SrasV1, PascalFrancis, Checkpoint, bibRecord, 000746

The spectrum of pathological changes in severe acute respiratory syndrome (SARS)

Identifieur interne : 000746 ( PascalFrancis/Checkpoint ); précédent : 000745; suivant : 000747

The spectrum of pathological changes in severe acute respiratory syndrome (SARS)

Auteurs : O. Y. Cheune [Hong Kong] ; J. W. M. Chan [Hong Kong] ; C. K. Ng [Hong Kong] ; C. K. Koo [Hong Kong]

Source :

Histopathology [ 0309-0167 ] ; 2004.

RBID : Pascal:04-0439506

Descripteurs français

Pascal (Inist)
- Spectre, Syndrome respiratoire aigu sévère, Coronavirus, Diffus, Lésion, Anatomopathologie.

English descriptors

KwdEn :
- Anatomic pathology, Coronavirus, Diffuse, Lesion, Severe acute respiratory syndrome, Spectrum.

Abstract

Aims: To analyse the lung pathology of severe acute respiratory syndrome (SARS) and correlate the findings with the time sequence of the disease. Methods and results: Ten patients with a clinical diagnosis of SARS, and virological confirmation of SARS coronavirus infection were identified. Histology in most cases showed diffuse alveolar damage, from early to late phases, and the changes corresponded to the time sequence. Other variable features include multinucleated giant cells, pneumocytes with cytomegaly and variable amounts of inflammatory cells and foamy macrophages. One case showed superimposed bronchopneumonia. No viral inclusions were found. Coronavirus particles were identified in pneumocytes by electron microscopy. Conclusions: The predominant pathological process of SARS is diffuse alveolar damage and, in patients who die from the disease, there is evidence of organization and fibrosis. There are apparently no histological features specific for this disease, and the aetiological diagnosis depends on virological and ultrastructural studies.

Affiliations:

Hong Kong

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Le document en format XML

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The spectrum of pathological changes in severe acute respiratory syndrome (SARS)

The spectrum of pathological changes in severe acute respiratory syndrome (SARS)

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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