Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases
Identifieur interne : 000704 ( PascalFrancis/Corpus ); précédent : 000703; suivant : 000705Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases
Auteurs : XUEYING SHI ; ENCONG GONG ; DONGXIA GAO ; BO ZHANG ; JIE ZHENG ; ZIFEN GAO ; YANFENG ZHONG ; WANZHONG ZOU ; BINGQUAN WU ; WEIGANG FANG ; SONGLIN LIAO ; SHENGLAN WANG ; ZHIGANG XIE ; MIN LU ; LIN HOU ; HAOHAO ZHONG ; HONGQUAN SHAO ; NING LI ; CONGRONG LIU ; FEI PEI ; JINGPING YANG ; YUPING WANG ; ZHIHUI HAN ; XIAOHONG SHI ; QIANYING ZHANG ; JIANGFENG YOU ; XIANG ZHU ; JIANG GUSource :
- The American journal of gastroenterology [ 0002-9270 ] ; 2005.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
OBJECTIVES: A significant percentage of confirmed severe acute respiratory syndrome (SARS) patients experienced gastrointestinal symptoms, and the viral sequence was detectable in the stool of most patients. At present, the knowledge of the pathology of the digestive system in SARS patients is limited. Because a resurgence of the SARS epidemic is constantly possible, there is an urgent need to understand the involvement of the digestive system in this new disease. METHODS: We performed seven SARS autopsies in which samples of alimentary tract and digestive glands were examined with routine pathology, electron microscopy (EM), in situ hybridization (ISH), immunohistochemistry, and real-time polymerase chain reaction (PCR). RESULTS: The main histopathological finding was atrophy of the mucosal lymphoid tissue. A few mucosal epithelial cells and lymphocytes in the intestine were positively stained for coronavirus with ISH. SARS-coronavirus (CoV)-like particles were found in the mucosal epithelial cells under EM and mild focal inflammation was detected in the alimentary tract. One patient who experienced severe diarrhea had pseudomembranous enteritis of the ileum. Fatty degeneration and central lobular necrosis were observed in the liver. No evidence of direct viral infection was found in the esophagus, the stomach, the salivary gland, the liver, or the pancreas. CONCLUSIONS: In addition to the lungs, the gastrointestinal tract is another target of SARS-CoV infection, as the intestinal epithelial cells and mucosal lymphoid tissue are infected. The findings provide possible explanations for the gastrointestinal symptoms and the presence of virus in the stool of SARS patients.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 05-0180762 INIST |
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ET : | Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases |
AU : | XUEYING SHI; ENCONG GONG; DONGXIA GAO; BO ZHANG; JIE ZHENG; ZIFEN GAO; YANFENG ZHONG; WANZHONG ZOU; BINGQUAN WU; WEIGANG FANG; SONGLIN LIAO; SHENGLAN WANG; ZHIGANG XIE; MIN LU; LIN HOU; HAOHAO ZHONG; HONGQUAN SHAO; NING LI; CONGRONG LIU; FEI PEI; JINGPING YANG; YUPING WANG; ZHIHUI HAN; XIAOHONG SHI; QIANYING ZHANG; JIANGFENG YOU; XIANG ZHU; JIANG GU |
AF : | Department of Pathology, Peking University Health Science Center/Beijing/Chine; Cancer Hospital, Peking University Health Science Center/Beijing/Chine; Beijing Ditan Hospital/Beijing/Chine |
DT : | Publication en série; Niveau analytique |
SO : | The American journal of gastroenterology; ISSN 0002-9270; Etats-Unis; Da. 2005; Vol. 100; No. 1; Pp. 169-176; Bibl. 37 ref. |
LA : | Anglais |
EA : | OBJECTIVES: A significant percentage of confirmed severe acute respiratory syndrome (SARS) patients experienced gastrointestinal symptoms, and the viral sequence was detectable in the stool of most patients. At present, the knowledge of the pathology of the digestive system in SARS patients is limited. Because a resurgence of the SARS epidemic is constantly possible, there is an urgent need to understand the involvement of the digestive system in this new disease. METHODS: We performed seven SARS autopsies in which samples of alimentary tract and digestive glands were examined with routine pathology, electron microscopy (EM), in situ hybridization (ISH), immunohistochemistry, and real-time polymerase chain reaction (PCR). RESULTS: The main histopathological finding was atrophy of the mucosal lymphoid tissue. A few mucosal epithelial cells and lymphocytes in the intestine were positively stained for coronavirus with ISH. SARS-coronavirus (CoV)-like particles were found in the mucosal epithelial cells under EM and mild focal inflammation was detected in the alimentary tract. One patient who experienced severe diarrhea had pseudomembranous enteritis of the ileum. Fatty degeneration and central lobular necrosis were observed in the liver. No evidence of direct viral infection was found in the esophagus, the stomach, the salivary gland, the liver, or the pancreas. CONCLUSIONS: In addition to the lungs, the gastrointestinal tract is another target of SARS-CoV infection, as the intestinal epithelial cells and mucosal lymphoid tissue are infected. The findings provide possible explanations for the gastrointestinal symptoms and the presence of virus in the stool of SARS patients. |
CC : | 002B05C02C |
FD : | Syndrome respiratoire aigu sévère; Intestin; Tissu; Forme léthale; Coronavirus |
FG : | Virose; Infection; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Poumon pathologie |
ED : | Severe acute respiratory syndrome; Gut; Tissue; Fatal course; Coronavirus |
EG : | Viral disease; Infection; Coronaviridae; Nidovirales; Virus; Respiratory disease; Lung disease |
SD : | Síndrome respiratorio agudo severo; Intestino; Tejido; Curso fatal; Coronavirus |
LO : | INIST-11062.354000125069790270 |
ID : | 05-0180762 |
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Pascal:05-0180762Le document en format XML
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<affiliation><inist:fA14 i1="02"><s1>Cancer Hospital, Peking University Health Science Center</s1>
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<author><name sortKey="Shenglan Wang" sort="Shenglan Wang" uniqKey="Shenglan Wang" last="Shenglan Wang">SHENGLAN WANG</name>
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<author><name sortKey="Zhigang Xie" sort="Zhigang Xie" uniqKey="Zhigang Xie" last="Zhigang Xie">ZHIGANG XIE</name>
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<author><name sortKey="Min Lu" sort="Min Lu" uniqKey="Min Lu" last="Min Lu">MIN LU</name>
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<author><name sortKey="Lin Hou" sort="Lin Hou" uniqKey="Lin Hou" last="Lin Hou">LIN HOU</name>
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<author><name sortKey="Haohao Zhong" sort="Haohao Zhong" uniqKey="Haohao Zhong" last="Haohao Zhong">HAOHAO ZHONG</name>
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<author><name sortKey="Hongquan Shao" sort="Hongquan Shao" uniqKey="Hongquan Shao" last="Hongquan Shao">HONGQUAN SHAO</name>
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<author><name sortKey="Ning Li" sort="Ning Li" uniqKey="Ning Li" last="Ning Li">NING LI</name>
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<author><name sortKey="Congrong Liu" sort="Congrong Liu" uniqKey="Congrong Liu" last="Congrong Liu">CONGRONG LIU</name>
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<author><name sortKey="Fei Pei" sort="Fei Pei" uniqKey="Fei Pei" last="Fei Pei">FEI PEI</name>
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<author><name sortKey="Jingping Yang" sort="Jingping Yang" uniqKey="Jingping Yang" last="Jingping Yang">JINGPING YANG</name>
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<author><name sortKey="Yuping Wang" sort="Yuping Wang" uniqKey="Yuping Wang" last="Yuping Wang">YUPING WANG</name>
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<author><name sortKey="Zhihui Han" sort="Zhihui Han" uniqKey="Zhihui Han" last="Zhihui Han">ZHIHUI HAN</name>
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<author><name sortKey="Xiaohong Shi" sort="Xiaohong Shi" uniqKey="Xiaohong Shi" last="Xiaohong Shi">XIAOHONG SHI</name>
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<author><name sortKey="Qianying Zhang" sort="Qianying Zhang" uniqKey="Qianying Zhang" last="Qianying Zhang">QIANYING ZHANG</name>
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<author><name sortKey="Jiangfeng You" sort="Jiangfeng You" uniqKey="Jiangfeng You" last="Jiangfeng You">JIANGFENG YOU</name>
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<author><name sortKey="Xiang Zhu" sort="Xiang Zhu" uniqKey="Xiang Zhu" last="Xiang Zhu">XIANG ZHU</name>
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<author><name sortKey="Jiang Gu" sort="Jiang Gu" uniqKey="Jiang Gu" last="Jiang Gu">JIANG GU</name>
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<author><name sortKey="Encong Gong" sort="Encong Gong" uniqKey="Encong Gong" last="Encong Gong">ENCONG GONG</name>
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<author><name sortKey="Dongxia Gao" sort="Dongxia Gao" uniqKey="Dongxia Gao" last="Dongxia Gao">DONGXIA GAO</name>
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<author><name sortKey="Bo Zhang" sort="Bo Zhang" uniqKey="Bo Zhang" last="Bo Zhang">BO ZHANG</name>
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<author><name sortKey="Jie Zheng" sort="Jie Zheng" uniqKey="Jie Zheng" last="Jie Zheng">JIE ZHENG</name>
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<author><name sortKey="Zifen Gao" sort="Zifen Gao" uniqKey="Zifen Gao" last="Zifen Gao">ZIFEN GAO</name>
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<author><name sortKey="Yanfeng Zhong" sort="Yanfeng Zhong" uniqKey="Yanfeng Zhong" last="Yanfeng Zhong">YANFENG ZHONG</name>
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<author><name sortKey="Wanzhong Zou" sort="Wanzhong Zou" uniqKey="Wanzhong Zou" last="Wanzhong Zou">WANZHONG ZOU</name>
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<author><name sortKey="Lin Hou" sort="Lin Hou" uniqKey="Lin Hou" last="Lin Hou">LIN HOU</name>
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<author><name sortKey="Haohao Zhong" sort="Haohao Zhong" uniqKey="Haohao Zhong" last="Haohao Zhong">HAOHAO ZHONG</name>
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<author><name sortKey="Fei Pei" sort="Fei Pei" uniqKey="Fei Pei" last="Fei Pei">FEI PEI</name>
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<author><name sortKey="Jingping Yang" sort="Jingping Yang" uniqKey="Jingping Yang" last="Jingping Yang">JINGPING YANG</name>
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<author><name sortKey="Yuping Wang" sort="Yuping Wang" uniqKey="Yuping Wang" last="Yuping Wang">YUPING WANG</name>
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<author><name sortKey="Zhihui Han" sort="Zhihui Han" uniqKey="Zhihui Han" last="Zhihui Han">ZHIHUI HAN</name>
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<author><name sortKey="Qianying Zhang" sort="Qianying Zhang" uniqKey="Qianying Zhang" last="Qianying Zhang">QIANYING ZHANG</name>
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<front><div type="abstract" xml:lang="en">OBJECTIVES: A significant percentage of confirmed severe acute respiratory syndrome (SARS) patients experienced gastrointestinal symptoms, and the viral sequence was detectable in the stool of most patients. At present, the knowledge of the pathology of the digestive system in SARS patients is limited. Because a resurgence of the SARS epidemic is constantly possible, there is an urgent need to understand the involvement of the digestive system in this new disease. METHODS: We performed seven SARS autopsies in which samples of alimentary tract and digestive glands were examined with routine pathology, electron microscopy (EM), in situ hybridization (ISH), immunohistochemistry, and real-time polymerase chain reaction (PCR). RESULTS: The main histopathological finding was atrophy of the mucosal lymphoid tissue. A few mucosal epithelial cells and lymphocytes in the intestine were positively stained for coronavirus with ISH. SARS-coronavirus (CoV)-like particles were found in the mucosal epithelial cells under EM and mild focal inflammation was detected in the alimentary tract. One patient who experienced severe diarrhea had pseudomembranous enteritis of the ileum. Fatty degeneration and central lobular necrosis were observed in the liver. No evidence of direct viral infection was found in the esophagus, the stomach, the salivary gland, the liver, or the pancreas. CONCLUSIONS: In addition to the lungs, the gastrointestinal tract is another target of SARS-CoV infection, as the intestinal epithelial cells and mucosal lymphoid tissue are infected. The findings provide possible explanations for the gastrointestinal symptoms and the presence of virus in the stool of SARS patients.</div>
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<fA08 i1="01" i2="1" l="ENG"><s1>Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases</s1>
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<fA11 i1="01" i2="1"><s1>XUEYING SHI</s1>
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<fA11 i1="02" i2="1"><s1>ENCONG GONG</s1>
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<fA11 i1="08" i2="1"><s1>WANZHONG ZOU</s1>
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<fA11 i1="10" i2="1"><s1>WEIGANG FANG</s1>
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<fA11 i1="24" i2="1"><s1>XIAOHONG SHI</s1>
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<fA11 i1="25" i2="1"><s1>QIANYING ZHANG</s1>
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<fA11 i1="26" i2="1"><s1>JIANGFENG YOU</s1>
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<fA11 i1="27" i2="1"><s1>XIANG ZHU</s1>
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<fA14 i1="01"><s1>Department of Pathology, Peking University Health Science Center</s1>
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<fC01 i1="01" l="ENG"><s0>OBJECTIVES: A significant percentage of confirmed severe acute respiratory syndrome (SARS) patients experienced gastrointestinal symptoms, and the viral sequence was detectable in the stool of most patients. At present, the knowledge of the pathology of the digestive system in SARS patients is limited. Because a resurgence of the SARS epidemic is constantly possible, there is an urgent need to understand the involvement of the digestive system in this new disease. METHODS: We performed seven SARS autopsies in which samples of alimentary tract and digestive glands were examined with routine pathology, electron microscopy (EM), in situ hybridization (ISH), immunohistochemistry, and real-time polymerase chain reaction (PCR). RESULTS: The main histopathological finding was atrophy of the mucosal lymphoid tissue. A few mucosal epithelial cells and lymphocytes in the intestine were positively stained for coronavirus with ISH. SARS-coronavirus (CoV)-like particles were found in the mucosal epithelial cells under EM and mild focal inflammation was detected in the alimentary tract. One patient who experienced severe diarrhea had pseudomembranous enteritis of the ileum. Fatty degeneration and central lobular necrosis were observed in the liver. No evidence of direct viral infection was found in the esophagus, the stomach, the salivary gland, the liver, or the pancreas. CONCLUSIONS: In addition to the lungs, the gastrointestinal tract is another target of SARS-CoV infection, as the intestinal epithelial cells and mucosal lymphoid tissue are infected. The findings provide possible explanations for the gastrointestinal symptoms and the presence of virus in the stool of SARS patients.</s0>
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<s5>08</s5>
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<fC03 i1="03" i2="X" l="ENG"><s0>Tissue</s0>
<s5>08</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Tejido</s0>
<s5>08</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Forme léthale</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Fatal course</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Curso fatal</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>10</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>38</s5>
</fC07>
<fN21><s1>122</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 05-0180762 INIST</NO>
<ET>Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases</ET>
<AU>XUEYING SHI; ENCONG GONG; DONGXIA GAO; BO ZHANG; JIE ZHENG; ZIFEN GAO; YANFENG ZHONG; WANZHONG ZOU; BINGQUAN WU; WEIGANG FANG; SONGLIN LIAO; SHENGLAN WANG; ZHIGANG XIE; MIN LU; LIN HOU; HAOHAO ZHONG; HONGQUAN SHAO; NING LI; CONGRONG LIU; FEI PEI; JINGPING YANG; YUPING WANG; ZHIHUI HAN; XIAOHONG SHI; QIANYING ZHANG; JIANGFENG YOU; XIANG ZHU; JIANG GU</AU>
<AF>Department of Pathology, Peking University Health Science Center/Beijing/Chine; Cancer Hospital, Peking University Health Science Center/Beijing/Chine; Beijing Ditan Hospital/Beijing/Chine</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>The American journal of gastroenterology; ISSN 0002-9270; Etats-Unis; Da. 2005; Vol. 100; No. 1; Pp. 169-176; Bibl. 37 ref.</SO>
<LA>Anglais</LA>
<EA>OBJECTIVES: A significant percentage of confirmed severe acute respiratory syndrome (SARS) patients experienced gastrointestinal symptoms, and the viral sequence was detectable in the stool of most patients. At present, the knowledge of the pathology of the digestive system in SARS patients is limited. Because a resurgence of the SARS epidemic is constantly possible, there is an urgent need to understand the involvement of the digestive system in this new disease. METHODS: We performed seven SARS autopsies in which samples of alimentary tract and digestive glands were examined with routine pathology, electron microscopy (EM), in situ hybridization (ISH), immunohistochemistry, and real-time polymerase chain reaction (PCR). RESULTS: The main histopathological finding was atrophy of the mucosal lymphoid tissue. A few mucosal epithelial cells and lymphocytes in the intestine were positively stained for coronavirus with ISH. SARS-coronavirus (CoV)-like particles were found in the mucosal epithelial cells under EM and mild focal inflammation was detected in the alimentary tract. One patient who experienced severe diarrhea had pseudomembranous enteritis of the ileum. Fatty degeneration and central lobular necrosis were observed in the liver. No evidence of direct viral infection was found in the esophagus, the stomach, the salivary gland, the liver, or the pancreas. CONCLUSIONS: In addition to the lungs, the gastrointestinal tract is another target of SARS-CoV infection, as the intestinal epithelial cells and mucosal lymphoid tissue are infected. The findings provide possible explanations for the gastrointestinal symptoms and the presence of virus in the stool of SARS patients.</EA>
<CC>002B05C02C</CC>
<FD>Syndrome respiratoire aigu sévère; Intestin; Tissu; Forme léthale; Coronavirus</FD>
<FG>Virose; Infection; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Poumon pathologie</FG>
<ED>Severe acute respiratory syndrome; Gut; Tissue; Fatal course; Coronavirus</ED>
<EG>Viral disease; Infection; Coronaviridae; Nidovirales; Virus; Respiratory disease; Lung disease</EG>
<SD>Síndrome respiratorio agudo severo; Intestino; Tejido; Curso fatal; Coronavirus</SD>
<LO>INIST-11062.354000125069790270</LO>
<ID>05-0180762</ID>
</server>
</inist>
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