Understanding helicases as a means of virus control.
Identifieur interne : 003C43 ( Main/Exploration ); précédent : 003C42; suivant : 003C44Understanding helicases as a means of virus control.
Auteurs : D N Frick [États-Unis] ; A M I. LamSource :
- Current pharmaceutical design [ 1381-6128 ] ; 2006.
Descripteurs français
- KwdFr :
- Antienzymes (pharmacologie), Antiviraux (pharmacologie), DNA primase (antagonistes et inhibiteurs), Helicase (), Helicase (antagonistes et inhibiteurs), Helicase (physiologie), Papillomaviridae (), Papillomaviridae (enzymologie), Protéines virales (antagonistes et inhibiteurs), Protéines virales non structurales (antagonistes et inhibiteurs), RNA helicases (), RNA helicases (antagonistes et inhibiteurs), RNA helicases (physiologie), Serine endopeptidases, Simplexvirus (), Simplexvirus (enzymologie), Virus du SRAS (), Virus du SRAS (enzymologie).
- MESH :
- antagonistes et inhibiteurs : DNA primase, Helicase, Protéines virales, Protéines virales non structurales, RNA helicases.
- enzymologie : Papillomaviridae, Simplexvirus, Virus du SRAS.
- pharmacologie : Antienzymes, Antiviraux.
- physiologie : Helicase, RNA helicases.
- Helicase, Papillomaviridae, RNA helicases, Serine endopeptidases, Simplexvirus, Virus du SRAS.
English descriptors
- KwdEn :
- Antiviral Agents (pharmacology), DNA Helicases (antagonists & inhibitors), DNA Helicases (chemistry), DNA Helicases (physiology), DNA Primase (antagonists & inhibitors), Enzyme Inhibitors (pharmacology), Papillomaviridae (drug effects), Papillomaviridae (enzymology), RNA Helicases (antagonists & inhibitors), RNA Helicases (chemistry), RNA Helicases (physiology), SARS Virus (drug effects), SARS Virus (enzymology), Serine Endopeptidases, Simplexvirus (drug effects), Simplexvirus (enzymology), Viral Nonstructural Proteins (antagonists & inhibitors), Viral Proteins (antagonists & inhibitors).
- MESH :
- chemical , antagonists & inhibitors : DNA Helicases, DNA Primase, RNA Helicases, Viral Nonstructural Proteins, Viral Proteins.
- chemical , chemistry : DNA Helicases, RNA Helicases.
- chemical , pharmacology : Antiviral Agents, Enzyme Inhibitors.
- chemical , physiology : DNA Helicases, RNA Helicases.
- drug effects : Papillomaviridae, SARS Virus, Simplexvirus.
- enzymology : Papillomaviridae, SARS Virus, Simplexvirus.
- chemical : Serine Endopeptidases.
Abstract
Helicases are promising antiviral drug targets because their enzymatic activities are essential for viral genome replication, transcription, and translation. Numerous potent inhibitors of helicases encoded by herpes simplex virus, severe acute respiratory syndrome coronavirus, hepatitis C virus, Japanese encephalitis virus, West Nile virus, and human papillomavirus have been recently reported in the scientific literature. Some inhibitors have also been shown to decrease viral replication in cell culture and animal models. This review discusses recent progress in understanding the structure and function of viral helicases to help clarify how these potential antiviral compounds function and to facilitate the design of better inhibitors. The above helicases and all related viral proteins are classified here based on their evolutionary and functional similarities, and the key mechanistic features of each group are noted. All helicases share a common motor function fueled by ATP hydrolysis, but differ in exactly how the motor moves the protein and its cargo on a nucleic acid chain. The helicase inhibitors discussed here influence rates of helicase-catalyzed DNA (or RNA) unwinding by preventing ATP hydrolysis, nucleic acid binding, nucleic acid release, or by disrupting the interaction of a helicase with a required cofactor.
DOI: 10.2174/138161206776361147
PubMed: 16611118
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002278
- to stream PubMed, to step Curation: 002278
- to stream PubMed, to step Checkpoint: 001F36
- to stream Ncbi, to step Merge: 001453
- to stream Ncbi, to step Curation: 001453
- to stream Ncbi, to step Checkpoint: 001453
- to stream Main, to step Merge: 003E04
- to stream Main, to step Curation: 003C43
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Understanding helicases as a means of virus control.</title><author><name sortKey="Frick, D N" sort="Frick, D N" uniqKey="Frick D" first="D N" last="Frick">D N Frick</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry & Molecular Biology, New York Medical College, Valhalla, NY 10595, USA. David_Frick@NYMC.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry & Molecular Biology, New York Medical College, Valhalla, NY 10595</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Lam, A M I" sort="Lam, A M I" uniqKey="Lam A" first="A M I" last="Lam">A M I. Lam</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:16611118</idno><idno type="pmid">16611118</idno><idno type="doi">10.2174/138161206776361147</idno><idno type="wicri:Area/PubMed/Corpus">002278</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002278</idno><idno type="wicri:Area/PubMed/Curation">002278</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002278</idno><idno type="wicri:Area/PubMed/Checkpoint">001F36</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001F36</idno><idno type="wicri:Area/Ncbi/Merge">001453</idno><idno type="wicri:Area/Ncbi/Curation">001453</idno><idno type="wicri:Area/Ncbi/Checkpoint">001453</idno><idno type="wicri:doubleKey">1381-6128:2006:Frick D:understanding:helicases:as</idno><idno type="wicri:Area/Main/Merge">003E04</idno><idno type="wicri:Area/Main/Curation">003C43</idno><idno type="wicri:Area/Main/Exploration">003C43</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Understanding helicases as a means of virus control.</title><author><name sortKey="Frick, D N" sort="Frick, D N" uniqKey="Frick D" first="D N" last="Frick">D N Frick</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry & Molecular Biology, New York Medical College, Valhalla, NY 10595, USA. David_Frick@NYMC.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry & Molecular Biology, New York Medical College, Valhalla, NY 10595</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Lam, A M I" sort="Lam, A M I" uniqKey="Lam A" first="A M I" last="Lam">A M I. Lam</name></author></analytic><series><title level="j">Current pharmaceutical design</title><idno type="ISSN">1381-6128</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (pharmacology)</term><term>DNA Helicases (antagonists & inhibitors)</term><term>DNA Helicases (chemistry)</term><term>DNA Helicases (physiology)</term><term>DNA Primase (antagonists & inhibitors)</term><term>Enzyme Inhibitors (pharmacology)</term><term>Papillomaviridae (drug effects)</term><term>Papillomaviridae (enzymology)</term><term>RNA Helicases (antagonists & inhibitors)</term><term>RNA Helicases (chemistry)</term><term>RNA Helicases (physiology)</term><term>SARS Virus (drug effects)</term><term>SARS Virus (enzymology)</term><term>Serine Endopeptidases</term><term>Simplexvirus (drug effects)</term><term>Simplexvirus (enzymology)</term><term>Viral Nonstructural Proteins (antagonists & inhibitors)</term><term>Viral Proteins (antagonists & inhibitors)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antienzymes (pharmacologie)</term><term>Antiviraux (pharmacologie)</term><term>DNA primase (antagonistes et inhibiteurs)</term><term>Helicase ()</term><term>Helicase (antagonistes et inhibiteurs)</term><term>Helicase (physiologie)</term><term>Papillomaviridae ()</term><term>Papillomaviridae (enzymologie)</term><term>Protéines virales (antagonistes et inhibiteurs)</term><term>Protéines virales non structurales (antagonistes et inhibiteurs)</term><term>RNA helicases ()</term><term>RNA helicases (antagonistes et inhibiteurs)</term><term>RNA helicases (physiologie)</term><term>Serine endopeptidases</term><term>Simplexvirus ()</term><term>Simplexvirus (enzymologie)</term><term>Virus du SRAS ()</term><term>Virus du SRAS (enzymologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>DNA Helicases</term><term>DNA Primase</term><term>RNA Helicases</term><term>Viral Nonstructural Proteins</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA Helicases</term><term>RNA Helicases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Enzyme Inhibitors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>DNA Helicases</term><term>RNA Helicases</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>DNA primase</term><term>Helicase</term><term>Protéines virales</term><term>Protéines virales non structurales</term><term>RNA helicases</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Papillomaviridae</term><term>SARS Virus</term><term>Simplexvirus</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Papillomaviridae</term><term>Simplexvirus</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Papillomaviridae</term><term>SARS Virus</term><term>Simplexvirus</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antienzymes</term><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Helicase</term><term>RNA helicases</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Serine Endopeptidases</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Helicase</term><term>Papillomaviridae</term><term>RNA helicases</term><term>Serine endopeptidases</term><term>Simplexvirus</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Helicases are promising antiviral drug targets because their enzymatic activities are essential for viral genome replication, transcription, and translation. Numerous potent inhibitors of helicases encoded by herpes simplex virus, severe acute respiratory syndrome coronavirus, hepatitis C virus, Japanese encephalitis virus, West Nile virus, and human papillomavirus have been recently reported in the scientific literature. Some inhibitors have also been shown to decrease viral replication in cell culture and animal models. This review discusses recent progress in understanding the structure and function of viral helicases to help clarify how these potential antiviral compounds function and to facilitate the design of better inhibitors. The above helicases and all related viral proteins are classified here based on their evolutionary and functional similarities, and the key mechanistic features of each group are noted. All helicases share a common motor function fueled by ATP hydrolysis, but differ in exactly how the motor moves the protein and its cargo on a nucleic acid chain. The helicase inhibitors discussed here influence rates of helicase-catalyzed DNA (or RNA) unwinding by preventing ATP hydrolysis, nucleic acid binding, nucleic acid release, or by disrupting the interaction of a helicase with a required cofactor.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><noCountry><name sortKey="Lam, A M I" sort="Lam, A M I" uniqKey="Lam A" first="A M I" last="Lam">A M I. Lam</name></noCountry><country name="États-Unis"><region name="État de New York"><name sortKey="Frick, D N" sort="Frick, D N" uniqKey="Frick D" first="D N" last="Frick">D N Frick</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003C43 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003C43 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:16611118
|texte= Understanding helicases as a means of virus control.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:16611118" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |