Programmed -1 ribosomal frameshifting in the SARS coronavirus.
Identifieur interne : 005185 ( Main/Exploration ); précédent : 005184; suivant : 005186Programmed -1 ribosomal frameshifting in the SARS coronavirus.
Auteurs : F. Dos Ramos [Royaume-Uni] ; M. Carrasco ; T. Doyle ; I. BrierleySource :
- Biochemical Society transactions [ 0300-5127 ] ; 2004.
Descripteurs français
- KwdFr :
- Cadres ouverts de lecture (génétique), Conformation d'acide nucléique, Données de séquences moléculaires, Génome viral, Mutation avec décalage du cadre de lecture (génétique), Ribosomes (génétique), Séquence d'acides aminés, Séquence nucléotidique, Transduction du signal (génétique), Virus du SRAS (génétique).
- MESH :
English descriptors
- KwdEn :
- MESH :
Abstract
Programmed -1 ribosomal frameshifting is an alternate mechanism of translation used by coronavirus to synthesize replication proteins encoded by two overlapping open reading frames. For some coronaviruses, the mRNA cis-acting stimulatory structures involved in this process have been characterized, but their precise contribution to ribosomal frameshifting is not completely understood. Recently, a novel coronavirus was identified as the causative agent of the severe acute respiratory syndrome. This review describes the mRNA motifs involved in programmed -1 ribosomal frameshifting in this virus.
DOI: 10.1042/BST0321081
PubMed: 15506971
Affiliations:
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Le document en format XML
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<term>Molecular Sequence Data</term>
<term>Nucleic Acid Conformation</term>
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<term>Ribosomes (genetics)</term>
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<term>Génome viral</term>
<term>Mutation avec décalage du cadre de lecture (génétique)</term>
<term>Ribosomes (génétique)</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>Transduction du signal (génétique)</term>
<term>Virus du SRAS (génétique)</term>
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<term>Signal Transduction</term>
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<term>Données de séquences moléculaires</term>
<term>Génome viral</term>
<term>Séquence d'acides aminés</term>
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<front><div type="abstract" xml:lang="en">Programmed -1 ribosomal frameshifting is an alternate mechanism of translation used by coronavirus to synthesize replication proteins encoded by two overlapping open reading frames. For some coronaviruses, the mRNA cis-acting stimulatory structures involved in this process have been characterized, but their precise contribution to ribosomal frameshifting is not completely understood. Recently, a novel coronavirus was identified as the causative agent of the severe acute respiratory syndrome. This review describes the mRNA motifs involved in programmed -1 ribosomal frameshifting in this virus.</div>
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<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Dos Ramos, F" sort="Dos Ramos, F" uniqKey="Dos Ramos F" first="F" last="Dos Ramos">F. Dos Ramos</name>
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