Nucleocapsid protein of SARS-CoV activates interleukin-6 expression through cellular transcription factor NF-kappaB.
Identifieur interne : 001D49 ( PubMed/Checkpoint ); précédent : 001D48; suivant : 001D50Nucleocapsid protein of SARS-CoV activates interleukin-6 expression through cellular transcription factor NF-kappaB.
Auteurs : Xue Zhang [République populaire de Chine] ; Kailang Wu ; Di Wang ; Xin Yue ; Degui Song ; Ying Zhu ; Jianguo WuSource :
- Virology [ 0042-6822 ] ; 2007.
Descripteurs français
- KwdFr :
- Cellules épithéliales (virologie), Cytoplasme (), Délétion de séquence, Facteur de transcription NF-kappa B (métabolisme), Fusion artificielle de gènes, Gènes rapporteurs, Humains, Immunoprécipitation, Interleukine-6 (génétique), Liaison aux protéines, Lignée cellulaire, Luciferases (analyse), Luciferases (génétique), Mutation, Noyau de la cellule (), Poumon (immunologie), Poumon (virologie), Protéines nucléocapside (immunologie), Protéines nucléocapside (métabolisme), Test de retard de migration électrophorétique, Transport de protéines, Virus du SRAS (immunologie).
- MESH :
- analyse : Luciferases.
- génétique : Interleukine-6, Luciferases.
- immunologie : Poumon, Protéines nucléocapside, Virus du SRAS.
- métabolisme : Facteur de transcription NF-kappa B, Protéines nucléocapside.
- virologie : Cellules épithéliales, Poumon.
- Cytoplasme, Délétion de séquence, Fusion artificielle de gènes, Gènes rapporteurs, Humains, Immunoprécipitation, Liaison aux protéines, Lignée cellulaire, Mutation, Noyau de la cellule, Test de retard de migration électrophorétique, Transport de protéines.
English descriptors
- KwdEn :
- Artificial Gene Fusion, Cell Line, Cell Nucleus (chemistry), Cytoplasm (chemistry), Electrophoretic Mobility Shift Assay, Epithelial Cells (virology), Genes, Reporter, Humans, Immunoprecipitation, Interleukin-6 (genetics), Luciferases (analysis), Luciferases (genetics), Lung (immunology), Lung (virology), Mutation, NF-kappa B (metabolism), Nucleocapsid Proteins (immunology), Nucleocapsid Proteins (metabolism), Protein Binding, Protein Transport, SARS Virus (immunology), Sequence Deletion.
- MESH :
- chemical , analysis : Luciferases.
- chemical , genetics : Interleukin-6, Luciferases.
- chemistry : Cell Nucleus, Cytoplasm.
- immunology : Lung, Nucleocapsid Proteins, SARS Virus.
- chemical , metabolism : NF-kappa B, Nucleocapsid Proteins.
- virology : Epithelial Cells, Lung.
- Artificial Gene Fusion, Cell Line, Electrophoretic Mobility Shift Assay, Genes, Reporter, Humans, Immunoprecipitation, Mutation, Protein Binding, Protein Transport, Sequence Deletion.
Abstract
High levels of interleukin-6 (IL-6) in the acute stage associated with lung lesions were found in SARS patients. To evaluate the mechanisms behind this event, we investigated the roles of SARS-CoV proteins in the regulation of IL-6. Results showed that the viral nucleocapsid (N) protein activated IL-6 expression in a concentration-dependent manner. Promoter analyses suggested that NF-kappaB binding element was required for IL-6 expression regulated by N protein. Further studies demonstrated that N protein bound directly to NF-kappaB element on the promoter. We also showed that N protein activated IL-6 expression through NF-kappaB by facilitating the translocation of NF-kappaB from cytosol to nucleus. Mutational analyses revealed that two regions of N protein were essential for its function in the activation of IL-6. These results provided new insights into understanding the mechanism involved in the function of SARS-CoV N protein and pathogenesis of the virus.
DOI: 10.1016/j.virol.2007.04.009
PubMed: 17490702
Affiliations:
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pubmed:17490702Le document en format XML
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<front><div type="abstract" xml:lang="en">High levels of interleukin-6 (IL-6) in the acute stage associated with lung lesions were found in SARS patients. To evaluate the mechanisms behind this event, we investigated the roles of SARS-CoV proteins in the regulation of IL-6. Results showed that the viral nucleocapsid (N) protein activated IL-6 expression in a concentration-dependent manner. Promoter analyses suggested that NF-kappaB binding element was required for IL-6 expression regulated by N protein. Further studies demonstrated that N protein bound directly to NF-kappaB element on the promoter. We also showed that N protein activated IL-6 expression through NF-kappaB by facilitating the translocation of NF-kappaB from cytosol to nucleus. Mutational analyses revealed that two regions of N protein were essential for its function in the activation of IL-6. These results provided new insights into understanding the mechanism involved in the function of SARS-CoV N protein and pathogenesis of the virus.</div>
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<Abstract><AbstractText>High levels of interleukin-6 (IL-6) in the acute stage associated with lung lesions were found in SARS patients. To evaluate the mechanisms behind this event, we investigated the roles of SARS-CoV proteins in the regulation of IL-6. Results showed that the viral nucleocapsid (N) protein activated IL-6 expression in a concentration-dependent manner. Promoter analyses suggested that NF-kappaB binding element was required for IL-6 expression regulated by N protein. Further studies demonstrated that N protein bound directly to NF-kappaB element on the promoter. We also showed that N protein activated IL-6 expression through NF-kappaB by facilitating the translocation of NF-kappaB from cytosol to nucleus. Mutational analyses revealed that two regions of N protein were essential for its function in the activation of IL-6. These results provided new insights into understanding the mechanism involved in the function of SARS-CoV N protein and pathogenesis of the virus.</AbstractText>
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<ReferenceList><Reference><Citation>FASEB J. 2007 May;21(7):1586-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17267381</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem Biophys Res Commun. 2004 Apr 2;316(2):476-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15020242</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Res Immunol. 1992 Sep;143(7):723-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1439144</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem J. 2004 Oct 1;383(Pt 1):13-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15294014</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Acta Biochim Biophys Sin (Shanghai). 2005 Sep;37(9):607-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16143815</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virus Genes. 2005 Jan;30(1):93-102</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15744567</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Science. 2003 May 30;300(5624):1394-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12730500</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2003 Mar;77(5):2922-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12584316</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Clin Virol. 2004 Aug;30(4):309-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15163419</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Annu Rev Med. 2000;51:245-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10774463</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Ann Intern Med. 1998 Jan 15;128(2):127-37</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9441573</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 2000 Dec 29;275(52):41028-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11024020</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Adv Immunol. 1997;65:1-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9238507</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem Biophys Res Commun. 2004 Feb 20;314(4):931-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14751221</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virus Res. 2001 Nov 28;80(1-2):75-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11597750</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 1995 May 12;270(19):11463-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7744784</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2000 Sep;74(17):8127-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10933723</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 2003 Feb 14;278(7):4770-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12471036</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Adv Exp Med Biol. 1995;380:259-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8830489</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Annu Rev Immunol. 1990;8:253-78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2188664</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Genes Dev. 1995 Nov 15;9(22):2723-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7590248</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 1997 Feb;71(2):918-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8995608</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem Biophys Res Commun. 2003 Nov 28;311(4):870-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14623261</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2002 May;76(10):4987-99</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11967315</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Immunol. 2003 Mar 15;170(6):3099-108</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12626566</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 1999 Apr 30;274(18):12933-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10212284</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Cell. 1986 Dec 26;47(6):921-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3096580</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Emerg Infect Dis. 2004 Mar;10(3):489-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15109419</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Mol Endocrinol. 1996 Jun;10(6):713-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8776731</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Front Biosci. 1996 Dec 01;1:d340-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9159238</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virus Res. 2005 Dec;114(1-2):23-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15992957</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Mol Cell Biol. 1990 May;10(5):2327-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2183031</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Genomics Proteomics Bioinformatics. 2003 May;1(2):145-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15626344</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Adv Immunol. 1993;54:1-78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8379461</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Int J Biochem Cell Biol. 2006;38(8):1417-28</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16546436</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2003 Dec 18;349(25):2431-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14681510</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2001 Oct;75(19):9345-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11533198</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Science. 2003 May 30;300(5624):1399-404</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12730501</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virology. 1990 Nov;179(1):463-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2171216</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Immunol Rev. 1992 Jun;127:25-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1380488</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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