Severe acute respiratory syndrome vaccine efficacy in ferrets : whole killed virus and adenovirus-vectored vaccines
Identifieur interne : 003470 ( Main/Exploration ); précédent : 003469; suivant : 003471Severe acute respiratory syndrome vaccine efficacy in ferrets : whole killed virus and adenovirus-vectored vaccines
Auteurs : Raymond H. See [Canada] ; Martin Petric [Canada] ; David J. Lawrence [Canada] ; Catherine P. Y. Mok [Canada] ; Thomas Rowe [États-Unis] ; Lois A. Zitzow [États-Unis] ; Karuna P. Karunakaran [Canada] ; Thomas G. Voss [États-Unis] ; Robert C. Brunham [Canada] ; Jack Gauldie [Canada] ; B. Brett Finlay [Canada] ; Rachel L. Roper [États-Unis]Source :
- Journal of general virology [ 0022-1317 ] ; 2008.
Descripteurs français
- KwdFr :
- Adénovirus humains (génétique), Animaux, Anticorps antiviraux (biosynthèse), Furets (immunologie), Furets (virologie), Humains, Modèles animaux de maladie humaine, Mâle, Poumon (anatomopathologie), Poumon (virologie), Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Tests de neutralisation, Vaccins antiviraux (génétique), Vaccins antiviraux (pharmacologie), Vaccins atténués (génétique), Vaccins atténués (pharmacologie), Vaccins inactivés (pharmacologie), Vaccins synthétiques (génétique), Vaccins synthétiques (pharmacologie), Vecteurs génétiques, Virus du SRAS (génétique), Virus du SRAS (immunologie).
- MESH :
- anatomopathologie : Poumon, Syndrome respiratoire aigu sévère.
- biosynthèse : Anticorps antiviraux.
- génétique : Adénovirus humains, Vaccins antiviraux, Vaccins atténués, Vaccins synthétiques, Virus du SRAS.
- immunologie : Furets, Syndrome respiratoire aigu sévère, Virus du SRAS.
- pharmacologie : Vaccins antiviraux, Vaccins atténués, Vaccins inactivés, Vaccins synthétiques.
- virologie : Furets, Poumon, Syndrome respiratoire aigu sévère.
- Pascal (Inist)
- Wicri :
- topic : Vaccin.
English descriptors
- KwdEn :
- Adenoviridae, Adenoviruses, Human (genetics), Animals, Antibodies, Viral (biosynthesis), Disease Models, Animal, Efficiency, Ferret, Ferrets (immunology), Ferrets (virology), Genetic Vectors, Humans, Lung (pathology), Lung (virology), Male, Microbiology, Neutralization Tests, SARS Virus (genetics), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (prevention & control), Severe Acute Respiratory Syndrome (virology), Severe acute respiratory syndrome, Vaccine, Vaccines, Attenuated (genetics), Vaccines, Attenuated (pharmacology), Vaccines, Inactivated (pharmacology), Vaccines, Synthetic (genetics), Vaccines, Synthetic (pharmacology), Vector, Viral Vaccines (genetics), Viral Vaccines (pharmacology).
- MESH :
- chemical , biosynthesis : Antibodies, Viral.
- genetics : Adenoviruses, Human, SARS Virus, Vaccines, Attenuated, Vaccines, Synthetic, Viral Vaccines.
- immunology : Ferrets, SARS Virus, Severe Acute Respiratory Syndrome.
- pathology : Lung, Severe Acute Respiratory Syndrome.
- chemical , pharmacology : Vaccines, Attenuated, Vaccines, Inactivated, Vaccines, Synthetic, Viral Vaccines.
- prevention & control : Severe Acute Respiratory Syndrome.
- virology : Ferrets, Lung, Severe Acute Respiratory Syndrome.
- Animals, Disease Models, Animal, Genetic Vectors, Humans, Male, Neutralization Tests.
Abstract
Although the 2003 severe acute respiratory syndrome (SARS) outbreak was controlled, repeated transmission of SARS coronavirus (CoV) over several years makes the development of a SARS vaccine desirable. We performed a comparative evaluation of two SARS vaccines for their ability to protect against live SARS-CoV intranasal challenge in ferrets. Both the whole killed SARS-CoV vaccine (with and without alum) and adenovirus-based vectors encoding the nucleocapsid (N) and spike (S) protein induced neutralizing antibody responses and reduced viral replication and shedding in the upper respiratory tract and progression of virus to the lower respiratory tract. The vaccines also diminished haemorrhage in the thymus and reduced the severity and extent of pneumonia and damage to lung epithelium. However, despite high neutralizing antibody titres, protection was incomplete for all vaccine preparations and administration routes. Our data suggest that a combination of vaccine strategies may be required for effective protection from this pathogen. The ferret may be a good model for SARS-CoV infection because it is the only model that replicates the fever seen in human patients, as well as replicating other SARS disease features including infection by the respiratory route, clinical signs, viral replication in upper and lower respiratory tract and lung damage.
Affiliations:
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See</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of British Columbia Centre for Disease Control</s1><s2>Vancouver, BC V5Z 4R4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>University of British Columbia Centre for Disease Control</wicri:noRegion></affiliation></author><author><name sortKey="Petric, Martin" sort="Petric, Martin" uniqKey="Petric M" first="Martin" last="Petric">Martin Petric</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of British Columbia Centre for Disease Control</s1><s2>Vancouver, BC V5Z 4R4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>University of British Columbia Centre for Disease Control</wicri:noRegion></affiliation></author><author><name sortKey="Lawrence, David J" sort="Lawrence, David J" uniqKey="Lawrence D" first="David J." last="Lawrence">David J. Lawrence</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of British Columbia Centre for Disease Control</s1><s2>Vancouver, BC V5Z 4R4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>University of British Columbia Centre for Disease Control</wicri:noRegion></affiliation></author><author><name sortKey="Mok, Catherine P Y" sort="Mok, Catherine P Y" uniqKey="Mok C" first="Catherine P. Y." last="Mok">Catherine P. Y. Mok</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of British Columbia Centre for Disease Control</s1><s2>Vancouver, BC V5Z 4R4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>University of British Columbia Centre for Disease Control</wicri:noRegion></affiliation></author><author><name sortKey="Rowe, Thomas" sort="Rowe, Thomas" uniqKey="Rowe T" first="Thomas" last="Rowe">Thomas Rowe</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Southern Research Institute</s1><s2>Birmingham, AL 35205</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Zitzow, Lois A" sort="Zitzow, Lois A" uniqKey="Zitzow L" first="Lois A." last="Zitzow">Lois A. Zitzow</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Southern Research Institute</s1><s2>Birmingham, AL 35205</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Karunakaran, Karuna P" sort="Karunakaran, Karuna P" uniqKey="Karunakaran K" first="Karuna P." last="Karunakaran">Karuna P. Karunakaran</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of British Columbia Centre for Disease Control</s1><s2>Vancouver, BC V5Z 4R4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>University of British Columbia Centre for Disease Control</wicri:noRegion></affiliation></author><author><name sortKey="Voss, Thomas G" sort="Voss, Thomas G" uniqKey="Voss T" first="Thomas G." last="Voss">Thomas G. Voss</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Southern Research Institute</s1><s2>Birmingham, AL 35205</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Brunham, Robert C" sort="Brunham, Robert C" uniqKey="Brunham R" first="Robert C." last="Brunham">Robert C. Brunham</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of British Columbia Centre for Disease Control</s1><s2>Vancouver, BC V5Z 4R4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>University of British Columbia Centre for Disease Control</wicri:noRegion></affiliation></author><author><name sortKey="Gauldie, Jack" sort="Gauldie, Jack" uniqKey="Gauldie J" first="Jack" last="Gauldie">Jack Gauldie</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Departments of Pathology and Molecular Medicine and Biology, McMaster University</s1><s2>Hamilton, ON L8N 3Z5</s2><s3>CAN</s3><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université McMaster</orgName></affiliation></author><author><name sortKey="Finlay, B Brett" sort="Finlay, B Brett" uniqKey="Finlay B" first="B. Brett" last="Finlay">B. Brett Finlay</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Michael Smith Laboratories and Departments of Biochemistry and Molecular Biology and Microbiology and Immunology, University of British Columbia</s1><s2>Vancouver, BC</s2><s3>CAN</s3><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, BC</wicri:noRegion></affiliation></author><author><name sortKey="Roper, Rachel L" sort="Roper, Rachel L" uniqKey="Roper R" first="Rachel L." last="Roper">Rachel L. Roper</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Brody School of Medicine, Department of Microbiology and Immunology, East Carolina University</s1><s2>Greenville, NC 27834</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of general virology</title><title level="j" type="abbreviated">J. gen. virol.</title><idno type="ISSN">0022-1317</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of general virology</title><title level="j" type="abbreviated">J. gen. virol.</title><idno type="ISSN">0022-1317</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviridae</term><term>Adenoviruses, Human (genetics)</term><term>Animals</term><term>Antibodies, Viral (biosynthesis)</term><term>Disease Models, Animal</term><term>Efficiency</term><term>Ferret</term><term>Ferrets (immunology)</term><term>Ferrets (virology)</term><term>Genetic Vectors</term><term>Humans</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Male</term><term>Microbiology</term><term>Neutralization Tests</term><term>SARS Virus (genetics)</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (pathology)</term><term>Severe Acute Respiratory Syndrome (prevention & control)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Severe acute respiratory syndrome</term><term>Vaccine</term><term>Vaccines, Attenuated (genetics)</term><term>Vaccines, Attenuated (pharmacology)</term><term>Vaccines, Inactivated (pharmacology)</term><term>Vaccines, Synthetic (genetics)</term><term>Vaccines, Synthetic (pharmacology)</term><term>Vector</term><term>Viral Vaccines (genetics)</term><term>Viral Vaccines (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adénovirus humains (génétique)</term><term>Animaux</term><term>Anticorps antiviraux (biosynthèse)</term><term>Furets (immunologie)</term><term>Furets (virologie)</term><term>Humains</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Poumon (anatomopathologie)</term><term>Poumon (virologie)</term><term>Syndrome respiratoire aigu sévère ()</term><term>Syndrome respiratoire aigu sévère (anatomopathologie)</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Tests de neutralisation</term><term>Vaccins antiviraux (génétique)</term><term>Vaccins antiviraux (pharmacologie)</term><term>Vaccins atténués (génétique)</term><term>Vaccins atténués (pharmacologie)</term><term>Vaccins inactivés (pharmacologie)</term><term>Vaccins synthétiques (génétique)</term><term>Vaccins synthétiques (pharmacologie)</term><term>Vecteurs génétiques</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenoviruses, Human</term><term>SARS Virus</term><term>Vaccines, Attenuated</term><term>Vaccines, Synthetic</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adénovirus humains</term><term>Vaccins antiviraux</term><term>Vaccins atténués</term><term>Vaccins synthétiques</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Furets</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Ferrets</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Vaccins antiviraux</term><term>Vaccins atténués</term><term>Vaccins inactivés</term><term>Vaccins synthétiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Vaccines, Attenuated</term><term>Vaccines, Inactivated</term><term>Vaccines, Synthetic</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Furets</term><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Ferrets</term><term>Lung</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Genetic Vectors</term><term>Humans</term><term>Male</term><term>Neutralization Tests</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adenoviridae</term><term>Animaux</term><term>Humains</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Syndrome respiratoire aigu sévère</term><term>Tests de neutralisation</term><term>Vaccin</term><term>Efficacité</term><term>Furet</term><term>Vecteur</term><term>Microbiologie</term><term>Syndrome respiratoire aigu sévère</term><term>Vecteurs génétiques</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although the 2003 severe acute respiratory syndrome (SARS) outbreak was controlled, repeated transmission of SARS coronavirus (CoV) over several years makes the development of a SARS vaccine desirable. We performed a comparative evaluation of two SARS vaccines for their ability to protect against live SARS-CoV intranasal challenge in ferrets. Both the whole killed SARS-CoV vaccine (with and without alum) and adenovirus-based vectors encoding the nucleocapsid (N) and spike (S) protein induced neutralizing antibody responses and reduced viral replication and shedding in the upper respiratory tract and progression of virus to the lower respiratory tract. The vaccines also diminished haemorrhage in the thymus and reduced the severity and extent of pneumonia and damage to lung epithelium. However, despite high neutralizing antibody titres, protection was incomplete for all vaccine preparations and administration routes. Our data suggest that a combination of vaccine strategies may be required for effective protection from this pathogen. The ferret may be a good model for SARS-CoV infection because it is the only model that replicates the fever seen in human patients, as well as replicating other SARS disease features including infection by the respiratory route, clinical signs, viral replication in upper and lower respiratory tract and lung damage.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Alabama</li><li>Caroline du Nord</li><li>Ontario</li></region><settlement><li>Hamilton (Ontario)</li></settlement><orgName><li>Université McMaster</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="See, Raymond H" sort="See, Raymond H" uniqKey="See R" first="Raymond H." last="See">Raymond H. See</name></noRegion><name sortKey="Brunham, Robert C" sort="Brunham, Robert C" uniqKey="Brunham R" first="Robert C." last="Brunham">Robert C. Brunham</name><name sortKey="Finlay, B Brett" sort="Finlay, B Brett" uniqKey="Finlay B" first="B. Brett" last="Finlay">B. Brett Finlay</name><name sortKey="Gauldie, Jack" sort="Gauldie, Jack" uniqKey="Gauldie J" first="Jack" last="Gauldie">Jack Gauldie</name><name sortKey="Karunakaran, Karuna P" sort="Karunakaran, Karuna P" uniqKey="Karunakaran K" first="Karuna P." last="Karunakaran">Karuna P. Karunakaran</name><name sortKey="Lawrence, David J" sort="Lawrence, David J" uniqKey="Lawrence D" first="David J." last="Lawrence">David J. Lawrence</name><name sortKey="Mok, Catherine P Y" sort="Mok, Catherine P Y" uniqKey="Mok C" first="Catherine P. Y." last="Mok">Catherine P. Y. Mok</name><name sortKey="Petric, Martin" sort="Petric, Martin" uniqKey="Petric M" first="Martin" last="Petric">Martin Petric</name></country><country name="États-Unis"><region name="Alabama"><name sortKey="Rowe, Thomas" sort="Rowe, Thomas" uniqKey="Rowe T" first="Thomas" last="Rowe">Thomas Rowe</name></region><name sortKey="Roper, Rachel L" sort="Roper, Rachel L" uniqKey="Roper R" first="Rachel L." last="Roper">Rachel L. Roper</name><name sortKey="Voss, Thomas G" sort="Voss, Thomas G" uniqKey="Voss T" first="Thomas G." last="Voss">Thomas G. Voss</name><name sortKey="Zitzow, Lois A" sort="Zitzow, Lois A" uniqKey="Zitzow L" first="Lois A." last="Zitzow">Lois A. Zitzow</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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