Severe acute respiratory syndrome vaccine efficacy in ferrets: whole killed virus and adenovirus-vectored vaccines.
Identifieur interne : 003088 ( Main/Merge ); précédent : 003087; suivant : 003089Severe acute respiratory syndrome vaccine efficacy in ferrets: whole killed virus and adenovirus-vectored vaccines.
Auteurs : Raymond H. See [Canada] ; Martin Petric [Canada] ; David J. Lawrence [Canada] ; Catherine P Y. Mok [Canada] ; Thomas Rowe [États-Unis] ; Lois A. Zitzow [États-Unis] ; Karuna P. Karunakaran [Canada] ; Thomas G. Voss [États-Unis] ; Robert C. Brunham [Canada] ; Jack Gauldie [Canada] ; B Brett Finlay [Canada] ; Rachel L. Roper [États-Unis]Source :
- The Journal of general virology [ 0022-1317 ] ; 2008.
Descripteurs français
- KwdFr :
- Adénovirus humains (génétique), Animaux, Anticorps antiviraux (biosynthèse), Furets (immunologie), Furets (virologie), Humains, Modèles animaux de maladie humaine, Mâle, Poumon (anatomopathologie), Poumon (virologie), Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Tests de neutralisation, Vaccins antiviraux (génétique), Vaccins antiviraux (pharmacologie), Vaccins atténués (génétique), Vaccins atténués (pharmacologie), Vaccins inactivés (pharmacologie), Vaccins synthétiques (génétique), Vaccins synthétiques (pharmacologie), Vecteurs génétiques, Virus du SRAS (génétique), Virus du SRAS (immunologie).
- MESH :
- anatomopathologie : Poumon, Syndrome respiratoire aigu sévère.
- biosynthèse : Anticorps antiviraux.
- génétique : Adénovirus humains, Vaccins antiviraux, Vaccins atténués, Vaccins synthétiques, Virus du SRAS.
- immunologie : Furets, Syndrome respiratoire aigu sévère, Virus du SRAS.
- pharmacologie : Vaccins antiviraux, Vaccins atténués, Vaccins inactivés, Vaccins synthétiques.
- virologie : Furets, Poumon, Syndrome respiratoire aigu sévère.
- Animaux, Humains, Modèles animaux de maladie humaine, Mâle, Syndrome respiratoire aigu sévère, Tests de neutralisation, Vecteurs génétiques.
English descriptors
- KwdEn :
- Adenoviruses, Human (genetics), Animals, Antibodies, Viral (biosynthesis), Disease Models, Animal, Ferrets (immunology), Ferrets (virology), Genetic Vectors, Humans, Lung (pathology), Lung (virology), Male, Neutralization Tests, SARS Virus (genetics), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (prevention & control), Severe Acute Respiratory Syndrome (virology), Vaccines, Attenuated (genetics), Vaccines, Attenuated (pharmacology), Vaccines, Inactivated (pharmacology), Vaccines, Synthetic (genetics), Vaccines, Synthetic (pharmacology), Viral Vaccines (genetics), Viral Vaccines (pharmacology).
- MESH :
- chemical , biosynthesis : Antibodies, Viral.
- genetics : Adenoviruses, Human, SARS Virus, Vaccines, Attenuated, Vaccines, Synthetic, Viral Vaccines.
- immunology : Ferrets, SARS Virus, Severe Acute Respiratory Syndrome.
- pathology : Lung, Severe Acute Respiratory Syndrome.
- chemical , pharmacology : Vaccines, Attenuated, Vaccines, Inactivated, Vaccines, Synthetic, Viral Vaccines.
- prevention & control : Severe Acute Respiratory Syndrome.
- virology : Ferrets, Lung, Severe Acute Respiratory Syndrome.
- Animals, Disease Models, Animal, Genetic Vectors, Humans, Male, Neutralization Tests.
Abstract
Although the 2003 severe acute respiratory syndrome (SARS) outbreak was controlled, repeated transmission of SARS coronavirus (CoV) over several years makes the development of a SARS vaccine desirable. We performed a comparative evaluation of two SARS vaccines for their ability to protect against live SARS-CoV intranasal challenge in ferrets. Both the whole killed SARS-CoV vaccine (with and without alum) and adenovirus-based vectors encoding the nucleocapsid (N) and spike (S) protein induced neutralizing antibody responses and reduced viral replication and shedding in the upper respiratory tract and progression of virus to the lower respiratory tract. The vaccines also diminished haemorrhage in the thymus and reduced the severity and extent of pneumonia and damage to lung epithelium. However, despite high neutralizing antibody titres, protection was incomplete for all vaccine preparations and administration routes. Our data suggest that a combination of vaccine strategies may be required for effective protection from this pathogen. The ferret may be a good model for SARS-CoV infection because it is the only model that replicates the fever seen in human patients, as well as replicating other SARS disease features including infection by the respiratory route, clinical signs, viral replication in upper and lower respiratory tract and lung damage.
DOI: 10.1099/vir.0.2008/001891-0
PubMed: 18753223
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pubmed:18753223Le document en format XML
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<term>Animals</term>
<term>Antibodies, Viral (biosynthesis)</term>
<term>Disease Models, Animal</term>
<term>Ferrets (immunology)</term>
<term>Ferrets (virology)</term>
<term>Genetic Vectors</term>
<term>Humans</term>
<term>Lung (pathology)</term>
<term>Lung (virology)</term>
<term>Male</term>
<term>Neutralization Tests</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (immunology)</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
<term>Severe Acute Respiratory Syndrome (pathology)</term>
<term>Severe Acute Respiratory Syndrome (prevention & control)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Vaccines, Attenuated (genetics)</term>
<term>Vaccines, Attenuated (pharmacology)</term>
<term>Vaccines, Inactivated (pharmacology)</term>
<term>Vaccines, Synthetic (genetics)</term>
<term>Vaccines, Synthetic (pharmacology)</term>
<term>Viral Vaccines (genetics)</term>
<term>Viral Vaccines (pharmacology)</term>
</keywords>
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<term>Animaux</term>
<term>Anticorps antiviraux (biosynthèse)</term>
<term>Furets (immunologie)</term>
<term>Furets (virologie)</term>
<term>Humains</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Poumon (anatomopathologie)</term>
<term>Poumon (virologie)</term>
<term>Syndrome respiratoire aigu sévère ()</term>
<term>Syndrome respiratoire aigu sévère (anatomopathologie)</term>
<term>Syndrome respiratoire aigu sévère (immunologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Tests de neutralisation</term>
<term>Vaccins antiviraux (génétique)</term>
<term>Vaccins antiviraux (pharmacologie)</term>
<term>Vaccins atténués (génétique)</term>
<term>Vaccins atténués (pharmacologie)</term>
<term>Vaccins inactivés (pharmacologie)</term>
<term>Vaccins synthétiques (génétique)</term>
<term>Vaccins synthétiques (pharmacologie)</term>
<term>Vecteurs génétiques</term>
<term>Virus du SRAS (génétique)</term>
<term>Virus du SRAS (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenoviruses, Human</term>
<term>SARS Virus</term>
<term>Vaccines, Attenuated</term>
<term>Vaccines, Synthetic</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adénovirus humains</term>
<term>Vaccins antiviraux</term>
<term>Vaccins atténués</term>
<term>Vaccins synthétiques</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Furets</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Ferrets</term>
<term>SARS Virus</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Vaccins antiviraux</term>
<term>Vaccins atténués</term>
<term>Vaccins inactivés</term>
<term>Vaccins synthétiques</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Vaccines, Attenuated</term>
<term>Vaccines, Inactivated</term>
<term>Vaccines, Synthetic</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Furets</term>
<term>Poumon</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Ferrets</term>
<term>Lung</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Models, Animal</term>
<term>Genetic Vectors</term>
<term>Humans</term>
<term>Male</term>
<term>Neutralization Tests</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Humains</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Tests de neutralisation</term>
<term>Vecteurs génétiques</term>
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<front><div type="abstract" xml:lang="en">Although the 2003 severe acute respiratory syndrome (SARS) outbreak was controlled, repeated transmission of SARS coronavirus (CoV) over several years makes the development of a SARS vaccine desirable. We performed a comparative evaluation of two SARS vaccines for their ability to protect against live SARS-CoV intranasal challenge in ferrets. Both the whole killed SARS-CoV vaccine (with and without alum) and adenovirus-based vectors encoding the nucleocapsid (N) and spike (S) protein induced neutralizing antibody responses and reduced viral replication and shedding in the upper respiratory tract and progression of virus to the lower respiratory tract. The vaccines also diminished haemorrhage in the thymus and reduced the severity and extent of pneumonia and damage to lung epithelium. However, despite high neutralizing antibody titres, protection was incomplete for all vaccine preparations and administration routes. Our data suggest that a combination of vaccine strategies may be required for effective protection from this pathogen. The ferret may be a good model for SARS-CoV infection because it is the only model that replicates the fever seen in human patients, as well as replicating other SARS disease features including infection by the respiratory route, clinical signs, viral replication in upper and lower respiratory tract and lung damage.</div>
</front>
</TEI>
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