Characterization of severe acute respiratory syndrome coronavirus genomes in Taiwan: Molecular epidemiology and genome evolution
Identifieur interne : 005428 ( Main/Exploration ); précédent : 005427; suivant : 005429Characterization of severe acute respiratory syndrome coronavirus genomes in Taiwan: Molecular epidemiology and genome evolution
Auteurs : Shiou-Hwei Yeh [Taïwan] ; Hurng-Yi Wang [Taïwan] ; Ching-Yi Tsai ; Chuan-Liang Kao [Taïwan] ; Jyh-Yuan Yang [Taïwan] ; Hwan-Wun Liu [Taïwan] ; Ih-Jen Su [Taïwan] ; Shih-Feng Tsai [Taïwan] ; Ding-Shinn Chen [Taïwan] ; Pei-Jer Chen [Taïwan]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2004.
Descripteurs français
- KwdFr :
- ADN viral (), ADN viral (génétique), ARN viral (génétique), Appariement de bases, Données de séquences moléculaires, Génome viral, Humains, Mutation, Phylogénie, Réaction de polymérisation en chaîne (), Syndrome respiratoire aigu sévère (épidémiologie), Séquence nucléotidique, Taïwan (épidémiologie), Virus du SRAS (), Virus du SRAS (génétique), Virus du SRAS (isolement et purification), Évolution moléculaire.
- MESH :
- génétique : ADN viral, ARN viral, Virus du SRAS.
- isolement et purification : Virus du SRAS.
- épidémiologie : Syndrome respiratoire aigu sévère, Taïwan.
- ADN viral, Appariement de bases, Données de séquences moléculaires, Génome viral, Humains, Mutation, Phylogénie, Réaction de polymérisation en chaîne, Séquence nucléotidique, Virus du SRAS, Évolution moléculaire.
- Wicri :
- geographic : Taïwan.
English descriptors
- KwdEn :
- Base Pairing, Base Sequence, DNA, Viral (chemistry), DNA, Viral (genetics), Evolution, Molecular, Genome, Viral, Humans, Molecular Sequence Data, Mutation, Phylogeny, Polymerase Chain Reaction (methods), RNA, Viral (genetics), SARS Virus (classification), SARS Virus (genetics), SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (epidemiology), Taiwan (epidemiology).
- MESH :
- chemical , chemistry : DNA, Viral.
- chemical , genetics : DNA, Viral, RNA, Viral.
- geographic , epidemiology : Taiwan.
- classification : SARS Virus.
- epidemiology : Severe Acute Respiratory Syndrome.
- genetics : SARS Virus.
- isolation & purification : SARS Virus.
- methods : Polymerase Chain Reaction.
- Base Pairing, Base Sequence, Evolution, Molecular, Genome, Viral, Humans, Molecular Sequence Data, Mutation, Phylogeny.
Abstract
Since early March 2003, the severe acute respiratory syndrome (SARS) coronavirus (CoV) infection has claimed 346 cases and 37 deaths in Taiwan. The epidemic occurred in two stages. The first stage caused limited familial or hospital infections and lasted from early March to mid-April. All cases had clear contact histories, primarily from Guangdong or Hong Kong. The second stage resulted in a large outbreak in a municipal hospital, and quickly spread to northern and southern Taiwan from late April to mid-June. During this stage, there were some sporadic cases with untraceable contact histories. To investigate the origin and transmission route of SARS-CoV in Taiwan's epidemic, we conducted a systematic viral lineage study by sequencing the entire viral genome from ten SARS patients. SARS-CoV viruses isolated from Taiwan were found closely related to those from Guangdong and Hong Kong. In addition, all cases from the second stage belonged to the same lineage after the municipal hospital outbreak, including the patients without an apparent contact history. Analyses of these full-length sequences showed a positive selection occurring during SARS-CoV virus evolution. The mismatch distribution indicated that SARS viral genomes did not reach equilibrium and suggested a recent introduction of the viruses into human populations. The estimated genome mutation rate was ≈0.1 per genome, demonstrating possibly one of the lowest rates among known RNA viruses.
Url:
DOI: 10.1073/pnas.0307904100
PubMed: 14983045
PubMed Central: 356986
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000742
- to stream Pmc, to step Curation: 000742
- to stream Pmc, to step Checkpoint: 001716
- to stream PubMed, to step Corpus: 002F42
- to stream PubMed, to step Curation: 002F42
- to stream PubMed, to step Checkpoint: 002D94
- to stream Ncbi, to step Merge: 000623
- to stream Ncbi, to step Curation: 000623
- to stream Ncbi, to step Checkpoint: 000623
- to stream Main, to step Merge: 005866
- to stream Main, to step Curation: 005428
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characterization of severe acute respiratory syndrome coronavirus genomes in Taiwan: Molecular epidemiology and genome evolution</title><author><name sortKey="Yeh, Shiou Hwei" sort="Yeh, Shiou Hwei" uniqKey="Yeh S" first="Shiou-Hwei" last="Yeh">Shiou-Hwei Yeh</name><affiliation wicri:level="1"><nlm:aff id="N0x9b670c8.0xa22b5a0">Division of Molecular and Genomic Medicine, National Health Research Institutes, Taipei 115, Taiwan;</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Division of Molecular and Genomic Medicine, National Health Research Institutes, Taipei 115</wicri:regionArea><wicri:noRegion>Taipei 115</wicri:noRegion></affiliation><affiliation><nlm:aff wicri:cut=" and" id="N0x9b670c8.0xa22b5a0">Hepatitis Research Center</nlm:aff></affiliation></author><author><name sortKey="Wang, Hurng Yi" sort="Wang, Hurng Yi" uniqKey="Wang H" first="Hurng-Yi" last="Wang">Hurng-Yi Wang</name><affiliation wicri:level="1"><nlm:aff id="N0x9b670c8.0xa22b5a0">Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan;</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Molecular Biology, Academia Sinica, Taipei 115</wicri:regionArea><wicri:noRegion>Taipei 115</wicri:noRegion></affiliation></author><author><name sortKey="Tsai, Ching Yi" sort="Tsai, Ching Yi" uniqKey="Tsai C" first="Ching-Yi" last="Tsai">Ching-Yi Tsai</name><affiliation><nlm:aff wicri:cut=" and" id="N0x9b670c8.0xa22b5a0">Hepatitis Research Center</nlm:aff></affiliation></author><author><name sortKey="Kao, Chuan Liang" sort="Kao, Chuan Liang" uniqKey="Kao C" first="Chuan-Liang" last="Kao">Chuan-Liang Kao</name><affiliation wicri:level="1"><nlm:aff id="N0x9b670c8.0xa22b5a0">Department of Medical Technology, National Taiwan University, Taipei 100, Taiwan;</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medical Technology, National Taiwan University, Taipei 100</wicri:regionArea><wicri:noRegion>Taipei 100</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Jyh Yuan" sort="Yang, Jyh Yuan" uniqKey="Yang J" first="Jyh-Yuan" last="Yang">Jyh-Yuan Yang</name><affiliation wicri:level="1"><nlm:aff id="N0x9b670c8.0xa22b5a0">Center for Disease Control, Taipei 115, Taiwan;</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Center for Disease Control, Taipei 115</wicri:regionArea><wicri:noRegion>Taipei 115</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Hwan Wun" sort="Liu, Hwan Wun" uniqKey="Liu H" first="Hwan-Wun" last="Liu">Hwan-Wun Liu</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="N0x9b670c8.0xa22b5a0">Institute of Preventive Medicine, National Defense Medical College, Taipei 237, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Preventive Medicine, National Defense Medical College, Taipei 237</wicri:regionArea><wicri:noRegion>Taipei 237</wicri:noRegion></affiliation></author><author><name sortKey="Su, Ih Jen" sort="Su, Ih Jen" uniqKey="Su I" first="Ih-Jen" last="Su">Ih-Jen Su</name><affiliation wicri:level="1"><nlm:aff id="N0x9b670c8.0xa22b5a0">Center for Disease Control, Taipei 115, Taiwan;</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Center for Disease Control, Taipei 115</wicri:regionArea><wicri:noRegion>Taipei 115</wicri:noRegion></affiliation></author><author><name sortKey="Tsai, Shih Feng" sort="Tsai, Shih Feng" uniqKey="Tsai S" first="Shih-Feng" last="Tsai">Shih-Feng Tsai</name><affiliation wicri:level="1"><nlm:aff id="N0x9b670c8.0xa22b5a0">Division of Molecular and Genomic Medicine, National Health Research Institutes, Taipei 115, Taiwan;</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Division of Molecular and Genomic Medicine, National Health Research Institutes, Taipei 115</wicri:regionArea><wicri:noRegion>Taipei 115</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Ding Shinn" sort="Chen, Ding Shinn" uniqKey="Chen D" first="Ding-Shinn" last="Chen">Ding-Shinn Chen</name><affiliation><nlm:aff wicri:cut=" and" id="N0x9b670c8.0xa22b5a0">Hepatitis Research Center</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="N0x9b670c8.0xa22b5a0">Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan;</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, National Taiwan University Hospital, Taipei 100</wicri:regionArea><wicri:noRegion>Taipei 100</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="N0x9b670c8.0xa22b5a0">Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei 100, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei 100</wicri:regionArea><wicri:noRegion>Taipei 100</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Pei Jer" sort="Chen, Pei Jer" uniqKey="Chen P" first="Pei-Jer" last="Chen">Pei-Jer Chen</name><affiliation><nlm:aff wicri:cut=" and" id="N0x9b670c8.0xa22b5a0">Hepatitis Research Center</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="N0x9b670c8.0xa22b5a0">Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan;</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, National Taiwan University Hospital, Taipei 100</wicri:regionArea><wicri:noRegion>Taipei 100</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="N0x9b670c8.0xa22b5a0">Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei 100, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei 100</wicri:regionArea><wicri:noRegion>Taipei 100</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">14983045</idno><idno type="pmc">356986</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC356986</idno><idno type="RBID">PMC:356986</idno><idno type="doi">10.1073/pnas.0307904100</idno><date when="2004">2004</date><idno type="wicri:Area/Pmc/Corpus">000742</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000742</idno><idno type="wicri:Area/Pmc/Curation">000742</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000742</idno><idno type="wicri:Area/Pmc/Checkpoint">001716</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001716</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:14983045</idno><idno type="wicri:Area/PubMed/Corpus">002F42</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002F42</idno><idno type="wicri:Area/PubMed/Curation">002F42</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002F42</idno><idno type="wicri:Area/PubMed/Checkpoint">002D94</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002D94</idno><idno type="wicri:Area/Ncbi/Merge">000623</idno><idno type="wicri:Area/Ncbi/Curation">000623</idno><idno type="wicri:Area/Ncbi/Checkpoint">000623</idno><idno type="wicri:doubleKey">0027-8424:2004:Yeh S:characterization:of:severe</idno><idno type="wicri:Area/Main/Merge">005866</idno><idno type="wicri:Area/Main/Curation">005428</idno><idno type="wicri:Area/Main/Exploration">005428</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Characterization of severe acute respiratory syndrome coronavirus genomes in Taiwan: Molecular epidemiology and genome evolution</title><author><name sortKey="Yeh, Shiou Hwei" sort="Yeh, Shiou Hwei" uniqKey="Yeh S" first="Shiou-Hwei" last="Yeh">Shiou-Hwei Yeh</name><affiliation wicri:level="1"><nlm:aff id="N0x9b670c8.0xa22b5a0">Division of Molecular and Genomic Medicine, National Health Research Institutes, Taipei 115, Taiwan;</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Division of Molecular and Genomic Medicine, National Health Research Institutes, Taipei 115</wicri:regionArea><wicri:noRegion>Taipei 115</wicri:noRegion></affiliation><affiliation><nlm:aff wicri:cut=" and" id="N0x9b670c8.0xa22b5a0">Hepatitis Research Center</nlm:aff></affiliation></author><author><name sortKey="Wang, Hurng Yi" sort="Wang, Hurng Yi" uniqKey="Wang H" first="Hurng-Yi" last="Wang">Hurng-Yi Wang</name><affiliation wicri:level="1"><nlm:aff id="N0x9b670c8.0xa22b5a0">Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan;</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Molecular Biology, Academia Sinica, Taipei 115</wicri:regionArea><wicri:noRegion>Taipei 115</wicri:noRegion></affiliation></author><author><name sortKey="Tsai, Ching Yi" sort="Tsai, Ching Yi" uniqKey="Tsai C" first="Ching-Yi" last="Tsai">Ching-Yi Tsai</name><affiliation><nlm:aff wicri:cut=" and" id="N0x9b670c8.0xa22b5a0">Hepatitis Research Center</nlm:aff></affiliation></author><author><name sortKey="Kao, Chuan Liang" sort="Kao, Chuan Liang" uniqKey="Kao C" first="Chuan-Liang" last="Kao">Chuan-Liang Kao</name><affiliation wicri:level="1"><nlm:aff id="N0x9b670c8.0xa22b5a0">Department of Medical Technology, National Taiwan University, Taipei 100, Taiwan;</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medical Technology, National Taiwan University, Taipei 100</wicri:regionArea><wicri:noRegion>Taipei 100</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Jyh Yuan" sort="Yang, Jyh Yuan" uniqKey="Yang J" first="Jyh-Yuan" last="Yang">Jyh-Yuan Yang</name><affiliation wicri:level="1"><nlm:aff id="N0x9b670c8.0xa22b5a0">Center for Disease Control, Taipei 115, Taiwan;</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Center for Disease Control, Taipei 115</wicri:regionArea><wicri:noRegion>Taipei 115</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Hwan Wun" sort="Liu, Hwan Wun" uniqKey="Liu H" first="Hwan-Wun" last="Liu">Hwan-Wun Liu</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="N0x9b670c8.0xa22b5a0">Institute of Preventive Medicine, National Defense Medical College, Taipei 237, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Preventive Medicine, National Defense Medical College, Taipei 237</wicri:regionArea><wicri:noRegion>Taipei 237</wicri:noRegion></affiliation></author><author><name sortKey="Su, Ih Jen" sort="Su, Ih Jen" uniqKey="Su I" first="Ih-Jen" last="Su">Ih-Jen Su</name><affiliation wicri:level="1"><nlm:aff id="N0x9b670c8.0xa22b5a0">Center for Disease Control, Taipei 115, Taiwan;</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Center for Disease Control, Taipei 115</wicri:regionArea><wicri:noRegion>Taipei 115</wicri:noRegion></affiliation></author><author><name sortKey="Tsai, Shih Feng" sort="Tsai, Shih Feng" uniqKey="Tsai S" first="Shih-Feng" last="Tsai">Shih-Feng Tsai</name><affiliation wicri:level="1"><nlm:aff id="N0x9b670c8.0xa22b5a0">Division of Molecular and Genomic Medicine, National Health Research Institutes, Taipei 115, Taiwan;</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Division of Molecular and Genomic Medicine, National Health Research Institutes, Taipei 115</wicri:regionArea><wicri:noRegion>Taipei 115</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Ding Shinn" sort="Chen, Ding Shinn" uniqKey="Chen D" first="Ding-Shinn" last="Chen">Ding-Shinn Chen</name><affiliation><nlm:aff wicri:cut=" and" id="N0x9b670c8.0xa22b5a0">Hepatitis Research Center</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="N0x9b670c8.0xa22b5a0">Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan;</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, National Taiwan University Hospital, Taipei 100</wicri:regionArea><wicri:noRegion>Taipei 100</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="N0x9b670c8.0xa22b5a0">Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei 100, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei 100</wicri:regionArea><wicri:noRegion>Taipei 100</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Pei Jer" sort="Chen, Pei Jer" uniqKey="Chen P" first="Pei-Jer" last="Chen">Pei-Jer Chen</name><affiliation><nlm:aff wicri:cut=" and" id="N0x9b670c8.0xa22b5a0">Hepatitis Research Center</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="N0x9b670c8.0xa22b5a0">Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan;</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, National Taiwan University Hospital, Taipei 100</wicri:regionArea><wicri:noRegion>Taipei 100</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="N0x9b670c8.0xa22b5a0">Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei 100, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei 100</wicri:regionArea><wicri:noRegion>Taipei 100</wicri:noRegion></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Base Pairing</term><term>Base Sequence</term><term>DNA, Viral (chemistry)</term><term>DNA, Viral (genetics)</term><term>Evolution, Molecular</term><term>Genome, Viral</term><term>Humans</term><term>Molecular Sequence Data</term><term>Mutation</term><term>Phylogeny</term><term>Polymerase Chain Reaction (methods)</term><term>RNA, Viral (genetics)</term><term>SARS Virus (classification)</term><term>SARS Virus (genetics)</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Taiwan (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN viral ()</term><term>ADN viral (génétique)</term><term>ARN viral (génétique)</term><term>Appariement de bases</term><term>Données de séquences moléculaires</term><term>Génome viral</term><term>Humains</term><term>Mutation</term><term>Phylogénie</term><term>Réaction de polymérisation en chaîne ()</term><term>Syndrome respiratoire aigu sévère (épidémiologie)</term><term>Séquence nucléotidique</term><term>Taïwan (épidémiologie)</term><term>Virus du SRAS ()</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (isolement et purification)</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Viral</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Taiwan</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN viral</term><term>ARN viral</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term><term>Taïwan</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Base Pairing</term><term>Base Sequence</term><term>Evolution, Molecular</term><term>Genome, Viral</term><term>Humans</term><term>Molecular Sequence Data</term><term>Mutation</term><term>Phylogeny</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ADN viral</term><term>Appariement de bases</term><term>Données de séquences moléculaires</term><term>Génome viral</term><term>Humains</term><term>Mutation</term><term>Phylogénie</term><term>Réaction de polymérisation en chaîne</term><term>Séquence nucléotidique</term><term>Virus du SRAS</term><term>Évolution moléculaire</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Taïwan</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Since early March 2003, the severe acute respiratory syndrome (SARS) coronavirus (CoV) infection has claimed 346 cases and 37 deaths in Taiwan. The epidemic occurred in two stages. The first stage caused limited familial or hospital infections and lasted from early March to mid-April. All cases had clear contact histories, primarily from Guangdong or Hong Kong. The second stage resulted in a large outbreak in a municipal hospital, and quickly spread to northern and southern Taiwan from late April to mid-June. During this stage, there were some sporadic cases with untraceable contact histories. To investigate the origin and transmission route of SARS-CoV in Taiwan's epidemic, we conducted a systematic viral lineage study by sequencing the entire viral genome from ten SARS patients. SARS-CoV viruses isolated from Taiwan were found closely related to those from Guangdong and Hong Kong. In addition, all cases from the second stage belonged to the same lineage after the municipal hospital outbreak, including the patients without an apparent contact history. Analyses of these full-length sequences showed a positive selection occurring during SARS-CoV virus evolution. The mismatch distribution indicated that SARS viral genomes did not reach equilibrium and suggested a recent introduction of the viruses into human populations. The estimated genome mutation rate was ≈0.1 per genome, demonstrating possibly one of the lowest rates among known RNA viruses.</p></div></front></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><noCountry><name sortKey="Tsai, Ching Yi" sort="Tsai, Ching Yi" uniqKey="Tsai C" first="Ching-Yi" last="Tsai">Ching-Yi Tsai</name></noCountry><country name="Taïwan"><noRegion><name sortKey="Yeh, Shiou Hwei" sort="Yeh, Shiou Hwei" uniqKey="Yeh S" first="Shiou-Hwei" last="Yeh">Shiou-Hwei Yeh</name></noRegion><name sortKey="Chen, Ding Shinn" sort="Chen, Ding Shinn" uniqKey="Chen D" first="Ding-Shinn" last="Chen">Ding-Shinn Chen</name><name sortKey="Chen, Ding Shinn" sort="Chen, Ding Shinn" uniqKey="Chen D" first="Ding-Shinn" last="Chen">Ding-Shinn Chen</name><name sortKey="Chen, Pei Jer" sort="Chen, Pei Jer" uniqKey="Chen P" first="Pei-Jer" last="Chen">Pei-Jer Chen</name><name sortKey="Chen, Pei Jer" sort="Chen, Pei Jer" uniqKey="Chen P" first="Pei-Jer" last="Chen">Pei-Jer Chen</name><name sortKey="Kao, Chuan Liang" sort="Kao, Chuan Liang" uniqKey="Kao C" first="Chuan-Liang" last="Kao">Chuan-Liang Kao</name><name sortKey="Liu, Hwan Wun" sort="Liu, Hwan Wun" uniqKey="Liu H" first="Hwan-Wun" last="Liu">Hwan-Wun Liu</name><name sortKey="Su, Ih Jen" sort="Su, Ih Jen" uniqKey="Su I" first="Ih-Jen" last="Su">Ih-Jen Su</name><name sortKey="Tsai, Shih Feng" sort="Tsai, Shih Feng" uniqKey="Tsai S" first="Shih-Feng" last="Tsai">Shih-Feng Tsai</name><name sortKey="Wang, Hurng Yi" sort="Wang, Hurng Yi" uniqKey="Wang H" first="Hurng-Yi" last="Wang">Hurng-Yi Wang</name><name sortKey="Yang, Jyh Yuan" sort="Yang, Jyh Yuan" uniqKey="Yang J" first="Jyh-Yuan" last="Yang">Jyh-Yuan Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005428 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005428 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:356986
|texte= Characterization of severe acute respiratory syndrome coronavirus genomes in Taiwan: Molecular epidemiology and genome evolution
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:14983045" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |