SrasV1, Main, Exploration, bibRecord, 004757

Molecular Evolution Analysis and Geographic Investigation of Severe Acute Respiratory Syndrome Coronavirus-Like Virus in Palm Civets at an Animal Market and on Farms‡

Identifieur interne : 004757 ( Main/Exploration ); précédent : 004756; suivant : 004758

Molecular Evolution Analysis and Geographic Investigation of Severe Acute Respiratory Syndrome Coronavirus-Like Virus in Palm Civets at an Animal Market and on Farms‡

Auteurs : Biao Kan ; Ming Wang ; Huaiqi Jing ; Huifang Xu ; Xiugao Jiang ; Meiying Yan ; Weili Liang ; Han Zheng ; Kanglin Wan ; Qiyong Liu ; Buyun Cui ; Yanmei Xu ; Enmin Zhang ; Hongxia Wang ; Jingrong Ye ; Guichang Li ; Machao Li ; Zhigang Cui ; Xiaobao Qi ; Kai Chen ; Lin Du ; Kai Gao ; Yu-Teng Zhao ; Xiao-Zhong Zou ; Yue-Ju Feng ; Yu-Fan Gao ; Rong Hai ; Dongzhen Yu ; Yi Guan ; Jianguo Xu

Source :

Journal of Virology [ 0022-538X ] ; 2005.

RBID : PMC:1212604

Descripteurs français

KwdFr :
- Animaux, Animaux domestiques (virologie), Chiens viverrins (virologie), Chine (épidémiologie), Données de séquences moléculaires, Flambées de maladies, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (génétique), Humains, Phylogénie, Protéines de l'enveloppe virale (génétique), Réservoirs d'agents pathogènes, Similitude de séquences d'acides aminés, Syndrome respiratoire aigu sévère (transmission), Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Séquence d'acides aminés, Variation génétique, Virus du SRAS (), Virus du SRAS (génétique), Virus du SRAS (isolement et purification), Viverridae (virologie), Évolution moléculaire.
MESH :
- génétique : Glycoprotéines membranaires, Protéines de l'enveloppe virale, Virus du SRAS.
- isolement et purification : Virus du SRAS.
- virologie : Animaux domestiques, Chiens viverrins, Syndrome respiratoire aigu sévère, Viverridae.
- épidémiologie : Chine, Syndrome respiratoire aigu sévère.
- Animaux, Données de séquences moléculaires, Flambées de maladies, Glycoprotéine de spicule des coronavirus, Humains, Phylogénie, Réservoirs d'agents pathogènes, Similitude de séquences d'acides aminés, Séquence d'acides aminés, Variation génétique, Virus du SRAS, Évolution moléculaire.
Wicri :
- geographic : République populaire de Chine.

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Animals, Domestic (virology), China (epidemiology), Disease Outbreaks, Disease Reservoirs, Evolution, Molecular, Genetic Variation, Humans, Membrane Glycoproteins (genetics), Molecular Sequence Data, Phylogeny, Raccoon Dogs (virology), SARS Virus (classification), SARS Virus (genetics), SARS Virus (isolation & purification), Sequence Homology, Amino Acid, Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (transmission), Severe Acute Respiratory Syndrome (virology), Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (genetics), Viverridae (virology).
MESH :
- chemical , genetics : Membrane Glycoproteins, Viral Envelope Proteins.
- geographic , epidemiology : China.
- classification : SARS Virus.
- epidemiology : Severe Acute Respiratory Syndrome.
- genetics : SARS Virus.
- isolation & purification : SARS Virus.
- transmission : Severe Acute Respiratory Syndrome.
- virology : Animals, Domestic, Raccoon Dogs, Severe Acute Respiratory Syndrome, Viverridae.
- Amino Acid Sequence, Animals, Disease Outbreaks, Disease Reservoirs, Evolution, Molecular, Genetic Variation, Humans, Molecular Sequence Data, Phylogeny, Sequence Homology, Amino Acid, Spike Glycoprotein, Coronavirus.

Abstract

Massive numbers of palm civets were culled to remove sources for the reemergence of severe acute respiratory syndrome (SARS) in Guangdong Province, China, in January 2004, following SARS coronavirus detection in market animals. The virus was identified in all 91 palm civets and 15 raccoon dogs of animal market origin sampled prior to culling, but not in 1,107 palm civets later sampled at 25 farms, spread over 12 provinces, which were claimed to be the source of traded animals. Twenty-seven novel signature variation residues (SNVs) were identified on the spike gene and were analyzed for their phylogenetic relationships, based on 17 sequences obtained from animals in our study and from other published studies. Analysis indicated that the virus in palm civets at the live-animal market had evolved to infect humans. The evolutionary starting point was a prototype group consisting of three viral sequences of animal origin. Initially, seven SNV sites caused six amino acid changes, at positions 147, 228, 240, 479, 821, and 1080 of the spike protein, to generate low-pathogenicity viruses. One of these was linked to the first SARS patient in the 2003-2004 period. A further 14 SNVs caused 11 amino acid residue changes, at positions 360, 462, 472, 480, 487, 609, 613, 665, 743, 765, and 1163. The resulting high-pathogenicity groups were responsible for infections during the so-called early-phase epidemic of 2003. Finally, the remaining six SNVs caused four amino acid changes, at positions 227, 244, 344, and 778, which resulted in the group of viruses responsible for the global epidemic.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1212604

DOI: 10.1128/JVI.79.18.11892-11900.2005
PubMed: 16140765
PubMed Central: 1212604

Affiliations:

Le document en format XML

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<author><name sortKey="Ye, Jingrong" sort="Ye, Jingrong" uniqKey="Ye J" first="Jingrong" last="Ye">Jingrong Ye</name>
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<author><name sortKey="Li, Machao" sort="Li, Machao" uniqKey="Li M" first="Machao" last="Li">Machao Li</name>
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<author><name sortKey="Cui, Zhigang" sort="Cui, Zhigang" uniqKey="Cui Z" first="Zhigang" last="Cui">Zhigang Cui</name>
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<author><name sortKey="Chen, Kai" sort="Chen, Kai" uniqKey="Chen K" first="Kai" last="Chen">Kai Chen</name>
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<author><name sortKey="Gao, Kai" sort="Gao, Kai" uniqKey="Gao K" first="Kai" last="Gao">Kai Gao</name>
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<author><name sortKey="Zhao, Yu Teng" sort="Zhao, Yu Teng" uniqKey="Zhao Y" first="Yu-Teng" last="Zhao">Yu-Teng Zhao</name>
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</affiliation>
</author>
<author><name sortKey="Zou, Xiao Zhong" sort="Zou, Xiao Zhong" uniqKey="Zou X" first="Xiao-Zhong" last="Zou">Xiao-Zhong Zou</name>
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<author><name sortKey="Feng, Yue Ju" sort="Feng, Yue Ju" uniqKey="Feng Y" first="Yue-Ju" last="Feng">Yue-Ju Feng</name>
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</affiliation>
</author>
<author><name sortKey="Gao, Yu Fan" sort="Gao, Yu Fan" uniqKey="Gao Y" first="Yu-Fan" last="Gao">Yu-Fan Gao</name>
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<author><name sortKey="Hai, Rong" sort="Hai, Rong" uniqKey="Hai R" first="Rong" last="Hai">Rong Hai</name>
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<author><name sortKey="Yu, Dongzhen" sort="Yu, Dongzhen" uniqKey="Yu D" first="Dongzhen" last="Yu">Dongzhen Yu</name>
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<author><name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name>
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</affiliation>
</author>
<author><name sortKey="Xu, Jianguo" sort="Xu, Jianguo" uniqKey="Xu J" first="Jianguo" last="Xu">Jianguo Xu</name>
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<series><title level="j">Journal of Virology</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Animals, Domestic (virology)</term>
<term>China (epidemiology)</term>
<term>Disease Outbreaks</term>
<term>Disease Reservoirs</term>
<term>Evolution, Molecular</term>
<term>Genetic Variation</term>
<term>Humans</term>
<term>Membrane Glycoproteins (genetics)</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Raccoon Dogs (virology)</term>
<term>SARS Virus (classification)</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (isolation & purification)</term>
<term>Sequence Homology, Amino Acid</term>
<term>Severe Acute Respiratory Syndrome (epidemiology)</term>
<term>Severe Acute Respiratory Syndrome (transmission)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Viral Envelope Proteins (genetics)</term>
<term>Viverridae (virology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Animaux domestiques (virologie)</term>
<term>Chiens viverrins (virologie)</term>
<term>Chine (épidémiologie)</term>
<term>Données de séquences moléculaires</term>
<term>Flambées de maladies</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Glycoprotéines membranaires (génétique)</term>
<term>Humains</term>
<term>Phylogénie</term>
<term>Protéines de l'enveloppe virale (génétique)</term>
<term>Réservoirs d'agents pathogènes</term>
<term>Similitude de séquences d'acides aminés</term>
<term>Syndrome respiratoire aigu sévère (transmission)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Syndrome respiratoire aigu sévère (épidémiologie)</term>
<term>Séquence d'acides aminés</term>
<term>Variation génétique</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (génétique)</term>
<term>Virus du SRAS (isolement et purification)</term>
<term>Viverridae (virologie)</term>
<term>Évolution moléculaire</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Glycoproteins</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>China</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéines membranaires</term>
<term>Protéines de l'enveloppe virale</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Animaux domestiques</term>
<term>Chiens viverrins</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Viverridae</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Animals, Domestic</term>
<term>Raccoon Dogs</term>
<term>Severe Acute Respiratory Syndrome</term>
<term>Viverridae</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Chine</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Disease Outbreaks</term>
<term>Disease Reservoirs</term>
<term>Evolution, Molecular</term>
<term>Genetic Variation</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Sequence Homology, Amino Acid</term>
<term>Spike Glycoprotein, Coronavirus</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Données de séquences moléculaires</term>
<term>Flambées de maladies</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Humains</term>
<term>Phylogénie</term>
<term>Réservoirs d'agents pathogènes</term>
<term>Similitude de séquences d'acides aminés</term>
<term>Séquence d'acides aminés</term>
<term>Variation génétique</term>
<term>Virus du SRAS</term>
<term>Évolution moléculaire</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Massive numbers of palm civets were culled to remove sources for the reemergence of severe acute respiratory syndrome (SARS) in Guangdong Province, China, in January 2004, following SARS coronavirus detection in market animals. The virus was identified in all 91 palm civets and 15 raccoon dogs of animal market origin sampled prior to culling, but not in 1,107 palm civets later sampled at 25 farms, spread over 12 provinces, which were claimed to be the source of traded animals. Twenty-seven novel signature variation residues (SNVs) were identified on the spike gene and were analyzed for their phylogenetic relationships, based on 17 sequences obtained from animals in our study and from other published studies. Analysis indicated that the virus in palm civets at the live-animal market had evolved to infect humans. The evolutionary starting point was a prototype group consisting of three viral sequences of animal origin. Initially, seven SNV sites caused six amino acid changes, at positions 147, 228, 240, 479, 821, and 1080 of the spike protein, to generate low-pathogenicity viruses. One of these was linked to the first SARS patient in the 2003-2004 period. A further 14 SNVs caused 11 amino acid residue changes, at positions 360, 462, 472, 480, 487, 609, 613, 665, 743, 765, and 1163. The resulting high-pathogenicity groups were responsible for infections during the so-called early-phase epidemic of 2003. Finally, the remaining six SNVs caused four amino acid changes, at positions 227, 244, 344, and 778, which resulted in the group of viruses responsible for the global epidemic.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Chen, Kai" sort="Chen, Kai" uniqKey="Chen K" first="Kai" last="Chen">Kai Chen</name>
<name sortKey="Cui, Buyun" sort="Cui, Buyun" uniqKey="Cui B" first="Buyun" last="Cui">Buyun Cui</name>
<name sortKey="Cui, Zhigang" sort="Cui, Zhigang" uniqKey="Cui Z" first="Zhigang" last="Cui">Zhigang Cui</name>
<name sortKey="Du, Lin" sort="Du, Lin" uniqKey="Du L" first="Lin" last="Du">Lin Du</name>
<name sortKey="Feng, Yue Ju" sort="Feng, Yue Ju" uniqKey="Feng Y" first="Yue-Ju" last="Feng">Yue-Ju Feng</name>
<name sortKey="Gao, Kai" sort="Gao, Kai" uniqKey="Gao K" first="Kai" last="Gao">Kai Gao</name>
<name sortKey="Gao, Yu Fan" sort="Gao, Yu Fan" uniqKey="Gao Y" first="Yu-Fan" last="Gao">Yu-Fan Gao</name>
<name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name>
<name sortKey="Hai, Rong" sort="Hai, Rong" uniqKey="Hai R" first="Rong" last="Hai">Rong Hai</name>
<name sortKey="Jiang, Xiugao" sort="Jiang, Xiugao" uniqKey="Jiang X" first="Xiugao" last="Jiang">Xiugao Jiang</name>
<name sortKey="Jing, Huaiqi" sort="Jing, Huaiqi" uniqKey="Jing H" first="Huaiqi" last="Jing">Huaiqi Jing</name>
<name sortKey="Kan, Biao" sort="Kan, Biao" uniqKey="Kan B" first="Biao" last="Kan">Biao Kan</name>
<name sortKey="Li, Guichang" sort="Li, Guichang" uniqKey="Li G" first="Guichang" last="Li">Guichang Li</name>
<name sortKey="Li, Machao" sort="Li, Machao" uniqKey="Li M" first="Machao" last="Li">Machao Li</name>
<name sortKey="Liang, Weili" sort="Liang, Weili" uniqKey="Liang W" first="Weili" last="Liang">Weili Liang</name>
<name sortKey="Liu, Qiyong" sort="Liu, Qiyong" uniqKey="Liu Q" first="Qiyong" last="Liu">Qiyong Liu</name>
<name sortKey="Qi, Xiaobao" sort="Qi, Xiaobao" uniqKey="Qi X" first="Xiaobao" last="Qi">Xiaobao Qi</name>
<name sortKey="Wan, Kanglin" sort="Wan, Kanglin" uniqKey="Wan K" first="Kanglin" last="Wan">Kanglin Wan</name>
<name sortKey="Wang, Hongxia" sort="Wang, Hongxia" uniqKey="Wang H" first="Hongxia" last="Wang">Hongxia Wang</name>
<name sortKey="Wang, Ming" sort="Wang, Ming" uniqKey="Wang M" first="Ming" last="Wang">Ming Wang</name>
<name sortKey="Xu, Huifang" sort="Xu, Huifang" uniqKey="Xu H" first="Huifang" last="Xu">Huifang Xu</name>
<name sortKey="Xu, Jianguo" sort="Xu, Jianguo" uniqKey="Xu J" first="Jianguo" last="Xu">Jianguo Xu</name>
<name sortKey="Xu, Yanmei" sort="Xu, Yanmei" uniqKey="Xu Y" first="Yanmei" last="Xu">Yanmei Xu</name>
<name sortKey="Yan, Meiying" sort="Yan, Meiying" uniqKey="Yan M" first="Meiying" last="Yan">Meiying Yan</name>
<name sortKey="Ye, Jingrong" sort="Ye, Jingrong" uniqKey="Ye J" first="Jingrong" last="Ye">Jingrong Ye</name>
<name sortKey="Yu, Dongzhen" sort="Yu, Dongzhen" uniqKey="Yu D" first="Dongzhen" last="Yu">Dongzhen Yu</name>
<name sortKey="Zhang, Enmin" sort="Zhang, Enmin" uniqKey="Zhang E" first="Enmin" last="Zhang">Enmin Zhang</name>
<name sortKey="Zhao, Yu Teng" sort="Zhao, Yu Teng" uniqKey="Zhao Y" first="Yu-Teng" last="Zhao">Yu-Teng Zhao</name>
<name sortKey="Zheng, Han" sort="Zheng, Han" uniqKey="Zheng H" first="Han" last="Zheng">Han Zheng</name>
<name sortKey="Zou, Xiao Zhong" sort="Zou, Xiao Zhong" uniqKey="Zou X" first="Xiao-Zhong" last="Zou">Xiao-Zhong Zou</name>
</noCountry>
</tree>
</affiliations>
</record>

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Molecular Evolution Analysis and Geographic Investigation of Severe Acute Respiratory Syndrome Coronavirus-Like Virus in Palm Civets at an Animal Market and on Farms‡

Molecular Evolution Analysis and Geographic Investigation of Severe Acute Respiratory Syndrome Coronavirus-Like Virus in Palm Civets at an Animal Market and on Farms‡

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