SrasV1, PascalFrancis, Corpus, bibRecord, 000704

Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases

Identifieur interne : 000704 ( PascalFrancis/Corpus ); précédent : 000703; suivant : 000705

Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases

Auteurs : XUEYING SHI ; ENCONG GONG ; DONGXIA GAO ; BO ZHANG ; JIE ZHENG ; ZIFEN GAO ; YANFENG ZHONG ; WANZHONG ZOU ; BINGQUAN WU ; WEIGANG FANG ; SONGLIN LIAO ; SHENGLAN WANG ; ZHIGANG XIE ; MIN LU ; LIN HOU ; HAOHAO ZHONG ; HONGQUAN SHAO ; NING LI ; CONGRONG LIU ; FEI PEI ; JINGPING YANG ; YUPING WANG ; ZHIHUI HAN ; XIAOHONG SHI ; QIANYING ZHANG ; JIANGFENG YOU ; XIANG ZHU ; JIANG GU

Source :

The American journal of gastroenterology [ 0002-9270 ] ; 2005.

RBID : Pascal:05-0180762

Descripteurs français

Pascal (Inist)
- Syndrome respiratoire aigu sévère, Intestin, Tissu, Forme léthale, Coronavirus.

English descriptors

KwdEn :
- Coronavirus, Fatal course, Gut, Severe acute respiratory syndrome, Tissue.

Abstract

OBJECTIVES: A significant percentage of confirmed severe acute respiratory syndrome (SARS) patients experienced gastrointestinal symptoms, and the viral sequence was detectable in the stool of most patients. At present, the knowledge of the pathology of the digestive system in SARS patients is limited. Because a resurgence of the SARS epidemic is constantly possible, there is an urgent need to understand the involvement of the digestive system in this new disease. METHODS: We performed seven SARS autopsies in which samples of alimentary tract and digestive glands were examined with routine pathology, electron microscopy (EM), in situ hybridization (ISH), immunohistochemistry, and real-time polymerase chain reaction (PCR). RESULTS: The main histopathological finding was atrophy of the mucosal lymphoid tissue. A few mucosal epithelial cells and lymphocytes in the intestine were positively stained for coronavirus with ISH. SARS-coronavirus (CoV)-like particles were found in the mucosal epithelial cells under EM and mild focal inflammation was detected in the alimentary tract. One patient who experienced severe diarrhea had pseudomembranous enteritis of the ileum. Fatty degeneration and central lobular necrosis were observed in the liver. No evidence of direct viral infection was found in the esophagus, the stomach, the salivary gland, the liver, or the pancreas. CONCLUSIONS: In addition to the lungs, the gastrointestinal tract is another target of SARS-CoV infection, as the intestinal epithelial cells and mucosal lymphoid tissue are infected. The findings provide possible explanations for the gastrointestinal symptoms and the presence of virus in the stool of SARS patients.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0002-9270`
A03		`1`		`@0 Am. j. gastroenterol.`
A05				`@2 100`
A06				`@2 1`
A08	`01`	`1`	`ENG`	`@1 Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases`
A11	`01`	`1`		`@1 XUEYING SHI`
A11	`02`	`1`		`@1 ENCONG GONG`
A11	`03`	`1`		`@1 DONGXIA GAO`
A11	`04`	`1`		`@1 BO ZHANG`
A11	`05`	`1`		`@1 JIE ZHENG`
A11	`06`	`1`		`@1 ZIFEN GAO`
A11	`07`	`1`		`@1 YANFENG ZHONG`
A11	`08`	`1`		`@1 WANZHONG ZOU`
A11	`09`	`1`		`@1 BINGQUAN WU`
A11	`10`	`1`		`@1 WEIGANG FANG`
A11	`11`	`1`		`@1 SONGLIN LIAO`
A11	`12`	`1`		`@1 SHENGLAN WANG`
A11	`13`	`1`		`@1 ZHIGANG XIE`
A11	`14`	`1`		`@1 MIN LU`
A11	`15`	`1`		`@1 LIN HOU`
A11	`16`	`1`		`@1 HAOHAO ZHONG`
A11	`17`	`1`		`@1 HONGQUAN SHAO`
A11	`18`	`1`		`@1 NING LI`
A11	`19`	`1`		`@1 CONGRONG LIU`
A11	`20`	`1`		`@1 FEI PEI`
A11	`21`	`1`		`@1 JINGPING YANG`
A11	`22`	`1`		`@1 YUPING WANG`
A11	`23`	`1`		`@1 ZHIHUI HAN`
A11	`24`	`1`		`@1 XIAOHONG SHI`
A11	`25`	`1`		`@1 QIANYING ZHANG`
A11	`26`	`1`		`@1 JIANGFENG YOU`
A11	`27`	`1`		`@1 XIANG ZHU`
A11	`28`	`1`		`@1 JIANG GU`
A14	`01`			`@1 Department of Pathology, Peking University Health Science Center @2 Beijing @3 CHN`
A14	`02`			`@1 Cancer Hospital, Peking University Health Science Center @2 Beijing @3 CHN`
A14	`03`			`@1 Beijing Ditan Hospital @2 Beijing @3 CHN`
A20				`@1 169-176`
A21				`@1 2005`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 11062 @5 354000125069790270`
A44				`@0 0000 @1 © 2005 INIST-CNRS. All rights reserved.`
A45				`@0 37 ref.`
A47	`01`	`1`		`@0 05-0180762`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 The American journal of gastroenterology`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 OBJECTIVES: A significant percentage of confirmed severe acute respiratory syndrome (SARS) patients experienced gastrointestinal symptoms, and the viral sequence was detectable in the stool of most patients. At present, the knowledge of the pathology of the digestive system in SARS patients is limited. Because a resurgence of the SARS epidemic is constantly possible, there is an urgent need to understand the involvement of the digestive system in this new disease. METHODS: We performed seven SARS autopsies in which samples of alimentary tract and digestive glands were examined with routine pathology, electron microscopy (EM), in situ hybridization (ISH), immunohistochemistry, and real-time polymerase chain reaction (PCR). RESULTS: The main histopathological finding was atrophy of the mucosal lymphoid tissue. A few mucosal epithelial cells and lymphocytes in the intestine were positively stained for coronavirus with ISH. SARS-coronavirus (CoV)-like particles were found in the mucosal epithelial cells under EM and mild focal inflammation was detected in the alimentary tract. One patient who experienced severe diarrhea had pseudomembranous enteritis of the ileum. Fatty degeneration and central lobular necrosis were observed in the liver. No evidence of direct viral infection was found in the esophagus, the stomach, the salivary gland, the liver, or the pancreas. CONCLUSIONS: In addition to the lungs, the gastrointestinal tract is another target of SARS-CoV infection, as the intestinal epithelial cells and mucosal lymphoid tissue are infected. The findings provide possible explanations for the gastrointestinal symptoms and the presence of virus in the stool of SARS patients.
C02	`01`	`X`		`@0 002B05C02C`
C03	`01`	`X`	`FRE`	`@0 Syndrome respiratoire aigu sévère @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Severe acute respiratory syndrome @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Síndrome respiratorio agudo severo @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Intestin @5 07`
C03	`02`	`X`	`ENG`	`@0 Gut @5 07`
C03	`02`	`X`	`SPA`	`@0 Intestino @5 07`
C03	`03`	`X`	`FRE`	`@0 Tissu @5 08`
C03	`03`	`X`	`ENG`	`@0 Tissue @5 08`
C03	`03`	`X`	`SPA`	`@0 Tejido @5 08`
C03	`04`	`X`	`FRE`	`@0 Forme léthale @5 09`
C03	`04`	`X`	`ENG`	`@0 Fatal course @5 09`
C03	`04`	`X`	`SPA`	`@0 Curso fatal @5 09`
C03	`05`	`X`	`FRE`	`@0 Coronavirus @2 NW @5 10`
C03	`05`	`X`	`ENG`	`@0 Coronavirus @2 NW @5 10`
C03	`05`	`X`	`SPA`	`@0 Coronavirus @2 NW @5 10`
C07	`01`	`X`	`FRE`	`@0 Virose`
C07	`01`	`X`	`ENG`	`@0 Viral disease`
C07	`01`	`X`	`SPA`	`@0 Virosis`
C07	`02`	`X`	`FRE`	`@0 Infection`
C07	`02`	`X`	`ENG`	`@0 Infection`
C07	`02`	`X`	`SPA`	`@0 Infección`
C07	`03`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`03`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`03`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`04`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`04`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`04`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`05`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`05`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`05`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`06`	`X`	`FRE`	`@0 Appareil respiratoire pathologie @5 37`
C07	`06`	`X`	`ENG`	`@0 Respiratory disease @5 37`
C07	`06`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 37`
C07	`07`	`X`	`FRE`	`@0 Poumon pathologie @5 38`
C07	`07`	`X`	`ENG`	`@0 Lung disease @5 38`
C07	`07`	`X`	`SPA`	`@0 Pulmón patología @5 38`
N21				`@1 122`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 05-0180762 INIST
ET :	Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases
AU :	XUEYING SHI; ENCONG GONG; DONGXIA GAO; BO ZHANG; JIE ZHENG; ZIFEN GAO; YANFENG ZHONG; WANZHONG ZOU; BINGQUAN WU; WEIGANG FANG; SONGLIN LIAO; SHENGLAN WANG; ZHIGANG XIE; MIN LU; LIN HOU; HAOHAO ZHONG; HONGQUAN SHAO; NING LI; CONGRONG LIU; FEI PEI; JINGPING YANG; YUPING WANG; ZHIHUI HAN; XIAOHONG SHI; QIANYING ZHANG; JIANGFENG YOU; XIANG ZHU; JIANG GU
AF :	Department of Pathology, Peking University Health Science Center/Beijing/Chine; Cancer Hospital, Peking University Health Science Center/Beijing/Chine; Beijing Ditan Hospital/Beijing/Chine
DT :	Publication en série; Niveau analytique
SO :	The American journal of gastroenterology; ISSN 0002-9270; Etats-Unis; Da. 2005; Vol. 100; No. 1; Pp. 169-176; Bibl. 37 ref.
LA :	Anglais
EA :	OBJECTIVES: A significant percentage of confirmed severe acute respiratory syndrome (SARS) patients experienced gastrointestinal symptoms, and the viral sequence was detectable in the stool of most patients. At present, the knowledge of the pathology of the digestive system in SARS patients is limited. Because a resurgence of the SARS epidemic is constantly possible, there is an urgent need to understand the involvement of the digestive system in this new disease. METHODS: We performed seven SARS autopsies in which samples of alimentary tract and digestive glands were examined with routine pathology, electron microscopy (EM), in situ hybridization (ISH), immunohistochemistry, and real-time polymerase chain reaction (PCR). RESULTS: The main histopathological finding was atrophy of the mucosal lymphoid tissue. A few mucosal epithelial cells and lymphocytes in the intestine were positively stained for coronavirus with ISH. SARS-coronavirus (CoV)-like particles were found in the mucosal epithelial cells under EM and mild focal inflammation was detected in the alimentary tract. One patient who experienced severe diarrhea had pseudomembranous enteritis of the ileum. Fatty degeneration and central lobular necrosis were observed in the liver. No evidence of direct viral infection was found in the esophagus, the stomach, the salivary gland, the liver, or the pancreas. CONCLUSIONS: In addition to the lungs, the gastrointestinal tract is another target of SARS-CoV infection, as the intestinal epithelial cells and mucosal lymphoid tissue are infected. The findings provide possible explanations for the gastrointestinal symptoms and the presence of virus in the stool of SARS patients.
CC :	002B05C02C
FD :	Syndrome respiratoire aigu sévère; Intestin; Tissu; Forme léthale; Coronavirus
FG :	Virose; Infection; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Poumon pathologie
ED :	Severe acute respiratory syndrome; Gut; Tissue; Fatal course; Coronavirus
EG :	Viral disease; Infection; Coronaviridae; Nidovirales; Virus; Respiratory disease; Lung disease
SD :	Síndrome respiratorio agudo severo; Intestino; Tejido; Curso fatal; Coronavirus
LO :	INIST-11062.354000125069790270
ID :	05-0180762

Links to Exploration step

Pascal:05-0180762

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases</title>
<author><name sortKey="Xueying Shi" sort="Xueying Shi" uniqKey="Xueying Shi" last="Xueying Shi">XUEYING SHI</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Pathology, Peking University Health Science Center</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="02"><s1>Cancer Hospital, Peking University Health Science Center</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="03"><s1>Beijing Ditan Hospital</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Encong Gong" sort="Encong Gong" uniqKey="Encong Gong" last="Encong Gong">ENCONG GONG</name>
</author>
<author><name sortKey="Dongxia Gao" sort="Dongxia Gao" uniqKey="Dongxia Gao" last="Dongxia Gao">DONGXIA GAO</name>
</author>
<author><name sortKey="Bo Zhang" sort="Bo Zhang" uniqKey="Bo Zhang" last="Bo Zhang">BO ZHANG</name>
</author>
<author><name sortKey="Jie Zheng" sort="Jie Zheng" uniqKey="Jie Zheng" last="Jie Zheng">JIE ZHENG</name>
</author>
<author><name sortKey="Zifen Gao" sort="Zifen Gao" uniqKey="Zifen Gao" last="Zifen Gao">ZIFEN GAO</name>
</author>
<author><name sortKey="Yanfeng Zhong" sort="Yanfeng Zhong" uniqKey="Yanfeng Zhong" last="Yanfeng Zhong">YANFENG ZHONG</name>
</author>
<author><name sortKey="Wanzhong Zou" sort="Wanzhong Zou" uniqKey="Wanzhong Zou" last="Wanzhong Zou">WANZHONG ZOU</name>
</author>
<author><name sortKey="Bingquan Wu" sort="Bingquan Wu" uniqKey="Bingquan Wu" last="Bingquan Wu">BINGQUAN WU</name>
</author>
<author><name sortKey="Weigang Fang" sort="Weigang Fang" uniqKey="Weigang Fang" last="Weigang Fang">WEIGANG FANG</name>
</author>
<author><name sortKey="Songlin Liao" sort="Songlin Liao" uniqKey="Songlin Liao" last="Songlin Liao">SONGLIN LIAO</name>
</author>
<author><name sortKey="Shenglan Wang" sort="Shenglan Wang" uniqKey="Shenglan Wang" last="Shenglan Wang">SHENGLAN WANG</name>
</author>
<author><name sortKey="Zhigang Xie" sort="Zhigang Xie" uniqKey="Zhigang Xie" last="Zhigang Xie">ZHIGANG XIE</name>
</author>
<author><name sortKey="Min Lu" sort="Min Lu" uniqKey="Min Lu" last="Min Lu">MIN LU</name>
</author>
<author><name sortKey="Lin Hou" sort="Lin Hou" uniqKey="Lin Hou" last="Lin Hou">LIN HOU</name>
</author>
<author><name sortKey="Haohao Zhong" sort="Haohao Zhong" uniqKey="Haohao Zhong" last="Haohao Zhong">HAOHAO ZHONG</name>
</author>
<author><name sortKey="Hongquan Shao" sort="Hongquan Shao" uniqKey="Hongquan Shao" last="Hongquan Shao">HONGQUAN SHAO</name>
</author>
<author><name sortKey="Ning Li" sort="Ning Li" uniqKey="Ning Li" last="Ning Li">NING LI</name>
</author>
<author><name sortKey="Congrong Liu" sort="Congrong Liu" uniqKey="Congrong Liu" last="Congrong Liu">CONGRONG LIU</name>
</author>
<author><name sortKey="Fei Pei" sort="Fei Pei" uniqKey="Fei Pei" last="Fei Pei">FEI PEI</name>
</author>
<author><name sortKey="Jingping Yang" sort="Jingping Yang" uniqKey="Jingping Yang" last="Jingping Yang">JINGPING YANG</name>
</author>
<author><name sortKey="Yuping Wang" sort="Yuping Wang" uniqKey="Yuping Wang" last="Yuping Wang">YUPING WANG</name>
</author>
<author><name sortKey="Zhihui Han" sort="Zhihui Han" uniqKey="Zhihui Han" last="Zhihui Han">ZHIHUI HAN</name>
</author>
<author><name sortKey="Xiaohong Shi" sort="Xiaohong Shi" uniqKey="Xiaohong Shi" last="Xiaohong Shi">XIAOHONG SHI</name>
</author>
<author><name sortKey="Qianying Zhang" sort="Qianying Zhang" uniqKey="Qianying Zhang" last="Qianying Zhang">QIANYING ZHANG</name>
</author>
<author><name sortKey="Jiangfeng You" sort="Jiangfeng You" uniqKey="Jiangfeng You" last="Jiangfeng You">JIANGFENG YOU</name>
</author>
<author><name sortKey="Xiang Zhu" sort="Xiang Zhu" uniqKey="Xiang Zhu" last="Xiang Zhu">XIANG ZHU</name>
</author>
<author><name sortKey="Jiang Gu" sort="Jiang Gu" uniqKey="Jiang Gu" last="Jiang Gu">JIANG GU</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">05-0180762</idno>
<date when="2005">2005</date>
<idno type="stanalyst">PASCAL 05-0180762 INIST</idno>
<idno type="RBID">Pascal:05-0180762</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000704</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases</title>
<author><name sortKey="Xueying Shi" sort="Xueying Shi" uniqKey="Xueying Shi" last="Xueying Shi">XUEYING SHI</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Pathology, Peking University Health Science Center</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="02"><s1>Cancer Hospital, Peking University Health Science Center</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="03"><s1>Beijing Ditan Hospital</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Encong Gong" sort="Encong Gong" uniqKey="Encong Gong" last="Encong Gong">ENCONG GONG</name>
</author>
<author><name sortKey="Dongxia Gao" sort="Dongxia Gao" uniqKey="Dongxia Gao" last="Dongxia Gao">DONGXIA GAO</name>
</author>
<author><name sortKey="Bo Zhang" sort="Bo Zhang" uniqKey="Bo Zhang" last="Bo Zhang">BO ZHANG</name>
</author>
<author><name sortKey="Jie Zheng" sort="Jie Zheng" uniqKey="Jie Zheng" last="Jie Zheng">JIE ZHENG</name>
</author>
<author><name sortKey="Zifen Gao" sort="Zifen Gao" uniqKey="Zifen Gao" last="Zifen Gao">ZIFEN GAO</name>
</author>
<author><name sortKey="Yanfeng Zhong" sort="Yanfeng Zhong" uniqKey="Yanfeng Zhong" last="Yanfeng Zhong">YANFENG ZHONG</name>
</author>
<author><name sortKey="Wanzhong Zou" sort="Wanzhong Zou" uniqKey="Wanzhong Zou" last="Wanzhong Zou">WANZHONG ZOU</name>
</author>
<author><name sortKey="Bingquan Wu" sort="Bingquan Wu" uniqKey="Bingquan Wu" last="Bingquan Wu">BINGQUAN WU</name>
</author>
<author><name sortKey="Weigang Fang" sort="Weigang Fang" uniqKey="Weigang Fang" last="Weigang Fang">WEIGANG FANG</name>
</author>
<author><name sortKey="Songlin Liao" sort="Songlin Liao" uniqKey="Songlin Liao" last="Songlin Liao">SONGLIN LIAO</name>
</author>
<author><name sortKey="Shenglan Wang" sort="Shenglan Wang" uniqKey="Shenglan Wang" last="Shenglan Wang">SHENGLAN WANG</name>
</author>
<author><name sortKey="Zhigang Xie" sort="Zhigang Xie" uniqKey="Zhigang Xie" last="Zhigang Xie">ZHIGANG XIE</name>
</author>
<author><name sortKey="Min Lu" sort="Min Lu" uniqKey="Min Lu" last="Min Lu">MIN LU</name>
</author>
<author><name sortKey="Lin Hou" sort="Lin Hou" uniqKey="Lin Hou" last="Lin Hou">LIN HOU</name>
</author>
<author><name sortKey="Haohao Zhong" sort="Haohao Zhong" uniqKey="Haohao Zhong" last="Haohao Zhong">HAOHAO ZHONG</name>
</author>
<author><name sortKey="Hongquan Shao" sort="Hongquan Shao" uniqKey="Hongquan Shao" last="Hongquan Shao">HONGQUAN SHAO</name>
</author>
<author><name sortKey="Ning Li" sort="Ning Li" uniqKey="Ning Li" last="Ning Li">NING LI</name>
</author>
<author><name sortKey="Congrong Liu" sort="Congrong Liu" uniqKey="Congrong Liu" last="Congrong Liu">CONGRONG LIU</name>
</author>
<author><name sortKey="Fei Pei" sort="Fei Pei" uniqKey="Fei Pei" last="Fei Pei">FEI PEI</name>
</author>
<author><name sortKey="Jingping Yang" sort="Jingping Yang" uniqKey="Jingping Yang" last="Jingping Yang">JINGPING YANG</name>
</author>
<author><name sortKey="Yuping Wang" sort="Yuping Wang" uniqKey="Yuping Wang" last="Yuping Wang">YUPING WANG</name>
</author>
<author><name sortKey="Zhihui Han" sort="Zhihui Han" uniqKey="Zhihui Han" last="Zhihui Han">ZHIHUI HAN</name>
</author>
<author><name sortKey="Xiaohong Shi" sort="Xiaohong Shi" uniqKey="Xiaohong Shi" last="Xiaohong Shi">XIAOHONG SHI</name>
</author>
<author><name sortKey="Qianying Zhang" sort="Qianying Zhang" uniqKey="Qianying Zhang" last="Qianying Zhang">QIANYING ZHANG</name>
</author>
<author><name sortKey="Jiangfeng You" sort="Jiangfeng You" uniqKey="Jiangfeng You" last="Jiangfeng You">JIANGFENG YOU</name>
</author>
<author><name sortKey="Xiang Zhu" sort="Xiang Zhu" uniqKey="Xiang Zhu" last="Xiang Zhu">XIANG ZHU</name>
</author>
<author><name sortKey="Jiang Gu" sort="Jiang Gu" uniqKey="Jiang Gu" last="Jiang Gu">JIANG GU</name>
</author>
</analytic>
<series><title level="j" type="main">The American journal of gastroenterology</title>
<title level="j" type="abbreviated">Am. j. gastroenterol.</title>
<idno type="ISSN">0002-9270</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The American journal of gastroenterology</title>
<title level="j" type="abbreviated">Am. j. gastroenterol.</title>
<idno type="ISSN">0002-9270</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus</term>
<term>Fatal course</term>
<term>Gut</term>
<term>Severe acute respiratory syndrome</term>
<term>Tissue</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
<term>Intestin</term>
<term>Tissu</term>
<term>Forme léthale</term>
<term>Coronavirus</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">OBJECTIVES: A significant percentage of confirmed severe acute respiratory syndrome (SARS) patients experienced gastrointestinal symptoms, and the viral sequence was detectable in the stool of most patients. At present, the knowledge of the pathology of the digestive system in SARS patients is limited. Because a resurgence of the SARS epidemic is constantly possible, there is an urgent need to understand the involvement of the digestive system in this new disease. METHODS: We performed seven SARS autopsies in which samples of alimentary tract and digestive glands were examined with routine pathology, electron microscopy (EM), in situ hybridization (ISH), immunohistochemistry, and real-time polymerase chain reaction (PCR). RESULTS: The main histopathological finding was atrophy of the mucosal lymphoid tissue. A few mucosal epithelial cells and lymphocytes in the intestine were positively stained for coronavirus with ISH. SARS-coronavirus (CoV)-like particles were found in the mucosal epithelial cells under EM and mild focal inflammation was detected in the alimentary tract. One patient who experienced severe diarrhea had pseudomembranous enteritis of the ileum. Fatty degeneration and central lobular necrosis were observed in the liver. No evidence of direct viral infection was found in the esophagus, the stomach, the salivary gland, the liver, or the pancreas. CONCLUSIONS: In addition to the lungs, the gastrointestinal tract is another target of SARS-CoV infection, as the intestinal epithelial cells and mucosal lymphoid tissue are infected. The findings provide possible explanations for the gastrointestinal symptoms and the presence of virus in the stool of SARS patients.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0002-9270</s0>
</fA01>
<fA03 i2="1"><s0>Am. j. gastroenterol.</s0>
</fA03>
<fA05><s2>100</s2>
</fA05>
<fA06><s2>1</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>XUEYING SHI</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>ENCONG GONG</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>DONGXIA GAO</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>BO ZHANG</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>JIE ZHENG</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>ZIFEN GAO</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>YANFENG ZHONG</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>WANZHONG ZOU</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>BINGQUAN WU</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>WEIGANG FANG</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>SONGLIN LIAO</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>SHENGLAN WANG</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>ZHIGANG XIE</s1>
</fA11>
<fA11 i1="14" i2="1"><s1>MIN LU</s1>
</fA11>
<fA11 i1="15" i2="1"><s1>LIN HOU</s1>
</fA11>
<fA11 i1="16" i2="1"><s1>HAOHAO ZHONG</s1>
</fA11>
<fA11 i1="17" i2="1"><s1>HONGQUAN SHAO</s1>
</fA11>
<fA11 i1="18" i2="1"><s1>NING LI</s1>
</fA11>
<fA11 i1="19" i2="1"><s1>CONGRONG LIU</s1>
</fA11>
<fA11 i1="20" i2="1"><s1>FEI PEI</s1>
</fA11>
<fA11 i1="21" i2="1"><s1>JINGPING YANG</s1>
</fA11>
<fA11 i1="22" i2="1"><s1>YUPING WANG</s1>
</fA11>
<fA11 i1="23" i2="1"><s1>ZHIHUI HAN</s1>
</fA11>
<fA11 i1="24" i2="1"><s1>XIAOHONG SHI</s1>
</fA11>
<fA11 i1="25" i2="1"><s1>QIANYING ZHANG</s1>
</fA11>
<fA11 i1="26" i2="1"><s1>JIANGFENG YOU</s1>
</fA11>
<fA11 i1="27" i2="1"><s1>XIANG ZHU</s1>
</fA11>
<fA11 i1="28" i2="1"><s1>JIANG GU</s1>
</fA11>
<fA14 i1="01"><s1>Department of Pathology, Peking University Health Science Center</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
</fA14>
<fA14 i1="02"><s1>Cancer Hospital, Peking University Health Science Center</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
</fA14>
<fA14 i1="03"><s1>Beijing Ditan Hospital</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
</fA14>
<fA20><s1>169-176</s1>
</fA20>
<fA21><s1>2005</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>11062</s2>
<s5>354000125069790270</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2005 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>37 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>05-0180762</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>The American journal of gastroenterology</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>OBJECTIVES: A significant percentage of confirmed severe acute respiratory syndrome (SARS) patients experienced gastrointestinal symptoms, and the viral sequence was detectable in the stool of most patients. At present, the knowledge of the pathology of the digestive system in SARS patients is limited. Because a resurgence of the SARS epidemic is constantly possible, there is an urgent need to understand the involvement of the digestive system in this new disease. METHODS: We performed seven SARS autopsies in which samples of alimentary tract and digestive glands were examined with routine pathology, electron microscopy (EM), in situ hybridization (ISH), immunohistochemistry, and real-time polymerase chain reaction (PCR). RESULTS: The main histopathological finding was atrophy of the mucosal lymphoid tissue. A few mucosal epithelial cells and lymphocytes in the intestine were positively stained for coronavirus with ISH. SARS-coronavirus (CoV)-like particles were found in the mucosal epithelial cells under EM and mild focal inflammation was detected in the alimentary tract. One patient who experienced severe diarrhea had pseudomembranous enteritis of the ileum. Fatty degeneration and central lobular necrosis were observed in the liver. No evidence of direct viral infection was found in the esophagus, the stomach, the salivary gland, the liver, or the pancreas. CONCLUSIONS: In addition to the lungs, the gastrointestinal tract is another target of SARS-CoV infection, as the intestinal epithelial cells and mucosal lymphoid tissue are infected. The findings provide possible explanations for the gastrointestinal symptoms and the presence of virus in the stool of SARS patients.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B05C02C</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Intestin</s0>
<s5>07</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Gut</s0>
<s5>07</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Intestino</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Tissu</s0>
<s5>08</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Tissue</s0>
<s5>08</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Tejido</s0>
<s5>08</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Forme léthale</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Fatal course</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Curso fatal</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>10</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>38</s5>
</fC07>
<fN21><s1>122</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 05-0180762 INIST</NO>
<ET>Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases</ET>
<AU>XUEYING SHI; ENCONG GONG; DONGXIA GAO; BO ZHANG; JIE ZHENG; ZIFEN GAO; YANFENG ZHONG; WANZHONG ZOU; BINGQUAN WU; WEIGANG FANG; SONGLIN LIAO; SHENGLAN WANG; ZHIGANG XIE; MIN LU; LIN HOU; HAOHAO ZHONG; HONGQUAN SHAO; NING LI; CONGRONG LIU; FEI PEI; JINGPING YANG; YUPING WANG; ZHIHUI HAN; XIAOHONG SHI; QIANYING ZHANG; JIANGFENG YOU; XIANG ZHU; JIANG GU</AU>
<AF>Department of Pathology, Peking University Health Science Center/Beijing/Chine; Cancer Hospital, Peking University Health Science Center/Beijing/Chine; Beijing Ditan Hospital/Beijing/Chine</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>The American journal of gastroenterology; ISSN 0002-9270; Etats-Unis; Da. 2005; Vol. 100; No. 1; Pp. 169-176; Bibl. 37 ref.</SO>
<LA>Anglais</LA>
<EA>OBJECTIVES: A significant percentage of confirmed severe acute respiratory syndrome (SARS) patients experienced gastrointestinal symptoms, and the viral sequence was detectable in the stool of most patients. At present, the knowledge of the pathology of the digestive system in SARS patients is limited. Because a resurgence of the SARS epidemic is constantly possible, there is an urgent need to understand the involvement of the digestive system in this new disease. METHODS: We performed seven SARS autopsies in which samples of alimentary tract and digestive glands were examined with routine pathology, electron microscopy (EM), in situ hybridization (ISH), immunohistochemistry, and real-time polymerase chain reaction (PCR). RESULTS: The main histopathological finding was atrophy of the mucosal lymphoid tissue. A few mucosal epithelial cells and lymphocytes in the intestine were positively stained for coronavirus with ISH. SARS-coronavirus (CoV)-like particles were found in the mucosal epithelial cells under EM and mild focal inflammation was detected in the alimentary tract. One patient who experienced severe diarrhea had pseudomembranous enteritis of the ileum. Fatty degeneration and central lobular necrosis were observed in the liver. No evidence of direct viral infection was found in the esophagus, the stomach, the salivary gland, the liver, or the pancreas. CONCLUSIONS: In addition to the lungs, the gastrointestinal tract is another target of SARS-CoV infection, as the intestinal epithelial cells and mucosal lymphoid tissue are infected. The findings provide possible explanations for the gastrointestinal symptoms and the presence of virus in the stool of SARS patients.</EA>
<CC>002B05C02C</CC>
<FD>Syndrome respiratoire aigu sévère; Intestin; Tissu; Forme léthale; Coronavirus</FD>
<FG>Virose; Infection; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Poumon pathologie</FG>
<ED>Severe acute respiratory syndrome; Gut; Tissue; Fatal course; Coronavirus</ED>
<EG>Viral disease; Infection; Coronaviridae; Nidovirales; Virus; Respiratory disease; Lung disease</EG>
<SD>Síndrome respiratorio agudo severo; Intestino; Tejido; Curso fatal; Coronavirus</SD>
<LO>INIST-11062.354000125069790270</LO>
<ID>05-0180762</ID>
</server>
</inist>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PascalFrancis/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000704 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Corpus/biblio.hfd -nk 000704 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    PascalFrancis
   |étape=   Corpus
   |type=    RBID
   |clé=     Pascal:05-0180762
   |texte=   Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration SRAS

Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases

Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases

Source :

Descripteurs français

English descriptors

Abstract

Notice en format standard (ISO 2709)

Format Inist (serveur)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri