Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases
Identifieur interne : 004D68 ( Main/Exploration ); précédent : 004D67; suivant : 004D69Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases
Auteurs : XUEYING SHI [République populaire de Chine] ; ENCONG GONG ; DONGXIA GAO ; BO ZHANG ; JIE ZHENG ; ZIFEN GAO ; YANFENG ZHONG ; WANZHONG ZOU ; BINGQUAN WU ; WEIGANG FANG ; SONGLIN LIAO ; SHENGLAN WANG ; ZHIGANG XIE ; MIN LU ; LIN HOU ; HAOHAO ZHONG ; HONGQUAN SHAO ; NING LI ; CONGRONG LIU ; FEI PEI ; JINGPING YANG ; YUPING WANG ; ZHIHUI HAN ; XIAOHONG SHI ; QIANYING ZHANG ; JIANGFENG YOU ; XIANG ZHU ; JIANG GUSource :
- The American journal of gastroenterology [ 0002-9270 ] ; 2005.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
OBJECTIVES: A significant percentage of confirmed severe acute respiratory syndrome (SARS) patients experienced gastrointestinal symptoms, and the viral sequence was detectable in the stool of most patients. At present, the knowledge of the pathology of the digestive system in SARS patients is limited. Because a resurgence of the SARS epidemic is constantly possible, there is an urgent need to understand the involvement of the digestive system in this new disease. METHODS: We performed seven SARS autopsies in which samples of alimentary tract and digestive glands were examined with routine pathology, electron microscopy (EM), in situ hybridization (ISH), immunohistochemistry, and real-time polymerase chain reaction (PCR). RESULTS: The main histopathological finding was atrophy of the mucosal lymphoid tissue. A few mucosal epithelial cells and lymphocytes in the intestine were positively stained for coronavirus with ISH. SARS-coronavirus (CoV)-like particles were found in the mucosal epithelial cells under EM and mild focal inflammation was detected in the alimentary tract. One patient who experienced severe diarrhea had pseudomembranous enteritis of the ileum. Fatty degeneration and central lobular necrosis were observed in the liver. No evidence of direct viral infection was found in the esophagus, the stomach, the salivary gland, the liver, or the pancreas. CONCLUSIONS: In addition to the lungs, the gastrointestinal tract is another target of SARS-CoV infection, as the intestinal epithelial cells and mucosal lymphoid tissue are infected. The findings provide possible explanations for the gastrointestinal symptoms and the presence of virus in the stool of SARS patients.
Affiliations:
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Hospital</s1><s2>Beijing</s2><s3>CHN</s3></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Encong Gong" sort="Encong Gong" uniqKey="Encong Gong" last="Encong Gong">ENCONG GONG</name></author><author><name sortKey="Dongxia Gao" sort="Dongxia Gao" uniqKey="Dongxia Gao" last="Dongxia Gao">DONGXIA GAO</name></author><author><name sortKey="Bo Zhang" sort="Bo Zhang" uniqKey="Bo Zhang" last="Bo Zhang">BO ZHANG</name></author><author><name sortKey="Jie Zheng" sort="Jie Zheng" uniqKey="Jie Zheng" last="Jie Zheng">JIE ZHENG</name></author><author><name sortKey="Zifen Gao" sort="Zifen Gao" uniqKey="Zifen Gao" last="Zifen Gao">ZIFEN GAO</name></author><author><name sortKey="Yanfeng Zhong" sort="Yanfeng Zhong" uniqKey="Yanfeng Zhong" last="Yanfeng Zhong">YANFENG ZHONG</name></author><author><name sortKey="Wanzhong Zou" sort="Wanzhong Zou" uniqKey="Wanzhong Zou" last="Wanzhong 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ZHONG</name></author><author><name sortKey="Hongquan Shao" sort="Hongquan Shao" uniqKey="Hongquan Shao" last="Hongquan Shao">HONGQUAN SHAO</name></author><author><name sortKey="Ning Li" sort="Ning Li" uniqKey="Ning Li" last="Ning Li">NING LI</name></author><author><name sortKey="Congrong Liu" sort="Congrong Liu" uniqKey="Congrong Liu" last="Congrong Liu">CONGRONG LIU</name></author><author><name sortKey="Fei Pei" sort="Fei Pei" uniqKey="Fei Pei" last="Fei Pei">FEI PEI</name></author><author><name sortKey="Jingping Yang" sort="Jingping Yang" uniqKey="Jingping Yang" last="Jingping Yang">JINGPING YANG</name></author><author><name sortKey="Yuping Wang" sort="Yuping Wang" uniqKey="Yuping Wang" last="Yuping Wang">YUPING WANG</name></author><author><name sortKey="Zhihui Han" sort="Zhihui Han" uniqKey="Zhihui Han" last="Zhihui Han">ZHIHUI HAN</name></author><author><name sortKey="Xiaohong Shi" sort="Xiaohong Shi" uniqKey="Xiaohong Shi" last="Xiaohong Shi">XIAOHONG SHI</name></author><author><name sortKey="Qianying Zhang" sort="Qianying Zhang" uniqKey="Qianying Zhang" last="Qianying Zhang">QIANYING ZHANG</name></author><author><name sortKey="Jiangfeng You" sort="Jiangfeng You" uniqKey="Jiangfeng You" last="Jiangfeng You">JIANGFENG YOU</name></author><author><name sortKey="Xiang Zhu" sort="Xiang Zhu" uniqKey="Xiang Zhu" last="Xiang Zhu">XIANG ZHU</name></author><author><name sortKey="Jiang Gu" sort="Jiang Gu" uniqKey="Jiang Gu" last="Jiang Gu">JIANG GU</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0180762</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 05-0180762 INIST</idno><idno type="RBID">Pascal:05-0180762</idno><idno type="wicri:Area/PascalFrancis/Corpus">000704</idno><idno type="wicri:Area/PascalFrancis/Curation">000286</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000578</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000578</idno><idno type="wicri:doubleKey">0002-9270:2005:Xueying Shi:severe:acute:respiratory</idno><idno type="wicri:Area/Main/Merge">005098</idno><idno type="wicri:Area/Main/Curation">004D68</idno><idno type="wicri:Area/Main/Exploration">004D68</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases</title><author><name sortKey="Xueying Shi" sort="Xueying Shi" uniqKey="Xueying Shi" last="Xueying Shi">XUEYING SHI</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Pathology, Peking University Health Science Center</s1><s2>Beijing</s2><s3>CHN</s3></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Cancer Hospital, Peking University Health Science Center</s1><s2>Beijing</s2><s3>CHN</s3></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Beijing Ditan Hospital</s1><s2>Beijing</s2><s3>CHN</s3></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Encong Gong" sort="Encong Gong" uniqKey="Encong Gong" last="Encong Gong">ENCONG GONG</name></author><author><name sortKey="Dongxia Gao" sort="Dongxia Gao" uniqKey="Dongxia Gao" last="Dongxia Gao">DONGXIA GAO</name></author><author><name sortKey="Bo Zhang" sort="Bo Zhang" uniqKey="Bo Zhang" last="Bo Zhang">BO ZHANG</name></author><author><name sortKey="Jie Zheng" sort="Jie Zheng" uniqKey="Jie Zheng" last="Jie Zheng">JIE ZHENG</name></author><author><name sortKey="Zifen Gao" sort="Zifen Gao" uniqKey="Zifen Gao" last="Zifen Gao">ZIFEN GAO</name></author><author><name sortKey="Yanfeng Zhong" sort="Yanfeng Zhong" uniqKey="Yanfeng Zhong" last="Yanfeng Zhong">YANFENG ZHONG</name></author><author><name sortKey="Wanzhong Zou" sort="Wanzhong Zou" uniqKey="Wanzhong Zou" last="Wanzhong Zou">WANZHONG ZOU</name></author><author><name sortKey="Bingquan Wu" sort="Bingquan Wu" uniqKey="Bingquan Wu" last="Bingquan Wu">BINGQUAN WU</name></author><author><name sortKey="Weigang Fang" sort="Weigang Fang" uniqKey="Weigang Fang" last="Weigang Fang">WEIGANG FANG</name></author><author><name sortKey="Songlin Liao" sort="Songlin Liao" uniqKey="Songlin Liao" last="Songlin Liao">SONGLIN LIAO</name></author><author><name sortKey="Shenglan Wang" sort="Shenglan Wang" uniqKey="Shenglan Wang" last="Shenglan Wang">SHENGLAN WANG</name></author><author><name sortKey="Zhigang Xie" sort="Zhigang Xie" uniqKey="Zhigang Xie" last="Zhigang Xie">ZHIGANG XIE</name></author><author><name sortKey="Min Lu" sort="Min Lu" uniqKey="Min Lu" last="Min Lu">MIN LU</name></author><author><name sortKey="Lin Hou" sort="Lin Hou" uniqKey="Lin Hou" last="Lin Hou">LIN HOU</name></author><author><name sortKey="Haohao Zhong" sort="Haohao Zhong" uniqKey="Haohao Zhong" last="Haohao Zhong">HAOHAO ZHONG</name></author><author><name sortKey="Hongquan Shao" sort="Hongquan Shao" uniqKey="Hongquan Shao" last="Hongquan Shao">HONGQUAN SHAO</name></author><author><name sortKey="Ning Li" sort="Ning Li" uniqKey="Ning Li" last="Ning Li">NING LI</name></author><author><name sortKey="Congrong Liu" sort="Congrong Liu" uniqKey="Congrong Liu" last="Congrong Liu">CONGRONG LIU</name></author><author><name sortKey="Fei Pei" sort="Fei Pei" uniqKey="Fei Pei" last="Fei Pei">FEI PEI</name></author><author><name sortKey="Jingping Yang" sort="Jingping Yang" uniqKey="Jingping Yang" last="Jingping Yang">JINGPING YANG</name></author><author><name sortKey="Yuping Wang" sort="Yuping Wang" uniqKey="Yuping Wang" last="Yuping Wang">YUPING WANG</name></author><author><name sortKey="Zhihui Han" sort="Zhihui Han" uniqKey="Zhihui Han" last="Zhihui Han">ZHIHUI HAN</name></author><author><name sortKey="Xiaohong Shi" sort="Xiaohong Shi" uniqKey="Xiaohong Shi" last="Xiaohong Shi">XIAOHONG SHI</name></author><author><name sortKey="Qianying Zhang" sort="Qianying Zhang" uniqKey="Qianying Zhang" last="Qianying Zhang">QIANYING ZHANG</name></author><author><name sortKey="Jiangfeng You" sort="Jiangfeng You" uniqKey="Jiangfeng You" last="Jiangfeng You">JIANGFENG YOU</name></author><author><name sortKey="Xiang Zhu" sort="Xiang Zhu" uniqKey="Xiang Zhu" last="Xiang Zhu">XIANG ZHU</name></author><author><name sortKey="Jiang Gu" sort="Jiang Gu" uniqKey="Jiang Gu" last="Jiang Gu">JIANG GU</name></author></analytic><series><title level="j" type="main">The American journal of gastroenterology</title><title level="j" type="abbreviated">Am. j. gastroenterol.</title><idno type="ISSN">0002-9270</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The American journal of gastroenterology</title><title level="j" type="abbreviated">Am. j. gastroenterol.</title><idno type="ISSN">0002-9270</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus</term><term>Fatal course</term><term>Gut</term><term>Severe acute respiratory syndrome</term><term>Tissue</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term><term>Intestin</term><term>Tissu</term><term>Forme léthale</term><term>Coronavirus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">OBJECTIVES: A significant percentage of confirmed severe acute respiratory syndrome (SARS) patients experienced gastrointestinal symptoms, and the viral sequence was detectable in the stool of most patients. At present, the knowledge of the pathology of the digestive system in SARS patients is limited. Because a resurgence of the SARS epidemic is constantly possible, there is an urgent need to understand the involvement of the digestive system in this new disease. METHODS: We performed seven SARS autopsies in which samples of alimentary tract and digestive glands were examined with routine pathology, electron microscopy (EM), in situ hybridization (ISH), immunohistochemistry, and real-time polymerase chain reaction (PCR). RESULTS: The main histopathological finding was atrophy of the mucosal lymphoid tissue. A few mucosal epithelial cells and lymphocytes in the intestine were positively stained for coronavirus with ISH. SARS-coronavirus (CoV)-like particles were found in the mucosal epithelial cells under EM and mild focal inflammation was detected in the alimentary tract. One patient who experienced severe diarrhea had pseudomembranous enteritis of the ileum. Fatty degeneration and central lobular necrosis were observed in the liver. No evidence of direct viral infection was found in the esophagus, the stomach, the salivary gland, the liver, or the pancreas. CONCLUSIONS: In addition to the lungs, the gastrointestinal tract is another target of SARS-CoV infection, as the intestinal epithelial cells and mucosal lymphoid tissue are infected. The findings provide possible explanations for the gastrointestinal symptoms and the presence of virus in the stool of SARS patients.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><noCountry><name sortKey="Bingquan Wu" sort="Bingquan Wu" uniqKey="Bingquan Wu" last="Bingquan Wu">BINGQUAN WU</name><name sortKey="Bo Zhang" sort="Bo Zhang" uniqKey="Bo Zhang" last="Bo Zhang">BO ZHANG</name><name sortKey="Congrong Liu" sort="Congrong Liu" uniqKey="Congrong Liu" last="Congrong Liu">CONGRONG LIU</name><name sortKey="Dongxia Gao" sort="Dongxia Gao" uniqKey="Dongxia Gao" last="Dongxia Gao">DONGXIA GAO</name><name sortKey="Encong Gong" sort="Encong Gong" uniqKey="Encong Gong" last="Encong Gong">ENCONG GONG</name><name sortKey="Fei Pei" sort="Fei Pei" uniqKey="Fei Pei" last="Fei Pei">FEI PEI</name><name sortKey="Haohao Zhong" sort="Haohao Zhong" uniqKey="Haohao Zhong" last="Haohao Zhong">HAOHAO ZHONG</name><name sortKey="Hongquan Shao" sort="Hongquan Shao" uniqKey="Hongquan Shao" last="Hongquan Shao">HONGQUAN SHAO</name><name sortKey="Jiang Gu" sort="Jiang Gu" uniqKey="Jiang Gu" last="Jiang Gu">JIANG GU</name><name sortKey="Jiangfeng You" sort="Jiangfeng You" uniqKey="Jiangfeng You" last="Jiangfeng You">JIANGFENG YOU</name><name sortKey="Jie Zheng" sort="Jie Zheng" uniqKey="Jie Zheng" last="Jie Zheng">JIE ZHENG</name><name sortKey="Jingping Yang" sort="Jingping Yang" uniqKey="Jingping Yang" last="Jingping Yang">JINGPING YANG</name><name sortKey="Lin Hou" sort="Lin Hou" uniqKey="Lin Hou" last="Lin Hou">LIN HOU</name><name sortKey="Min Lu" sort="Min Lu" uniqKey="Min Lu" last="Min Lu">MIN LU</name><name sortKey="Ning Li" sort="Ning Li" uniqKey="Ning Li" last="Ning Li">NING LI</name><name sortKey="Qianying Zhang" sort="Qianying Zhang" uniqKey="Qianying Zhang" last="Qianying Zhang">QIANYING ZHANG</name><name sortKey="Shenglan Wang" sort="Shenglan Wang" uniqKey="Shenglan Wang" last="Shenglan Wang">SHENGLAN WANG</name><name sortKey="Songlin Liao" sort="Songlin Liao" uniqKey="Songlin Liao" last="Songlin Liao">SONGLIN LIAO</name><name sortKey="Wanzhong Zou" sort="Wanzhong Zou" uniqKey="Wanzhong Zou" last="Wanzhong Zou">WANZHONG ZOU</name><name sortKey="Weigang Fang" sort="Weigang Fang" uniqKey="Weigang Fang" last="Weigang Fang">WEIGANG FANG</name><name sortKey="Xiang Zhu" sort="Xiang Zhu" uniqKey="Xiang Zhu" last="Xiang Zhu">XIANG ZHU</name><name sortKey="Xiaohong Shi" sort="Xiaohong Shi" uniqKey="Xiaohong Shi" last="Xiaohong Shi">XIAOHONG SHI</name><name sortKey="Yanfeng Zhong" sort="Yanfeng Zhong" uniqKey="Yanfeng Zhong" last="Yanfeng Zhong">YANFENG ZHONG</name><name sortKey="Yuping Wang" sort="Yuping Wang" uniqKey="Yuping Wang" last="Yuping Wang">YUPING WANG</name><name sortKey="Zhigang Xie" sort="Zhigang Xie" uniqKey="Zhigang Xie" last="Zhigang Xie">ZHIGANG XIE</name><name sortKey="Zhihui Han" sort="Zhihui Han" uniqKey="Zhihui Han" last="Zhihui Han">ZHIHUI HAN</name><name sortKey="Zifen Gao" sort="Zifen Gao" uniqKey="Zifen Gao" last="Zifen Gao">ZIFEN GAO</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Xueying Shi" sort="Xueying Shi" uniqKey="Xueying Shi" last="Xueying Shi">XUEYING SHI</name></noRegion><name sortKey="Xueying Shi" sort="Xueying Shi" uniqKey="Xueying Shi" last="Xueying Shi">XUEYING SHI</name><name sortKey="Xueying Shi" sort="Xueying Shi" uniqKey="Xueying Shi" last="Xueying Shi">XUEYING SHI</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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