SrasV1, Main, Exploration, bibRecord, 003495

In vitro inhibition of coronavirus replications by the traditionally used medicinal herbal extracts, Cimicifuga rhizoma, Meliae cortex, Coptidis rhizoma, and Phellodendron cortex

Identifieur interne : 003495 ( Main/Exploration ); précédent : 003494; suivant : 003496

In vitro inhibition of coronavirus replications by the traditionally used medicinal herbal extracts, Cimicifuga rhizoma, Meliae cortex, Coptidis rhizoma, and Phellodendron cortex

Auteurs : Hye-Young Kim [Corée du Sud] ; Hyun-Soo Shin [Corée du Sud] ; Hyun Park [Corée du Sud] ; Youn-Chul Kim [Corée du Sud] ; YONG GAB YUN [Corée du Sud] ; Sun Park [Corée du Sud] ; Ho-Joon Shin [Corée du Sud] ; Kyongmin Kim [Corée du Sud]

Source :

Journal of clinical virology [ 1386-6532 ] ; 2008.

RBID : Pascal:08-0139729

Descripteurs français

Pascal (Inist)
- Coronavirus, Replication in vitro, Phellodendron, Réplication, Antiviral, Microbiologie, Virologie.

English descriptors

KwdEn :
- Antiviral, Coronavirus, In vitro replication, Microbiology, Phellodendron, Replication, Virology.

Abstract

Background: A search for new anti-coronaviral drugs to treat coronaviral infections was motivated by an outbreak of severe acute respiratory syndrome (SARS). Objectives: In order to find drugs that treat coronavirus infections, including SARS, we screened traditional medicinal herbal extracts and evaluated their antiviral activities on coronavirus replication. Study design: We employed a plaque assay to evaluate the effect of 22 medicinal herbal extracts on virus replication. We determined the 50% effective concentration (EC₅₀) of each extract that was necessary to inhibit the replication of mouse hepatitis virus A59 (MHV-A59); we also determined 50% cytotoxic concentrations (CC₅₀) for each extract. Northern and Western blot analyzes were performed to investigate antiviral activity in MHV-infected DBT cells, including virus entry, viral RNA and protein expression, and virus release. Coronavirus specific inhibition was also demonstrated using porcine epidemic diarrhea virus (PEDV). Results: Cimicifuga rhizoma, Meliae cortex, Coptidis rhizoma, Phellodendron cortex and Sophora subprostrata radix decreased the MHV production and the intracellular viral RNA and protein expression with EC₅₀ values ranging from 2.0 to 27.5 μg/ml. These extracts also significantly decreased PEDV production and less dramatically decreased vesicular stomatitis virus (VSV) production in vitro. Conclusions: The extracts selected strongly inhibited MHV replication and could be potential candidates for new anti-coronavirus drugs.

Affiliations:

Corée du Sud

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000310
to stream PascalFrancis, to step Curation: 000678
to stream PascalFrancis, to step Checkpoint: 000275
to stream Main, to step Merge: 003601
to stream Main, to step Curation: 003495

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">In vitro inhibition of coronavirus replications by the traditionally used medicinal herbal extracts, Cimicifuga rhizoma, Meliae cortex, Coptidis rhizoma, and Phellodendron cortex</title>
<author><name sortKey="Kim, Hye Young" sort="Kim, Hye Young" uniqKey="Kim H" first="Hye-Young" last="Kim">Hye-Young Kim</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Microbiology, Ajou University School of Medicine</s1>
<s2>Suwon</s2>
<s3>KOR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Suwon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shin, Hyun Soo" sort="Shin, Hyun Soo" uniqKey="Shin H" first="Hyun-Soo" last="Shin">Hyun-Soo Shin</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Microbiology, Ajou University School of Medicine</s1>
<s2>Suwon</s2>
<s3>KOR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Suwon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Park, Hyun" sort="Park, Hyun" uniqKey="Park H" first="Hyun" last="Park">Hyun Park</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Zoonosis Research Center, Wonkwang University</s1>
<s2>Iksan, Chonbuk</s2>
<s3>KOR</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Iksan, Chonbuk</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Infection Biology, School of Medicine, Wonkwang University</s1>
<s2>Iksan, Chonbuk</s2>
<s3>KOR</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Iksan, Chonbuk</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Youn Chul" sort="Kim, Youn Chul" uniqKey="Kim Y" first="Youn-Chul" last="Kim">Youn-Chul Kim</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Zoonosis Research Center, Wonkwang University</s1>
<s2>Iksan, Chonbuk</s2>
<s3>KOR</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Iksan, Chonbuk</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>College of Pharmacy, Wonkwang University</s1>
<s2>Iksan, Chonbuk</s2>
<s3>KOR</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Iksan, Chonbuk</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yong Gab Yun" sort="Yong Gab Yun" uniqKey="Yong Gab Yun" last="Yong Gab Yun">YONG GAB YUN</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Zoonosis Research Center, Wonkwang University</s1>
<s2>Iksan, Chonbuk</s2>
<s3>KOR</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Iksan, Chonbuk</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Oriental Medicine, Wonkwang University</s1>
<s2>Iksan, Chonbuk</s2>
<s3>KOR</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Iksan, Chonbuk</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Park, Sun" sort="Park, Sun" uniqKey="Park S" first="Sun" last="Park">Sun Park</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Microbiology, Ajou University School of Medicine</s1>
<s2>Suwon</s2>
<s3>KOR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Suwon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shin, Ho Joon" sort="Shin, Ho Joon" uniqKey="Shin H" first="Ho-Joon" last="Shin">Ho-Joon Shin</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Microbiology, Ajou University School of Medicine</s1>
<s2>Suwon</s2>
<s3>KOR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Suwon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Kyongmin" sort="Kim, Kyongmin" uniqKey="Kim K" first="Kyongmin" last="Kim">Kyongmin Kim</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Microbiology, Ajou University School of Medicine</s1>
<s2>Suwon</s2>
<s3>KOR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Suwon</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Zoonosis Research Center, Wonkwang University</s1>
<s2>Iksan, Chonbuk</s2>
<s3>KOR</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Iksan, Chonbuk</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">08-0139729</idno>
<date when="2008">2008</date>
<idno type="stanalyst">PASCAL 08-0139729 INIST</idno>
<idno type="RBID">Pascal:08-0139729</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000310</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000678</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000275</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000275</idno>
<idno type="wicri:doubleKey">1386-6532:2008:Kim H:in:vitro:inhibition</idno>
<idno type="wicri:Area/Main/Merge">003601</idno>
<idno type="wicri:Area/Main/Curation">003495</idno>
<idno type="wicri:Area/Main/Exploration">003495</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">In vitro inhibition of coronavirus replications by the traditionally used medicinal herbal extracts, Cimicifuga rhizoma, Meliae cortex, Coptidis rhizoma, and Phellodendron cortex</title>
<author><name sortKey="Kim, Hye Young" sort="Kim, Hye Young" uniqKey="Kim H" first="Hye-Young" last="Kim">Hye-Young Kim</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Microbiology, Ajou University School of Medicine</s1>
<s2>Suwon</s2>
<s3>KOR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Suwon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shin, Hyun Soo" sort="Shin, Hyun Soo" uniqKey="Shin H" first="Hyun-Soo" last="Shin">Hyun-Soo Shin</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Microbiology, Ajou University School of Medicine</s1>
<s2>Suwon</s2>
<s3>KOR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Suwon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Park, Hyun" sort="Park, Hyun" uniqKey="Park H" first="Hyun" last="Park">Hyun Park</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Zoonosis Research Center, Wonkwang University</s1>
<s2>Iksan, Chonbuk</s2>
<s3>KOR</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Iksan, Chonbuk</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Infection Biology, School of Medicine, Wonkwang University</s1>
<s2>Iksan, Chonbuk</s2>
<s3>KOR</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Iksan, Chonbuk</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Youn Chul" sort="Kim, Youn Chul" uniqKey="Kim Y" first="Youn-Chul" last="Kim">Youn-Chul Kim</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Zoonosis Research Center, Wonkwang University</s1>
<s2>Iksan, Chonbuk</s2>
<s3>KOR</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Iksan, Chonbuk</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>College of Pharmacy, Wonkwang University</s1>
<s2>Iksan, Chonbuk</s2>
<s3>KOR</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Iksan, Chonbuk</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yong Gab Yun" sort="Yong Gab Yun" uniqKey="Yong Gab Yun" last="Yong Gab Yun">YONG GAB YUN</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Zoonosis Research Center, Wonkwang University</s1>
<s2>Iksan, Chonbuk</s2>
<s3>KOR</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Iksan, Chonbuk</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Oriental Medicine, Wonkwang University</s1>
<s2>Iksan, Chonbuk</s2>
<s3>KOR</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Iksan, Chonbuk</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Park, Sun" sort="Park, Sun" uniqKey="Park S" first="Sun" last="Park">Sun Park</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Microbiology, Ajou University School of Medicine</s1>
<s2>Suwon</s2>
<s3>KOR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Suwon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shin, Ho Joon" sort="Shin, Ho Joon" uniqKey="Shin H" first="Ho-Joon" last="Shin">Ho-Joon Shin</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Microbiology, Ajou University School of Medicine</s1>
<s2>Suwon</s2>
<s3>KOR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Suwon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Kyongmin" sort="Kim, Kyongmin" uniqKey="Kim K" first="Kyongmin" last="Kim">Kyongmin Kim</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Microbiology, Ajou University School of Medicine</s1>
<s2>Suwon</s2>
<s3>KOR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Suwon</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Zoonosis Research Center, Wonkwang University</s1>
<s2>Iksan, Chonbuk</s2>
<s3>KOR</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Corée du Sud</country>
<wicri:noRegion>Iksan, Chonbuk</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of clinical virology</title>
<title level="j" type="abbreviated">J. clin. virol.</title>
<idno type="ISSN">1386-6532</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of clinical virology</title>
<title level="j" type="abbreviated">J. clin. virol.</title>
<idno type="ISSN">1386-6532</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral</term>
<term>Coronavirus</term>
<term>In vitro replication</term>
<term>Microbiology</term>
<term>Phellodendron</term>
<term>Replication</term>
<term>Virology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term>
<term>Replication in vitro</term>
<term>Phellodendron</term>
<term>Réplication</term>
<term>Antiviral</term>
<term>Microbiologie</term>
<term>Virologie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: A search for new anti-coronaviral drugs to treat coronaviral infections was motivated by an outbreak of severe acute respiratory syndrome (SARS). Objectives: In order to find drugs that treat coronavirus infections, including SARS, we screened traditional medicinal herbal extracts and evaluated their antiviral activities on coronavirus replication. Study design: We employed a plaque assay to evaluate the effect of 22 medicinal herbal extracts on virus replication. We determined the 50% effective concentration (EC<sub>50</sub>
) of each extract that was necessary to inhibit the replication of mouse hepatitis virus A59 (MHV-A59); we also determined 50% cytotoxic concentrations (CC<sub>50</sub>
) for each extract. Northern and Western blot analyzes were performed to investigate antiviral activity in MHV-infected DBT cells, including virus entry, viral RNA and protein expression, and virus release. Coronavirus specific inhibition was also demonstrated using porcine epidemic diarrhea virus (PEDV). Results: Cimicifuga rhizoma, Meliae cortex, Coptidis rhizoma, Phellodendron cortex and Sophora subprostrata radix decreased the MHV production and the intracellular viral RNA and protein expression with EC<sub>50</sub>
 values ranging from 2.0 to 27.5 μg/ml. These extracts also significantly decreased PEDV production and less dramatically decreased vesicular stomatitis virus (VSV) production in vitro. Conclusions: The extracts selected strongly inhibited MHV replication and could be potential candidates for new anti-coronavirus drugs.</div>
</front>
</TEI>
<affiliations><list><country><li>Corée du Sud</li>
</country>
</list>
<tree><country name="Corée du Sud"><noRegion><name sortKey="Kim, Hye Young" sort="Kim, Hye Young" uniqKey="Kim H" first="Hye-Young" last="Kim">Hye-Young Kim</name>
</noRegion>
<name sortKey="Kim, Kyongmin" sort="Kim, Kyongmin" uniqKey="Kim K" first="Kyongmin" last="Kim">Kyongmin Kim</name>
<name sortKey="Kim, Kyongmin" sort="Kim, Kyongmin" uniqKey="Kim K" first="Kyongmin" last="Kim">Kyongmin Kim</name>
<name sortKey="Kim, Youn Chul" sort="Kim, Youn Chul" uniqKey="Kim Y" first="Youn-Chul" last="Kim">Youn-Chul Kim</name>
<name sortKey="Kim, Youn Chul" sort="Kim, Youn Chul" uniqKey="Kim Y" first="Youn-Chul" last="Kim">Youn-Chul Kim</name>
<name sortKey="Park, Hyun" sort="Park, Hyun" uniqKey="Park H" first="Hyun" last="Park">Hyun Park</name>
<name sortKey="Park, Hyun" sort="Park, Hyun" uniqKey="Park H" first="Hyun" last="Park">Hyun Park</name>
<name sortKey="Park, Sun" sort="Park, Sun" uniqKey="Park S" first="Sun" last="Park">Sun Park</name>
<name sortKey="Shin, Ho Joon" sort="Shin, Ho Joon" uniqKey="Shin H" first="Ho-Joon" last="Shin">Ho-Joon Shin</name>
<name sortKey="Shin, Hyun Soo" sort="Shin, Hyun Soo" uniqKey="Shin H" first="Hyun-Soo" last="Shin">Hyun-Soo Shin</name>
<name sortKey="Yong Gab Yun" sort="Yong Gab Yun" uniqKey="Yong Gab Yun" last="Yong Gab Yun">YONG GAB YUN</name>
<name sortKey="Yong Gab Yun" sort="Yong Gab Yun" uniqKey="Yong Gab Yun" last="Yong Gab Yun">YONG GAB YUN</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003495 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003495 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:08-0139729
   |texte=   In vitro inhibition of coronavirus replications by the traditionally used medicinal herbal extracts, Cimicifuga rhizoma, Meliae cortex, Coptidis rhizoma, and Phellodendron cortex
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration SRAS

In vitro inhibition of coronavirus replications by the traditionally used medicinal herbal extracts, Cimicifuga rhizoma, Meliae cortex, Coptidis rhizoma, and Phellodendron cortex

In vitro inhibition of coronavirus replications by the traditionally used medicinal herbal extracts, Cimicifuga rhizoma, Meliae cortex, Coptidis rhizoma, and Phellodendron cortex

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri