SrasV1, PubMed, Corpus, bibRecord, 002278

Understanding helicases as a means of virus control.

Identifieur interne : 002278 ( PubMed/Corpus ); précédent : 002277; suivant : 002279

Understanding helicases as a means of virus control.

Auteurs : D N Frick ; A M I. Lam

Source :

Current pharmaceutical design [ 1381-6128 ] ; 2006.

RBID : pubmed:16611118

English descriptors

KwdEn :
- Antiviral Agents (pharmacology), DNA Helicases (antagonists & inhibitors), DNA Helicases (chemistry), DNA Helicases (physiology), DNA Primase (antagonists & inhibitors), Enzyme Inhibitors (pharmacology), Papillomaviridae (drug effects), Papillomaviridae (enzymology), RNA Helicases (antagonists & inhibitors), RNA Helicases (chemistry), RNA Helicases (physiology), SARS Virus (drug effects), SARS Virus (enzymology), Serine Endopeptidases, Simplexvirus (drug effects), Simplexvirus (enzymology), Viral Nonstructural Proteins (antagonists & inhibitors), Viral Proteins (antagonists & inhibitors).
MESH :
- chemical , antagonists & inhibitors : DNA Helicases, DNA Primase, RNA Helicases, Viral Nonstructural Proteins, Viral Proteins.
- chemical , chemistry : DNA Helicases, RNA Helicases.
- chemical , pharmacology : Antiviral Agents, Enzyme Inhibitors.
- chemical , physiology : DNA Helicases, RNA Helicases.
- drug effects : Papillomaviridae, SARS Virus, Simplexvirus.
- enzymology : Papillomaviridae, SARS Virus, Simplexvirus.
- chemical : Serine Endopeptidases.

Abstract

Helicases are promising antiviral drug targets because their enzymatic activities are essential for viral genome replication, transcription, and translation. Numerous potent inhibitors of helicases encoded by herpes simplex virus, severe acute respiratory syndrome coronavirus, hepatitis C virus, Japanese encephalitis virus, West Nile virus, and human papillomavirus have been recently reported in the scientific literature. Some inhibitors have also been shown to decrease viral replication in cell culture and animal models. This review discusses recent progress in understanding the structure and function of viral helicases to help clarify how these potential antiviral compounds function and to facilitate the design of better inhibitors. The above helicases and all related viral proteins are classified here based on their evolutionary and functional similarities, and the key mechanistic features of each group are noted. All helicases share a common motor function fueled by ATP hydrolysis, but differ in exactly how the motor moves the protein and its cargo on a nucleic acid chain. The helicase inhibitors discussed here influence rates of helicase-catalyzed DNA (or RNA) unwinding by preventing ATP hydrolysis, nucleic acid binding, nucleic acid release, or by disrupting the interaction of a helicase with a required cofactor.

DOI: 10.2174/138161206776361147
PubMed: 16611118

Links to Exploration step

pubmed:16611118

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Understanding helicases as a means of virus control.</title>
<author><name sortKey="Frick, D N" sort="Frick, D N" uniqKey="Frick D" first="D N" last="Frick">D N Frick</name>
<affiliation><nlm:affiliation>Department of Biochemistry & Molecular Biology, New York Medical College, Valhalla, NY 10595, USA. David_Frick@NYMC.edu</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lam, A M I" sort="Lam, A M I" uniqKey="Lam A" first="A M I" last="Lam">A M I. Lam</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2006">2006</date>
<idno type="RBID">pubmed:16611118</idno>
<idno type="pmid">16611118</idno>
<idno type="doi">10.2174/138161206776361147</idno>
<idno type="wicri:Area/PubMed/Corpus">002278</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002278</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Understanding helicases as a means of virus control.</title>
<author><name sortKey="Frick, D N" sort="Frick, D N" uniqKey="Frick D" first="D N" last="Frick">D N Frick</name>
<affiliation><nlm:affiliation>Department of Biochemistry & Molecular Biology, New York Medical College, Valhalla, NY 10595, USA. David_Frick@NYMC.edu</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lam, A M I" sort="Lam, A M I" uniqKey="Lam A" first="A M I" last="Lam">A M I. Lam</name>
</author>
</analytic>
<series><title level="j">Current pharmaceutical design</title>
<idno type="ISSN">1381-6128</idno>
<imprint><date when="2006" type="published">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (pharmacology)</term>
<term>DNA Helicases (antagonists & inhibitors)</term>
<term>DNA Helicases (chemistry)</term>
<term>DNA Helicases (physiology)</term>
<term>DNA Primase (antagonists & inhibitors)</term>
<term>Enzyme Inhibitors (pharmacology)</term>
<term>Papillomaviridae (drug effects)</term>
<term>Papillomaviridae (enzymology)</term>
<term>RNA Helicases (antagonists & inhibitors)</term>
<term>RNA Helicases (chemistry)</term>
<term>RNA Helicases (physiology)</term>
<term>SARS Virus (drug effects)</term>
<term>SARS Virus (enzymology)</term>
<term>Serine Endopeptidases</term>
<term>Simplexvirus (drug effects)</term>
<term>Simplexvirus (enzymology)</term>
<term>Viral Nonstructural Proteins (antagonists & inhibitors)</term>
<term>Viral Proteins (antagonists & inhibitors)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>DNA Helicases</term>
<term>DNA Primase</term>
<term>RNA Helicases</term>
<term>Viral Nonstructural Proteins</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA Helicases</term>
<term>RNA Helicases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term>
<term>Enzyme Inhibitors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>DNA Helicases</term>
<term>RNA Helicases</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Papillomaviridae</term>
<term>SARS Virus</term>
<term>Simplexvirus</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Papillomaviridae</term>
<term>SARS Virus</term>
<term>Simplexvirus</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Serine Endopeptidases</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Helicases are promising antiviral drug targets because their enzymatic activities are essential for viral genome replication, transcription, and translation. Numerous potent inhibitors of helicases encoded by herpes simplex virus, severe acute respiratory syndrome coronavirus, hepatitis C virus, Japanese encephalitis virus, West Nile virus, and human papillomavirus have been recently reported in the scientific literature. Some inhibitors have also been shown to decrease viral replication in cell culture and animal models. This review discusses recent progress in understanding the structure and function of viral helicases to help clarify how these potential antiviral compounds function and to facilitate the design of better inhibitors. The above helicases and all related viral proteins are classified here based on their evolutionary and functional similarities, and the key mechanistic features of each group are noted. All helicases share a common motor function fueled by ATP hydrolysis, but differ in exactly how the motor moves the protein and its cargo on a nucleic acid chain. The helicase inhibitors discussed here influence rates of helicase-catalyzed DNA (or RNA) unwinding by preventing ATP hydrolysis, nucleic acid binding, nucleic acid release, or by disrupting the interaction of a helicase with a required cofactor.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16611118</PMID>
<DateCompleted><Year>2006</Year>
<Month>06</Month>
<Day>08</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>07</Month>
<Day>28</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">1381-6128</ISSN>
<JournalIssue CitedMedium="Print"><Volume>12</Volume>
<Issue>11</Issue>
<PubDate><Year>2006</Year>
</PubDate>
</JournalIssue>
<Title>Current pharmaceutical design</Title>
<ISOAbbreviation>Curr. Pharm. Des.</ISOAbbreviation>
</Journal>
<ArticleTitle>Understanding helicases as a means of virus control.</ArticleTitle>
<Pagination><MedlinePgn>1315-38</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Helicases are promising antiviral drug targets because their enzymatic activities are essential for viral genome replication, transcription, and translation. Numerous potent inhibitors of helicases encoded by herpes simplex virus, severe acute respiratory syndrome coronavirus, hepatitis C virus, Japanese encephalitis virus, West Nile virus, and human papillomavirus have been recently reported in the scientific literature. Some inhibitors have also been shown to decrease viral replication in cell culture and animal models. This review discusses recent progress in understanding the structure and function of viral helicases to help clarify how these potential antiviral compounds function and to facilitate the design of better inhibitors. The above helicases and all related viral proteins are classified here based on their evolutionary and functional similarities, and the key mechanistic features of each group are noted. All helicases share a common motor function fueled by ATP hydrolysis, but differ in exactly how the motor moves the protein and its cargo on a nucleic acid chain. The helicase inhibitors discussed here influence rates of helicase-catalyzed DNA (or RNA) unwinding by preventing ATP hydrolysis, nucleic acid binding, nucleic acid release, or by disrupting the interaction of a helicase with a required cofactor.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Frick</LastName>
<ForeName>D N</ForeName>
<Initials>DN</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry & Molecular Biology, New York Medical College, Valhalla, NY 10595, USA. David_Frick@NYMC.edu</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lam</LastName>
<ForeName>A M I</ForeName>
<Initials>AM</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R01 AI052395</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 AI052395-04</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>AI052395</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United Arab Emirates</Country>
<MedlineTA>Curr Pharm Des</MedlineTA>
<NlmUniqueID>9602487</NlmUniqueID>
<ISSNLinking>1381-6128</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004791">Enzyme Inhibitors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C060028">NS3 protein, flavivirus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C084422">NS3 protein, hepatitis C virus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D017361">Viral Nonstructural Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.7.-</RegistryNumber>
<NameOfSubstance UI="D019915">DNA Primase</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.1.-</RegistryNumber>
<NameOfSubstance UI="C062021">helicase-primase, Human herpesvirus 1</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.21.-</RegistryNumber>
<NameOfSubstance UI="D012697">Serine Endopeptidases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.6.4.-</RegistryNumber>
<NameOfSubstance UI="D004265">DNA Helicases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.6.4.13</RegistryNumber>
<NameOfSubstance UI="D020365">RNA Helicases</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004265" MajorTopicYN="N">DNA Helicases</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019915" MajorTopicYN="N">DNA Primase</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004791" MajorTopicYN="N">Enzyme Inhibitors</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D027383" MajorTopicYN="N">Papillomaviridae</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020365" MajorTopicYN="N">RNA Helicases</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012697" MajorTopicYN="N">Serine Endopeptidases</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018139" MajorTopicYN="N">Simplexvirus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017361" MajorTopicYN="N">Viral Nonstructural Proteins</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014764" MajorTopicYN="N">Viral Proteins</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName>
</MeshHeading>
</MeshHeadingList>
<NumberOfReferences>239</NumberOfReferences>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year>
<Month>4</Month>
<Day>14</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2006</Year>
<Month>6</Month>
<Day>9</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2006</Year>
<Month>4</Month>
<Day>14</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">16611118</ArticleId>
<ArticleId IdType="pmc">PMC3571686</ArticleId>
<ArticleId IdType="mid">NIHMS117595</ArticleId>
<ArticleId IdType="doi">10.2174/138161206776361147</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Eur J Biochem. 2003 Apr;270(8):1645-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12694177</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2004;32(13):4060-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15289579</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2004 Aug 15;18(16):1981-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15289463</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12455-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15310852</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Microbiol. 2004 Aug;7(4):412-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15358261</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chem Biol. 2004 Sep;11(9):1293-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15380189</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2004 Oct 1;119(1):47-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15454080</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antimicrob Agents Chemother. 2003 Jun;47(6):1798-804</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12760851</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2003 May 29;423(6939):512-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12774115</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2003 May 30;300(5624):1394-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12730500</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2003 May 30;300(5624):1399-404</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12730501</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2003 Jun 27;278(26):23311-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12660239</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2003 Nov 21;278(47):47002-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12968023</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS Lett. 2003 Nov 20;554(3):485-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14623116</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 2003 Dec 1;22(23):6205-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14633980</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2003 Nov 28;278(48):48084-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12966097</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2003 Nov;12(5):1113-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14636571</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 1999 Oct 15;99(2):167-77</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10535735</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochemistry. 1999 Nov 23;38(47):15493-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10569931</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Structure. 1999 Nov 15;7(11):1353-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10574797</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 1999 Dec 15;65(2):155-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10581388</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1999 Dec 10;274(50):35889-98</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10585474</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Microbiol. 1999 Dec;34(5):867-77</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10594814</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biol. 2000 Jan;20(1):34-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10594006</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS Lett. 2000 Jan 7;465(1):74-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10620709</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochemistry. 2000 Jan 11;39(1):205-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10625495</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2000 Jan 27;403(6768):447-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10667799</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gene. 2000 Jan 25;242(1-2):369-79</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10721731</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2000 Jun;74(11):5213-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10799597</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochemistry. 2000 May 2;39(17):5174-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10819985</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2000 Jun;74(12):5726-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10823882</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Biochem. 2000 Jun;267(12):3685-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10848986</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2000 Jul;81(Pt 7):1649-58</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10859369</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2000 Jun 9;101(6):589-600</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10892646</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 2000 Jul 17;19(14):3799-810</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10899133</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>RNA. 2000 Jul;6(7):1056-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10917600</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2000 Oct;74(19):8803-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10982322</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Biochem. 2000;69:651-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10966472</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2000 Oct;81(Pt 10):2481-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10993936</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2000 Oct;74(20):9586-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11000230</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2000 Dec;81(Pt 12):3099-106</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11086141</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Biophys Res Commun. 2000 Dec 20;279(2):557-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11118325</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2001 Jan;75(1):205-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11119590</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2001 Jan 15;29(2):565-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11139627</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2001 Jan 5;291(5501):121-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11141562</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2001 Feb;75(4):1611-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11160659</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2001 Feb;75(4):1708-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11160669</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Biochem Sci. 2001 Jan;26(1):47-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11165517</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2001 Apr;75(7):3220-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11238848</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1988 Jan;85(2):396-400</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2829184</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 1988 Jul 25;16(14A):6585-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2840645</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 1989 Jun 26;17(12):4713-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2546125</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1989 Dec 15;264(35):20835-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2556383</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS Lett. 1990 Mar 12;262(1):145-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2156730</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 1990 Dec 11;18(23):7003-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2263459</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Biochem. 1991 Jan 1;195(1):49-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1846811</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1105-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1847509</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1991 Mar 5;266(7):4484-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1847923</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1992 Jan;66(1):469-79</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1309257</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1992 Jan 23;355(6358):374-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1731253</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 1992 Apr 17;256(5055):350-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1533057</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Evol. 1992 Apr;34(4):351-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1569588</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1992 Jul;66(7):3986-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1318393</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biol. 2001 Apr;21(8):2706-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11283250</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2001 May 18;276(20):17610-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11278618</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2001 Jun 22;276(25):22426-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11304544</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8381-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11459979</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2001 Sep;75(17):8289-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11483774</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2001 Aug;8(2):251-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11545728</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Prog Nucleic Acid Res Mol Biol. 2001;70:77-118</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11642367</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Biol. 2001 Nov 2;313(4):683-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11697897</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2001 Dec;75(24):12114-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11711602</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Biochem. 2001;70:39-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11395402</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochemistry. 2002 Feb 19;41(7):2372-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11841230</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2003 Apr 1;31(7):1935-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12655010</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2000 Feb;74(4):1794-800</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10644352</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1994 Feb 4;269(5):3283-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8106366</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 1994 Feb 15;199(1):176-87</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8116241</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1994 Aug;68(8):4829-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7518528</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Biochem. 1994 Sep 1;224(2):677-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7925384</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1994 Dec 30;269(52):33069-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7806535</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Biol. 2001 Nov 30;314(3):543-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11846566</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 2002 Mar 1;21(5):1168-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11867545</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol Methods. 2002 May;103(1):75-88</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11906735</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Biol. 2002 Mar 19;12(6):472-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11909532</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Biol. 2002 Mar 15;317(1):41-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11916378</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2002 Apr;8(4):386-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11927945</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2002 Apr;8(4):392-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11927946</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antimicrob Agents Chemother. 2002 May;46(5):1231-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11959550</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antimicrob Agents Chemother. 2002 Jun;46(6):1766-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12019088</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 2002 Jun 3;21(11):2757-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12032088</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2002 Jun 1;30(11):2280-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12034814</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2002 May 10;296(2):321-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12069530</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Genes. 2002 Jun;24(3):275-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12086149</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochemistry. 2002 Aug 13;41(32):10332-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12162749</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2002 Jul 20;299(1):122-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12167347</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2002 Aug 16;277(33):29377-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12034714</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Top Med Chem. 2002 Oct;2(10):1093-109</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12173969</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2002 Aug 30;277(35):32036-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12039955</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antiviral Res. 2002 Sep;55(3):397-412</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12206878</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Hepatol. 2002 Nov;37(5):660-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12399234</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Biochim Pol. 2002;49(3):597-614</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12422230</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14722-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12411580</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2002 Nov 22;277(47):44886-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12244108</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2003 Jan;77(1):571-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12477861</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Biol. 2003 Jan 31;325(5):913-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12527299</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2003 Jan;11(1):127-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12535527</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):898-903</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12552114</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2003 Mar;77(6):3549-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12610130</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Q Rev Biophys. 2002 Nov;35(4):431-78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12621862</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Microbiol Mol Biol Rev. 2003 Mar;67(1):86-156, table of contents</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12626685</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2003 Apr;77(7):3950-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12634355</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Q Rev Biophys. 2003 Feb;36(1):1-69</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12643042</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Struct Biol. 1997 Sep;4(9):686-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9302992</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1997 Oct;71(10):7220-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9311795</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Biochem. 1997 Nov 15;250(1):47-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9431989</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 1998 Feb 15;12(4):538-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9472022</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Structure. 1998 Jan 15;6(1):89-100</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9493270</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1998 Mar 27;273(13):7390-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9516436</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurovirol. 1998 Feb;4(1):59-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9531012</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1998 Jun;72(6):4874-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9573254</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1998 Jun 5;273(23):14247-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9603930</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1998 Jun 12;273(24):15045-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9614113</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7957-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9653122</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1998 Jul 24;273(30):18906-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9668067</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1998 Sep;72(9):6979-87</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9696789</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 1999 Jan 15;27(2):551-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9862979</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2003 Jul 15;31(14):3918-28</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12853607</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2003 Jul 18;278(29):26765-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12730224</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Biol. 2003 Aug 1;331(1):139-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12875841</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2003 Jul 25;114(2):157-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12887917</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Structure. 2003 Aug;11(8):1025-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12906833</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gene. 2003 Jul 17;312:1-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12909336</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2003 Sep;84(Pt 9):2305-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12917450</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2003 Sep;84(Pt 9):2323-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12917452</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Chem. 2003 Sep 11;46(19):4149-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12954067</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Drug News Perspect. 2003 Jul-Aug;16(6):355-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12973446</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2003 Oct 10;278(41):39578-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12917423</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Chem. 2003 Oct 23;46(22):4776-89</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14561097</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2003 Nov 7;278(45):44514-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12944414</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1999 Oct 15;274(42):30303-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10514525</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Biol. 1965 May;12:88-118</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14343300</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Biophys Res Commun. 2004 Dec 17;325(3):670-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15541341</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antiviral Res. 2004 Dec;64(3):161-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15550269</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Genet. 2004;38:819-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15568995</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Chem. 2004 Jan 1;47(1):18-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14695816</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2004 Jan 9;279(2):1269-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14585830</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2004 Jan 29;427(6973):465-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14749837</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Drug Targets Infect Disord. 2003 Dec;3(4):383-400</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14754437</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Pharm Des. 2004;10(3):315-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14754390</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Struct Biol. 2004 Apr-May;146(1-2):11-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15037234</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biochem. 2004 Feb;135(2):245-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15047727</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Structure. 2004 Apr;12(4):583-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15062081</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4373-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15070725</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2004 Jun;78(11):5619-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15140959</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Struct Mol Biol. 2004 Jun;11(6):526-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15146171</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Struct Mol Biol. 2004 Jun;11(6):531-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15146172</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2004 Jun 18;279(25):26005-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15087464</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2004 Jul;78(14):7833-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15220459</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2004 Jul 22;430(6998):476-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15269774</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>RNA. 2004 Aug;10(8):1277-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15247433</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Pharm Des. 2004;10(17):2063-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15279545</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Pharm Des. 2004;10(17):2123-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15279551</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol (Mosk). 2004 May-Jun;38(3):553-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15285626</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Pathol. 2004 Oct;165(4):1163-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15466383</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2004;32(18):5519-28</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15479787</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2004 Oct 29;119(3):381-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15507209</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1979 Feb;76(2):610-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">218212</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Biochem. 1979 Jan 15;93(2):387-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">218815</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1981 Jan;78(1):205-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6454135</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1982 Oct 25;257(20):12426-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6288720</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1982 Oct 7;299(5883):529-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6289124</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 1983 Aug;34(1):115-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6136341</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1983 Nov 25;258(22):14017-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6315716</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 1982;1(2):231-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6325156</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 1982;1(8):945-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6329717</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1984 Oct 25;259(20):12925-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6092351</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Jan;79(2):696-704</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15613297</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2005 Mar 18;280(11):10797-806</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15634684</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12398-402</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7809048</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1995 Mar;69(3):1720-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7853509</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1995 Mar 31;270(13):7462-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7706292</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Rep. 1994;20(2):97-107</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7536299</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3869-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7731998</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 1995 May 11;23(9):1590-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7784215</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1995 Aug 25;270(34):20215-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7650041</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1995 Oct;69(10):6131-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7545242</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1995 Sep 22;270(38):22236-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7673202</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Biophys Res Commun. 1995 Oct 4;215(1):160-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7575585</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS Lett. 1995 Dec 4;376(3):221-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7498546</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 1996 Mar 1;217(1):367-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8599224</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 1992 Apr;73 ( Pt 4):989-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1321883</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Biochem. 1992;61:55-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1323237</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10935-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1332061</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1993 Jan 15;268(2):1220-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8380408</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1993 Feb;67(2):989-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8380474</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 1993 Feb 11;21(3):751-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8382805</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1993 Apr 15;268(11):8105-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8385138</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1993 Jun 5;268(16):11798-802</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8505308</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5086-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8389467</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1993 Oct;67(10):6152-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8396675</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 1993 Nov;197(1):265-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8212562</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 1993 Sep;12(9):3703-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8253092</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2004 Oct 25;328(2):208-18</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15464841</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochemistry. 1996 Feb 20;35(7):2218-28</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8652563</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1996 Aug 9;271(32):19625-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8702659</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Biophys Res Commun. 1996 Aug 14;225(2):654-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8753814</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1996 Oct 4;271(40):24449-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8798703</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Biochem. 1996;65:169-214</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8811178</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1996 Nov;70(11):8169-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8892948</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1996 Oct 25;271(43):26825-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8900164</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1996 Nov 28;384(6607):379-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8934527</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1996 Dec;70(12):8477-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8970970</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 1997 Jan 17;275(5298):377-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8994032</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1997 Feb 14;272(7):4623-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9020191</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 1997 Feb 3;228(1):98-106</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9024814</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1997 Mar 20;386(6622):299-302</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9069291</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3579-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9108019</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1997 May 13;94(10):5012-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9144181</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1997 Jun;71(6):4461-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9151837</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 1997 Jul 1;25(13):2620-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9185573</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Struct Biol. 1997 Jun;4(6):463-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9187654</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Biochem. 1997;66:347-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9242911</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 1997 Aug 22;90(4):635-47</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9288744</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1999 Feb 12;274(7):4447-58</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9933649</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1999 Apr;73(4):2909-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10074139</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1999 Apr;73(4):3108-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10074162</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1999 Mar 19;274(12):8068-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10075707</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 1999 Mar;80 ( Pt 3):701-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10092010</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 1999 Apr 2;97(1):75-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10199404</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4295-300</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10200256</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochemistry. 1999 Apr 20;38(16):5164-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10213622</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS Lett. 1999 Apr 1;448(1):19-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10217401</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Biol. 1999 Jul 2;290(1):137-48</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10388562</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pathol. 1999 Sep;189(1):12-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10451482</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1999 Oct;73(10):8798-807</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10482634</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 1999 Sep 1;261(2):216-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10497107</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002278 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 002278 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    PubMed
   |étape=   Corpus
   |type=    RBID
   |clé=     pubmed:16611118
   |texte=   Understanding helicases as a means of virus control.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i   -Sk "pubmed:16611118" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration SRAS

Understanding helicases as a means of virus control.

Understanding helicases as a means of virus control.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki