Reduced bone mineral density in male Severe Acute Respiratory Syndrome (SARS) patients in Hong Kong.
Identifieur interne : 004678 ( Main/Exploration ); précédent : 004677; suivant : 004679Reduced bone mineral density in male Severe Acute Respiratory Syndrome (SARS) patients in Hong Kong.
Auteurs : E M C. Lau [Hong Kong] ; F W K. Chan ; D S C. Hui ; A K L. Wu ; P C LeungSource :
- Bone [ 8756-3282 ] ; 2005.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Densité osseuse (physiologie), Hong Kong, Humains, Mâle, Os et tissu osseux (anatomopathologie), Os et tissu osseux (physiopathologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (physiopathologie), Virus du SRAS (physiologie).
- MESH :
- anatomopathologie : Os et tissu osseux, Syndrome respiratoire aigu sévère.
- physiologie : Densité osseuse, Virus du SRAS.
- physiopathologie : Os et tissu osseux, Syndrome respiratoire aigu sévère.
- Adulte, Adulte d'âge moyen, Hong Kong, Humains, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus.
- Wicri :
- geographic : Hong Kong.
English descriptors
- KwdEn :
- MESH :
- geographic : Hong Kong.
- pathology : Bone and Bones, Severe Acute Respiratory Syndrome.
- physiology : Bone Density, SARS Virus.
- physiopathology : Bone and Bones, Severe Acute Respiratory Syndrome.
- Adult, Aged, Aged, 80 and over, Humans, Male, Middle Aged.
Abstract
During the Severe Acute Respiratory Syndrome (SARS) outbreak in Hong Kong in 2003, patients were treated with very high doses of corticosteroid and ribavirin. The detrimental effects of such treatment on the bone mineral density (BMD) of SARS patients are unknown. To compare the BMD of SARS patients with normal range data, a cross-sectional survey was conducted. The bone mineral density of 224 patients with SARS, who were treated with an average of 2753 mg (SD = 2152 mg) prednisolone and 29,344 mg (SD = 15,849 mg) of ribavirin was compared to normal data. Six percent of men had a hip BMD Z score of < or =-2 (P = 0.057 for testing the hypothesis that >2.5% of subjects should have a Z score of < or =-2). Moreover, there was a negative association (r = -0.25, P = 0.023) between the duration of steroid therapy and BMD in men. We conclude that male SARS patients had lower BMD at the hip than normal controls, and this could be attributed to prolonged steroid therapy.
DOI: 10.1016/j.bone.2005.04.018
PubMed: 15993669
Affiliations:
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Lau</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong. edithmclau@netvigator.com</nlm:affiliation><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Chan, F W K" sort="Chan, F W K" uniqKey="Chan F" first="F W K" last="Chan">F W K. Chan</name></author><author><name sortKey="Hui, D S C" sort="Hui, D S C" uniqKey="Hui D" first="D S C" last="Hui">D S C. Hui</name></author><author><name sortKey="Wu, A K L" sort="Wu, A K L" uniqKey="Wu A" first="A K L" last="Wu">A K L. Wu</name></author><author><name sortKey="Leung, P C" sort="Leung, P C" uniqKey="Leung P" first="P C" last="Leung">P C Leung</name></author></analytic><series><title level="j">Bone</title><idno type="ISSN">8756-3282</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Bone Density (physiology)</term><term>Bone and Bones (pathology)</term><term>Bone and Bones (physiopathology)</term><term>Hong Kong</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>SARS Virus (physiology)</term><term>Severe Acute Respiratory Syndrome (pathology)</term><term>Severe Acute Respiratory Syndrome (physiopathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Densité osseuse (physiologie)</term><term>Hong Kong</term><term>Humains</term><term>Mâle</term><term>Os et tissu osseux (anatomopathologie)</term><term>Os et tissu osseux (physiopathologie)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Syndrome respiratoire aigu sévère (anatomopathologie)</term><term>Syndrome respiratoire aigu sévère (physiopathologie)</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Hong Kong</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Os et tissu osseux</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Bone and Bones</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Densité osseuse</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Bone Density</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Os et tissu osseux</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Bone and Bones</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Hong Kong</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Hong Kong</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During the Severe Acute Respiratory Syndrome (SARS) outbreak in Hong Kong in 2003, patients were treated with very high doses of corticosteroid and ribavirin. The detrimental effects of such treatment on the bone mineral density (BMD) of SARS patients are unknown. To compare the BMD of SARS patients with normal range data, a cross-sectional survey was conducted. The bone mineral density of 224 patients with SARS, who were treated with an average of 2753 mg (SD = 2152 mg) prednisolone and 29,344 mg (SD = 15,849 mg) of ribavirin was compared to normal data. Six percent of men had a hip BMD Z score of < or =-2 (P = 0.057 for testing the hypothesis that >2.5% of subjects should have a Z score of < or =-2). Moreover, there was a negative association (r = -0.25, P = 0.023) between the duration of steroid therapy and BMD in men. We conclude that male SARS patients had lower BMD at the hip than normal controls, and this could be attributed to prolonged steroid therapy.</div></front></TEI><affiliations><list><country><li>Hong Kong</li></country><settlement><li>Sha Tin</li></settlement><orgName><li>Université chinoise de Hong Kong</li></orgName></list><tree><noCountry><name sortKey="Chan, F W K" sort="Chan, F W K" uniqKey="Chan F" first="F W K" last="Chan">F W K. Chan</name><name sortKey="Hui, D S C" sort="Hui, D S C" uniqKey="Hui D" first="D S C" last="Hui">D S C. Hui</name><name sortKey="Leung, P C" sort="Leung, P C" uniqKey="Leung P" first="P C" last="Leung">P C Leung</name><name sortKey="Wu, A K L" sort="Wu, A K L" uniqKey="Wu A" first="A K L" last="Wu">A K L. Wu</name></noCountry><country name="Hong Kong"><noRegion><name sortKey="Lau, E M C" sort="Lau, E M C" uniqKey="Lau E" first="E M C" last="Lau">E M C. 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