Nucleocapsid protein of SARS-CoV activates interleukin-6 expression through cellular transcription factor NF-κB
Identifieur interne : 003648 ( Main/Exploration ); précédent : 003647; suivant : 003649Nucleocapsid protein of SARS-CoV activates interleukin-6 expression through cellular transcription factor NF-κB
Auteurs : Xue Zhang [République populaire de Chine] ; Kailang Wu [République populaire de Chine] ; Di Wang [République populaire de Chine] ; Xin Yue [République populaire de Chine] ; Degui Song [République populaire de Chine] ; Ying Zhu [République populaire de Chine] ; Jianguo Wu [République populaire de Chine]Source :
- Virology [ 0042-6822 ] ; 2007.
Descripteurs français
- KwdFr :
- Cellules épithéliales (virologie), Cytoplasme (), Délétion de séquence, Facteur de transcription NF-kappa B (métabolisme), Fusion artificielle de gènes, Gènes rapporteurs, Humains, Immunoprécipitation, Interleukine-6 (génétique), Liaison aux protéines, Lignée cellulaire, Luciferases (analyse), Luciferases (génétique), Mutation, Noyau de la cellule (), Poumon (immunologie), Poumon (virologie), Protéines nucléocapside (immunologie), Protéines nucléocapside (métabolisme), Test de retard de migration électrophorétique, Transport de protéines, Virus du SRAS (immunologie).
- MESH :
- analyse : Luciferases.
- génétique : Interleukine-6, Luciferases.
- immunologie : Poumon, Protéines nucléocapside, Virus du SRAS.
- métabolisme : Facteur de transcription NF-kappa B, Protéines nucléocapside.
- virologie : Cellules épithéliales, Poumon.
- Cytoplasme, Délétion de séquence, Fusion artificielle de gènes, Gènes rapporteurs, Humains, Immunoprécipitation, Liaison aux protéines, Lignée cellulaire, Mutation, Noyau de la cellule, Test de retard de migration électrophorétique, Transport de protéines.
English descriptors
- KwdEn :
- Artificial Gene Fusion, Cell Line, Cell Nucleus (chemistry), Cytoplasm (chemistry), Electrophoretic Mobility Shift Assay, Epithelial Cells (virology), Genes, Reporter, Humans, Immunoprecipitation, Interleukin-6 (genetics), Luciferases (analysis), Luciferases (genetics), Lung (immunology), Lung (virology), Mutation, NF-kappa B (metabolism), Nucleocapsid Proteins (immunology), Nucleocapsid Proteins (metabolism), Protein Binding, Protein Transport, SARS Virus (immunology), Sequence Deletion.
- MESH :
- chemical , analysis : Luciferases.
- chemical , genetics : Interleukin-6, Luciferases.
- chemistry : Cell Nucleus, Cytoplasm.
- immunology : Lung, Nucleocapsid Proteins, SARS Virus.
- chemical , metabolism : NF-kappa B, Nucleocapsid Proteins.
- virology : Epithelial Cells, Lung.
- Artificial Gene Fusion, Cell Line, Electrophoretic Mobility Shift Assay, Genes, Reporter, Humans, Immunoprecipitation, Mutation, Protein Binding, Protein Transport, Sequence Deletion.
Abstract
High levels of interleukin-6 (IL-6) in the acute stage associated with lung lesions were found in SARS patients. To evaluate the mechanisms behind this event, we investigated the roles of SARS-CoV proteins in the regulation of IL-6. Results showed that the viral nucleocapsid (N) protein activated IL-6 expression in a concentration-dependent manner. Promoter analyses suggested that NF-κB binding element was required for IL-6 expression regulated by N protein. Further studies demonstrated that N protein bound directly to NF-κB element on the promoter. We also showed that N protein activated IL-6 expression through NF-κB by facilitating the translocation of NF-κB from cytosol to nucleus. Mutational analyses revealed that two regions of N protein were essential for its function in the activation of IL-6. These results provided new insights into understanding the mechanism involved in the function of SARS-CoV N protein and pathogenesis of the virus.
Url:
DOI: 10.1016/j.virol.2007.04.009
PubMed: 17490702
PubMed Central: 7103332
Affiliations:
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Le document en format XML
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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName><placeName><settlement type="city">Wuhan</settlement><region type="province">Hubei</region></placeName></affiliation></author><author><name sortKey="Yue, Xin" sort="Yue, Xin" uniqKey="Yue X" first="Xin" last="Yue">Xin Yue</name><affiliation wicri:level="4"><nlm:aff id="aff1">State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName><placeName><settlement type="city">Wuhan</settlement><region type="province">Hubei</region></placeName></affiliation></author><author><name sortKey="Song, Degui" sort="Song, Degui" uniqKey="Song D" first="Degui" last="Song">Degui Song</name><affiliation wicri:level="1"><nlm:aff id="aff2">College of Biological Sciences, Guangxi Normal University, Guilin 541004, P.R. 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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName><placeName><settlement type="city">Wuhan</settlement><region type="province">Hubei</region></placeName></affiliation></author><author><name sortKey="Wu, Jianguo" sort="Wu, Jianguo" uniqKey="Wu J" first="Jianguo" last="Wu">Jianguo Wu</name><affiliation wicri:level="4"><nlm:aff id="aff1">State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName><placeName><settlement type="city">Wuhan</settlement><region type="province">Hubei</region></placeName></affiliation></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><idno type="eISSN">1096-0341</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Artificial Gene Fusion</term><term>Cell Line</term><term>Cell Nucleus (chemistry)</term><term>Cytoplasm (chemistry)</term><term>Electrophoretic Mobility Shift Assay</term><term>Epithelial Cells (virology)</term><term>Genes, Reporter</term><term>Humans</term><term>Immunoprecipitation</term><term>Interleukin-6 (genetics)</term><term>Luciferases (analysis)</term><term>Luciferases (genetics)</term><term>Lung (immunology)</term><term>Lung (virology)</term><term>Mutation</term><term>NF-kappa B (metabolism)</term><term>Nucleocapsid Proteins (immunology)</term><term>Nucleocapsid Proteins (metabolism)</term><term>Protein Binding</term><term>Protein Transport</term><term>SARS Virus (immunology)</term><term>Sequence Deletion</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Cellules épithéliales (virologie)</term><term>Cytoplasme ()</term><term>Délétion de séquence</term><term>Facteur de transcription NF-kappa B (métabolisme)</term><term>Fusion artificielle de gènes</term><term>Gènes rapporteurs</term><term>Humains</term><term>Immunoprécipitation</term><term>Interleukine-6 (génétique)</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Luciferases (analyse)</term><term>Luciferases (génétique)</term><term>Mutation</term><term>Noyau de la cellule ()</term><term>Poumon (immunologie)</term><term>Poumon (virologie)</term><term>Protéines nucléocapside (immunologie)</term><term>Protéines nucléocapside (métabolisme)</term><term>Test de retard de migration électrophorétique</term><term>Transport de protéines</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Luciferases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Interleukin-6</term><term>Luciferases</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Luciferases</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Cell Nucleus</term><term>Cytoplasm</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Interleukine-6</term><term>Luciferases</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Poumon</term><term>Protéines nucléocapside</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Lung</term><term>Nucleocapsid Proteins</term><term>SARS Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>NF-kappa B</term><term>Nucleocapsid Proteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de transcription NF-kappa B</term><term>Protéines nucléocapside</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cellules épithéliales</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Epithelial Cells</term><term>Lung</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Artificial Gene Fusion</term><term>Cell Line</term><term>Electrophoretic Mobility Shift Assay</term><term>Genes, Reporter</term><term>Humans</term><term>Immunoprecipitation</term><term>Mutation</term><term>Protein Binding</term><term>Protein Transport</term><term>Sequence Deletion</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cytoplasme</term><term>Délétion de séquence</term><term>Fusion artificielle de gènes</term><term>Gènes rapporteurs</term><term>Humains</term><term>Immunoprécipitation</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Mutation</term><term>Noyau de la cellule</term><term>Test de retard de migration électrophorétique</term><term>Transport de protéines</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>High levels of interleukin-6 (IL-6) in the acute stage associated with lung lesions were found in SARS patients. To evaluate the mechanisms behind this event, we investigated the roles of SARS-CoV proteins in the regulation of IL-6. Results showed that the viral nucleocapsid (N) protein activated IL-6 expression in a concentration-dependent manner. Promoter analyses suggested that NF-κB binding element was required for IL-6 expression regulated by N protein. Further studies demonstrated that N protein bound directly to NF-κB element on the promoter. We also showed that N protein activated IL-6 expression through NF-κB by facilitating the translocation of NF-κB from cytosol to nucleus. Mutational analyses revealed that two regions of N protein were essential for its function in the activation of IL-6. These results provided new insights into understanding the mechanism involved in the function of SARS-CoV N protein and pathogenesis of the virus.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Akira, S" uniqKey="Akira S">S. 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Wu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Hubei</li></region><settlement><li>Wuhan</li></settlement><orgName><li>Université de Wuhan</li></orgName></list><tree><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Zhang, Xue" sort="Zhang, Xue" uniqKey="Zhang X" first="Xue" last="Zhang">Xue Zhang</name></region><name sortKey="Song, Degui" sort="Song, Degui" uniqKey="Song D" first="Degui" last="Song">Degui Song</name><name sortKey="Wang, Di" sort="Wang, Di" uniqKey="Wang D" first="Di" last="Wang">Di Wang</name><name sortKey="Wu, Jianguo" sort="Wu, Jianguo" uniqKey="Wu J" first="Jianguo" last="Wu">Jianguo Wu</name><name sortKey="Wu, Kailang" sort="Wu, Kailang" uniqKey="Wu K" first="Kailang" last="Wu">Kailang Wu</name><name sortKey="Yue, Xin" sort="Yue, Xin" uniqKey="Yue X" first="Xin" last="Yue">Xin Yue</name><name sortKey="Zhu, Ying" sort="Zhu, Ying" uniqKey="Zhu Y" first="Ying" last="Zhu">Ying Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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