Kong] ; J. W. M. Chan [Hong Kong] ; C. K. Ng [Hong Kong] ; C. K. Koo [Hong Kong]Source :
- Histopathology [ 0309-0167 ] ; 2004.
Descripteurs français
- Pascal (Inist)
English descriptors
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Abstract
Aims: To analyse the lung pathology of severe acute respiratory syndrome (SARS) and correlate the findings with the time sequence of the disease. Methods and results: Ten patients with a clinical diagnosis of SARS, and virological confirmation of SARS coronavirus infection were identified. Histology in most cases showed diffuse alveolar damage, from early to late phases, and the changes corresponded to the time sequence. Other variable features include multinucleated giant cells, pneumocytes with cytomegaly and variable amounts of inflammatory cells and foamy macrophages. One case showed superimposed bronchopneumonia. No viral inclusions were found. Coronavirus particles were identified in pneumocytes by electron microscopy. Conclusions: The predominant pathological process of SARS is diffuse alveolar damage and, in patients who die from the disease, there is evidence of organization and fibrosis. There are apparently no histological features specific for this disease, and the aetiological diagnosis depends on virological and ultrastructural studies.
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Chan</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, Queen Elizabeth Hospital</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Medicine, Queen Elizabeth Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Ng, C K" sort="Ng, C K" uniqKey="Ng C" first="C. K." last="Ng">C. K. Ng</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, Queen Elizabeth Hospital</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Medicine, Queen Elizabeth Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Koo, C K" sort="Koo, C K" uniqKey="Koo C" first="C. K." last="Koo">C. K. Koo</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Intensive Care Unit, Queen Elizabeth Hospital</s1><s3>HKG</s3><sZ>4 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Intensive Care Unit, Queen Elizabeth Hospital</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">04-0439506</idno><date when="2004">2004</date><idno type="stanalyst">PASCAL 04-0439506 INIST</idno><idno type="RBID">Pascal:04-0439506</idno><idno type="wicri:Area/PascalFrancis/Corpus">000831</idno><idno type="wicri:Area/PascalFrancis/Curation">000159</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000746</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000746</idno><idno type="wicri:doubleKey">0309-0167:2004:Cheune O:the:spectrum:of</idno><idno type="wicri:Area/Main/Merge">005E97</idno><idno type="wicri:Area/Main/Curation">005A48</idno><idno type="wicri:Area/Main/Exploration">005A48</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The spectrum of pathological changes in severe acute respiratory syndrome (SARS)</title><author><name sortKey="Cheune, O Y" sort="Cheune, O Y" uniqKey="Cheune O" first="O. Y." last="Cheune">O. Y. Cheune</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology, Queen Elizabeth Hospital</s1><s3>HKG</s3><sZ>1 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Pathology, Queen Elizabeth Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Chan, J W M" sort="Chan, J W M" uniqKey="Chan J" first="J. W. M." last="Chan">J. W. M. Chan</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, Queen Elizabeth Hospital</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Medicine, Queen Elizabeth Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Ng, C K" sort="Ng, C K" uniqKey="Ng C" first="C. K." last="Ng">C. K. Ng</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, Queen Elizabeth Hospital</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Medicine, Queen Elizabeth Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Koo, C K" sort="Koo, C K" uniqKey="Koo C" first="C. K." last="Koo">C. K. Koo</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Intensive Care Unit, Queen Elizabeth Hospital</s1><s3>HKG</s3><sZ>4 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Intensive Care Unit, Queen Elizabeth Hospital</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Histopathology</title><title level="j" type="abbreviated">Histopathology</title><idno type="ISSN">0309-0167</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Histopathology</title><title level="j" type="abbreviated">Histopathology</title><idno type="ISSN">0309-0167</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anatomic pathology</term><term>Coronavirus</term><term>Diffuse</term><term>Lesion</term><term>Severe acute respiratory syndrome</term><term>Spectrum</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Spectre</term><term>Syndrome respiratoire aigu sévère</term><term>Coronavirus</term><term>Diffus</term><term>Lésion</term><term>Anatomopathologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aims: To analyse the lung pathology of severe acute respiratory syndrome (SARS) and correlate the findings with the time sequence of the disease. Methods and results: Ten patients with a clinical diagnosis of SARS, and virological confirmation of SARS coronavirus infection were identified. Histology in most cases showed diffuse alveolar damage, from early to late phases, and the changes corresponded to the time sequence. Other variable features include multinucleated giant cells, pneumocytes with cytomegaly and variable amounts of inflammatory cells and foamy macrophages. One case showed superimposed bronchopneumonia. No viral inclusions were found. Coronavirus particles were identified in pneumocytes by electron microscopy. Conclusions: The predominant pathological process of SARS is diffuse alveolar damage and, in patients who die from the disease, there is evidence of organization and fibrosis. There are apparently no histological features specific for this disease, and the aetiological diagnosis depends on virological and ultrastructural studies.</div></front></TEI><affiliations><list><country><li>Hong Kong</li></country></list><tree><country name="Hong Kong"><noRegion><name sortKey="Cheune, O Y" sort="Cheune, O Y" uniqKey="Cheune O" first="O. Y." last="Cheune">O. Y. Cheune</name></noRegion><name sortKey="Chan, J W M" sort="Chan, J W M" uniqKey="Chan J" first="J. W. M." last="Chan">J. W. M. Chan</name><name sortKey="Koo, C K" sort="Koo, C K" uniqKey="Koo C" first="C. K." last="Koo">C. K. Koo</name><name sortKey="Ng, C K" sort="Ng, C K" uniqKey="Ng C" first="C. K." last="Ng">C. K. Ng</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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